Functional Medicine Approach to ADHD with Dr. John Neustadt
Tue, Feb 28, 2023 4:50PM • 2:14:32
SUMMARY KEYWORDS
adhd, talk, patients, test, nutrients, create, symptoms, week, deficiencies, diet, functional medicine, pathway, day, great, fish oil, amino acids, high, biochemistry, supplements, iron
SPEAKERS
Bill Clearfield
Bill Clearfield 01:49
on
01:55
there Anna
Bill Clearfield 02:13
Hi there. I you for coming. Thank you, Jay. We usually start around five or a little after so most of our folks show up right around then. Okay great. Okay, so just just relax and just the How did you find us? This is a new name for has Rafael Sanchez. Oh, okay, great. If you want to want to want us to add you to our mailing list, please send me your email you can send to send it to me in the chat and nobody else has to see it. We’re here. We’re here every Tuesday. At five o’clock. Okay, great. Thank you. Can you can send send it to me. We’ve been doing this for about two and a half years. And all of our stuff is all of our videos are on our website. I’ll put up post that in a bit module right now. D orange slash Okay, great. For last week, Zana because somehow it ended up on YouTube and of course they took it off within an hour and I haven’t been able to find my web lady to to do another to get a different link but we put it in the email address in the email this week. I put a link for it if you want to see last week we had Dr McCulloh on Peter McCullough you know who he is? Yes, definitely. Somatic somatic clearings edit. Somatic learning, learning. So manic learning. Okay, well, we’re always looking for speakers. So if there’s something you’d like to present are more than weren’t happy. To welcome you and new at it. We only bite on Thursdays so you should be safe. Okay, all right. Thank you. So, okay, so just relax and we’ll let everybody in. As they come. We usually end up with about anywhere from 20 to 40. More than a normal night. We had I think we had 85 for Dr. Mercola last week. So our speakers here Dr. New stat. Thank you for coming again.
05:08
Oh, my pleasure. I’m excited to be here and always,
Bill Clearfield 05:10
always always. You were you were extremely well received and, and asked back so I always take a little little survey and you’re you’re right, you’re right at the top.
05:22
Oh, wonderful. Well it’s always a pleasure to be able to share what I’ve learned and and help improve patient outcomes and how clinicians think and operate and so it’s it’s an honor.
Bill Clearfield 05:36
Okay, so we usually as you know, we started right around five we’ll be letting folks in as they go. And, sure. We’ll try and mute everybody so they don’t they don’t interfere and I’ll make Joel my co host.
05:57
I’m just going to mute myself and turn off my video until or my camera till we’re ready. Okay,
Bill Clearfield 06:02
that’s fine. I got you as co host Joe. Okay.
06:11
Sounds good. Thank you.
Bill Clearfield 06:12
Got it. Okay. Okay. So don’t know quite the crowd we had last week. No. Yeah. So didn’t didn’t take them long that I don’t know why that I don’t know why it got posted to YouTube because I you know, I always told her not to do that. Ended up there anyway, so I haven’t found her yet. So, but you will have the link. I’m gonna. I’m gonna put it put it in the in the email link where? Dr. Mercola here’s the link again. Here’s the link for Dr. Mercola video. They sent him a message saying up they blocked us and he said yeah, that’s normal. So I guess you get used to it after a while. So it wasn’t like he was surprised. Not at all. So I sent you that article from the New York Post 10 things they think they got all wrong.
07:40
Yeah. The mask the children, this six month old babies. That’s just freakin criminal. There’s no other way to put it
07:58
but children’s children’s health defense is suing the CDC and they’re going to sue any state who tries to implement vaccinating a six month year old baby so we’ll see how that goes. Okay,
Bill Clearfield 08:22
great. So Dr. Cooper Steen. Welcome again. You were one of our originals way back when and we hadn’t seen you for a while. So thank you for coming back. Those of you that heard Dr. Newstead before I know he’s a pretty dynamic speaker. He’s got a lot of good information to offer. If you weren’t here last week, a couple of names. If you want Dr. McCullough’s video if you go on our website that somehow it ended up on YouTube, which they they took it off. So it’s right here in the chat is the link for it. And you can you can get it. It’s about an hour and a half. So somebody’s sending me What’s the link for today? It’s the same as always. So you let these folks in and
09:23
all You betcha. Yeah, sure can.
09:29
Hey, we talked about doctors defense last week. And then Bill. So tonight anybody who wants to be involved with doctors defense, like to help Dr. McCulloch doctor, new stat bill and all you guys. If they send an email to bill that says doctors defense on it. They will be invited to a Zoom meeting by you Joe next week and 4pm and then we can form a separate committee or do what we need to do.
Bill Clearfield 10:04
Is that in many laboratories, Joe I muted you by mistake.
10:13
So is that requires a contract to do that, and
10:18
that’s okay. I’ll start trying to new people myself. Just trying to get down trying to write down the notes.
10:27
I’m gonna put a message in the chat so people can write to Bill and say they’d like to be part of a thing. All they have to do in this subject is say doctors defense and we’ll take it from there. I’ll put it in the chat.
10:41
Sounds perfect
10:48
Alright, what’s up guys?
10:52
How are you can hear me?
10:53
You mentioned how you doing? You’re fine.
10:56
Doing good. The 10 Minutes video that I made about CDPR which is chronic disease prevention management. They removed it from YouTube although I didn’t have anything against vaccine. I think everybody maybe some of you watched that 10 Minutes video. And I was just from promoting chronic disease prevention management. And everything is pathology with signs with evidence chemistry. Nothing fantasy or you know, saying anything outside the box. And everything I said is Big Pharma product, anti histamine, oxytocin, methylene, blue. ivermectin, yes, and all that but I present the reason why because they didn’t have the tea. At 17. So I’m showing all the pathophysiology, the core chemistry, there is no, they cannot dispute it. Okay, it’s not data. It’s not the cases of this and that where people they say, Well, it’s good to be placebo. This is basically chemistry pathophysiology, mechanism of action, and it’s undisputable and they remove it. See? Which is I think as Dr. Cruzi watch that video, right. Do you see anything out of the I mean, anything
12:17
I did not I don’t even think you said the word vaccine once. I thought it was excellent. I thought it was one of the best recruiting videos I’ve seen and it was prime. It wasn’t even it didn’t feel like you were recruiting it felt outrageously educational. So it just you know we have medical tyranny, there’s just no doubt. You know, I just got a letter, by the way. In a post it from the FDA, saying that I shouldn’t use exosomes, it wasn’t threatening. Well, Karen, tell them exactly.
12:52
It said they think you may be using regenerative medicine products, blah, blah, blah that that they have said they’re going to start going after and that the discretionary period is over. So it’s very, very light. They didn’t specifically accuse him of anything. They didn’t say it was doing anything on his website. They said he may be and we have that to put up so you guys can read it.
13:22
So it was not threatening. It didn’t recommend any corrective action because my website there’s a giant disclaimer that says you know, we can’t treat or cure anything and you know, this is purely educational but it’s the it’s the first warning shot. And you know, the next letter will probably be you know, more more unpleasant and I just want everybody to see it so that they know, but usually I’ve always been told that you get several warning letters before you get into trouble. And then somebody else told me oh no, they just barge into your clinic with their guns like they did to Dr. Wright, who taught everybody about bioidentical hormones back in the day. So I don’t know and don’t know if anybody has had any experiences that they want to share. That would be great.
Bill Clearfield 14:12
John Burgess down.
14:16
I have been advised to keep my mouth shut and get out of the way. So I’m going to be very polite and do that. But we are going to form a committee where I can speak to my friends in the committee but not allowed to on open mic like this.
Bill Clearfield 14:31
Okay. Well, no, it was said was if anybody has experienced your name, your name just popped up popped into my mind that’s
14:39
Zoom is zoom encrypted. And protected because I was always told it was that our congressmen Is that not true? What do you say Doctor?
14:48
They’re definitely listen to us especially
Bill Clearfield 14:50
screw. I would assume that we’re being every when I had my doing with the AOA if I if I sneeze the wrong way they knew about it before I was finished. So
15:05
I was even thinking about sneezing they know about it. Yeah.
15:10
But that’s crazy. How do we how do we how do we get on your private group so we can talk more openly and what are we going to use? What telegram or signal or how are we going to do it?
15:22
Everything has been compromised, including signal I sent. I put a note in the chat. So anybody who responds by emailing bill with doctors defense in the subject, will be invited to a zoom next week. And then we’ll put a whole new committee together and do what we can to help our friends. So you
15:45
were weakened. That’s the only way that zoomed the autonomy, physician autonomy. I think that title is very good. You know, no physician, as a physician autonomy. I think that’s a good title. And with your wife, I think she will do great because she’s a lawyer and a medical doctor. I think we can create that committee and recruit the lawyers from other states and then we will try to pick up those lawyers who are ready defending the physician autonomy and freedom of speech and there’s many of them on YouTube if we can reach out to those lawyers and see if they can be invited. There’s a lady her name is forgot her name, but she was talking highly about physician autonomy and how you know, people are talking about the vaccine and how they’ve been suppressed. I think if we can pick up those lawyers and find out how we can reach out to them. It’s better than hiring a lawyer who has no background or has no experience or skills.
16:47
Just want to get this in perspective. You might remember what Dr. McCulloch said last week, he has 100 lawyers is done no good, because the courts are that corrupt? So we have to get realistic about this not get our hopes up just because we’re right or legal. Or we’re good. That can have almost nothing to do with reality. So well, issues.
17:14
I want to add just one little thing, Stephen, in one of our previous meetings mentioned, an organization that’s going to be a new medical board called quote the body with a $50 a month membership, you know, to create an independent medical board. And I don’t know if Dr. Burgess you’ve networked with Stephen, he’s the guy that stood up at the Senate in Florida. And sent a bunch of he’s here.
Bill Clearfield 17:44
He’s here now.
17:45
Stephen is the color so the cool he’s the game so we’re hoping we can share with him as well.
Bill Clearfield 17:53
He’s our speaker next week also. So
17:55
yeah, presentation for you guys. Yeah, so I’m working with Dr. Avery Jackson, who is leading the body. And I think we should definitely put a meeting together with him again, we attempted that previously. But he was stuck in a brain surgery for late to the night. Come to meet and speak with us about this project. But I think we should try to host that again. Then maybe I can coordinate
Bill Clearfield 18:19
that yet. Let those brain surgeries get in the way of progress here. Again.
18:24
I’ll also I’ll also reach out I’m gonna do my best to reach out to Pam popper. She’s extremely busy. She created mega and she’s doing the same thing. And the mega I think he believe it or not stands for Make America Great Again. And what she’s doing is she’s created some lawyers in this group to defend licensed practitioners and non licensed practitioners from what’s going on. There. We believe there’s a million and a half non licensed practitioners now. coaches, consultants, energy people, blah, blah, blah, are to be attacked. Also. They’re starting to say that people like me are practicing medicine devices, or even coming after people like me for profits to stop suicide per se. So let’s see if I can get her involved also a pretty big driving force.
19:18
And well just one last thing Dr. Clearfield, there’s naturopaths and I’m affiliated with that would love to participate and I need you guys to greenlight it, but there’s two naturopaths and work out of my office. There’s one who refers to me, who’s an expert at Rice. She’s a former ICU nurse, and with her rage machine, she’s literally shrunk to wow. Okay, so I don’t know if we want to keep it just to this group now or later. Add other like you like that gentleman said non licensed healers like naturopath in the state of Indiana and Kentucky cannot be licensed but they’re still doing a lot of good work. And I think the more the more people that we you know, add to this organization of medical defense and medical freedom, the more power we’ll have the more you know $50 donations or more so, just a thought.
Bill Clearfield 20:21
Okay, I hate to break Yes. Time for the presentation. We have we have a speaker, Dr. Newstead I know you’re there somewhere. Yes,
20:32
I’m here just patiently listening. Very interesting conversation.
Bill Clearfield 20:37
Yeah, we rather we’d rather do the medical stuff and not all this other baloney with the men. Unfortunately, as you know, probably yourself. You know, it’s like when when I got my letter from the AOA that I was hostile to the AOA that’s why they terminated us. I said I wasn’t hostile to them. They were hostile to us. So And with that, Dr. John Lewis that please take over introduce yourself and give it a
21:05
go and we’re gonna thank you so much. So, as, as a naturopathic doctor in a licensed state, California, I can tell you that there are definitely benefits and drawbacks for practicing in licensed versus unlicensed state. So if anybody wants to have more conversations about including naturopathic doctors how to reach naturopathic doctors, I’d be happy to discuss that with you. I am actually the vice president of my state, naturopathic medical association, as well. So if you’re interested in getting the word out about what you do, let me know I’d be happy to have that conversation and see how I might be able to help as well. Tonight’s topic is about functional medicine for ADHD, bipolar, and depression. I don’t know. You know, I think folks can ask questions on mute if they want. Let me share my screen. I don’t really since I’m I don’t know if that’s the case. But feel free to interrupt me and ask questions at any time. I enjoy. I enjoy conversations as we go along. I’ve got to tell you this presentation started out probably eight nine years ago. I’ve given this several time for CPE credits I’ve given it a grand rounds talks at Bastyr University. And over the last couple of years my appreciation for ADHD has evolved and changed and mature not just from a sense of having treated it clinically and researched it and also depression but now having a teenage a teenager who has been diagnosed with ADHD and going through that process has been fascinating, has been an eye opener and is expanded my knowledge, empathy and information that I’ll be sharing with you today. So I hope that perspective as well as helpful. I am just quick overview. You know, we’re going to talk about why functional medicine I’m sure to this group. It’s it’s a no brainer. But what is typically not understood among clinicians is the historical underpinnings of medical biochemistry, which then evolved into functional medicine. And then looking at that versus genetics and then how we apply those concepts clinically within a neuro psychiatric conditions specifically this subset my research and passion in this field prompted me to write three books they’re really the first one revolution in health through nutritional biochemistry is for the general public. The second one on the actually was the third one but the one on the right foundations and applications and medical biochemistry and clinical practice. That is for clinicians, those those of you or folks out there who want to understand better the contrast between the conventional approach my my business partner at the time was MD PhD. So he talked about how conventionally he was taught to approach these conditions. I would talk about from the naturopathic or functional medical approach and then laying out cases from my clinic with with some chart notes and and obviously redacted labs and then how to create treatment plans. So one of the holes within this field that I found that the Institute for Functional Medicine wasn’t addressing, and labs like meta metrics at the time, which was subsequently purchased by Genova and others is that the labs can tell you one or two analyte and they could interpret a couple of analytes for you and tell you what they mean. But they couldn’t put that in the context of the patient and the case that you’re dealing with, nor can they help you create treatment plans and how to manage those those patients is to for functional medicine, did a is doing a much better job and has done a much better job at that and talking about how to manage patients. But wasn’t really giving a historical framework, or the philosophy behind functional medicine that I found satisfying. So that’s all in the book, and I’m going to be in the foundations and applications book and I’m going to be discussing quite a bit of that this evening as well to give context to the talk. I was one of the editors for manometric second addition of their their textbook laboratory evaluations for integrative and functional medicine. If you can find a copy of it now. It is phenomenal. It is the best resource I have ever found. I think it was swept up in the purchase of meta metrics by Genova and I don’t believe they’re publishing any more. I think there’s some some use copies available online, but it is an incredible resource for anybody who wants to dive into this more. They hired me after Dr. Braley saw my article on mitochondrial dysfunction and molecular pathways of disease reached out to me to make their textbook more clinically relevant. So that’s what I did. I went through the chapters and gave more clinical applications. And in fact there is the paper if you are interested you can scan the QR code on the right it’ll take you to my website where you can download the PDF of that paper. I do have a dietary supplement company NBI was started in 2006 Out of my medical clinic because I couldn’t find the dose or combination of nutrients I needed. That clinical trials show worked and that were already in existing products on on the market and it’s grown from from there I say this as as as much as a disclaimer so you understand my background, but also to inform you that these products are available there through full script Emerson, Doctor supplement store, and for anybody who wants to use these with their patients, these all came out of clinical need. And I’m going to talk about their application within the context of some of the patients as well. There’s a coupon code if you create a wholesale wholesale account on our website at NBI health.com. And just so you know the level of research that we’re doing the level of of of belief that I have in these products and how important they are clinically although they are bacterial pathogens Hi can you yourself please I appreciate it. The the level of research although these are dietary supplements or some talk about, you know, regulatory environment previously, so I just will say that they are not. The research has not been reviewed by the FDA. They’re not intended to diagnose, treat or prevent or cure any disease, but they are so powerfully and promoting health and supporting health that there are some very unique guarantees that we’re offering. The osteo K and osteo K minis are two of those. These are really our flagship lead products. Not just will they support and promote healthy bone mineral density but they will maintain strong bones they had the clinical dose of mk 445 milligrams per day shown to maintain strong bones as indicated by fewer fractures, more than 70% fewer fractures in clinical trials. So if if patients or the general public customers are using these we guarantee that it will stabilize and improve bone density within six months. But more importantly, because a bone density test only predicts 44% of women with osteoporosis who will break a bone and only 21% of men. They will maintain strong bones if somebody breaks a bone we will refund their money for all qualifying purchases between their bone density tests. So there’s more information about that and all the clinical trials on the website as well. So enough of that, let’s talk about functional medicine. Why functional medicine. So functional medicine takes the guessing game out of treating patients is no longer a shotgun approach. Like you all if you’re working with nutrition with patients, you’ve probably had the same experience that I have where people will come in and they’ve got literally I’ve had patients come in with a duffel bag of supplements or a box of supplements and they’ve just been trying different things. Similarly, even if they haven’t been discovering it on the on their own and doing research on the internet, even have clinicians that are just I call it cooking without a recipe. Try a little bit of this and see what happens and a little bit of that. Functional Medicine takes the guessing game out of it and this really dates back for concept to the early 1900s from 1902. It was the earliest work to discuss biochemical individuality with Dr. Garrett in Lancet. And these are observations without Captain Nuria.
29:55
Really a decrease ability to metabolize phenylalanine to tyrosine and there’s the block and the pathway and the consequences, really arthritis and adulthood, all sorts of problems. But he observed that there’s really an alternative course of metabolism so he was the first one to observe that it’s really about metabolism and aberrations in metabolism. And then you get into the Michaelis Menten equation. I don’t know if I’m giving anybody anybody starting to hyperventilate now remembering back to biochemistry, but it’s really about the activation energy and enzyme kinetics that was in 1913. So prior 19 1902 Dr. Garrett didn’t even know about you know the enzyme kinetics and the Michaelis Menten equation and then we jumped forward to Well, here’s the equation if you want to know you have the the substrate binding to the enzyme, and the enzyme requires cofactors vitamins and minerals. And I put a pin in that because that’s going to become very important in a few minutes. But then you got Watson and Crick with their double helix model of of DNA. And he walked into a pub and announced he found the secret of life, which was a little bit of hyperbole, but because the reality is genes don’t really do anything by themselves. Post translational modification of amino acids creates more proteins. than actually the genes encoding them. They’re about 30,000 to 40,000 protein coding genes, but 500,000 proteins, and that’s really where the rubber meets the road, in the biochemistry, not the genes itself but downstream, the micro environment that the genes are bathed in and that the proteins are made then and do the enzymes have the nutrients the vitamins and minerals that they need to function. In 1956 Dr. Roger Williams, first was the first one to articulate the concept of biochemical individuality. In his book and popularized it. And he said that nutrition applied with due concern for individual genetic variations offers the solution to many baffling health problems. You know, this is not new information. You know, this is dating back 19 Oh to 1956 and yet, not surprisingly, the conventional medical system has been very slow to pick this up and be teaching this in medical schools and work this into conventional protocols, unfortunately. So it can be assumed according to Dr. Williams and I believe he was correct that whenever an extreme genetic character appears in an individual, it shouldn’t be taken as an indication unless there’s proof otherwise, that less extreme and graduated genetic characters of the same sort exist in other individuals as well. And we see that played out Dr. Ame, Bruce Ames at UC Berkeley proved this, and I’m going to get to that research shortly. But is genetics the real cause of disease? Well, according to the CDC, now, it’s not maybe as as you know, when we’re young when we’re born, there are inborn errors of metabolism that that can be deadly and could cause developmental delays. But as we get older, it’s diet and lifestyle that are the drivers of disease and mortality. Over 60% of chronic diseases are caused by poor diet and lifestyle. And look what we have here in these statistics in 2014. Alone, Americans a 20 billion donut 63 per person. And since I don’t really eat doughnuts, maybe one a year, somebody’s eating a lot more than that summer with ice cream. And when you’re looking at refined flours, you’ve got 85% You know, most of magnesium most calcium B complex vitamins are all destroyed during during the refining of grains to make make flour for for baking. And in fact, the Behavioral Risk Factor survey in 2015 revealed that 40% of US adults eat less than one fruit and 22% Eat less than one vegetable per day. So if you’ve got a patient sitting in front of you, and they’re an adult, they’re likely at risk for nutritional deficiencies or they’ve already got them. And it’s affecting their biochemistry and it’s affecting their health. And this statistics just go on and on if you want to you want to read more. In fact, research suggests that lifestyle factors are responsible for 80% of most common cancers in the US like breast, prostate and colon cancers, as well as about 33%. You know, one in three cancer deaths. They’re all the citations if anybody wants to dig into them, and now DeBRUCE Ames. Brilliant he was the he created the metod mutagenicity tests. And then he went on to work on single nucleotide polymorphisms and looking at variations among genes that produce the same enzyme for biochemical reactions and enzyme kinetics. And so if you have a single nucleotide polymorphism what happens is it changes the enzyme kinetics and in decrease it increases the energy of activation, meaning that the substrate and the enzyme it can’t get down to the products you get a block and in the in the upstream metabolism. So let’s say you’re trying to convert tryptophan downstream to serotonin, that if there’s a if you’re you have a single nucleotide polymorphism and you can’t get downstream you’re gonna get a block in that pathway. And you’re gonna get a buildup for example of tryptophan or with federal kidney area with phenyl, alanine or this M citations I’m gonna just move on from that I kind of did reviewed a little bit of that already. There’s a long presentation, so I’m gonna I’m going to just skip over some some things. So here’s the PKU as an example. It historically viewed as irreversible the the catalysis of federal alanine to tyrosine is catalyzed by phenylalanine hydroxylase enzyme and there’s a deficiency in that enzyme in this genetic disorder can lead to neurotoxicity and mental retardation. And there are about over 500 mutations in genes coding for that enzyme. And the range of enzyme activities can be from near normal mild PKU to to 95% suppressed and severe PKU and over half of the children have one of the milder phenotypes. So conventionally, you’re talking about a phenol alanine restricted diet. And it can be very isolating socially, it’s very difficult to follow. And it’s it’s challenging, especially in pregnant women. So 9099 Again, this is not new stuff. Several clinical trials were run tetrahydrobiopterin is a cofactor for the p h enzyme, and that was used to see if they could restore activity to that enzyme by giving higher amounts of the cofactor to push the reaction downstream to restore the activity of the enzyme. And it worked there’s 12 month one of the studies 12 months duration 38 children. The bottom line is that a child’s phenylalanine level is decreased by more than 30% that was considered responsive to therapy and all children with mild hyper phenol anemia and 17 of 21. So 87% with mild PKU responded to Tetra hydro hydro by Opteron treatment. Among the responders you had phenyl alanine decreased from 37 to 92%. So this is simple inexpensive, easy, and it’s one example of many opportunities that exist when clinicians start thinking more biochemically. And biochemical biochemistry you know simply is how the how the body uses vitamins, minerals, fats, and proteins to do its job. And now things like nutritional deficiencies, a single nucleotide polymorphisms. infections, allergies, environmental toxins, all can interfere with the proper biochemical functioning and create disease. And that gets to sort of the medical biochemistry or the postulates that I developed. As I was working with this clinically, which is, first the law of parsimony. Let’s not complicate things when we don’t need to write. The simpler explanation is usually the best explanation to describe a suite of presenting symptoms. Symptoms are biochemical in nature. And biochemistry, like I mentioned, to how the body uses all the nutrients and how things can interfere with that. If a person was not sick last year or last month, and they are now then something’s changed in their biochemistry, through good intake, functional testing, the underlying causes multiple symptoms, I’m left out the word symptoms there can be analyzed simultaneously because one pathway, one nutrient is involved in multiple symptoms. Magnesium, for example, is used for over 200 biochemical reactions in the body and iron as well. modifications of biochemical functioning uses targeted therapies require clinicians, specifically become trained to properly conceptualize, interpret and apply this multivariate approach to dynamic physiological processes, and it can be curative.
39:58
So here’s kind of the overview of the progression of how these insidious nutritional deficiencies develop and it’s not quick they happen slowly over time. So it can be confusing it can be hard to track down you know, the the underlying cause, but you first get some initial biochemical alterations, no overt symptomatology, and then impaired cellular function followed by morphological and functional changes, and then finally diagnosed pathology. So really we’re talking about when you’re looking at nutrients and nutritional medicine, the reservoir model this was talked to taught to me by Dr. Howard modell, who is my physiology, brilliant physiology, professor, and really, we are hetero chemo tropes. Yes, as humans, we cannot produce our own nutrients. We have to get our nutrients and our energy from outside of our body. And those nutrients come from diet or dietary supplements, those are our inputs. And then you have a whole list of of outputs of things that that reduce that level of nutritional reservoir that we have in our body stress increases how fast we burn through our water soluble vitamins and protein pregnancy increases the risk for nutritional deficiencies because that growing fetus is just consuming all of those nutrients in flour inflammatory bowel disease or malabsorption may decrease your ability to to accumulate and assimilate nutrients menses medications, exercise, etc, etc. This is only a partial list of things that decreases our reservoir of nutrients in our body. And it’s more than just testing this is important because I think even when you’re talking about functional medicine, there can be an over reliance on on testing and testing is important, but it’s also important to treat the whole person because we want to look at the underlying cause. And according to the CDC, over 60% of chronic diseases are caused by diet and lifestyle. Lifestyle is a big part of it. Evaluating someone’s sleep someone’s stress is very important. Someone’s exercise all of that in terms of just testing because the goal at least my goal clinically was the testing was used to identifying the underlying nutritional insufficiencies that existed, so that I could create a custom nutritional program for somebody give high amounts of the nutrients that they were low in or missing so that they could jump so it would jumpstart their biochemistry, they would start feeling better quickly. As I was working with them over three months to improve their diet and lifestyle. So that over that three month period of time as they’re feeling better and transitioning, hopefully into living better and eating better, we can start pulling away those nutrients as they become sufficient. In those nutrients. We’ve increased those levels and through diet and lifestyle moving forward, they can reduce the risk for a relapse, they can reduce or reduce the risk for getting nutritional deficiencies down the road. But fortunately, what I found is this testing is so powerful but even if somebody came back a year or two years later and they had some symptoms, the pathways and the deficiencies correlate so well to symptoms, I could pull up an old test, and I wouldn’t have to retest and sit and look and say, Okay, here’s where you had deficiencies before those correlate to some of the symptoms may be just for you longer term, you may need one or two bottles of dietary supplements to maintain you feeling better, instead of them, like I said, coming in with a whole bag of dietary supplements that doctors have prescribed, and they’re just going to leave them on them for the rest of their life with no plan to get them off of them. So more than just testing also looks at the microbiome, hormonal system looking at environmental toxin exposures, which you can test for with functional testing as well. Drug nutrient depletions and mindset. Also whether they have a growth mindset, whether they’re managing stress properly, where they’re at in their life, in terms of mental emotional health. So clinical applications, these are all clinical applications that I’ve treated, that are discussed in in my textbook and today I’m focusing obviously on neuro psychiatric conditions. So when we look at depression and ADHD, we’re really looking at a spectrum. You know, it’s not they’re really not as discreet as I think people in the popular press want to make them out to be. It’s really a continuum. They all have an overlap of symptoms like a Venn diagram, they all have problems with concentration, decision making forgetfulness, negative thoughts, self destructive thoughts, sadness, etc, etc, all of them. And in fact, they’re pathophysiology of all three of them. They’re not well defined. They’re not well understood. Yes. There are some things we definitely know, now a depth more than we did 3040 years ago. But for these conditions, you know, the underlying pathophysiology, it’s multifactorial, it doesn’t come down to one thing. It’s not a one size fits all. There’s not one explanation for every patient. And conventional medicine really doesn’t have a great explanation for these conditions. So let’s look at the fundamental cause, in my opinion. It’s really about systems are out of balance. They’re unbalanced, it’s stress, whether it’s physiological stress because of a nutritional deficiencies, whether it’s personal issues, creating stress, insomnia, either difficulty falling asleep with sleep plays delay or sleep phase advance, creating stress in the body, immune activation with infections, allergies, you know pain, where someone’s in chronic pain. Maybe they can’t get comfortable, they’re not able to exercise. They’re depressed because of the pain. It could because of hormone imbalances was not in there and should be on the list of hormones also as thyroid. It could be because of diet. Whether it’s food out it is poor diet. Or food intolerances, nutritional deficiencies and lifestyle. So there are several functional pathways that are really for me the the key functional pathways to understand as a baseline, and that’s the dopamine epinephrine pathway serotonin, thyroid hormone production. What I call the lytic pathways are life policies glycolysis proteolysis, citric acid cycle and the electron transport chain. So the last three bullet points there are all about feeding nutrients, fats, sugars and proteins down into eventually the mitochondria and to create ATP. So let’s look at dopamine quickly. So the initial amino acid is phenyl. alanine, it’s an essential nutrient essential meaning our bodies can’t produce it has to come from diet or dietary supplements. And then that goes down its pathway all the way to tyrosine. And there’s a split there’s a break in the pathway goes up then to to thyroid hormone. It goes down its pathway continues down to dopamine, norepinephrine and epinephrine and the cofactors there are listed between each other step. So B, three B six, vitamin C, copper, B 12, folic acid, Sammy, and iron and you could test for almost all of these. So with a plasma amino acids test, you can look at phenyl, alanine and tyrosine if those are if those are normal, great. If they’re low, it means they are they are low, that actually you need to boost them with extra amino acids. If the phenyl alanine is high, but the tyrosine is low, it means there’s a block at that stage in the pathway and that’s how you can start to put things together and then you can look at the cofactors then that are tested the B three and the iron for example and say okay, I found that alanine is high or even normal but tyrosine is low. Are they low and B three, the urinary organic acids can be tested for B complex vitamins a serum ferritin test is the most sensitive indicator for iron deficiency. And you can start to put this puzzle together and piece the pathways together. So for the B complex vitamins, you know, 123 and five, you’ve got several urinary organic acids that are indicators indicators for those with urinary organic acids, it’s like TSH if those are elevated. I mean somebody’s low for their biochemistry. One of the nice things about this testing with urinary organic acids, unlike a serum test or a plasma amino acids test, urinary organic acids is a functional test meaning it’s specific for their biochemistry. It’s telling you for their enzymes for their enzyme kinetics, do they have enough of the nutrient because if they don’t, the enzyme won’t be functioning properly. It needs more of the cofactors in order to function. And when it doesn’t have that, like I mentioned before, there’s it’s like a dam or a block in the river and the water backs up behind it and then it spills out into the urine and it’s detected as elevated or high urinary organic acids, which are markers for certain nutrients. So de homovanillic you another urinary organic acid marker as a marker for dopamine. V six insufficiency, you’ve got a kind urine cow you’re kind of erratic or kind, urinate, and xante urinate for B 12 MMA and follow a form in a glutamate iron serum ferritin is the most sensitive indicator for iron status. The lab reference values are so broad to be clinically irrelevant. I’ve seen all the way as low low as 10 all the way up to over 200. I like the work of Russell Blaylock and his recommendation that we shoot for about 90 to 110 and in fact, there’s a clinical trial of women who complained of fatigue who had ferritin less than 50 they were given iron their ferritin went above 50 and their fatigue decreased by 50%. So I like I shoot especially if they’re symptomatic I want to get that ferritin serum ferritin up least above 50 But I shoot closer to 80 or 90 if possible. For minerals you want RBC minerals, that’s where they concentrate all the minerals except calcium concentrate inside the blood cells. That’s where they do their job. So the gold standard and nutritional testing is the RBC or with recite tests. Vitamin C quinolinic acid is a is a nonspecific marker for CNS inflammation. So that could indicate that they require additional antioxidants, vitamin C just being one of them. Serotonin pathway very similar. Tryptophan is the essential amino acid and those are the nutrients required to go down as pathway to produce serotonin and melatonin.
51:06
Quick story back here real quick on the epinephrine and dopamine This is a an anecdote. So my my my business partner who was my business partner at the time, I co wrote the books with him. He came into my clinic MD PhD, very well trained Harvard, Cornell MIT, and he and I met and he had been I had been diagnosed with adult and mature onset asthma, adult onset asthma. And it was recommended, not surprising steroids. We met at a Summer Arts Festival. I’m not violating HIPAA. This is in our books. We’ve talked about it. I’m radio shows together. So it’s in the public domain. And he said, What do you do? I told him as a naturopathic doctor, he had never heard of it. He said, What does that mean? I told him and he asked me what I would do for for adult onset. Asthma. I asked him a few questions. You know, he said he had asthma. I asked him if he had it as a kid. He said, No, I said, Try, Sammy, and you could see it there at the last step of the conversion of norepinephrine, epinephrine. Epinephrine, among other things, as you may know, is a bronchodilator. So I just didn’t try Sammy. I did. We went away. I didn’t hear from him for months. Suddenly, he showed up at my clinic. He tried the steroids that gave him a lot of the side effects, insomnia, jitteriness, and he knew that it would create osteoporosis and potentially an early death. And so he came into my office he tried to scam me he felt better. He came to my office said okay, work me out. So I did extensive testing. I ran an ion panel on him which was meta metrics his panel now Genova has it, which tests hundreds of analytes it’s urinary organic acids, plasma amino acids, RBC minerals, essential fatty acids, metals, toxic metals, and the list goes on and on. And in fact, I pieced this this pathway together for him in the office and I showed him on a diagram. And what happened is everything was normal. phenyl alanine, you know, his homovanillic paid for dopamine was normal. His B six, you know, kind urinate was normal. The B three markers were normal, and then you get to dopamine and then the marker for epinephrine and norepinephrine. just plummeted and his RBC copper was low, and his RBCs zinc was high. So what happened is he had heard that zinc was healthy for and good for prostate health. So he thought, well, if some zinc was good, a lot of things must be even better. So he was taking really high doses of zinc and without taking copper, zinc and copper have to be balanced and about an eight to 10 to one ratio of zinc to copper. Otherwise, zinc can create a copper deficiency can knock out your copper, and that’s exactly what he did. He induced his own asthma because he induced his own copper deficiency, which depleted his epinephrine and created the symptom that we call asthma. And that conventionally he was told just take steroids for the rest of your life because we have no explanation of what’s going on. I threw a zinc in the trash. I gave him copper the rest is so comprehensive. I found some other things going on. Bottom line three days later, His breathing was normal. And he’s never had he never had to go on to inhalers after that. That’s the power of this testing that specific personalized approach. Thyroid you need selenium and iodine. The conversion of phenylalanine to tyrosine. We already talked about in peripheral conversion. You need selenium, zinc and vitamin D. Now getting into fats, carbohydrates and proteins, you need B vitamins and lipoic acid l carnitine. To shuttle fats into the Krebs cycle, to then pull it through the citric acid cycle. I’m not going to go through all the details here. But in the rectangles there you see the different nutrients that are used in each step of the way to pull those precursors down the pathway to continue the conversion to continue to produce NADH to feed into the electron transport chain to produce ATP. You even know co Q 10 down there towards the bottom and then for just the mitochondrial functioning for the electron transport chain. You know, this is all what’s required for the TCA cycle, all the nutrients and this is in the article, my article if you want to pull it up, that I referenced earlier that’s available on my website NBI health.com. And those are all the nutrients so if you were to try and just say well, I think it’s riboflavin or I think it’s cookie 10 Or I think it’s copper. You that’s impossible. It’s ridiculous. The testing takes all the guesswork out of it. So let’s look at some clinical applications. So, you know, we all know what is medicine it’s really about pattern recognition. So your personal medical history, family and social history view review of symptoms, diet, read, a review of systems diet recall. And then I like to ask patients, what do you love? Because there could be a psychological component of, you know, they’re really just not giving themselves permission. Maybe they need counseling, maybe they just need to find something that lights them up. So the overall approach when I’m creating treatment plans and I like to treat, you know, teach clinicians about this is really it’s about first diet and lifestyle. The dietary supplements are there, towards the end of all my treatment plans really to replenish somebody so they feel good, but the diet and lifestyle are the foundations, we want to reestablish the foundations for long term health. The plans are for three months. I’m just reading that last bullet here. See what I didn’t mention after three months. So typically what I do is after two weeks, so I review the the program with them. I give them their their their their treatment plan. I then do a follow up for two weeks. That’s typically just a quick check in to see how they’re doing on the supplements. If there are too many minerals, for example, that have been recommended or prescribed to them, then they can get an osmotic diarrhea. If sometimes with the complex, you know B vitamins if it’s too much, they may end up getting a little some nausea. So if it’s too many dietary supplements or too many nutrients and they feel overwhelmed, either physiologically they’re not reacting well to that how aggressive it is. Or they just it’s a lot for them to juggle. Then at that two week mark is a good time to check in and say okay, you can modify things you can prioritize things, you can stretch out the plan a little longer, but most of the time, the vast majority of time people are doing great on this plan. They don’t need to really modify anything a quick check in just to see how they’re doing. And oftentimes when it comes to psychiatric issues, we already are seeing benefits. They’re already starting to report improvements because biochemistry is like a it’s like a car and nutrients are like gasoline for the engine. When you’re out of gas, the engines not going to run. But as soon as you put gas in that car, it starts and it’ll go and our biochemistry is similar. Our biochemistry is primed and designed to function when given the raw materials to do so. So as soon as you give those raw materials, people start to feel better quickly. And then I liked that I liked the giving the high dose of the dietary supplements. They start feeling better quickly they start getting some results in then they’re more motivated to continue because the dietary changes, the lifestyle changes take more work and effort over the long term. Typically I tell patients, look this is a three month program. Don’t change your diet overnight. Huge changes done too quickly are not sustainable. And this is teaching you how to eat to promote your health for the rest of your life. So whether it’s over four weeks or six weeks, whatever company is comfortable, make that change slowly because especially if there’s a family involved in it will or they have a partner it’s going to involve them as well. And it often requires shopping differently. Having different snacks in the house having different spices in the house. Over time their taste buds will start to change especially if they’re getting a lot of packaged and processed foods and have a high sugar diet once they start to wean off of that and so it’s a process.
59:43
So let’s look at blood sugar regulation. So low blood sugar can be a rollercoaster and it can create all those same symptoms of depression, mood dysregulation and, and ADHD. Don’t be a difficulty concentrating. So with blood sugar regulation you know, I ask people are they worse? are symptoms worse in the afternoon? Usually a couple hours after lunch do they get that postprandial drop in in energy? You know, that’s an indicator that they’re having a bit of poor blood sugar control. A possible solution is just making sure they get adequate protein. Most people I find despite the keto diet and the high protein diet craze, they’re not getting enough diet. I talked about this. I believe in the last talk I gave on on osteoporosis, you know, most people aren’t getting enough diet. So enough diet enough enough most people are not getting enough protein. So the protein the basic calculation in general is about one gram per kilogram per body weight. I actually like to go higher than that typically 1.2 1.3 grams per kilogram body weight per day, and I give handouts to patients and say Look, don’t change your diet overnight for the first couple of days. Just focus on eating how you’ve been eating, organizing your supplements, start taking your supplements, but calculate write down everything you’re eating for two days and each day calculate how much protein you’re getting. And then I also have them calculate how much dietary fiber they’re getting. And my goal for people is a minimum of 30 grams of dietary fiber a day fiber is important for microbiome health. It’s important for blood sugar regulation. It’s perfect. It’s important for colonic colonic site health. But it’s also aware that there’s this fiber where the fiber is found. It’s found in Whole Foods, not as a supplement. It’s found in whole vegetables and whole fruits and those have the vitamins, the minerals and the other plant nutrients that our bodies need to thrive. So I just have them focus on those two components, protein and fiber. And then once they do that for two days and calculate it, they have a baseline they know where they that they’re at and then they know what their goal is and they can start transitioning into eating that way over time. Looking at stomach acid, if they may have symptoms of hypochlorhydria as people get older hypochlorhydria is a bigger issue. There’s a higher risk for it and that can cause a gut dysbiosis it can cause leaky gut it can cause problems with assimilating, digesting and assimilating nutrients and predispose people to infections as well. So what I liked there’s prevalence of of hyper and a core hydrea. And obviously, if they’re on acid blockers, that is a real problem. That’s definitely going to create, create it and it creates an increased risk for hip fractures by up to 60%. After four years. By the way, just as an aside in terms of medication induced osteoporosis, the the the standard of care with people who had osteoporosis induced by acid blocking medications was to just give a bisphosphonate. The assumption was, you know, we use it for other types of osteoporosis, postmenopausal osteoporosis, we’re going to just give it for for this as well. Well, somebody decided to finally study that there been several clinical trials. What was found is people who combine in acid blocking meditate medication like a PPI with an oral bisphosphonate like Alendronate on oral bisphosphonate. their risk of fracture was 50% higher than people who were just taking the bisphosphonate. If they were taking the bisphosphonate plus the PPI. There their front risk of fracture increased, so a cautionary tale there when it comes to prescribing medications when the mechanism of action that induced the disease is different, doesn’t always work out to the advantage that we hope. So gut associated lymphoid tissue and microbiome 80% of the immune system is clustered around the gut. And so you know, malabsorption food intolerances is a big issue that also can if someone has hypochlorhydria that can increase their risk for food intolerances and even if they have normal stomach acid. Food intolerances can be a big big issue. So I always like to test IgG food allergies or food intolerances as well. Especially if they have the most common symptoms, which are gas and bloating and post nasal drip. fatigue after eating is also another possible symptom of immune activation caused by a food intolerance difficulty losing weight. You know may be a result of food intolerances as well. When you have severe food intolerances, you can get systemic effects. You can get migratory joint pain, you can get migratory rashes, and so those are just things to look at as well in terms of a review of systems. So, in three months, I talked about this, this treatment plan. And then you know, just they follow up after three months as needed. And essentially the bottom line is to get them healthy so they don’t have to take pills for the rest of their life. Maybe a multivitamin. Maybe one or two supplements as needed, moving forward on as on a per case and an individual basis. So let’s look at some cases here. So endogenous depression and a 52 year old woman, and endogenous meeting years and years and years she had a long long life long history of depression, suicidal ideations as young as five years old, and a history of one attempt. She had insomnia and occasional migraine headaches also complained of difficulty losing weights. These are the tests that was order, you know, the trial profile, which is now Genova so how I decide on one profile versus the another one. So the triad profile is plasma, amino acid, urinary organic acids and IgG, 90 food antibodies, tests. It doesn’t have the toxic metals, it doesn’t have the RBC minerals, it doesn’t have the essential fatty acids. It doesn’t have a sometimes I’ll do and then an add on microbial ecology still profile. So how I decide is the number of systems involved, the more systems that are involved in a review of systems and the longer they’ve had the symptoms will help determine whether I do a subset of the testing or I do more extensive testing. So here are her test results. And I’ve got to move this bar out of the way here. So I put these in. These are her actual test results, and I put in category so urinary organic acids out of peat and Super Eight are indicators of an inability to pull fats into the citric acid cycle essentially to burn fats for energy. And you can see those are towards the high end of normal. And one of the challenges I’ve seen repeatedly I’ve had people bring in functional test results and they weren’t feeling getting better. They’d seen other practitioners and the doctors missed the subtlety. They were just going maybe off of what the computer from the lab recommended they do and how they how they approach the patient. But there are subtleties involved in interpreting that was really important. If you want to get an expertise in this and get the really get the best possible results with your patients. You will make a study of this so pyruvate was elevated. That’s an inability to decrease sugars for energy. Built burn sugars for energy, by the way if lactate had been elevated as well. One of the things that’s also a marker of an inability to, you know fully use glycolysis to burn sugars for energy. What I like to ask patients in a review a systems is when you exercise, do you find your muscles start burning faster and they get tired quicker than they used to? If they do that could be the lactate buildup, the lactic acid builds up in their muscle quickly because they’re not being able to burn their sugar, which is the first preferred energy source and we’ve start exercising that short term burst of energy and so that lactic acid builds up faster and they get fatigued quicker, and they get that lactic acid burn she had functional deficiencies for B vitamins and fall you know folic acid, so B 123 a beat that’s what the Alpha keto so capillary methyl Melanie for B 12 For a minute glutamate from B for folic acid, the urinary organic acid dihydroxy phenol appropriately is a marker for potential Clostridium overgrowth. So you can get that nonspecifically on you know potential gut dysbiosis adda urinary organic acids. I pretend I pretend I prefer a microbial ecology profile because you can look at yeast bacterial and parasites all simultaneously and they can all create the same symptoms. So to get a more specific and more comprehensive look, I prefer that test if I am suspecting a gut dysbiosis she was low and Muthiah meth ironing and she was learning 3d And she had allergies, moderate or severe allergies to you know, dairy, casein milk and brewers yeast.
1:09:30
So her plan avoid all allergies. So when I say don’t change your diet for two days, except with a caveat, if they have severe allergies, I want them to get that out of their life immediately because we know that is causing a problem and if you don’t get the exposure out of their diet, then whatever you’re trying to do, you’re it’s like pushing a boulder up a hill. You know if there’s a lot of resistance you want to get the resistance out of the picture so you can help them heal as fast as possible. Relaxation for the stress exercise. I like the five second breathing just teaching people how to breathe you know they breathe into the count of five, hold to the count of five breathe out to the count of five it focuses on them on their breath, and helps rebalance that parasympathetic and sympathetic nervous system to just calm people down as well. And then dietary supplements. And so the dietary supplements supreme multivitamin which I created for my my patients that does not have iron in it, by the way, and that’s because frankly, if people need iron, the amount of iron that’s in a multivitamin is typically to load or punish them. And so fair assault which is the iron product that I created, is the highest dose iron bisglycinate product on the market. 45 milligrams very easy on the GI tract. And the replenishment dose is somebody who has iron deficiency anemia is one to two milligrams per kilogram body weight per day so you can go higher than 45 I’ve doubled it in patients 45 milligrams twice a day without any GI complaints at all. Whereas the the ferrous you know iron sulfate or iron glucan aid it just tears up their their their gut, cramping constipation and the iron the fairest solve that I created. This does not a brain blend. Another one it’s really for for mitochondrial health is how I started to conceptualize it but it really does much more than that because Assa T L carnitine has also been shown to promote healthy dopamine production, Alpha Lipoic Acid and as to carnitine help to promote healthy insulin regulation and healthy blood sugar regulation. I also see when triglycerides are high. This can decrease triglycerides on blood tests. The Huperzine A is an acetylcholine esterase inhibitor, so it helps promote healthy memory and the tumeric and you know for antioxidant protection, all of those cross the blood brain barrier to get into the central nervous system, really to promote and support healthy memory, energy mood learning focus and recall. This is frankly one of my my favorite formulas because people get results from it. You they it’s noticeable. Yeah, they notice it quickly. Belly rescue it’s a prebiotic and probiotic blend 15 probiotic species 25,000,000,020 colony forming units. Then things that I don’t have Matthias and glycine powder, B B complex co q 10, B sublingual B 12 And then an antimicrobial mixture of Berberine from different plants for the dysbiosis potential dysbiosis that was their three month bottom line so unstructured avoid all the foods like I mentioned two weeks later first follow up. She reported that she was following the plan diligently her mood was quote shockingly stable and that she was not experiencing much depression or anxiety, anxiety and that was just two weeks. After six weeks she reported continued improvement in her depression and then her pants fit looser on her I do not like people using scales to measure their weight. I tell people to stay off the scale so if they are eating healthy, if they are exercising, they are going to be putting on muscle. If you’re putting on muscle muscle weighs more than fat that scale isn’t going to move. In fact that scale may actually go up. And so people are just focusing on that number on the scale. They may feel disheartened because the numbers not moving in the direction they hope the most sensitive indicator is if their pants start fitting looser and that’s what I asked my patients after three months reporting complete resolution of her depression for the first time in her life. One year later to follow up she was still depression free. By the way. One of the reasons why I got into this is because when I was first in clinical practice, in my solo practice, I found myself sitting in front of patients presenting their plans to them super excited as a young doc telling them to follow this program spend all this money because as you probably know many of these things are not reimbursed by insurance. I’ve got to pay out of pocket for the nutritional consultations and the dietary supplements and I saw their eyes start glazing over and I was really in effect just saying believe me trust me change your diet change your lifestyle take all these nutrients spend all this money over three months and just believe me with the testing it’s also provides them third party validation. It’s no longer just believe me it’s here. Here’s the numbers on the test. My compliance went up to almost 100%. And so that’s another benefit of this testing and this approach, depression and a 26 year old woman, so three year history of depression and fatigue. She had other complaints, so other systems involved her share colds, she said would linger longer than others. She had post nasal drip almost all the time. premenstrual migraines, abdominal gas and bloating, brain fog orthostatic hypotension all the time. That’s a quote. She had an increase in 10 pounds in the last couple of years, which she could not lose despite how much he exercise. And her fatigue or energy was a three out of 10 with 10 being messed so there are more than three body systems involved. So I ordered more comprehensive testing. I ordered the ion panel plus an IgG 90 Food antibodies plus a serum chemistries, all through meta metrics and the test results. She had deficiencies in all 10 essential amino acids all 10 of them. She was bottomed out. Her ferritin was low and she had multiple mineral deficiencies, elevated free radical damage and elevated lipid peroxides which is a marker for free radical damage to fats, which is a risk factor for cardiovascular disease. She had low vitamin D and she had low Omega six fatty acids she had functional vitamin deficiencies for energy production, impaired liver detoxification pathways, intestinal bacterial and fungal overgrowth and severe food intolerance to multiple foods. So this is how comprehensive This is the incredible amount of data that this approach can provide. And then what do you do with it? Well, that’s how you put the plans together that helps you deal with it. So here are her here are her results. You can see this the food allergies at the top. You can see then the list of amino acid deficiencies and below that she had low normal minerals low chromium, copper, magnesium, manganese. Selenium was was on the lower end of normal. And so she was in a world of hurt. You know zinc was low No wonder she felt so crappy. You have five hydroxy indle asks acetate that’s a marker for serotonin production low serotonin production. So that’s associated with depression should a low CO Q 10 Should elevated lipid peroxides vitamin D insufficiency So frankly, I would like vitamin D above 50 For immune health, for bone health and fracture read associated with fracture reduction it needs to be between 30 to 44. But I like to see that you know, 50s and 60s so she was half of where I would have liked to see it to go there. The Omega SIX series fatty acids, and deer rabbit atoll is a specific marker for yeast or candida infection. So there’s the plan after two weeks her energy increase you no longer experience post nasal drip as soon as you get those foods out of the diet. A lot of those symptoms then will go away that were associated with that immune activation after six weeks or their gene increased to nine out of 1010 being best no post nasal drip no migraine headaches and no abdominal bloating no longer got lightheaded when she stood up. And her mood had also completely, you know, improved and normalized after 12 weeks, completely resolved. So, diet and lifestyle you can get the handouts that I talked about the protein handout and the fiber hand up from my website. There’s the URL there if you’d like them.
1:18:24
And here are the recommendations that I have for intestinal dysbiosis you can use an antifungal like a nice statin is fantastic. It’s safe, it’s old and I do I love that or you can go with plant extracts, plus a probiotic then to replenish and help rebalance that gut microbiome. I did had to do a customized amino acid blend, metabolic metabolic maintenance, created a customized amino acid blend for me I don’t know if they still do that. But that was the company that I used for that provided extra glutamine powder for the gut healing. Glutamine is the preferred energy source for the gut mucosa and that helps with healing of that intestinal lining. Provide a contrail dysfunction the brain blend, multivitamin and minerals supreme multivitamin Farah Solv. As I mentioned, extra B complex vitamins specific and magnesium amino acid ki lay 300 milligrams at bedtime and a multi mineral formula so extra minerals as well, for 32 Just for 30 days to get her minerals have not everything is necessarily for three months. You know 30 days on that to boost it and get a quick jumpstart on the minerals also high you know good amounts of minerals in the multivitamin. But so not everything is for the full three months fatty acids and then NAC to help liver detoxification pathway. It boosts glutathione and then if symptoms are continued possible additional workups could be a hormonal panel. Gluten sensitivity panel but we didn’t need it. I liked interroll I like it Tara labs by the way for their gluten sensitivity panels. Alright ADHD. So global prevalence now five about 5.2% among children, adolescents 60 to 70% persist into adulthood. The symptoms you know inattention, hyperactivity impulsivity, but it is also a syndrome of contradictions and paradoxes. So every negative has a match positive and vice versa. So they can be your inability to concentrate. Yet they also have hyper focus for things that they’re interested in. These people will focus they have an incredible ability to hyper focus and some of them are incredibly successful. Because of that Elon Musk has ADHD. Certainly Richard Branson, who started Virgin Airlines and many other companies has ADHD. And so you can help them identify where their strengths are and use those strengths to their advantage while you’re working with them. There are people who are you know, experts in that if you’re not if you’re just doing the more biochemical functional piece, but their experience and I learned this as I was going through this with my child, it’s like they’ve been dried. They’re driving a Ferrari, their brain is going at the speed of a Ferrari, but they only have bicycle brakes to stop. And part of that they they’re thinking currently is is the brain may parts of the brain may mature slower and some people may then grow out of it. That’s evidenced with connectomes group of neurons that light up together. When engaged in tasks and like frying an egg and you look at functional MRI, they can see specific groups lighting up on certain tasks, and that’s called the task positive network. And then we light when people are daydreaming, you get what’s called the default mode network. And this is from the work of the book down below. It’s a great book ADHD 2.0. By the way, to physicians for last 2025 years they’ve been focusing exclusively on ADHD. And what happens is people are switching between the the TPN and the dmn. And there’s a toggle switch, but in ADHD, that’s dysregulated. And so they can’t toggle one off versus the other and so their mind is jumping back and forth. And it’s that dysregulation that creates so many problems and it’s not just that looking at functional nutrition, but functional approach means also, you know, how is the neurology functioning and what can we do to improve its function? There’s tends to be challenges with the vestibular cerebellar system as well. With ADHD affects motor control and balance and if you can improve that system, you can improve some ADHD symptoms. There is a the work in the 1960s looking at movement and ADHD patients had dyslexia using balance exercise has become developed by a chiropractor into a franchise called Brain Balance achievement centers and I can tell you, it’s discussing in the book ADHD 2.0, and they talk a little bit about the research behind it from my own personal anecdotal experience. With my own child. That combined with the nutritional approach, combined with taking brain blend, combined with trying to get adequate sleep and diet. The results have been astounding with the ability to regulate emotions with the ability to focus. So if this isn’t on your radar I really recommend people look into this Brain Balance achievement centers and the research and see for your patients about referring them. It is a program and it is a it is a commitment. It is typically two or three days a week for an hour a time for six months and they take you through a series of exercises each time and track the progress. So let’s look at genetics versus environment in ADHD. So accepting extremely rare cases. There are no genes of major effect in ADHD. The amount of heritability related to genotype environment interactions is unknown. And Snipper heritability indicate that he shares genetic liability with many other common psychiatric conditions including anxiety and mood disorders. You get that overlap again, that Venn diagram, there’s not a real clean clear cut separation between all of these disorders. And the effect size is unknown for for genes. What we do know is for biological parents and siblings of patients with ADHD there’s a two to eight times higher risk of them also having ADHD so let’s look at nutrition. There are deficiencies that have been implicated in the research with ADHD symptoms, deficiencies of iron, copper and manganese, as if you remember from the dopamine and epinephrine pathway, iron and copper are both required for dopamine and production are actually iron as required for dopamine production and then dopamine going to epinephrine requires copper and ADHD is considered a deficiencies in catecholamines. So it’s not surprising then that there may be an underlying deficiency or that’s keeping the body from producing enough. Essential fatty acid deficiencies also have been implicated. Although I’m not so clear the research on supplementing with essential fatty acids has not necessarily been all positive. But a lot of the studies did test for deficiencies in essential fatty acids. First, synthetic food coloring in one study a percent of children with ADHD may have symptoms related to synthetic food coloring, specifically blue, so getting food out of their food coloring and food additives out of their diet. is important. As I mentioned a Hypo dopaminergic conditions so that’s where that you know, brain blend is important for promoting healthy dopamine production. That’s where making sure if you don’t want to test even making sure that they’re getting some extra minerals and mineral support may be important. I am a fan if you’re going to do any tests to test their serum ferritin especially in girls because of menses because of the risk of iron deficiency with with girls and women. So the dopamine hypothesis has undergone a lot you know, nuanced revisions in recent years but it’s still the core line of thinking with ADHD.
1:26:45
Again, back to that brain blend. They all cross the blood brain barrier up regulates dopamine receptors attenuates microglial activation and release it and fam inflammatory mediators in the CNS and improve glutathione status. At ADHD medications, there’s quite a few as you may know, but a study looking for from 1993 to 2003. They killed 90 children. It put them into sudden cardiac arrest strokes created strokes and rapid heart rate I actually had a patient who had those symptoms in Canada. They required patients before being put on these medications required to do an evaluation and a risk screening for sudden cardiac events looking at family history before prescribing these in the US that shouldn’t be done but it’s it’s not. It’s an extremely rare complication. The benefits definitely can outweigh the risks using these medications. But I do think as simple asking a few questions about family history is important. I talked about the Canadian medical study. So let’s look at diet a little more about diet. There are 5000 food additives used in food, ADHD, I’d said up to 8% of that one study. Other researchers looked at said up to 50% of hyperactive children, which ADHD has hyperactivity is one of the hallmarks but not always and let me just tell you in girls, there are so many girls that are being not diagnosed with ADHD because that stereotypical the child that can’t sit still crawling over the desk running around the classroom, disrupting the room that is more typical for boys and girls. It shows up very differently. And so making sure if if there are challenges with school if there are challenges with completing homework if there are challenges with maintaining friends, that if there are challenges at home and behavioral issues that are going on impulsivity that may be going on even if they don’t seem like the Hallmark, you may want to refer them for or or if you’re able to work them up and evaluate them for ADHD. Blood sugar dysregulation When blood sugar drops what happens people have difficulty focusing and concentrating and they can become jittery. And those are symptoms of ADHD that can be confused with ADHD and really, they’re just not eating well. I have this case with a seven year old patient of mine. He was getting in fights. He was dying at school he was diagnosed with ADHD. His mom brought him in and he’s got to be kicked out of school. If it happened again, and I did evaluation I ended up not doing any testing with him. Because what was really clear through the intake and just a review of systems he wasn’t getting enough sleep and his diet such he was having sugar for breakfast, not having any protein at lunch. And so he had blood sugar dysregulation. I prescribed him an extra hour to two hours of sleep a night a strict bedtime. He had to have protein with every snack protein with breakfast and protein with every meal. Just with that. And then I did look at actually I did one urinary organic acids test. I didn’t do any blood tests. He showed a functional deficiency of vitamin B six, gave him a little bit of B six, changed his diet changed a little bit and changed his bedtime and all of his symptoms went away. Food intolerances also, that can create problems difficulty focusing can cause behavioral changes. So looking at that that may be involved. Here’s the 21 year old man I was talking about him and ended up with a rapid heartbeat rate he was on medications for ADHD and depression. 14 years previously was the onset when his parents started to divorce and separate. He was apathetic. He had difficulty concentrating, focusing on tasks completing tasks when he was not taking his Adderall. His energy was seven out of 10 went on the Adderall and plummeted to three to four out of 10 without the medication, had sleep phase delay and advanced so difficulty falling asleep and staying asleep and he was getting palpitations more than twice a week. Shortness of Breath three to four times a week even at rest in a sitting position and was getting orthostatic hypotension weekly. Here’s an medications Adderall, Zola Pam no supplements. In addition to being referred to local counselor he undertook biochemical testing. So I did refer him for counseling and I did the try out panel and here is the results. So as pyruvate was towards the high end and normal difficulty burning sugars for energy, so difficulty with blood sugar regulation, functional deficiencies and B complex vitamins vitamin B six and folic acid. He was low in dopamine production. He was had an elevated marker for free radical damage. He was low and essential in amino acids vailian serine, taurine, and tyrosine tyrosine goes down its pathway to produce dopamine, a mood elevating hormone a hormone that’s associated with task initiation and task task completion and motivation and focus. So treatment fiber protein, omega three fatty acids from diet, supplements brain blend be complex folic acid extra folic acid, amino acids, whey protein powder, taurine powder tyrosine, so, not, you know, very kind of a broad spectrum amino acid powder with whey protein, but then more of the ones he was deficient in for short periods. of time to really boost those up. Additional supplements, vitamin C acid, Sal Mathias owning an STL cysteine tumor extract. After three months, things stabilized. He’d completely discontinued Adderall and Zolder. Pim, his energy without the Adderall was up to eight to nine out of 10. And he can focus for longer periods of time. He was able to complete tasks without difficulties as Depression had resolved, and he no longer experienced mood fluctuations. He characterizes sleep as good and he had no more palpitations, not surprisingly the palpitations were probably being caused by the Adderall, a 16 year old male with ADHD no medications. Tried melatonin for sleep with limited benefit. post nasal drip and congestion. Chronically I ordered the triad profile also had inbuilt pulse control issues. Here are the results. Again, functional deficiencies it’s the same thing over and over just in a unique patterns, deficiencies in vitamins and minerals or amino acids or or an infection. It’s some combination of those two methyl hip right I haven’t talked about that. Yeah, that’s a organic acid, urinary organic acid that’s a specific marker for detoxification pathway elevated methionine and tryptophan so he actually had enough tryptophan, but he wasn’t able to pull it down its pathway efficiently to produce serotonin severe allergies, quite a few lots of allergies, food allergies going on. similar treatment you know, avoid allergies and purposely give nutritional support and then consider possible future testing if things didn’t resolve microbial ecology profile if there was intestinal infections present. Like the symptoms of intestinal infections and food intolerances are almost identical gas and bloating post nasal drip so you don’t necessarily test them both. If it’s just a GI complaints and those are the symptoms I typically will test them both if they can afford it. But if I’m running a panel anyway, and there’s not a strong indicator of a an infection, then a food intolerance panel is typically word I would run first. After two weeks patients bomb reported our son was sleeping better. He could tell the total difference after using one tablet 30 minutes before bedtime over the past two weeks. Notice his irritability is less his mood is better falls asleep better. He’s making the dietary changes as food improved. So here’s the conclusion. Look, depression bipolar ad I didn’t talk about bipolar it’s a combination of these things right you get mood fluctuations up up and down. These are spectrums of the same types of symptoms. The only the differences in the degree of severity and whether some on the extreme end of things are present or not. The the underlying causes are similar patterns of nutritional deficiencies, vitamins, minerals, amino acids, fatty acids, the naturopathic approach, the not lifestyle, dietary modifications, nutritional medicine, physical medicine, medication, and an even more personalized approach using this functional medicine testing. And an approach to creating treatment plans can give even greater benefit and better results.
1:36:15
So here’s the conclusion. You know modern laboratory technology has made the promise of customized medicine reality it’s here. Genetic testing can be helpful for some things, but This to me is much more effective for the vast and relevant for the vast majority of patients. The medical biochemistry, it’s the outgrowth of more than 100 years of clinical observations, clinical trials and research and development. It’s more relevant than that in medicine than genetics for most cases. And then through the sophisticated testing and understanding of biochemistry, skilled clinicians can promote health and, and cure disease. So I’m happy to take questions, happy to connect with people. There’s my email, my website, through LinkedIn, Facebook, let me know how I can be of more service to you all. And I’m happy to take questions.
Bill Clearfield 1:37:04
Thank you so much, John. That was terrific. My pleasure. And thank you. Yeah, thank you for thank you for attending. We, we really appreciate it. Anybody. Someone asked if you ever use lab corps amino acid test if they can’t afford you know,
1:37:26
the product so LabCorp actually would outsource you there there. Your amino acid test to gin to meta metrics before? I don’t know who’s doing it. Now they’re doing it in house. The challenge I have with LabCorp is the reporting. They don’t test all the amino acids that I that I really want but if that’s all they can afford, if that’s if that’s what will be covered, then it’s better than than nothing. You just have to really understand what the analytes mean and how to interpret them and make sure at least for some of these key pathways that you’ve got, you’ve got enough for the B complex vitamins for the B six for the B 12 for the folic acid because look there serum B 12 could be normal. But if there methylmalonic acid is elevated, they have a functional deficiency. You can be you know what is normal mean anyway, on a lab test, you know, in terms of a serum value, it means we’ve looked at 100 or 1000 specimen and we’re just gonna say 95% are normal two and a half percent are abnormal two and a half percent that are higher abnormal, it has nothing to do with with health and optimal levels. So they’re gonna have a normal serum B 12. But if they’re methyl melanated is high, they’re still functionally deficient. And then you’ve got to do a methylated B 12. Because they may unless you you do test and this is where genetic testing may be helpful. Test for a genetic the genetic snip to know if they can actually methylated B 12 and a methylation deficiency. So I just give them methylated forms anyway, so it doesn’t really matter.
Bill Clearfield 1:39:01
Right? Yeah, I know that they’re a little difficult to interpret. It takes me two hours to do one of those tests. I don’t do enough of them. Maybe but you know, because it’s the language it’s not it’s not easy language to navigate through.
1:39:15
Well, it’s like anything, it’s like, you know, if you were put an EKG in front of me I’d be like shit I don’t like the one of the engineers I don’t have to ask somebody for help and you know, look at some Interpretive Guide or something, you know, but you know, I know Doc’s that read them like they read the morning paper like it just in the more of these you look at it. Yeah, it just becomes second nature.
Bill Clearfield 1:39:36
Oh, about cytokine panels. Do you use those at all? I never run them. Okay. All right. Question. ways to get people off of acid blocking medicines without it backfiring and worsening symptoms.
1:39:50
So there’s a blog on my website called stop the burn. I recommend you take a look at that because it’s got I’ve been asked this question so many times I created a blog on it. My approach was specific examples. So it’s about identifying the underlying cause, right. So the the low hanging fruit or dietary modifications there are about five of the most common food triggers for acid reflux. This orange citrus so oranges, a raw garlic and onions, chocolate, coffee, peppermint, spicy food, things like that. And so they can experiment with getting off of all of those and see if it goes away. Other trade there may be other triggers as well. Tomatoes is also one of the most common triggers to tomato products. The other thing is an h pylori infection. So a lot of people may be walking around with undiagnosed H. Pylori. Infections. A gastric biopsy is not a great test for determining an h pylori infection, infection and neither is a serum antibodies test. I prefer a stool test because the immune antibody complexes are being produced in the by the gut associated lymphoid tissue and it’s going to be eliminated in the stool. So you can detect it much easier and more sensitive in the stool. So I prefer that and looking at for h pylori, in terms of h pylori. Also I asked people in terms of screening questions do they get and this is also similar for low stomach acid. Do they feel full quicker and do they stay full longer? That can be a symptom of both h pylori infection and low stomach acid frequent irritations you know burping that can also be a symptom of of low stomach acid and h pylori infection. So, if I that I like to diagnose it, obviously getting to the underlying cause if that’s what’s causing their acid reflux because one symptom of h pylori infection is acid reflux, then we want to kill it. And there are lots of protocols are not lots, but there’s some protocols for doing that. Both conventionally and with integrative medicine. And so, and then there are other things that can stop DGL for example, can be good for acid reflux D glycerides, as needed licorice and there are some other things that I go through in the blog
Bill Clearfield 1:42:22
incarna seems that when you use
1:42:25
I don’t have any experience with that. But I’m all for if it works. I you know, maybe it works great. I just don’t know.
Bill Clearfield 1:42:30
Okay, how about h pylori, and autoimmune thyroid disease? You see association with that, between those with those two? I
1:42:39
don’t think I’ve treated enough patients with with with both of those to know.
Bill Clearfield 1:42:43
Okay, all right, because I’ve had actually some success where we’ve actually reversed the autoimmune thyroid disease, particularly when we treated the H. Pylori one guy had he had one guy had it for 20 years. And amazing, the, the antibodies went away and the thyroid became normal once we treat it as H. Pylori. So this is actually a good question. I know it’s kind of practical. How do you get patients to actually get the testing done? They get you know, they’ll get a kit and then you know, they kind of just play with it or just let I don’t want to pay for it or whatnot. I mean, I get that a lot too. So.
1:43:24
Right so So, here’s so people who came to me in a cash practice, so it was very self selecting it was I you know, I practice essentially the medicine of desperation. People who came to me were highly motivated because they’ve been sick for many years. Some of them have been to major medical centers like the Mayo Clinic or University of Washington, and they either weren’t getting better, they were getting worse or they plateaued and they were just looking for a different, your rigorous way to try and feel better. So they were highly motivated. So if it’s a urine kit or a stool kit, they just collect their specimen at home, and they ship it off and they they pay for it directly to the lab, or that’s one way to do it. What I would do is I would collect payment for the test. So they would pay me for the test. And therefore they’ve already paid for the task before they’ve walked out of the office. So you know, what choice do they have? I mean, I guess they could say I’ve changed my mind and I give them their money back but that never happened. I had then in the lab would just bill me just Bill my my clinic and symbol if it is a patient that if we’ve got to do a blood draw, then then I would just do it in my in my office. They would bring in if it’s a combination urine and serum or plasma, they would collect the urine and bring it in at the time of their blood draw and then I would process everything and ship it into the stool. They bring in their stool sample as well and I would ship that in the kit as well for them.
Bill Clearfield 1:45:08
Okay, great. Yeah. What I found is that if I have them, take care of the get the kit themselves or I have the lab send them the kit. Three quarters of them, don’t you know, it doesn’t get done when they pay us that it gets done.
1:45:21
Right. And that’s what I found too. Yeah.
Bill Clearfield 1:45:26
Can you say more about treating bipolar patients?
1:45:31
So I don’t have I don’t have a huge
1:45:34
number of bipolar patients. All I can say is, in my experience, the limited experience that I have and that’s why I didn’t really put cases in because I don’t have as many as I do with ADHD and and depression is that it’s it’s a similar approach. There’s some dysfunction going on biochemically, but they need to be doing other things as well. Look, this is not a panacea. This is this approach is not the cure is not is not doesn’t give results to 100% of the people 100% of the time. I can tell you, for most patients that I worked with, they got significant improvement. Some of them like the bipolar patient, I’m thinking of also did acupuncture got better? So is it was it the acupuncture was it what I was doing? Was it a combination when you’re working with multiple variables simultaneously? It can be challenging to understand what exactly is it he was also doing counseling? The bottom line is he got better?
Bill Clearfield 1:46:45
Yeah, I usually tell them when I asked him was it was 123 or four. The answer is usually yes. That’s right. Whatever works, what is the usual cost of testing? And if they’re you’re taking supplements, do you have them stopped before they have to do the test? Yeah, so
1:47:02
for the I’ll take the second question. First. The I have them stop all dietary supplements 72 hours before if they’re on antimicrobials, antifungal antibiotics if you’re going to do a stool test, or you’re looking at urinary organic acid markers for a dysbiosis you want to have stuff off all of those for a couple of weeks before collecting the specimen. So at least 72 hours without any dietary supplements to get a clean catch on the urine to really try and get a clean picture as I described to him. We want to know what your biochemistry is doing without extra supplements in there. So we can see what you actually need in terms of the cost of the test. I you know, I don’t know what the current costs are right now but with with Genova I believe that you know, you’re you’re talking a couple $100 minimum
Bill Clearfield 1:47:58
I think the GI effects test is around 400 somewhere somewhere around
1:48:02
Yeah, I was thinking more if you’re just looking at a urinary organic acids test, you know, if you’re looking at you know,
Bill Clearfield 1:48:09
we since we’re not CME we can I don’t know how you do it. I use an outfit called Rupa health and they pretty much bundled everything together. It’s all in one place and they have Genova. They have they have just about they have about 35 of the functional medicine labs, and you can order any one at any one of the tests from anyone there.
1:48:28
I’ve heard great things about Rupa health. Yeah,
Bill Clearfield 1:48:30
they, they, you know, they, they’ll, they’ll build it for you. You can you can we can pay them they’ll bill insurance as if it’s eligible and and you know, you’ll they’ll even give you a comparisons you know, if you want to do a stool test, there’s they have Genova there’s named four or five of the big ones and they have more so so we we’ve been using them and made it a lot easier. And it’s kind of a one stop shop. So are mold and ADHD connected.
1:49:04
I don’t know. That’s an interesting question. I don’t know I mean, mold definitely causes CNS disruptions and difficulty with concentrating and brain fog and, you know, energy dysregulation. So,
Bill Clearfield 1:49:19
we have, that’s from Anna Fishbein, there’s a couple of lectures just a couple of weeks ago, one from Dr. Campbell and then one from Dr. Dennis. They were two weeks in a row. And they’re two of our mold experts. So go back and get that
1:49:34
they talked about ADHD. I don’t,
Bill Clearfield 1:49:37
I don’t recall. So but I’ll be in touch with Dr. Campbell shortly so I will make sure to bring it up and and I’ll let you know what our slides here at aos er d.org/webinars. Somebody asked about your slides, they’ll be up there within usually 24 to 48 hours. Couple of nice presentations. Thank you for being here. Dr. Cruz. Do you have it of course to teach do you use the Omega three six test you test omega threes and sixes? I guess that
1:50:15
so I do when I ordered the ion panel. That’s what’s on there. One of the cases that I discussed that she had low Omega six fatty acids. But yeah, I do but not typically. Most people probably aren’t getting enough. The standard American diet is high in Omega six and low in omega three. So I always do a diary call with patients. I do a 24 hour diary call. It’s not perfect, but my in my experience. People tend to eat the similar pattern of foods over and over and over day after day. So it gives I think, a good general idea. So I just asked him in my intake. What did you have for breakfast, lunch and dinner? Do you crave any foods and you know how much coffee and how much water you drink? And that gives me a good general idea of of their overall diet. So it’s, you know, can be assumed that most people probably aren’t getting enough omega three fatty acids in general. Is that contributing to their overall health? I don’t know but in the recommendations for consuming more protein I always talk to them about you know, consuming more more more fish and lean protein sources. So that’ll decrease their Omega six consumption and increase our omega three consumption.
Bill Clearfield 1:51:31
Okay, great. Um, I got a loved one from Dr. Cruz here. So let’s on fish oil versus other Omega three reasons to just answer that. I research article promotes 50 to 60 grams of fish oil a day for 30 to 60 days to wake up patients from coma. When I think about that,
1:51:51
I know nothing about that. That’s amazing. I can aroma that’s a huge amount. I’d be concerned about blood viscosity at that dose, but I guess it doesn’t matter.
Bill Clearfield 1:52:03
You have to do it IV I suppose or an NG to learn. Dr. Perlmutter is against fish oils or its other omega threes.
1:52:12
So I wonder why. So the so like omega threes and this is one of the chapters in the laboratory evaluations for the wonders of functional medicine, the meta metrics textbook that I that I edited. There are short chain Omega threes and long chain omega three fatty acids. It’s considered currently that the most biologically active or the longer chain, EPA and DHA I cosa Penta ik acid and docosahexaenoic acid, the shorter chain fatty acids omega three fatty fatty acids are found in nuts and seeds. People have a hard time converting those short term short chain fatty acids to the longer chain fatty acids that are found in fish. So I am a fan of fish oil because you’re getting those longer chain fatty acids.
Bill Clearfield 1:53:11
Rafeal you wrote this I’m not sure I’m getting this right. Right.
1:53:17
I want to I’ll just comment on this because it’s easier. One How do I get these studies to you Dr. Clearfield? So everybody else can see. And there’s another group that Dr. Hans is you know with Dr. Farr Shan and he’s always promoting efficient oil product and he’s not a fish oil product but an Omega three oil product and he claims is much better and safer than fish oil. And then there’s other experts like Paul martyr, who have come out against fish oil, but this study is phenomenal. And I want you know, people like our lecture today and you and anybody else to comment, and it’s 25 case studies, all these people were in a coma from head injury, explosions, strokes, and they were given 15 to 60 grams per day per ng or PEG tube. And they all woke up and they returned to reasonable function or normal function and the rat study is extremely compelling, because they put helmets on these little rats, and they drop lead weights on them after feeding them fish oil or regular mice food and they did you know swim testing and maze testing. And the ones that were on fish oil after the same lead weight was dropped on the helmeted head remained good fish would remain skillful at swimming and mains running. And when they sacrificed the mice, the ones who were not taking fish oil had massive neuronal injury in spite of the helmet, whereas the ones that had the helmet and fish oil had no neuronal injury, and they were sacrificed, you know, at the end of their lifespan, which is say 90 days or whatever it was three months. So if we all took large amounts of fish oil, and we get into a car accident, our concussion or our head injury would be much, much less based on this study. And so I want to share it with everybody here, but I don’t know how to do that in the zoom. So I’m just want to email it to you. I guess. I
Bill Clearfield 1:55:22
don’t know how to you know how to find me.
1:55:25
Okay. All right.
Bill Clearfield 1:55:26
We’ll put it on. We’ll put it up. On our website.
1:55:30
Perfect. Okay.
Bill Clearfield 1:55:31
Send it. Okay. We’ll do right. You’re not shy. Well, Dr. Newstead, Dr. Cooper Stein tells us that there’s one textbook online on Amazon for 350 bucks. Wow. We should have we should have our organization by it and then sort of just make copies. So, no, Andrea has her hand up so you know, what is I don’t even know what that means. Oh, there’s a hand up. Yeah. Hang on. Speak. Yes. Go ahead, speak. Sure. Thank
1:56:13
you. I’m hailing from Halifax, Nova Scotia. And up here in Canada. We have a Dr. Cindy Culkin, who has identified a very strong correlate for a lab marker with bipolar disorder. And what she has discovered, and I think she’s posted it in the published it in the British Journal of Psychiatry, is, is insulin resistance is strongly correlated with treatment resistance and bipolar disorder. And when you correct insulin resistance and she’s performing a Homa IR calculation, on a fasting serum glucose and fasting serum insulin, and so for those who are found to be insulin resistant. While she was treated with metformin, I’m more a fan of Berberine myself. And like I said they their condition stabilized. They still required some conventional bipolar treatment, but they at least were sensitive to it. So even if it were naturopathic treatments, the point is that they become more treatment sensitive when they have insulin sensitivity.
Bill Clearfield 1:57:40
Okay, I can use that any comment?
1:57:46
No,
1:57:47
I mean, I’m I’m really surprised I guess but I don’t really have a comment.
Bill Clearfield 1:57:51
Okay, um, I think that’s all the comments except for all the thank yous and great presentation and we really appreciate you being with us. I put in here a couple of times. First of all, this is my email if you need me do CTR bi l nine at Gmail. There’s a link for the video here in the chat for Dr. McCullough’s talk last week in case you didn’t know this, we had Dr. Peter McCullough on and somehow our video ended up on YouTube, which lasted not even an hour before they took it down. So I have it on Vimeo and you can get it there if you’re interested. Next week, we got stuck. Well, I keep calling his he’s our doctor. I don’t care what anybody says Stephen Hartman. He’s going to be talking about exercise and resistance.
1:58:48
Yes, next week will be muscle centric medicine approach the principles of exercise
Bill Clearfield 1:58:53
science. There you go. I didn’t know you were still great. Okay. I will not be here probably I am going to visit the grandkids. So Joe will be your host and I’m sure it will go a lot smoother than when I run things because it’s a lot more competent. Tomorrow night doctor on doctor for shins channel I will be speaking on Hashimotos thyroiditis integrative medicine versus conventional medical model. So that’s tomorrow night and Dr. For shins channel. And thank you Dr. Fortune for that. And thank Claudia. Also comment from Dr. Cruz fish oil help the former FDA agents daughter and wife with many years of bipolar disorder. Okay, so I think we know that Cindy cochon. Kalkan is on YouTube. Got that message. So maybe we can get in touch with her and have her tomorrow Dr. Farshid Do you have a link for tomorrow night’s you talk tomorrow? Anybody that wants it? I’m sure I have it somewhere.
2:00:01
Yes, I have it. I can share it right. No, I really appreciate that. I think this meeting our meeting was an extension of yours and that
Bill Clearfield 2:00:12
we always include Dr. Hall also because otherwise his feelings get hurt. So
2:00:19
I think it’s so educational every time I come in, learn something new. Yeah, I apply to patients. Do you have anything for tinnitus or tinnitus? That just doesn’t go away. We tried the the photodynamic therapy. We tried the C exosomes. i We we’ve tried really all treatments. We’ve even tried the tuning fork that was recommended by many physicians that kind of like helps.
2:01:09
I do I do have a suggestion and that is chiropractic or, and or regenerative injections.
Bill Clearfield 2:01:19
Okay, I use vinto Septon is a supplement 10 milligrams a day. d d v p which is its posterior pituitary. Here’s my my memory missing. It’s a the the nose spray for the posterior was not oxytocin, the other the other hormone here’s my basketball pressing. There you go. That’s it. He can also use it as a 0.1 milligram or 0.2 milligram tablet. You’d use it sublingual once a day. And then I do battlefield acupuncture so the regular acupuncture
2:02:04
put that in a text Dr. Clearfield
Bill Clearfield 2:02:08
Yeah, twice a week for I was looking at Dr. Dr. fortunes. Link for tomorrow night.
2:02:17
It’s actually a fortune. I’ve heard some people have success with you know, like high dose B vitamins with a Myers cocktail and also ozone to the ears and the nose. And, you know, it’s not a slam dunk but roughly a third of patients respond to improve circulation to the ear. And someone pointed out fish oil improves circulation and gingko but you gotta be careful because they can bleed with particularly with gingko but I know two patients who went to a friend of mine and got like, you know, 20 sessions of ear ozone and nasal ozone. Their allergies improved and their tinnitus improved. It wasn’t it didn’t disappear completely. And then I’ve also heard people saying high dose Myers cocktail with a lot of B vitamins helped I don’t know what the mechanism is, but so
Bill Clearfield 2:03:19
Okay. Here’s here’s my little protocol here kind of broken up between Dr fortunes link tomorrow. We know Septon I spelled that right being D I N O CPT Ionic is I spelled it wrong. 10 milligrams. Once a day. There’s no precedent 0.1 or zero startup 0.1 can go to 0.2 daily, or there’s also a nasal spray, one spray twice a day. And then I do it the battlefield acupuncture, twice, two times a week for four weeks and then once a week until it’s gone and then it comes back. It comes back. If you don’t know what battlefield acupuncture is, we can do a class on that. So
2:04:05
we should because I don’t know anything about it except that the VA at the Louis and Lynn Louisville, Kentucky is now offering it and it’s paid for by the Government for VA bats. So it’s got a lot of clout if the VA is paying for it. Yeah, I’d love to learn about it.
Bill Clearfield 2:04:23
I mean, it’s $5 worth of material it takes takes 10 minutes tops I can teach anybody how to do and in less than an hour. It’s really a great technique for shock, trauma, acute pain, chronic pain. It’s not a permanent technique, but you know, somebody shows up in your office bend over to pick something up and they bend over and you know, as long as they didn’t fracture anything or you know, you can get them out of pain in less than 10 minutes. Headache. Somebody comes in what am i How many of you have migraine headache? Again, less than 10 minutes and you know you never 90% successful wow I can’t ever remember somebody’s not at least getting some sort of improvement. It’s really it’s really a powerful technique. It’s like I said it’s it’s five that cost us $5 Max most of little these little tiny your needles doesn’t take 10 minutes I’ll do it. I haven’t would do it in the waiting room will sit there and just just do it there. So and sometimes you want to 10 meetup needles, tops five on each side. And sometimes you don’t even need to do that. Usually one or two can do it so we can do a class on that when we have an opening.
2:05:43
One along those lines. Dr. Clearfield anybody can look this up on YouTube Dr. Larry Melek. Me ll I C. K has migraine protocol. And it’s phenomenal. You can watch him do it in the emergency department. He’s an emergency physician 2.5 milligrams 0.5% Marcaine injected Paris finally at C seven and he’s got this in the video. He’s at the University of Georgia emergency department. And this chick comes in with a severe migraine headache ocular pain, dental pain because she’s got a really bad cavity and within 20 minutes her migraines gone. Her eye pain is gone and her teeth are gone because the nerves at the in the paraspinal aspect of your of your neck innervate your entire scalp and eyes and face. And I’ve done that several times and it works very quickly. And sometimes these people need a series but sometimes you break the migraine and they don’t have migraines for a long time. And so it’s worth looking up Larry Melek migraine procedure on YouTube.
2:07:00
Okay, great.
Bill Clearfield 2:07:02
Okay, um, tomorrow night’s talk like Dr. Fortune is at 8pm Your time I think that’s when it is right. 5pm Pacific. So I think that’s when it is. Yes. Right. And again, in the chat here, here’s here’s the link right here. And the you need to put a code in there too. As a as CPE. And I think Claudia is getting me to come to your conference to speak on Sunday to June so.
2:07:39
So really looking forward to that. That’d be amazing.
Bill Clearfield 2:07:42
Yeah, so, so we’re looking forward to that. I also will be at a MMG at the end of April in, in Miami. And it’s really a nice venue. It’s the real National Golf golf course. And they’re, they’re a really fun group. They’re a lot more laid back than the bigger group and we have a really good time with them. So if you’re in the Miami area, and they’re not they’re not nearly as expensive and they’re a lot more outgoing. I found so they had me Of course they they that sometimes they’re a little unrealistic. They had me doing they gave me 45 minutes to do thyroid and cortisol. So I have 45 minutes for both of those topics. Wow. And so it will be the cliffnotes. So
2:08:36
Dr. Great lecture and yes, they didn’t hear your answer. Do you offer training or a textbook that kind of guides us on what you lectured on because it was awesome, but I need to get better educated on how you do what you do.
2:08:55
Thank you for the feedback I wrote my textbook foundations and applications of medical biochemistry in practice to help train doctors and teach them how this this approach so I would recommend you do that. The one caveat is I had proprietary tests with meta metrics at that time. So unfortunately, or fortunately I use the names of those tests, which is essentially the meta si t 400. is essentially the ion panel with serum chemistries and a microbial stool analysis added on or the meta ct 150 Is the try out panel. But that’s how to interpret that when you look at the testing if you if you read the book.
2:09:38
Okay. And then your supplements you said
2:09:42
if you have questions on the if you have questions on sorry, excuse me, if you have questions on the book or anything if you want to run anything clinically by me just feel free to reach out.
2:09:52
Okay, and your supplements you said are available through full scripts or only at your website.
2:09:58
So we have wholesale accounts through our website. Emerson has our full line. full script is onboarding us currently so I think they have five of our products or top five sellers, but not the full one.
Bill Clearfield 2:10:13
It’s NBI health.com Is that it?
2:10:17
Yes. Yeah.
Bill Clearfield 2:10:19
So Okay. All right, sir. Yeah, I don’t
2:10:21
know if you need to get healthy dot store is also onboarding us right now. I don’t know if anybody has those that platform but they’re also bringing us on.
Bill Clearfield 2:10:31
That’s wrong. NBI health.com Right.
2:10:35
Yeah, I’ll put it in here. Yeah.
Bill Clearfield 2:10:37
You do it. I got I got it wrong there. So
2:10:44
there you go.
Bill Clearfield 2:10:53
Right, anybody else? comments questions? Lance tomorrow night Dr. Fortune is gonna have a rollicking good time. And next week, Joel will be your host. I will be with my grandchildren. So probably won’t won’t make it. And Dr. Dr. Hartman will be on. We have Dr. Patel’s the week after that. He’s the minister glutathione on March 21, we have something a little different. We have Dr. Marlene single Siegel, who is a veterinarian who’s going to be talking about Furbabies. So just something a little bit different. Week after that, we’re going to have John Cummings and he runs body site if you know what that that is, it’s a website. They do a lot of dietary exercise programs that you can program for your patients and it’ll send out diet diets and exercises and on a daily basis for a month to two months at a time. I’ve been using them for almost since I started them when they started 10 years ago. And we have Dr. Brad Watts will be back again and other good stuff. So thank you again Dr. New stat. One of the one of the one of the problems with being competent is that you we asked you to come back I love it. I love like like like you know being able to be able to fix things around the house. Nobody bothers me. They give me one shot at it and then they realize that I’m I’m all firms.
2:12:40
I wanted to also remind everybody that next week’s when we’re going to open the Zoom one hour early, and I’ll open it John with you about the 45 350 to make sure we don’t have no problems. And then we could talk freely about what we think needs to be done to help doctors and non licensed practitioners and practitioners and natural paths and because Nevada is one of the two states besides Arizona, where I could actually train under Dr. Fong and become a homeopath. So there’s a whole lot of issues going on with everything that’s happening right now. And I’d love to hear everybody’s input. Excellent.
Bill Clearfield 2:13:17
So yeah, we’ll send that out also. And, and I actually I have I while we while you were speaking, Dr. Newstead I have a I’m going to be speaking to Dr. Jackson tomorrow. We’re going to get him on to to do a he’s dead from that the body the you know that the learned the medical is good. I’m glad to hear that. So we’ll get we’ll get him on so I gave me some time to call him tomorrow. So I’ll be speaking with him anymore. Excellent. Yeah, we’ll get him on to. Okay, everybody. It’s getting late. So after 10 o’clock back East. Anything before you go,
2:13:57
then. Anything. Thank you. heartfelt thanks. Okay,
Bill Clearfield 2:14:01
Dr. newstagged. We can’t thank you enough. And please don’t be a stranger. And come back anytime. And you know, we are here every Tuesday night at 8pm. Eastern 5pm. Pacific. Okay. All right, everybody. Good night.
2:14:18
Please witness a Zoom meeting tomorrow.
Bill Clearfield 2:14:21
Tomorrow’s at 8pm Eastern 5pm PST Pacific. Thank you, Jay.