Another View of the Endocannab…d System with Dr. Robert Quinn
Tue, Oct 24, 2023 4:53PM • 1:46:07
SUMMARY KEYWORDS
cbd, thc, endocannabinoids, people, endocannabinoid system, type, cannabinoids, terpenes, talked, receptors, call, plants, cannabis, product, slide, good, studies, phyto cannabinoids, psilocybin, pain
SPEAKERS
Bill Clearfield
00:38
Hey Rafeal
Bill Clearfield 01:40
Well just hang tight and we’ll we’ll be with our friends soon. So you missed me right yeah. Go on for two whole days. I know
02:13
will the other doctor come back? Which one?
02:17
The one that was going to speak tonight about natural.
Bill Clearfield 02:20
Yeah, yeah. Yeah she just wasn’t feeling well. She wasn’t she got a sore throat or a virus or something. Yeah, she’s been on she’s, she’s on a lot. So,
02:30
okay
Bill Clearfield 02:34
I got somebody texting me they want the link. So let me go get that okay.
02:41
In fact here she is
03:04
Dr. Patel
03:15
I hope you’re feeling better. Why isn’t ringing What’s that? Oh, I thought I turned my phone off. How are you Johnny D besides muted? Yeah.
03:38
Happy to see you and the rest of the crowd a bunch of good stuffs happening. So you and I need to talk a little bit. Okay. And I’m also dealing with Are we recording now? Not yet. Yeah. So I’m also dealing with our stem cell experts and I’m trying to plug that into the Caribbean so we can do research out of the country. And that ties in with our medical school wanting to do research with us and deal with such experts as Bill clear field. All these other guys in this group.
Bill Clearfield 04:15
They know that we’re our names muddy with with the AOA.
04:19
Yeah, they admire you and love you but they don’t want to associate their name with you. They only refer to you and about 10 others as the experts in integrative medicine and that includes a few things they don’t want to touch. That’s homeopathy, that bioidentical hormones, verbal acupuncture, you know, so they don’t want to dirty their name and lose their you know, job which makes a lot of money man. So that would be stupid like we are and keep telling the. So we’re the fall guy. We’re the fall guy. They’re referring to last few people as the experts.
Bill Clearfield 05:01
Okay. You know, again, kicking around, you know, alternative names for our group and I didn’t do that. I didn’t do that. Day. I
05:17
did it for you.
Bill Clearfield 05:21
We don’t want to record just yet. So shut it off. How about the alliance of misinformation? Yeah, might as well you know, you know, they’re gonna we’re gonna get accused of it. We might as well embrace it.
05:38
Wow.
05:40
I have to admit, I talked to the some of the top people in the science recently and things like stem cells. And I would they were completely shocked to hear what I had to say. And I was completely shocked that they had no idea what’s going on with you know World Politics war murder all that shit. As they didn’t have a close like wow, that’s okay. It’s way it is an IBM being they’ve just had no exposure.
Bill Clearfield 06:10
Well, you know us you stick your stick your head in the stem cell world and don’t don’t poke out of it and until they come come with with guns blazing.
06:22
News, News watchers, they watch the news. That’s where they get all their
06:26
information. On Monday I the information I had the stem cells are totally legal. Everything’s fine. Don’t worry about it. Everything’s cool. And then the next day I hear totally illegal. You can’t do it. Yeah. So different people saying different things right and doesn’t know what the left hand is doing. But those who are trying to do research, we can do the research not in the United States, but we can do the research out of the United States and then we have something to stand on.
Bill Clearfield 06:56
Right. So anyway,
07:02
going back to coin is here, but it’s the same with cannabis. There’s no proof because there’s no research allowed and we get in the same situation with a lot of these things.
Bill Clearfield 07:15
Are you can tell he can tell he’s serious tonight. He’s got a shirt on. So it’s part of the dress code. I apologize for the confusion this week. Though. We were supposed to have Dr. Patel on but she’s under the weather so we we got Dr. Quinn to jump in as it last minute.
07:43
coming off the bench. Yeah,
Bill Clearfield 07:45
coming off the right. So we’ll get with Dr. We’ll have Dr. Patel in next month. And we’ll take it from there. We also have Dr. ruddy was it was it was also available today too. But so a plethora of riches for you know, as the as substitutes. So, yeah, that’s that’s good. So it’s about five o’clock.
08:14
So Dr. Quinn,
08:16
yeah. Okay, so let’s see. So, I pull up the thing and and share screen right right.
Bill Clearfield 08:23
I should show you your shell you you’re you’re just desktop there, hit Share, and then you should be good to go.
08:35
Out we’re ready to record right.
08:36
Yeah, yeah, yeah, well, we will be since I figured out what I’m doing. Here. I bring up the PowerPoint and usually it’ll tell me where to share screen
Bill Clearfield 08:46
but I don’t see it. At the bottom there it should there should be a green thing that says Share Screen.
08:52
Yeah, sure should be I
08:58
see it all the time. Whenever I join these things and I just don’t see it on mine.
09:03
Mm hmm.
Bill Clearfield 09:10
Um, anybody have any idea
09:14
huh?
09:17
Yeah. I don’t know why it’s not doing that. Stand Alone. I’m going through all these little doggone icons down here.
Bill Clearfield 09:24
Right should be 1234
09:27
the six left is it at the top of the screen if you like scroll up and bring something down. That’s using Apple
09:37
checking that too and I just don’t, I just don’t and again, every time I come on one of these things, and I and somebody’s got their presentation going my boss always says Share Screen.
09:51
Yeah. It’s in between the chat start summary.
09:56
Yeah, yeah, I see it all the time, except online. All it’s showing me is you know, you have your various things open. That’s what it’s showing me at the bottom.
10:08
Wow. Anybody know if you have to sign it,
10:11
women, women well, let me go back one step back and see what they got. Move your cursor to the screen you will pop up Am I getting close to closer? Yeah, yeah. You’re there. Okay.
Bill Clearfield 10:29
Static ballots.
10:31
Okay. Is that Is that okay? Right there because I’ve got all these little thumbnails on the left. Does that matter?
Bill Clearfield 10:37
If you rather them there if not go to slideshow and then go to go here. Show and then it’ll take you to save start at the beginning and it will take the whole screen.
10:46
You know what I don’t mind doing this if nobody else minds, because every now and then when when I’m listening to something. Then the slide goes on. It’s like, oh, I missed one point from the slide back. Right. So just in case, you know, as long as it doesn’t bother anybody, we can focus on the center. I’m good.
Bill Clearfield 11:06
Well, you know how to duck Burgesses, you know?
11:10
I mean, I’m easy.
11:12
Oh, okay. You know, Joel is the one I worry about, but you know, what can I say?
11:17
Yeah, yeah,
11:19
it’s the beard. Okay. Um, shall we shall we jump in here, jump in. All right, as long as you can hear me, it’s good. Okay. There’s a couple of things that I’m going to say in the very beginning here. First of all, I love this topic, and I love doing this thing. And as a consequence, I probably have five or six different presentations that I’ve given to different groups. And when Dr. Clearfield asked me to do this, what I tried to do was snagged some things that I thought were appropriate for this from various things. So you’ll see different style slides. That’s all I’m about to say. And then based on the history of what I’ve done, where I’ve been what I’ve been doing, you’re gonna see some that are called Kohana. That was our compounding pharmacy and Regenerative Medicine Center. We operated in San Luis Obispo for about 12 years where a lot of this came from a lot of the research came out of there and everything so please don’t let that dissuade you in any way. What we
12:22
really figured out
12:25
was that yeah, we need homeostatic balance balances everything. And then when when the big information hit about the endocannabinoid system all they talked about was endocannabinoid balance and then putting everything together, all the research and papers and podcasts and everything kind of indicated. This is something that is pretty important to us. So homeostatic balances that is definitely the key to life. And the endocannabinoid system, kind of regulates or governs just about every system. I do want to give some credit here to some of the people that I think are phenomenal in this industry. The upper left is Dr. Raphael, Ms. Shulam, who Dr. Block mentioned last week and I want to give Dr blocked a lot of credit for the presentation that he gave you saved me a son a ton of time, not having to go into some of the old details and the laws and all that kind of stuff. And of course, speaking of the laws, I’m just going to say right now everything’s illegal. And then that way nobody gets in trouble. Okay. So as he said, Be careful if you if you’re in a state that allows this watch out for the federal government. I’m going to show you one of the most interesting things that you’ve never heard as we go along here. Speaking of regulatory agencies, FDA state boards, it strikes me as unbelievable, and when I get to that slide, I’ll probably break into a sweat. But anyway, Dr. Maas, Shulam has the upper left and the upper right is Dr. Ethan Russo, who I refer to as the American father of cannabinoid medicine, and then on the lower part, many of you will recognize Dr. Dustin Souillac. I think he’s clinician supreme. If you ever listened to Him, LISTEN to His podcasts, have his products, anything like that. I consider him one of the world’s foremost authorities in the treatment aspect of this obviously Dr. Maha Shula was research. Dr. Russo is that way too. I don’t think either of them have quite the practice and the knowledge that Dr. Souillac does. And he’s a member of society of cannabis clinicians, one of the leaders there, which I’m a member as well if you need any more information on cannabinoid medicine and treatment. That is a phenomenal place to go. And then Dr. Russo said very simply the endocannabinoid system regulates regulation. Okay, well, what does this mean? How does it do this? Well we want to balance and we want to optimal health. And this slide is the as it says, The Kohana wellness to all of the aspects that we feel need to be balanced for health. You’ll notice on here that these arrows and these arrows actually do mean something. Some of these things go both ways. Some of them are only one way, but if you notice on the right hand side, building the endocannabinoid system is as going both ways with detox and homeostatic balance and all of that if you look at supplementation there’s not really anything here that boosts supplementation, that’s just something we got to do. Okay, and then here are the systems 12 systems that seek homeostasis and on the top, you know, I pointed down there to the endocannabinoid system. This is where we can actually see effects of our endocannabinoids as well as phyto cannabinoids, which obviously mean they come from plants. On all of these systems, everything from endocrine to digestive, reproductive, cardiovascular, everything is touched by the endocannabinoids. And as an example of this, and homeostasis, human body’s really adaptable, extremely adaptable, and you can see there with the gentleman I don’t know what he’s doing, whether he’s fishing or without side of an igloo, you know, extreme cold, right blood thickens, heart rate slows, metabolism slows, we adapt to that kind of thing. And then of course, on the lower right, yeah, we adapt to that to fight or flight type of thing. digestion slows, heart rate increases, pupils, dilate, all of that kind of stuff. One thing I think I found out recently that I guess everybody knew except me is that when you’re in the fight or flight type of thing, your blood is able to coagulate faster, in case you get bid, I did not know that. Right? Now when it’s over at the very bottom when it’s over, everything goes back into balance. How does that happen? You don’t run out of adrenaline it doesn’t fall out of your body and if another you know animal comes at you, you’re gonna get another boost. of adrenaline. Right? It’s just It doesn’t actually completely go away or dissipate or get used up. What happens is the endocannabinoid system kicks in and starts to balance you back to the way you were. And this is how it is back to back when the adrenaline Yeah,
17:21
can erupt real quick. So know a lot of the veterans combat veteran specifically and a lot of the responders first responders after they go into extreme situations and they come out and they slow back down. Quite a few of them have heart attacks or strokes because that system doesn’t actually balance out. I’m wondering if the CBD would keep that from happening.
17:46
It can and Joel, that’s great. Thank you for the transition into my next slide, because that’s exactly what I’m showing here. But anyway, so let me let me cover this one and then we’ll hit that so when you go back into balance, right the endocannabinoid system, its regulatory. It was discovered in the 1990s, as Dr. Block mentioned by Raphael was Shulam. And as he mentioned, he I think he kind of proposed it and then others took off on it. Dr. Russo Ethan Russo jumped on that thing and then talked about the entourage effect. And then I went, what I find interesting is that it’s in almost all animals, I think they say except for sea squirts, or something really weird like that, and you’re born with it. And it’s there. Even if you’ve never even heard of cannabis. You have an endocannabinoid system and we’d be dead without it. What I like to have people think about is something rather amazing to me is that if we’re born with an endocannabinoid system, and we have endocannabinoids, then and our bodies know how to handle these, obviously why? Is it that sometimes people are against using cannabinoid medicine and pregnancy? I mean, we all panic, we all jump into lots that’s got to be a Class C can’t do it. Right? Well, you know, there are some things coming out that say maybe you can and if somebody has intractable seizures or something like that, that’s gonna cause you know, an abortion type of situation. Maybe you got to do that or nausea, you know, throwing up completely all of the time. Maybe this is an answer to it. And again, just to get you to think, why can’t we augment that in in mothers? I don’t have that answer. Joel, here’s your slide. Okay. So memory and stress, and we depend upon this for balance, but we don’t always get it. Now, if you look on the pictures on the right, there’s your picture of a highly stressful situation in combat. Okay. And the picture on the left I think is New York City downtown. And this is what is pretty cool about what the endocannabinoid system does, is it helps you forget, it helps you forget. So if you’re walking down the street on this busy street, and you look around and you see cars and you see buildings and you see lights and you see people and you see dogs or whatever you see, right? You do not memorize everything that you saw the endocannabinoid system allows you to be selective and to forget, and as Joel mentioned, over here on the right with the combat, that’s what we want, in a lot of cases to happen. We don’t want those memories that may be burned into the brain, and there are a lot of different studies out almost as many studies as there are theories on how CBD and I’ll generally say CBD and I mean cannabinoids how this may help this type of situation. And it’s there’s a lot of experimentation done on this Joel and a lot of people have got tremendous success. I think that if we combine this with psycho mimetic or whatever you want to call these kinds of things, this type of medicine, it’s more or less powerful on the brain, whether we talked about psilocybin you know, and five HT to a receptors of a serotonin receptor that psilocybin hits. CBD also hits that receptor. And then so MDMA, you know, for PTSD, there are a lot of things that are coming out right now that I say coming out, they’ve been in research for decades. And now I think we as a people are starting to realize that there might be some better things that are there that we might be able to take advantage of. And there are a lot of studies going on with this. When I mentioned in the beginning, watch out for the illegalities. That of course is the catch 22 federally illegal so it’s hard to get supply. It’s hard to get approved to do a study. And from what I understand, I haven’t tried this. They say that if you want to get approved for a study, whether it’s NIH or somebody and you want grants, you have to call it marijuana and we can get into where that name came from. Right and I refuse to use that that’s that’s derogatory and racial. And then you also probably better have in there’s something about you don’t think it works. And you got a chance of getting the study funded now. That’s hearsay. I have not done this myself. But it makes sense to me and the people that I’ve talked to have kind of, you know, to shake their head and say, yeah, that’s pretty much it. Okay. Now this stress management thing is really pretty cool. If you look in the in this box and these stupid little arrows, this is something that I did because I’m bad at this. But if you’re giving a presentation, okay, and if you see on the bottom left and you’re at presentation number one, right? Your endocannabinoid system is kind of low and your cortisol right? Your stress management system is pretty high. Right? Okay, so the second time you do it, presentation number two, your endocannabinoid system is kind of aware of what is happening. And so it gets higher, and your stress seems to be a little bit lower. By the time you get to the third one, you can see what’s happening, right? Your cortisol before the thing gets lower. If the third time you give a presentation, you can actually eat before you get it, give it whereas in the first time, there’s no way you’re going to be able to eat You’re too nervous. Okay, and then by the time we get to the fourth one, everything is normal. Everything is balanced out and you probably don’t even feel as much adrenaline as you did the first time. This is how the Endocannabinoid tone comes in. And that’s a very critical type of term endocannabinoid tone. Alright, now the endocannabinoid system itself, they say is ubiquitous, is pervasive. And it’s critical and plays a key role in many nervous system functions. And I just picked a couple here out of that, a crazy chart that had 12 of them and nervous system and check this out. I mean, everything from pleasure all the way down to you know to pain integration of the of the senses, but notice the second one is memory and forgetting, okay, and neuroplasticity, which is really a big buzz thing happening now and all the things that we can do to maintain our cognition through neuroplasticity, this also helps and then the immune system like gene transcription, all of these other things and and pro inflammatory cascades, tons of stuff for the immune system and when you’re when you’re helping the immune system I think you’re also kind of hand in hand. You know, it’s one of those reversible arrows with the immune system. And and as far as, oh, I guess you’d say anything that kind of causes an inflammatory type of response. Now features of the endocannabinoid system. There are three parts. That’s it, okay. And boy, is it complex and confusing. We’ve got the receptors.
25:24
And then we have the lions and the receptors. Most common you notice a CB one, CB two and now CB three, they’re talking about individual ones in the brain. And these are the ones that people talk about. I have a slide here that shows you there must be dot 30 different types of receptors. This is what is known as a promiscuous type of substance whether it’s our endocannabinoids or phyto, cannabinoids, a touchy everything, you just can’t limit it to one thing, right? So, those are the ligations. Now, the arachidonate waggons most common are a which is a record Donald F and olamide, otherwise known as anandamide, and then to AG which is to record Donald glycerol, right. And then the one in green here, PA. If I don’t cover this enough, I will be angry with myself because through the research that I’ve done for a number of years, this is one of the most fantastic products, molecules, chemical compounds, supplements, whatever you want to call it, Pullmantur left and dolomite. It is phenomenal and everybody can benefit from this type of thing. And then the last part of it the third part of the enzymes which which make them and break them a they’re make, they’re responsible for making the ligands or breaking them down and somatically and then the balance of all this again is referred to as ECS tone. And then when you have decreases in the tone that gives you a host of physiological problems, and then it has been categorized and characterized as endocannabinoid deficiency syndrome. Now since we’re talking about syndromes right here, I’m going to touch a little bit. I don’t have slides on this but just a little bit because Dr. Block mentioned this, the hyperemesis syndrome right and that’s due to THC, and that’s not most people that are on this call. Can’t say completely. This generally comes from people who do high dose THC routinely over a long period of time. And as he mentioned, the crazy thing is the only thing that seems to stop that is getting in the shower. I don’t even I mean, Dr. Russo has gone into a lot of deep dive into how that works and all that kind of stuff. And I say there’s a very small percentage of that. But as we all know, negative publicity sometimes carries the day. And once they discovered this, that oh, that’s all some people needed to say, Oh, it’s a bad drug. I think you’re going to have to try to get that. That’s that’s where I truly believe you’re going to have to use a lot of THC over a long period of time routinely. To try to get that type of thing is just not that easy. And it’s not that prevalent. And the treatment is or the answer is you have to stop. There’s no such thing as going away and not coming back as far as I’ve read in literature. You have to stop and you’re done. And that’s that’s horrible for a lot of people out there and we don’t need to go into that type of thing. Let’s see. The receptors in the endocannabinoid system are the most abundant protein receptors in the human body. There are more CB receptors in the brain than any other combination of receptors in the entire body. The second most prevalent area for CB receptors is the uterus and that is why
29:03
cramps can be relieved
29:07
through phyto cannabinoid use. I’ve got a stepdaughter with this personal experience. It’s unbelievable. Just unbelievable. I you know you don’t want to go to ER and you know, get shots at Demerol or whatever they’re doing nowadays in there. That’s just not the answer. This has really really helped. Okay, features of the endocannabinoid system. And here are the chemical structures of the two main endocannabinoids right anandamide, to ag and notice these are the things that I just had talked about the three separate parts of the system, the end at the endogenous ligands. And then here’s where some of the receptors are that these things hit. And then here’s some of the enzymes that will decorate them. The one that’s most popular as they call it, FDA FA H has folic acid and amide hydrolyze. Sometimes they mess that up sometimes, but that’s the main one that that kind of breaks these down.
30:05
And notice
30:09
the similarities and structure here. I know we’re all chemistry majors like me, so we appreciate these
30:14
structures.
30:18
Here’s a little slide here, which is showing pictures of I think it’s kind of neat, the post synaptic nerve and presynaptic nerve areas. This is what is critical to understand two main things here. Most of our neurotransmitters go pre synapse to post synapse, right very, very obviously, you stick a pin in your finger pain is in the brain you feel that the nerve transmission goes you know from your finger to your spinal cord to your brain back and says you know, ouch don’t do that. Now, the endocannabinoid system and this is endocannabinoids and phyto. Cannabinoids work in a retro grade manner. First of all, they are not stored in vesicles like our neurotransmitters, our neurotransmitters are stored and they are released bangles really fast. And as we all know, it’s not always a regulated type of thing. Someone can scare you and either, you know, your adrenaline flies and maybe it’s way over what it should be. And it may take you a few minutes to calm down even though you know what it was. You can you can cognate on that and say, Well, you know, it shouldn’t be that bad, but man, my heart’s still beating. Alright, so what brings it back? The endocannabinoid and how does it do that it works retrograde? It goes from the post synapse to the presynaptic area to stop the release or at least inhibit the release of the neurotransmitters. The big difference is this. Our endocannabinoids are not stored. They’re made on demand. Right? So if you have pain, something like that, that is where the endocannabinoids are going to work. Most prevalently they’re not going to be inhibiting your digestion or promoting your digestion at that time. Right. I hope I’m clear on this that these are site specific they are not stored the endocannabinoids and are subject to this pattern. The phyto cannabinoids and I cover this again in another slide. The phyto cannabinoids are not right. Whether it is CBD or THC or CBD and CBG or C you know any of these things. These cannabinoids go everywhere. And that is my answer to when people say, Well, this is just hocus pocus. I mean my neighbor, you know, uses CBD for pain. My other neighbor menstrual cramps. My friend uses it for irritable bowel syndrome. Oh wait a minute seizures. Oh, come on. How can it do that? Well, we’ve got these receptors all over our body and the phyto cannabinoids are indiscriminate. They go everywhere and they act where where they’re needed. And I think that’s really important. And also the other important thing is, as far as I know, now, there is no way to measure the amount of endocannabinoids that you have unless you do some type of a lumbar puncture, or something like that, which they don’t allow that here. It’s my understanding that some countries during their experimentation stuff will allow this to measure levels of anandamide. I don’t know that for a fact. I just know that we cannot do that here. So if somebody has an endocannabinoid deficiency or deficiency syndrome, it comes up as list of symptoms and we have a whole slew of things that we use to treat this type of thing. And guess what? It’s just like everything else right diet exercise, detox supplements. The whole thing, right? All that boosts the endocannabinoid system. When I was talking about the receptors and that type of thing, here’s a little list of some of the things that it is that it hits. Okay, including Cox two and all of these people or people are gamma and all of these different things, the trip fees, everything. It’s, again, it’s a promiscuous type of situation. It’s just it’s not really readily discernible to say, here’s the only action that it has and that’s probably why it does so many things. Then here’s another one of these slides for people that like this kind of thing. And then you can notice on the right that folic acid amide hydrolase, the FDA enzyme breaking these things down. I won’t spend too much time on that. This I think is important, and that’s the endocannabinoid deficiency syndrome. And the thing that I find interesting, it can be congenital or acquired. They I think we’ve all heard of these cases where somebody doesn’t feel pain there was a famous case out of the UK of a woman who didn’t feel pain and they were scared to death. You know that she was going to hurt herself and wish she did and didn’t know that she could break a bone and wouldn’t feel it burners that wouldn’t feel it. I believe she has since passed away. But apparently, it was an over abundance of anandamide, which blocked all the pain receptors. Right? So this can happen and that’s why I put it here. It can be congenital or it can be acquired through the deficiency syndrome. And then most of the disease states are marked by these type of things right here mood imbalances, stress related disorders. When we talk about stress and anxiety, I want to point out here that the prevailing attitude is that CBD alone CBD isolate it can be effective for anxiety. Other than that, you’re going to find that it requires pretty much the entourage effect, or at least full spectrum cannabinoids, that one of them by themselves is not going to be therapeutically valuable. It takes the whole group and then contributory factors here age, gender, menstrual cycle, diet, all of these things that we know about lack of sleep, stress, all of these things that are pounded into our heads on every lecture that we hear that we need to take care of this type of thing at the bottom these maladies proven to be directly related to the deficiency syndrome, migraine, fibromyalgia and irritable bowel syndrome. Are some that if you if you read any of the studies put out by Dr. Russo. His famous one is called taming THC. Phenomenal, phenomenal paper, and it’s older than you believe. But it’s got tremendous information in there. And where I think he goes into these types of things where the this is, quote unquote been proven as much as we’re gonna get proof on it that it works and then endometriosis. Okay, can help with this as well and that and that’s just cells Gone Wild, right? I mean, they’re, they’re cells that have escaped the uterine cavity and gone into the gut and all of this and we have tremendous diversity of symptoms. That ladies have the is very difficult to diagnose. You can’t tell what it is in a lot of cases. And so it can be endometriosis, and it’s proposed that cannabinoids will help in that situation. Now when I mentioned how do we treat this the deficiency syndrome and this is the stuff that we know that we hear about that we do all the time, right heel to get UK prebiotics, probiotics, you know eat right avoid pro inflammatory foods eat good fats omegas right the proper omegas exercise muscle is the currency of longevity. I think that if we go back to caveman days, that the most important thing that we had was muscle. If you didn’t have it, you didn’t eat. You couldn’t catch anything. You couldn’t do anything. Right so over the evolutionary period, we know that we need to exercise and have muscle and what does that do? It also boosts the endocannabinoid system, and then Family Health. And what this basically is is is not a genetic type of thing I have your like eye color, you know endocannabinoids I can do anything with that. But you have to be mindful of unhealthy habits that you have. That would be I guess, watching NFL football on Sunday in your easy chair and eating popcorn and bonbons and not getting up. That is a pretty unhealthy type of habit that probably will contribute to the deficiency syndrome. And then of course sleep there’s so much stuff out now on sleep, it’s unbelievable to balance everything. And then cannabis as a supplement we can use and I put here consider the use of right because we are we’re dancing that legal line where sometimes we can get into hot water. If we recommend too strongly something like this. And if you step back and you take a look at why.
39:56
Well, if these things didn’t work, then they wouldn’t worry about people recommending them or people using but since they work, now they’re worried about it. So that’s how you get in trouble. Okay, and I think we all we all know what that that’s like with the regulatory agencies and that kind of thing. Okay, but for the right person in the right set and setting. endocannabinoid boosts with the phyto cannabinoids can be a very helpful thing. Let’s leave it at that and then treating the endocannabinoid deficiency syndrome. And here’s the little little molecules of what happens here. Keep in mind and this is important to show the yellow highlighted the THC is stronger binding affinity for receptors than anandamide does, it will knock those things out of those receptors. And if I don’t say it in the future, somewhere I will tell you right now THC binds to receptors CBD does not it is a negative allosteric modulator. It modifies the receptor site and can cause inhibition of THC binding. And so some people if there’s if they take too much THC, some people will actually try to take a lot of CBD to lessen the effect of the THC. And that brings up the point when there are therapeutics here and people who are cannabis naive and they take oral products. The onset of action is very slowly Dr. Block covered this last week. onset of action can be 30 minutes to an hour and people get into trouble for two reasons. They don’t think it’s working and they take too much and then the second reason is that when you ingest THC orally, it is broken down into delta nine THC is what we’re talking about. It is broken down into 11 hydroxy THC which is stronger than delta nine. So your psycho type of effects are going to be enhanced even more the intoxicating effects we’ll call it, we’re going to be enhanced even more and that’s why sometimes people get into a little bit of problems taking oral if they don’t know what they’re doing. And one of my slides here I have if this is recommended to anybody Well, we suggest that you get a professional type of help. And I’m not really talking about bud tenders, or as Dr. Sue let calls them dispensary agents. I’m not talking about that I those people worry me because you know a patient who may need a CBD type of thing can go into a dispensary and say, you know, I take vaso tech, is it okay if I take CBD and you go, Oh my God, this this this naive person is going to answer this question. You know, so that kind of scares me so I think people should seek professional type of input. There’s a strong pharmacy groups that provide this type of information for free. They go through the polymorphisms you know, the cannabinoids are are what is it SIP three, a SIP to C Nine are the enzymes that regulate these. And if you certain medications, you have that problem as well. So there can be interactions there. Some of the interactions are, as we say theoretical drug drug interactions, some of them do exist and some of them are not real powerful. But should be noted. And here’s my favorite one. This is on the left and Olamide is produced endogenously and exogenously poems, egg yolks, soy and the structure and I will show you the structure of this. It is looks more like anandamide than the cannabinoids do. And it’s synthesized by all of our cells, and it’s produced in high levels during stress to the body, and it influences the endocannabinoid system receptors and it doesn’t bind directly, but it enhances the endocannabinoid system activity. And it can reduce mast cell activation, right which I think there’s a lot of information coming out on mast cell activation, and P AE can actually help with that type of situation and neuro protection, pain relief, anti inflammatory, and it stimulates people receptors and it is a direct flaw inhibitor competitive binding is greater than anandamide, that and then it has direct action on the so called CB three or the G protein coupled receptors. GPR 55 GPR 55, I think is involved in in cancer, but I’m not really
44:43
too two versed in that.
44:47
Okay, and then here’s the structures of of anandamide and PE. I mean, these are incredibly similar. I mean, look at and the lower left, Delta nine tetrahydrocannabinol is not even close. It’s not even an enantiomer even when the when the carbons twist and all these things you know, we can’t think of these things as two dimensional or three dimensional and and they end up planar type of structure the benzene ring generally is tilted and that does not look anything like anandamide. However PE A sure does there there are no ring structures in it. No saturated benzene ring structures. So this stuff can really help augment the endocannabinoid deficiency syndrome. Just as a little plug here, we put this in the products that we make and it’s our little secret thing. And I always dare people out there these other CBD manufacturers Yeah, give it a try. Try to put that in there. This stuff does not play nicely with things. It is hard to incorporate. But it is so valuable. Okay. Moving on with this. Don’t pay attention to thing on the right that Kohana prison thing. That’s corporate stuff, but misconceptions cannabis is good for everyone and everything. That’s just not true. The other one is CBD that’s the good cannabinoid THC is the bad one. That’s that’s wrong. CBD is the driving force. No, it is not the driving force as they say THC drives the bus and all the other endocannabinoids are helping. Right? Cannabis has no side effects that is not true. And then isolate and this is the big one in the market today. CBD isolate, they love to put they love to put THC free, right CBD isolate will CBD isolate is extremely weak, I think of it in this 10 of terms. CBD if you look at a certificate of analysis or you do any kind of chemical analysis of a plant, and you look at the phyto cannabinoid components of this plant you’re going to find that most of the time CBD will be dominant unless it’s been bred out. And why is that? Why did nature do that? Because CBD is a weak molecule in order to balance that plant and remember the plant produces these things for itself, not for us. It produces these things to ward off, you know, bugs and then also terpenes to get out there and the smell and it brings in pollinators it does everything for itself. Okay, so when when we talk about the chemical constituents of these plants, CBD is pretty weak. It requires a lot to balance that plant. Hence it requires a lot if it’s being extracted to produce therapeutic effects and I think most of us know that that the first CBD was done by GW Pharmaceuticals who is now called Jazz and they came up with EPI dialects for seizures for Gervais syndrome and Lennox Gaston syndrome in children. Until that stuff came out I don’t think I ever heard of those those seizure syndromes. Maybe that’s just me. Very, very rare. A whole lot of it is required a whole lot and it to isolate CBD to make a CBD isolate as opposed to a full spectrum product. It takes not only a lot of the company original comp on the original call to bar, but there’s extra steps in the processing. So it’s harder to do and it doesn’t work as well. But we like to say that it’s popular that way and then people will claim CBD effects. Now if you go back to the days of Dr. Mushroom, and all of the studies and all of the things that were done in Israel and everywhere else and by the way, I just love this fact, back in the 60s and I can’t speak for today, but cannabis is totally illegal in Israel. It was then the supply that he got came from the US. We supplied him to do the research on it. So all of the research that came out was on basically on full spectrum products. But the marketers here in the US decided that they would claim therapeutic effects of the full spectrum as being attributed to the CBD because there’s a lot of it there. And that’s the mono molecular thinking. One drug, one dose or multiple doses. One effect, one disease state, right. And that’s not the way nature does it. Okay, we don’t have that out in nature. I mean, you can’t even eat an orange and just get vitamin C out of it. Right. There are other things in there. Right? That’s the way nature does it not and I believe that’s the way that it was intended to be. Alright, and so some of our concepts are down here. I won’t bore you with this kind of stuff. But at the very bottom. If cannabis is used as a treatment modality one needs professional assistance. And I think that’s very true. And if there’s anything that you need to know, I would say I don’t know if you can see this, pick up this book by Dr. Souillac. Right. This is phenomenal Handbook of cannabis for clinicians got everything in there. So if you if you need to know that or you have answers, and what I tell a lot of people is and especially pain management physicians, if someone comes to you and asks you about your opinion on cannabis, and does it work for pain and does it work for this? And if you say no, they’re going to find somebody else who’s going to say yes, because they kind of know the answer. They’ve either experienced it or they’ve heard about or they’ve read about it and all of that right. So I don’t think any of us should have our eyes and minds closed to this type of thing. Okay, now endocannabinoids versus phyto cannabinoids and some of this is just in slide form. And I’ve talked about these things already difficult to make the endocannabinoids or need and site specific phyto cannabinoids indiscriminate and their non targeted sites of activity. We talked about that already. Okay, characteristics of cannabis. Okay, now here’s the thing. strains. This gets me because strains that’s a microbial term, the the mycologists and all of these people. That’s what microbes are. They’re strains. These are cultivars. Roses are cultivars there are strains, right. And what has happened with crossbreeding the terms indica and sativa actually are no longer apropos. They’ve actually done studies where they’ve given people the product and they’ve asked them to tell me if this is an indica or sativa. And in a huge percentage of the time they get it wrong. They just don’t know. Indica in the proper vernacular indica stands for into college. So that’s supposed to be sedating. And sativa is supposed to be more creative and mind focus and all of that kind of stuff. But with crossbreeding, we don’t know if these things even work anymore.
52:36
The plants themselves don’t look the same for a long time. Way back when when people were growing outside they would want to grow the indica plants. And the cannabis plants as opposed to hemp or sativa strains because the sativa strains and hemp grow really tall and thin. And the thing was, they said well, helicopters can come over and they can find you that way so you better grow to small plants. And so they started crossbreeding them to get the effects they wanted. and on it went, okay. Yeah, so some of the other characteristics. They may help to unbundle psychological distress syndromes. One thing that is kind of prevalent and it’s very difficult to measure is they talk about standing next to your pain the only way that I can kind of say something and it might be related to this is that if if you’ve ever like sprained an ankle, let’s say the first time you do that, psychologically you are a mess. I mean, you don’t know when that’s going to go away. You don’t know how that’s going to heal. You don’t know if you can limp around on it. You don’t know why it’s so purple. You. You just are totally unaware of that. All right, the next time you do it, you are not nearly as stressed out. You know, it’s going to take a couple of weeks. Yeah, the purple goes down, the swelling is gonna go down. I’m going to be fine. Okay. That is kind of what these cannabinoids do with pain is it’s almost like you’ve been through it. You’re standing next to it or you can look at it more objectively. Then you did before and it was subjective and you experienced every negative thing and now it’s almost like the guy next to you is like, oh, yeah, yeah, I know. Yeah, the pain and I know it’s there, but I can still enjoy the movie, you know, whatever it is. And I think that is an extremely important aspect of this and at the bottom, in bold and yellow. Cannabis reduces suffering, opioids don’t do that. I think they bring on a little suffering. All right, and then I gotta throw these things in here because this is all of the things that you can find any place. Notice in the upper right, this is more than 85 cannabinoids, and there’s more than 120 And the reason I have this in there is just because if needed, you can find charts on this if perchance you’re interested or you have patients that want to know or whatever, you can find certain cultivar or dominant cannabinoids that will target certain things. And here they are. Notice at the top CBD and anxiety Okay, so a lot of this stuff combination THC CBD, right and here you go, Joel PTSD, depression, stress, right? These things have been shown to help. And remember, as we all know, it’s really difficult to to do clinical studies. You know, double blind crossover is almost impossible on this because people know what they’re getting. And it’s hard to get product. They tell me that if you get the University of Mississippi stuff that is better than it used to be. It used to be laughable the quality and the fungus that was in it was laughable and I think they picked up their game and I also heard University of Kentucky or somebody like that is also now allowed to provide this. I don’t know who does the studies on it, but they are the providers. Here’s another little chart right here a little bit easier to read. And it’s kind of neat, because these are the cannabinoids that kind of show. These type of effects and this is what are we going to say? As clinicians we’re gonna say, yeah, that may work. But as scientists we’re gonna say, Well, I don’t know. I don’t I don’t see all the evidence. And when I tell people is that if if this stuff didn’t work, why would people still be doing it? And if you’ve experienced any of this yourself these things do work. This is not hocus pocus medicine, this works. And then here’s some characteristics and the one that I like to point out and until proven otherwise, THC can actually kill cancer cells but CBD can only inhibit the growth and that is an important characteristic. If there are cancer people that decide that they want to take CBD isolate from the local dispensary because they have cancer. Or and I won’t say dispensary I should change that to say CBD stores. I know here in Las Vegas. I mean we have CBD stores. They don’t sell THC and then of course we have dispensaries that sell the THC and are kind of averse to anything with CBD in it. Well, if somebody goes into to a store and they get a CBD product and they think it’s going to cure their cancer, they’re sadly mistaken. It might help. But as we all know, there’s so much more to it. Don’t look to this as a sole agent and don’t expect CBD to knockout cancer. It’s just not going to do it. The other thing is as we say can cause euphoria and as Dr. Block mentioned last week, in the 80s they came out with a product called Marinol which was straight THC and instead of euphoria it caused dysphoria. I dispensed a bunch of that. Okay, we call them Marinol. Balls, because they just roll around uncontrollably. It’s hard to count them trying to bad pharmacist problem, but they didn’t work very well at all and I did not have a single patient that ever wanted a refill. There’s no I’ll go back to smoking. This stuff doesn’t work and it makes me feel like crap. So there you go. Now directly stimulates the five HT one serotonin receptors, as as Dr. Block mentioned, you know, psilocybin and all of that’s an entirely different lecture that we could go I mean, I can give you hours on these five H T one and what psilocybin does on these receptors and how it works in the different areas of the brain in which it works. And I mainly point this out for Joel and those guys, my heart goes out to the veterans, part of our company. We donate part of our profits to wounded warriors, things like that. Okay, we believe that these people should be treated with the best thing there and although I spent my my entire career messing around with the various pharmaceutical drugs and whatnot, I’m kind of sour to that. Let’s say yes, there’s a place for it. If you’ve got to collect your clot and you’re in trouble, give me some activation. I need that. But otherwise, some of the chronic management things, we’re not doing the right thing. We’re using acute medicine to treat chronic problems, as we all know, it hasn’t worked out well. And so when we have things that work, I believe that they should be they should be used real quickly. The SSRIs which I believe will become obsolete, sometime, whether it’s in a year five years or 20 years, they’ll become obsolete, because they are basically horrible drugs. They do not hit the five HTT to a serotonin receptor. They do not hit that. But they and as I mentioned before, I never know what it meant when it said oh, these are SSRIs what is selective serotonin reuptake. What does that mean? Well, it’s selective receptors. And what you need to know is psilocybin hits them all. That’s nature. And that’s the way it’s meant to be and that’s why it can increase neuroplasticity. And all of these things that SSRIs don’t do. And then of course, what happens if you don’t have enough serotonin? Well, then the reuptake inhibitor is not going to do a very good job. All right. So on we go, I’ll get off the soapbox here. But again, these products are phenomenal. And I think what’s what’s really cool is if you look at the very top of this slide, the chemical composition is the same 21 carbon atoms 30 Hydrogen, two oxygens, okay. And two chemistry geeks like me, this is impressive. It’s just you know, you can see down here on the little picture in the red, the difference but oh boy therapeutics different. I mean, that’s, that’s for sure. Okay. And then characteristics of THC. We talked about this. What I think is funny is that if you look at some of the literature, euphoria is classified as a side effect. Wow. Okay, I try to wrap your head around that one. Okay. And then down in the CBD mechanism is completely different. I don’t know if if you want to look at some of these things. Here. You know, I just glanced through the THC thing. I’m trying to make sure we get, you know, cover all this stuff. There are what I talked about on that greater acceptance of illness and current situation that’s a real thing hard to measure that greater appreciation of surroundings improve focus, you know, the, the memory thing the short term memory loss can be mitigated by getting cultivars with alpha pining in there, that helps focus.
1:02:12
And it the short term memory loss they say at parties is real funny when somebody forgets where their keys are. But if it’s something that’s important, it’s not so funny. And it can be mitigated with the proper terpene concentrations which we’ll hit here in just a second. Here is something that I find interesting that shocked me that I had to put this in hemp oil right over here and tells you all of these different characteristics, but looking at cannabis oil I mean, it is way more effective. And I just don’t like the thing over here with this GMOs and all that kind of stuff. The trans fats, there’s additives in hemp oil, it’s just not a good idea. I think it might be real good for textiles, but that’s about it. Okay. I’m just gonna take a break here to give you a chance to maybe look at some of this kind of stuff in case any of this interests you and again, if you want to hop back to it, the slides are on the left hand side here. Let’s go to isolate versus full spectrum I covered a little bit of that. One thing that’s important here is that CBD isolates have a biphasic dose response curve. So you take a bunch of it and it can help it can help it can help goes up peaks, and then you take more and you take more and then the response is starts to go down and you get worse. Right so the old adage of flu is good a lot it’s better does not hold. And one thing I think is extremely fun, is that hemp is the second best heavy metal plant key later in the world. I believe sunflowers are number one. Don’t hold me to that. Why is that important? Well, not only did they plan handball over Chernobyl, but they won’t do it for Daiichi Fukushima. Right because they don’t allow it. But what’s important here then, is that where the plants are grown California is known to have heavy levels of arsenic in the soil, various areas throughout the state. These plants are chelating these metals inside the plants, right and then people who are smoking this, to me it’s like mainlining heavy metals. Alright, isn’t it the same kind of thing because burning does not burn off a heavy metal. Right? You know, it’s not hot enough to do that when you’re smoking these things. You got a better chance within ingestibles topicals Rekkles trophies you got a better shot at maybe your body kind of helping to to detox some of this stuff and we don’t even want to get into the the pesticides. I will give you an example on this. Pesticides in this you can take your product of various labs and there’s a lot of testing labs out there and they’re not standardized. Right. So you can be using certain pesticides and in some cases you can find a lab that does not test for that pesticide. That chemical in that pesticide. Let’s put it that way. And now you’re able to show that you have a clean product. This is criminal. I do not like this. The other example I will give you is that in San Luis Obispo where I came from. I talked to a lot of growers there. I had patients who were growers. And what they said was they had organic pesticides they sprayed during the daytime and these were the people who sprayed the plants I’m talking about not the farmers. These are the people that sprayed the plants in the daytime. You’re using organics at night using the bad stuff. And they’re spraying for the bugs at night using toxic chemicals. Right. So yeah, when you ask me, does this industry need some regulation? Yeah, it sure does. Okay, now, the full spectrum stuff if you look down at the bottom, it contains less than 0.3% thc. When derived from hemp, federal government in the Farm Bill, we call it 2018 said if you have a cultivar that has less than 0.3% THC in it. It’s hemp. Wow. Thanks for that. Okay, that opens the door to a lot of things. Somewhere along the way, they’re gonna have to close these loopholes. And the loopholes also include, as Dr. Bloch mentioned last week, Delta eight THC and these things like that because these chemists are pretty smart guys and they’re going to modify this molecule to do whatever they can to get people high. We’ve also got works a full spectrum work synergistically with THC and the other cannabinoids and terpenes. Okay, and then ratios and terpene content. I don’t want to get into this too much because there’s a lot of research now talking about the therapeutics of various cultivars are not only due to the cannabinoid content, but maybe even more due to the particular terpene profile. I think that is where some of the research is really going now. And then if you look at the bottom, some of the terpenes you know, laminated mood myrcene sedating that can Alpha pinene as I mentioned, memory and alertness. Okay. We won’t get too much into this because terpenes is an entire whole new type of lecture. Sometimes you hear them called terpenoids. Right? Well, terpenes are carbon and hydrogen and terpenoids have carbon, hydrogen and oxygen. And there are hundreds of these in the plants hundreds, and they are made for various reasons, by the plant for themselves, not for us. And then here at the bottom is the most important thing is that therapeutics here terpenoids may be responsible for distinction between common effects. And I think that’s one of the most important things right here. Above you know, there’s the pharmacology stuff. And then you know, that’s the kind of stuff that interests some of us and bores the heck out of others. Here’s terpenes nice little chart here. Kind of give you an idea of the aroma and what they are. If you notice this carry off line on the far right. Okay. The government doesn’t know what to do. With that. Because carry off Lin is a cannabinoid that has terpene properties. So they’re gonna outlaw that. Well, it’s in a lot of different things. So they don’t know what to do. So they’re just going to ignore it, I guess for now. Right? It has terpenoid effects as well as cannabinoid type of effects. Okay, now, here, here comes some of the things that if we get to the brass tacks of this thing, what important features should you look for in a product? Soil content? I kind of touched on that just a little bit as it grown organically or from conventional hemp. The extraction information is important. There are a lot of different ways to extract this. There’s co2 extraction, there’s alcohol, there’s butane, there’s ice extraction, there’s all kinds of different ways to extract this. And then you want to look at a certificate of analysis. Make sure it’s third party testing because we want to know about heavy metals and what we call the nasty sides pesticides, herbicides, and fungicides, and then moles as well. And then the amount of THC present in some of these things, ratios of cannabinoids and at the very bottom, I believe the product should be made by professionals. And that’s just my personal opinion on it. Okay, here is the fun slide and I promise we’re almost done. Okay, this is PCCA I don’t know if you guys have ever heard of this. This is professional compounding Centers of America. They supply the compounding pharmacies, them and mutt deskah and a couple of others supply most of the raw chemicals and drugs or compounders is where we get everything. They came up with cannabidiol greater than 98% and that’s what they call it. cannabidiol greater than 98% powder. Now, in my farm, I got some of this stuff. I wanted to some of our people to try it. I had some physicians that were very willing to prescribe it. Let’s let’s see what happens. Let’s see if it works. Okay, and there’s more to it than that, you know, harm reduction and all that.
1:10:51
But they came out with this
1:10:54
after Epidiolex hit the market. And if you notice down here at the bottom cannabidiol powder information in this is critical. It was considered at an API active pharmaceutical ingredient drug by the FDA. Finished compounds required a prescription. Okay, it did now remember Epidiolex came out as as scheduled three and then it went off schedule. And that’s when these guys hit not for over the counter use had to be prescription only. Alright complies with section 503 A of the FD and C act. What that means 503 A pharmacies are pharmacies that can compound for specific patients only you can’t make batches of things in anticipation of getting prescriptions. Those are manufacturers those are 503 B facilities you may be aware of that. Those of you I’m sure Dr. Clearfield when you when you deal with hormones. That’s the type of thing that is very, very much in play. It’s 503. A facility will make it for your specific patients. Okay, you can’t just have batches of it. That’s important. It has to be a component of an FDA approved product will that be dialects is FDA approved and that CBD, okay, it’s not a DEA controlled substance. Well, once it got D scheduled, that criteria was met minimum assay, the purity and this is the kicker minimum has to be a 98% with THC content. less than point 1% synthetic and not derived from hemp or marijuana. Okay PCCA and forgive me I can’t remember what they derived from whether it was home or something. I’m really missing that but anyway, it doesn’t matter. And it has to be free of pesticides and unwanted plant materials, no contaminants. These guys made stuff, met all the criteria and the FDA came down
1:13:07
and they made them pull it
1:13:09
and you why what’s the difference between this and estrogen? What Why can’t you compound you know, compound with estrogen powder testosterone. Why? Why can’t we do that? Well, because Big Pharma doesn’t want you to and so what they said and I talked to PCC about this because we were going to do a study together. And then they gave me the bad news. It’s been pulled, send your stuff back. Can’t even sell it what you have on the shelf. And the reason was that the FDA said you have to prove that your product you have to tell us how much THC is in there and it has to be less than 1% See what we said THC content has to be less than 1%. And they said we have zero. And they said prove to us that your THC content is down to zero. This there are no instruments strong enough to do this. And they said See you can’t do it pull the product. I was completely flabbergasted. But I guess I understand it Okay, here comes the part that I’m just going to hit you with two slides and this is the shameless plug for our company and what we do and we make kennosuke nickels and these are you know all of the wonderful soil Bronwyn and all of that the parameters that we go by and we use CBD and we use cannabis, but we put in other pharmaceuticals in there like amino acids nutraceuticals homeopathics, herbs everything in there to target specific type of needs and people and you can see the the amino acid tryptophan theanine if anybody has ever taken theanine, it’s a wonderful substance phenyl alanine, the only amino acid that’s been shown to help with pain and it also helps tremendously tremendous amount of studies with using this and pain in dogs as well. Okay, and then nutraceuticals we all know about curcumin and many people know about MSM, glucosamine and all that kind of stuff anti inflammatory, for pain, and we just we make these things. Okay. And then well, where do you start? What what do I do as a practitioner? If somebody has taught me about this or wanting to do something want to know something or I wanted to start I want somebody to try it. Then here’s the kind of type of thing that I think people should pay attention to. Okay, and it’s very, very similar to a lot of the stuff that we’ve shown on a lot of the slides. And there’s obviously interpatient variation. And all that kind of stuff at the desired delivery system down there. If you notice, I’ve got in there trophies which we talked about last week, capsule sprays, that type of thing. And it really does require a nice little conversation with your patient on what to look out for and what to do. Our company does provide that I challenge people to go on to some of the big companies that provide CBD column up and asked me to talk to the scientist or the formulator and see what you get. Okay, probably not a lot of success. Okay. And the last slide is thank you very much. I hope people are still there. That’s name phone number, email and our website in case you want any more information or want to talk to any of us. So if anybody is there and you have any questions,
1:16:47
we can do that. All right. Thank you very much there. Yes, thank you. Okay, a
Bill Clearfield 1:17:01
lot of thing. I hope I answered Joel, do heavy metals cross the alveolar blood stream barrier.
1:17:08
Oh, yes. That’s you know what, I don’t have studies on that. But boy, oh, boy. Have I heard horror stories about this. I mean, and across the blood brain barrier. As it crosses everything.
1:17:25
Heavy metals are tiny.
1:17:28
I mean, compared to drugs,
1:17:30
one of the sources originally and not just looking at the plant material as contaminated source, but some of the equipment that was using for the vaping that was coming from China had heavy metal release, and it was just cheaply designed stuff. That was a use once and throw away. A lot a problem in the 2014 through 17 period with vaporizers used in the unregulated market. Well, yeah,
1:18:13
thanks for that. I had forgotten about that. And then we all know about the vitamin E oil and the vapes and all that. So, yeah, there needs to be some regulation. First, I think there needs to be recognition and then regulation. These have to be recognized as products that can have some benefit.
Bill Clearfield 1:18:34
Or have you aerosolized by smoking?
1:18:40
I wish I knew. I’m gonna have to tell you that. I don’t really know. But my thought is, yes. And I can base this on a lot of different things. One happens to be forest fires. Okay. So there’s a lot of mercury in topsoil in the earth. And we’ve dug up a lot of the Earth and Mercury will be released into the atmosphere, and then it will fall down everywhere and it falls down. In forests. And when a forest fire occurs, the metals are up in that plume. And that’s one of the things I mean, when you breathe smoke from a forest fire, you’re breathing a lot of nasty stuff, and that’s why they get out. Okay, and it’s full of metals and Mercury specifically. So I think that’s kind of what I’m using as an answer.
Bill Clearfield 1:19:35
Yeah, we’ve had quite a few of those here, you know, Oh, yeah. We get we get the smoke from California fires here.
1:19:43
Yeah, it’s California doing everybody in again.
Bill Clearfield 1:19:47
So there’s a question what COA SCS certificate of analysis?
1:19:52
No, yeah, sorry. Yeah. Certificate of analysis. Yeah. And that’s mandatory. And now most providers do that anyway. But I’ll tell you, that’s not regulated either. You know, I mean, I can get a cert, I can get more than one certificate of analysis. And I can have a product that looks really, really good. And I can create a product that’s really, really bad and I can post the good, CMA online. Right? So you can cheat. And that’s, again, you know, that is the main reason we got into this is because we want these things to be pharmaceutically elegant, we don’t want to cheat, we want therapeutic products, and we want people to use and treat this like medicine.
1:20:35
Okay to follow up on my question with the vets and the responders. A lot of the respond or the responders, you know, law enforcement especially they can’t do THC, federal government employees same thing you know, and active duty military, same thing. It would we have to almost overdose them on the CBS the CBDa CBD G CBD everything to try to bring them into without the THC.
1:21:08
Okay, first of all, John, glad you asked that question. I get this a lot. It’s a sad state of affairs that this is the way this is without our I’ll say accurate monitoring. The testing facilities and mechanisms for this are not extremely accurate and they’re all over the board and they use different methodologies. So one lab can say one thing and I think we’ve seen this in a lot of our testing anyway, where labs differ whether it’s, you know, quest, you know, versus somebody else. They differ. It’s not standardized. So Some labs will report some and some will report none. Okay, so we can’t take that chance. The other thing about this is that this is like a six pack of beer in one regards. You know, you can stop at the store. On the way home from a stressful day at work, grab a six pack of beer, get home and have one beer and you’re okay. You drink the whole six pack and you might be drooling. Okay, I don’t want you doing anything, especially driving your car when you’re in that situation. So why is it that it’s it’s all or none with THC? Well, the testing is not there to figure out the effects of certain doses and we’re going to be stuck with this model. And when people ask me, Well, you know, your price What do I do? You know, what if I get drug tested and all that kind of stuff? And I always test them? Look, I tell them very simply, if you’re that concerned about don’t do it, all right. But if you have need for this, and you’ve had good therapeutic outcomes, results, and that type of thing. Go get yourself tested, and see what shows up. Because I’ll tell you right now, if it’s a topical type of thing like that we make for pain. You’re not gonna find THC in it. There’s no instrument it’s going to be sensitive and sensitive enough to find that remain. Go get tested. Just got Go Go get drug tested.
1:23:27
Oh wow. See how much THC you
1:23:30
have or Yeah, yeah. If you’ve been using a product see if see if you if you pop positive.
1:23:36
No, I you know, that goes back to when I was using. I was on my switch from smoking to the Rick Simpson oil and the Rick Simpson oil according to the dispensary here, you know, with their certified analysis and so forth. It was supposedly around 5050 thc CBD and it increased appetite. Big time. It was pretty insane. And I didn’t have a lot. And so I was like, wow, okay, and I didn’t get high. It was pretty powerful. Yeah,
1:24:10
and boy, what you were you were positive on that? I
1:24:13
would guess. Yeah, no doubt, no doubt. So, yeah,
1:24:17
there’s a lot of therapeutic stuff, having, you know, a lot of claims and all that with RSO. That it’s something that people have really benefited from, it wouldn’t still be around if it didn’t work. Right. I’m curious.
1:24:36
I’m sorry. No, excellent
1:24:37
talk. I’m just like blown away. Oh, thanks. Yeah, it has been
1:24:42
I’m curious. So why is marijuana that name derogatory, or where did it come from?
1:24:50
Mexicans way back when? 1800s. Really? They were Yeah, they were all if you can trace this crazy stuff back to poncho via and that’s and that’s like Dr. Block said, you know, he was the who was the first one committed terrorist acts on US soil, and they said they were all high on the ganja. And they call it module one. And I don’t know whether the Mexicans did or the the Anglos did, but that’s what they named it and right now I believe it is racially motivated is a derogatory term in in my in my estimation, it it is something that should not be called that. It is Cannabis sativa l all everything comes from that all cultivars hemp even comes from that out of I believe out of Afghan Afghanistan way back when I think Dr. Black covered that. It was used various parts of the world grown everywhere. It’s a weed grows everywhere. And people began to use it and it was attributed to criminals from Mexico using marijuana. Well, I
1:26:07
never heard that and I’m from that age group where it was you know, marijuana and, and in the Midwest, they grew ditch weed which was from him and Mary Jane and pot.
1:26:23
Yeah, exactly. And, and the sad thing to my thinking is that in the 1930s, there was a pharmacists in Santa Barbara, California that led the charge to make this illegal and if he was alive, I’d go down there and kick his ass.
1:26:47
Oh, by the way, I think marijuana means the merry one. The happy the happy guy that smiling and laughing and and that took on racial overtones.
1:26:59
Yeah, didn’t didn’t they also have like people from foreign countries. I don’t know whether it was like from Google Message like India or or the Indies. Something like came over and they wanted to stop them from coming here. Because they said they were all high on this. A lot of you know political stuff that’s still going on. It’s all
1:27:27
the bad stuff started in the 30s. Remember when was the Hearst was trying to make money off his pine forest. So they had to stop the production of hemp and then that’s what led to the crazy stuff man was to make money out of trees and cut down the out. That’s what it was about.
1:27:46
Yeah, unbelievable.
1:27:47
Another great what’s what’s the difference? The terpenes from the plants, THC and him. What’s the difference between them and the terpenes from regular plants and regular foods?
1:28:04
Great question, Joel. And that’s something I have in the slide. I didn’t touch on it. There are no terpenes in cannabis that are not found elsewhere. That does not have anything unique to that plant. Okay, so little lavender. We all know about that. Well, you know, what about limonene you walk down the aisle in this in the store down the detergent aisle and you’re smelling limonene All right. I mean, these terpenes are ubiquitous, they’re everywhere. And these plants do not have any that are not found somewhere. Else. That’s a great question. Thank you.
1:28:52
Right. Can I ask a question? Sure. Go ahead. Sure. Well, what I’m curious about is what fraction or component is responsible for culinary enhancement or sensory enhancement? And then when you when people imbibe, what does it do to hormonal hormonal balance is throw something out and they say, say sometimes the next day there’s a withdrawal. And what does it take for the hormones to rebalance? And I thought that’s an interesting question.
1:29:33
Yeah, I look at it this way. The endocannabinoid system helps balance hormones. And now we’re taking phyto cannabinoids are augmenting that. Now if there are I’m sure there’s interpatient variations here. If there are people that are have hormones that aren’t balanced very well, you can have an effect. There is also such a thing and Dr. Clearfield Mayer, maybe you know about this when they talked about menstruating women. In the first part of the cycle, it takes less of the phyto cannabinoids to have an effect. than it does later on in the cycle.
Bill Clearfield 1:30:21
You have a higher higher level of estrogens and
1:30:26
Yeah, exactly. And so somehow there is an interplay between these and remember, is is trying to balance everything so you’re, you know, when your estrogen is high, sure, you know, we’re getting balanced and all that kind of stuff. But also, you know, through neuro transmission, there are brakes and that’s kind of what these cannabinoids do. They put the brakes on
1:30:50
things. What do you show us, John?
1:30:54
June you Trosky CBD with melatonin goes under the lip? Yeah, open the gum. So it’s a quality product.
1:31:05
Yeah, and we make something very similar but we also put L tryptophan in there.
1:31:10
That’s more calming. Even better. Yeah.
1:31:17
Your knowledge is really amazing. Dr. Quinn, it’s yeah,
1:31:21
thank you. If I may, if I may throw up.
1:31:28
A little bit of a downer. Excellent.
1:31:34
Some of you may not know that we recently had a suicide in the group and don’t know how to even proceed. But those that are involved are moving forward. And with that being said, with suicide on the rise, and not six What do you think Dr. Quinn would be the easiest, fastest solution besides detoxification. I’m talking about throwing something in there and I’m thinking 5050 CBD THC and in for the vets or the responders who can’t do that. It’s got to be some type of CBD overload with some type of supplement and hormone stabilization. I just, you know,
1:32:32
okay, well, I’m going to tell you this. I am fully fully on the psilocybin bandwagon. Me too. Me too. I’m now doing research on a combination product with some psilocybin in there and cannabinoids to balance the system. EULA Simon is probably one of the most amazing things we have ever run across. And I say that because of the effect on the brain. It can completely knock out depression and things like that due to the the serotonin to a receptor five HT to A. There are studies done by oh don’t draw blank now. A UC San Francisco Professor he’s a Brit. I’ll come up with it. And they’re doing this with micro dosing, which is about one milligram moderate dosing, which is 10 milligrams wow and therapeutic dosing, which is 25 milligrams and then we have the heroic dosing which is 50 to 100 milligrams. Now let me tell you this, it his study, and and the results and the things they have gotten are phenomenal. They have I believe it is at 67% remission
1:34:10
of treatment, failed
1:34:15
depressive patients on our standard antidepressants, whether that’s tricycle six tetracyclic or SSRIs SNRIs. Right. They have got a 67% remission rate using psilocybin. But I will tell you this, it’s not go eat a magic mushroom. It’s not do that. And those things basically are 1%. The active compound in there is psilocin. It’s psilocybin. is a general term. Joel, I’m telling you, we have got to get this to the people. We have got to get it to him and I’m trying to do my best to research and come up with products for these people. It is a two dose system. Think about that. But it’s not a take it and go away. You need to have the right as they say set and setting. You need to be monitored by professionals. Carhartt Harris is his name Carhartt Harris Okay. Mr. Hart ferrets I UC San Francisco or have you heard of Marcus
1:35:31
Cottrell? Oh, of course. Okay. Yeah. So if cars Harris if we can get a hold of him and possibly Harris and they can
1:35:42
you know, oh, we’ve we’ve, we’ve
1:35:46
gone on that could be huge. And the government wants this Believe it or not, in a weird way. It just has to be you know,
1:35:54
they have to, but let me let me just back up real fast to let you know that his results were done and it is very specific. You have to professionals one has to be a psychiatrist. And they still call it a trip. Okay. And this is not what the one milligram the micro dosing No, not a problem. You don’t even notice that. Okay, but when you get to 10 and 25 milligrams, you start to, quote unquote, what us as lay people call it hallucinate. It changes the neuronal connections, it actually can grow new neurons. It does so many things for the brain. And it is like a five to 10 hour session. And they have got it nailed. The first hour you’re just starting to come on the second hour. You will feel anxiety, you will go through this because your circuits are rewiring and what it does is it allows you to be more receptive to this sounds stupid, the earth and good and they call it you get a feeling of oceanic boundlessness try to describe that.
1:37:05
You know, Dr. Burgess has been telling me this for years. I’ll just be honest.
1:37:12
And here’s the thing, then after that, your your perception of the depressive type of incidents or things or whatever goes away seemed to dissipate. Now, you get a certain result with one treatment with two treatments and it’s not like the next day. It’s weeks later. They do it again. And that’s it.
1:37:39
Done. That’s what I’ve heard what I’ve heard. Wow. Well it’s
1:37:43
so amazing to me. So as I said, I want to be the guy that kind of, you know, we have researchers, and we have practitioners and then we got people like me in the middle, that kind of want to take the research and create something for the practitioners. And that’s what I want to do.
1:38:04
And you know, Dr. Thomas, Dr. Lewis, R. Avi, Dr. Thomas Lewis and Dr. Horse Carter. Yeah. And you know, Dr. alasa, Dr. Farr shy and they’re all They’re all on board with us. So I think together this whole group of all of you it’s you know, and plus the body. Plus, Stefan, I think it’s just gonna grow into something that’s really going to be really, really
1:38:31
wiki Joel, and with you. I think it’s going to take somebody to move a mountain here, it’s going to take some organization, it’s going to take some dedication, it’s going to take some funding, no doubt about it. And that’s what we have to do. So I’m also working with funding people, which is extremely difficult, you know, I mean, is but but to me, I mean, this is this is what I’m going to do until the day I fall over, because I truly believe that there is a need and we can fill that need without doing things that are forced down our
Bill Clearfield 1:39:02
throats.
1:39:05
Amen. Beautifully said thank you. Thank you very much. So Dr. Chlorophyll, it’s all up to you.
Bill Clearfield 1:39:13
Raw. There we go. Okay. No worries. I’ll have this I’ll have this licked by Thursday. No pressure.
1:39:27
I have one more question for Dr. Quinn. When people get COVID I believe it throws people out of balance. So what you’re talking about psilocybin can that up, rebalance them or bring them back to normality a little quicker?
1:39:43
Yeah.
1:39:45
That Dr. Carhart Harris, I believe was one speaking about this and saying that yeah, definitely it does. It does. I mean, COVID at you know, HIV, anything that is throwing off and I don’t know that much about the brain, you know, I mean, I know a little bit about the hippocampus and the prefrontal cortex, but I don’t know all this other stuff that these guys know these neuro psychiatrists and all of this stuff, neurologists. And they have got this nailed to where these things act in the brain and they will tell you, you know, COVID here, you know, affects a substantial Niagra. Now then they got they got all this stuff nailed. And then they can tell you this is where it acts and this is how it does it. And of course, you know,
1:40:33
we got to get them as speakers.
1:40:35
Oh boy. You know, it will blow you away. It will blow you away if you’re if you want to get down into the weeds and and find out about this, you can do it. If you’d like and Joel, I want to do this for you. I’m going to see if I can come up with some of these studies and send them to you. But the problem is, they’re so detailed. They’re so in depth, you know, because that’s kind of what the scientific community demands. And like I said, there we got the patients and the people treating the patients on one side, we got the researchers and scientists on the other side. And what does that thing they say it can take in medical practice that can take more than 10 years, sometimes 20 years to get from the bench to the bedside. That’s where we are.
1:41:25
You know, there’s there. There’s so much going on. Dr. Hartsfield has a whole bunch of stuff going on in Arkansas. Dr. Hall has a whole lot going on in his area. I think even Florida Yeah, and I know Stefan Hartman, he has a lot going on, you know, and then you’ve got a body in Michigan. So we just got to keep spreading all this stuff together, and we’ll figure it out. And yeah, I
1:41:54
hope you’re right. Over right. To Dr. Cliff, is there any other stuff I didn’t look there’s a bunch of stuff. I can chat. I don’t know.
Bill Clearfield 1:42:03
No, I think we covered it all. Okay, good. Let me look one more time. I think we got it all yet. Yeah, we got we got it all.
1:42:12
So Excellent. Excellent. So last slide. If anybody needs to get a hold of me and my reputation is that I’ll talk to anybody anytime about anything.
Bill Clearfield 1:42:24
Okay, I knew you were like I said, when we started I knew you were serious because you had a shirt on tonight. Yeah,
1:42:29
you bet. Yeah, it was the dress code.
Bill Clearfield 1:42:33
Okay, so thank you. So much. And like I said, this was last minute. We really appreciate it. Otherwise they’d have to listen to me. The that’s you know, you know, for whatever whether that’s worth next week we have so I know it’s I know it’s Halloween. Oh, we have somebody very special. Dr. David and I are going to not pronounce his name correctly. A jabi who is the director of the brain and body foundation. His specialty is sickle cell anemia and dementia. He is a community educator for the outsiders. Association, and he is the host of Africa’s number one rated television show. Oh wow. So he he is going to be dynamite. So spread the word. I’ll try to get it get it out to as many as possible. And it should be extremely interesting. No.
1:43:35
74 in Vegas right now. 74 in Vegas, your awareness or
1:43:41
ethical
Bill Clearfield 1:43:46
Okay. Anybody else have any comments or questions? Wait something else in the chat.
1:43:51
Hold on. Great talk, Robert.
Bill Clearfield 1:43:55
There you go.
1:43:57
Thank you.
Bill Clearfield 1:43:58
Thank you so much. Okay, everybody. So again next week, Doctor I hope I’m saying it right that jabi And, John, you got anything for us?
1:44:09
Everything’s beautiful. Love to talk. Thanks. Okay. And
Bill Clearfield 1:44:15
Donna was great seeing you don lives in Houston. I was in Houston this week for the AMG meeting and we had a great time there. So and anybody else have any comments, questions? Anybody have any word on peptides? That of course was a big topic down there since they have a whole course on peptides. So
1:44:39
I missed I missed that Zoom. With Stephen Harmon and the body. Oh, tonight. Yeah. Did you did you get to see a doc?
Bill Clearfield 1:44:48
Me? No, I missed her. Awesome.
1:44:50
I’ll get a hold of Stefan and see if he can send me a recording. And then we put it up on your website, though. So the week
Bill Clearfield 1:44:56
so the week after doctor’s job is next week, the week after that November 7, we’re going to have Jay Campbell coming on again. And you know, he’s
1:45:04
big in the peptide world. Right, right. Oh, good.
Bill Clearfield 1:45:08
He was even mentioned in a hit piece in The Wall Street Journal last Friday. So I think I have the links if anybody wants wants it, so so they were not favorable to work towards him. So but you know, he’s, he’s a rather interesting and passionate, personal so so that’s our next two weeks and we’ll see you next time. Next week. Same time, same station.
1:45:39
Thank you, everybody.
Bill Clearfield 1:45:40
Thank you so much. And I’ll be sending you Bob the participant list shortly.
1:45:45
Okay, perfect. Thanks, everybody. Bye,
Bill Clearfield 1:45:47
everybody. See you next week. Same time, same station.
1:45:50
All right. Can I