Tue, 3/8 5:07PM • 2:59:57
SUMMARY KEYWORDS
cancer, tumor, cytotoxic t cells, immune system, patient, polarize, lymphocytes, antibodies, cells, cancer cells, kill, activate, antigen, interleukin, drugs, secreting, cytokines, interferon gamma, macrophages, giving
SPEAKERS
Bill Clearfield
00:25
Oh no, he was there before me. He’s in there. He’s listed as unique now I got you waiting there on the waiting
00:44
yeah
00:49
all right. I don’t know what happened everybody did it itself. It clicked off itself wasn’t me.
01:00
Not you know,
01:01
it wasn’t I didn’t do anything it just I know. It says I’m in two rooms which I don’t know I don’t even know why. And over here is Dr. Patel’s husband and it has my name on it. I have no idea why. So
01:16
okay, that’s fine. Just let’s do I can share without without even. Let me see. You share it. Yeah. Can you see me Oh, can you see it?
01:31
It says Dr. alasa started screen sharing. Yeah, there you go. Okay, great.
01:35
So let’s do Okay, so you want to wait till you want me start?
01:42
Well, it’s after five. I think we got everybody back. That was one that you know that was on. I don’t know what happened. I didn’t do anything. It just he did it itself. I know. So it says on one I’m on two different. So you know it has doctor. This is Dr. Patel’s husband down here and as my name wanted to and I don’t know why.
02:06
Okay, so let’s start. Ah, you want to record it or what? Yeah.
02:18
Go for it. Basically. I think we have a problem here that we need to know that the lifetime cancer risk faced by any of us is a toss of a coin, which is 50%. And that’s a big thing, right? Imagine that 50% of us were going to have cancer at one time of our of our lifespan or lifetime. And we work on reducing that risk. And the medical community need to recognize that risk can we need to develop some protocols, some cocktails, that we need to take it every day in order to lower that risk and I think I was developing it with Dr. Mike Beamer, a cocktail of polyphenols of wishes quicker Kim in a quick question three and ECGC metal and blue those are tan and then you if you have anything you suggest let’s let’s develop together a cocktail that we can take every day. That would help us to reduce that that the chance which is 50% and I mean that if how much people have been here, let’s say we are 15 around 15 That’s mean seven people have passed we’re gonna have cancer for sure. And the risk of 50% can go up if you have family history of your have any other risk factors that may contribute to increase that then you will increase. I will increase the chance of having cancer so we really need to do something about it. And I need all of you doctors to join together and come up with that cocktail that we can develop which will help to lower that risk for even if we can drop it from 50 to 40 to 30 that will be a great choice. Great thing. CBD is one thing. It does help to reduce the risk of cancer so people who are selling the CBD I think it’s a good thing to do. Okay, so let’s go with this next slide. And I don’t know why Okay, here we go. Now, also, it is very important to understand the basic of immunology you know, in order for us to learn any kind of language. If you want to learn French or language or Italian language, then you need to learn their alphabets and their basics of their language. So the same thing in immunology. If you want to learn immunology, you need to learn the updated basics of immunology and immunology is changing I mean before we only know about th one and th two but then something came up which is th 17 and T regs so there’s a new informations that needs to be learned need to be added in our curriculum in order to understand the pathophysiology of almost all chronic diseases. So as well, cardiac diseases to have some sort of immune imbalance whether it’s degenerative autoimmune, cancer, they all have some components of immune imbalance that needs to be fixed. That’s why we now start doing what we call the cytokine profile, and lymphocyte mapping for all all types of foreign disease and it’s not just for autoimmune or allergies, but also for cancer for degenerative for metabolic. It’s good to have that because it could be a factor in the pathophysiology of those of these diseases. And understanding that the immune system it’s really regulated and controlled by what the macrophage eats. Okay, so that will determine the direction of your immune system that determines the polarization of immune system that determines the substance of your T cells. The T cell differentiation, you can say, or CBC differentiation. It’s all based on what the macrophage eats. So, if the macrophage eats bacteria, or fungus, then what will happen to your lymphocytes, you will have polarizations of the immune system into th 17 Right and you will have your macrophage start producing and releasing
06:55
interferon gamma and interleukin seven and that leads to sorry, it will secrete the tumor growth factor, transforming growth factor and interleukin seven into the six and that will polarize the immune system into T at 17. And th 17 starts secreting all this cytokines interleukin six and that will cause the differentiation of your white blood cells into neutrophils. So if the macrophages is bacterial fungus, then the macrophages will start secreting all the cytokines that will differentiate your lymphocytes into th 17 And then th 17 will start secreting interleukin 17, interleukin six transforming growth factors, and this will lead to CBC differentiation to neutral fields so you will see neutrophilia Right, and that’s what you need in order to fight bacteria. Do you need neutrophils in order to fight fungus? You need neutrophils but of course you don’t want too much of neutrophils. You want enough of neutrophil that kills the bacteria enough neutrophils that will kill the fungus if you have too much of neutrophil then you would have inflammation and you have damage and that’s why when we are treating those diseases we are giving antibiotics or antifungal to kill the germ of the germ but the same time because the immune system may be over producing nitro fields and overreacting. There th 17 is overreacting and interleukin six is overreacting. Then we need to look at something that will inhibit and lower density you can six and that’s what we do in Lyme disease. Lyme disease. We’re looking to kill the bug but also decrease the over overreaction of the th 17 By giving some anti inflammatory. You can say ivermectin is one, low dose Naltrexone is second methylene blue. All of this will help to decrease the th 17 over reaction over reactivity which goes to destruction of the tissue and also you need to give the antibiotics or antifungal that kills the bacteria and kill the fungus most of the anti fungal they do kill the fungus but at the same time, they inhibit the th 17 And to do kinetics production, so that’s a good thing. So it must have antifungal drugs. They do have antibiotic effect, but also they have some sort of anti inflammatory effect. by inhibiting this inflammation which is mediated by T at 70. So it’s very important to know that inflammation is our difference, not just one type of inflammation when you call inflammation, there is inflammation, mainly dominated by D at 17. To do consents, there is inflammation dominated by th one and cytotoxic T cells. There is inflammation mediated by th two and that’s dollars you Thanks. So there’s different kinds of formations. And in the state of giving steroids was suppressed everything, all those kinds of inflammations and put the patient at risk of having cancer and an infection. It’s good to really determine what kind of inflammation and come up with a drug that will have it specifically that kind of inflammation. I think that’s that’s better when we are managing inflammatory diseases in general. So, then if the macrophages eat virally infected cells of cancer, what will happen those macrophages, they will differentiate to m one and then damn one will secrete interferon and interleukin 12 and that will cause the polarization of your immune system to the naive T cells. To become what th one and then th one start secreting all those cytokines to stimulate the differentiation of cytotoxic T cells and CDA into 92 cytotoxic T cells and that’s how you know your th one response or it gives you that that cytotoxic T cells that will go and, and fight those infected cells and kill those cells that’s been infected with the virus by attaching to it and secreting all those. Sorry to toxic chemicals that will open up pores into those infected cells and blow them up right. Or they will be attacking those cytotoxic T cells that will be attacking the cancer cells and release those those cytotoxic chemicals that will blow up those cancer cells. So that’s how you’re when we want to kill cancer cells or infected cells with viruses. We need th one cytotoxic T cells polarizations in order to destroy the cancer and that’s how your your immune system respond to to the cancer pathogens are a six sales being infected with virus. Now what about if the macrophages is eating parasites in the gut or allergies, pollens or whatever? Then the macrophages will be polarizing into m two and that’s secreting all the cytokines interleukin four and cause a polarization of your lymphocytes into th two and then you will start producing immunoglobulin E and you would have is in Ophelia and basal philia. That’s how we destroy the parasites right and that’s how we manifest the patient’s manifest with with allergic reactions because of interleukin four and how it’s stimulating the mast cells release of histamines right, and how the immunoglobulins react with those other genes and and release the histamines and gives you that allergic reactions. That we experienced with patient for example with asthma or eczema. But when the macrophages East yourself antigens, right, then what would happen those macrophages day turn into M regs and they start secreting interleukin. 10 Transforming growth factor beta and they will polarize the immune system to T Rex and that will suppress the immune system right will suppress all the three effectors lymphocytes with the th one or th two or kit 17. So this interleukin 10 goes a suppression of those effector lymphocytes which is th one th two and th 17 and prevent your immune system from attacking your self antigen. So that gives you what we call the immune tolerance. So now we understand that your lymphocytes differentiation, your CBC differentiation is really depend on what matricide just eats. Right and that will determine the fate of your lymphocytes and welser will determine the face of your CBC what direction so if you see and you CBC lymphocytosis then you think oh this could be cancer a viral infection right? If you see in your CPC isn’t a feel or vaso fields and you think all this could be allergy or parasite infection and then if you see your and Cbc ninja field and you think oh this could be fungus or this could be bacterial infection. And so the CBC differential also helps us to know exactly where your immune system is moving to right. What about the natural killer cells? natural killer cells really can be activated by by any of those cytokines it can be activated by interferon gamma. It can be integrated by interleukin four interleukin six. So it’s a general the natural killer cells, they’re not specific and they just kill the germs or kill the cancer. There’s it’s a nonspecific immune response what’s very important, innate immune response. So we need those natural killer cells. They are considered lymphocytes. They are considered like CDA lymphocytes, cytotoxic T lymphocytes, but cytotoxic T lymphocytes are more specific right? This one natural killer cells they are generally they are they just destroy any infected cells or any or any cancer in general, regardless of of what kind of kind of what kind of cancer it is or what kind of viruses so it’s a kind of okay, so, um, you know, then come logy with
15:36
cancer.
15:38
In the old school, they are focusing those mainstream and colleges they’re focusing on on just destroying the cancer regardless of the tumor microenvironment at that time, we have no clue about your microbiome in regarding of regardless of the immune status, because there’s doctors, colleges, they just throw chemotherapy, and they focusing is only to destroy that cancer, right. So those cancer cells they have certain metabolism different from the normal cells. They target that the double isn’t a bit more chemicals that will inhabit that metabolic pathway in the cancer or that will increase the free radicals and induce apoptosis in the cancer like radiotherapy or photodynamic therapy. But that’s what we do as the mainstream and colleges, we do X ray, we do radiation, we do chemotherapy, we may do for the dynamic therapy, and we may end up if it’s you know, it’s early and assessable. Then we can just remove that cancer by surgery. That’s the old school is funneled to tunnel kind of vision and focusing only on how we destroy the cancer. But But recently, it’s not just about killing the cancer, it’s also changing the tumor microenvironment and making the tumor microenvironment. From favorable microenvironment to hostile micro environments. And we call the micro environment and that’s required a lot of repurposing drugs. We’re going to talk about it in the coming slides of how you can change it to micro environments so it become hostile environment of the tumor that will inject the tumor and that’s the that’s the new field of medicine of oncology and as integrative doctors, I think you can do better than that. May the mainstream ecologist focusing only on destroying cancer by radiation and by chemotherapy and even by photodynamic therapy, and by removing the tumor by surgery, they’re now recently changed. It’s changed the way that we’ve managed cancer and we can both also changing the tumor microenvironment and we’re going to discuss all the protocols that leads to change in the tumor microenvironment. So there’s a change there and we need to adapt those changes as integrative doctors we can do better than the mainstream oncology. If we start translating all those recent protocols and publications about managing cancers and how to think outside the box, and not just kind of thinking about killing the cancer and interfering with the metabolism of the cancer and pleasing the upper ptosis by using radiation or chemotherapy. Or or photodynamic therapy or radiofrequency ablation but also how we can change the tumor microenvironment using all those repurposing drugs that we’re going to talk about. The other thing is that we need to also enhance the immune system to kill the cancer by polarizing the immune system into th one m one and we’re going to talk about how we can polarize the immune system to th one m one in the coming slides. Now. It’s very important to understand and know that the immune system is 24/7 Checking on all the density of your cells. And we know that that cancer in marriage, every mean it’s like every second you would have cancer cells emerging from your body. But your immune system will identify them and destroy them and that kind of face where the immune system is controlling and making some sort of immune surveillance be killed and controlling your cells from becoming cancer and eliminating it destroying it like like the police. When you see the police when they see criminals, they go and they and they and they capture them and eliminate them and put them in jail. Your immune system does the same thing. They’re like policing and if they find foreign sales, sales, weird sales, they go and they destroy them. They don’t really put them in jail, but they destroy them eliminate them. And that’s basically called elimination. So this is the face of the immune surveillance. It’s called what elimination but it happened that you know, your the tumor cells can emerge and you can have some subclinical growth of tumor but it’s not constantly growing. It’s it’s fixed it growth of tumor.
20:31
That certain way was able to evade the immune surveillance, but it still the immune system is able to kill those cancer cells in the number that is equal to the number of the sales that is of cancer that’s emerging. So when you see that balance of the cancer cells that’s that’s growing equal to the number of cells that’s dying by the immune system. This face is called what equilibrium and and that’s where you see subclinical tumor that’s not really detected by all the diagnostic approach that we are doing the traditional ones. And we really need to work on the stage of this face and try to reverse it back into elimination. And that’s why we’re talking about putting together a cocktail of polyphenols of methylene blue of low dose Naltrexone of all those ingredients that we think CBD and give it to the patients on on daily doses because it’s very critical especially knowing that 50% of us going to have cast 50 percents a big number. And we need to reduce that number by by coming up with something it’s got to be medical necessity that everybody has to take it it’s going to be part of our regimen, not luxury thing, but something that every person above 50 years old, especially because that’s where the cancer most of the time comes up to 50 needs to be taking it in order to lower that percentage of 50% of the risk of developing cancer and and moving the face of equilibrium back to elimination. If we start taking those cocktails of polyphenols and laws their time MATLAB blue we’re going to discuss how and why all those drugs works and how it works. If your cancer cells are able to evade the immune system that’s called Escape, and that’s where the immune system is unable to catch up with the growth of the tumor and that’s what the patient has full blown blown cancer or clinical cancer. And we really need to stop that from happening. And it’s better if we stop it from the moving equilibrium back to elimination because once this the cancer is developing and growing, it’s really hard to control with all the methods that we have. But and the success rate of managing cancer. It’s very poor. It’s very low, even up today. So we need to work on the beginning and prevention and instead of letting the tumor escape the immune system completely. And so we know for the fact that immune system is is checking on every cells on your body and if it become weird and foreign and humorless. Then your immune system will start detecting them and eliminate them right. So how they eliminate them macrophage will eat them. And the macrophage when they eat those cancer cells, they secrete interferon gamma and and interferon gamma can activate the natural killer cells. And other killer cells can kill those cancer. Cancer cells nonspecifically that’s that’s the innate immune system, but then also, your macrophages when they eat those cancer and they start breaking the antigen of the cancer
24:17
and they start expressing it on their surface on their major histocompatibility complex type two and they’re presenting it to the naive T cells and they have two cells to differentiate into th one and th one along with macrophages that’s been active and one they start secreting chemicals, interferon gamma, and interleukin 12 and that will activate the cytotoxic T cells and then cytotoxic T cells will catch that cancer will combine with that cancer and will destroy the cancer by secreting chemicals that will open up pores into the cancer membrane and blow them up. So that is called the cytotoxic immune system. That’s how we are killing cancer. So it’s very important in killing cancer that we have to have functional th one m one and cytotoxic T cells antibodies and nitro field will not do that much. killing the cancer asked the cytotoxic T cells so it’s very important that the immune system has to be kept polarize into m one th one and anything that prevents it from polarizing to m one. th one sided toxic T cells that will lead to immune suppression that leads to the cancer to flourish and growth. And we’re looking for all the protocols and all the drugs that will help to polarize the immune system all the way to th one m one in order to get rid from from those cancer. And so your immune system has to be all the time balanced and has the capacity to polarize th one cytotoxic T cells at any time. If you are getting sick or you are your immune system has been compromised, and your immune system is unable to polarize into th one and one for certain reason maybe because of being sick is there’s cortisol is high that suppress the immune system. And that’s the word that portunity of the cancer can emerge and develop. So keeping us or keeping your patients and humans in general and the public healthy is very important, because that’s the way we can prevent the cancer from emerging. So sickness and immune suppression and bad lifestyle that we have the lifestyle that we’re living, the diet that we eat, all of this can affect your immune balance, and it will suppress your immune system and that’s where the counselor can take advantage over that and escape your immune system. So so that’s what we call the the elimination. And if you know your tumor cells, there is some growth, but it’s the number of the steel that’s growing as cancer is equal to number of cells that’s dying by your immune system. So that’s the equilibrium face and it’s very important to shift the equilibrium face to elimination phase using the protocol that we’re talking about is your lifestyle needs to change diet needs to be changed maybe a cocktail of supplements and certain drugs, anti cancer drugs that we now we know we’re going to learn about it. That may help to shift the phase from equilibrium to elimination. Before escapes before the tumor escapes the immune system. So what makes the tumor escapes the immune system? Well, the GMR cells they have many mechanism of escape, I’m going to talk about them. But one one way is that the tumor antigen is not immunogenic.
28:03
It’s not that much different from your normal cells so your immune system cannot be recognize it as a foreign and that’s why we call low immunogenicity of us tumor, and that’s where the immune system cannot be polarized into th one and one or cytotoxic T cells because they don’t recognize them as as porn so it’s low immunogenicity. That’s one way that the tumor can escape. The immune system. But there are many other mechanism and then you don’t have enough of the immune system that specifically can eliminate that cancer cells and that cancer still will start growing and cooperating but that’s one mechanism. There’s many other mechanism beside low immunogenicity of the tumor cells. There is another mechanism we’re going to talk about is one of them is that the tumor secretes blockades, antigens or chequebook point that on the surface that will turn off your cytotoxic T cells. And that’s like PD one. When they react with cytotoxic T cells. It’s like a key and a lock and they turn off the cytotoxic T cells they suppress your cytotoxic immunity and and that leads to the tumor to escape the immune system. So that’s one way the other ways tumor may secretes interleukin 10 interleukin six and polarize the immune system away from th one and one polarized immune system to th 17 producing atrophy what I want to do with Nutrafin atrophy cannot kill the cancer, our polarized immune system into th two and and produce immunoglobulin histamine. So what I want to do with histamine and immunoglobulin E will not kill that cancer. So your cancer cells will secrete chemicals that will polarize the immune system away from th one on one so that’s one of the way that the tumor can escape the the immune system and and and you see here those are the mechanism of escape here if you if you see it here, is one is of course the the tumor cells it’s become less immunogenic. So that’s one way the antigens that they produce are not being recognized by the immune system as immunogenic it will not activate the immune system. So that’s one so reducing tumor antigen. The other ways that those cancer cells in order to become cancer, they really have to be the bar of apoptosis. Normally the cancer cells how they die, you know, they generate free radicals and free radicals will stimulate the Pitocin and kill the cancer. Right. But what happened if the apoptotic genes they are resistance to that free radical, it’s supposed to stimulate that proptosis like it, those apoptotic genes there are becoming vbucks and sensitive, and you need a really higher free radicals higher higher in order to kill that cancer. So there would be problem and apoptosis. So you have apoptosis resistance, right? So in order to kill that cancer, you need to have phones that will have photosensitizers accumulating the cancer DNA enough high free radicals to kill that cancer. That’s one way or radiotherapy. So you need to have high high high free radicals because that normal radicals that kills the normal cells, it’s not enough to build the tumor cells, and that’s why we use chemotherapy radiotherapy in order to increase the free radicals enough to induce apoptosis in tumor cells. The other thing you may have problems and mutation in the oncogenes, oncogenes are the genes responsible the cell perforations normally the cells, when they reach a certain diversions they stop by by contact with other other surface they that signal will stop them from from dividing and that prevent the sales from going crazy and stopped division. So the sales do have the do stimulate to external stimulus and that control. The oncogenes that control the cell proliferation and the cell cycle. But in case that you have mutation and that genes were they’re not responding anymore to their to the external signals, and then the cells will start dividing uncontrollably and they would have that that that tumor, right.
32:41
And so, we need to work on that too. There’s lots of drugs that doesn’t have it and the the cell divisions and whether it’s chemotherapy or other repurposing drugs in managing tumor, the other thing is that the tumor can secrete cytokines. We talked about them to your concerns, interleukin four, interleukin 10 and polarize the immune system away from th one m one. So that’s one way is by secreting those suppressing cytokines that polarize the immune system into th 17 and neutrophils so what what do you want to do with neutrophils to pick it up kill the cancer or the tumors that expressing PDL one or CTLA four or PDL? One for example, PD one, and PD one when the Yaqub Pdl, one of the cytotoxic T cells, they turn them off those like keylock, they turn off the cytotoxic T cells, and we turn off the side look, citizens or citizens cannot kill those cells anymore. And we’re going to talk about it and see how we can block those PDL one by using antibody blockades, that will activate those cytotoxic T cells and again their functions and kill the cancer cells using those specific antibodies, tumor cells to secrete prostaglandin h2 and prostaglandin h2 Does polarize the immune system away from th one m one so when the macrophages and environment have too much of this prostaglandin to they polarize into embrace in a state of polarizing to everyone. And, and the other thing is that you will have the fibroblast also, the tumor microenvironment. We talked about the fibroblast and how the the fibroblasts secretes fibrosis and the fibrosis squeeze the blood vessels and the blood vessels when the squeezed they prevent the lymphocytes from infiltrating the tumor then it will have a cold tumor because you don’t have enough lymphocytes going into the into the tumor because of the fibrosis squeezing those those blood vessels. And those fibroblasts also they can secrete chemotaxis chemicals that will attract those suppressive cells those T Rex and those T regs will inhabit the cytotoxic T cells and they will inherit the and polarize that the macrophages into emrax Even M one they turn them into M Right. They turn them off those T regs can turn the M the M M one, which is the factor which we needed for killing the cancer into M Right. Which is the suppressor macrophages, and that would definitely suppress the immune from attacking the cancer. So all of this method so all of this way of paddlefish pathophysiology we need to learn about them because then we can start developing drugs and protocols that would help to block this and various all those methods are and why the tumors tricking the body and and polarizing the immune system away from M one and th one as you see it here. All this needs to be reverse it by drugs, whether it’s chemotherapy, whether they’re repurposing drugs, what we talked about or the antibodies that were blocked the PD one, we’re gonna talk about all those protocols and how we can navigate all those methods of the cancers using all the tricks to escape the immune system.
36:23
So
36:26
So here we have the immune therapy. It could be passive, or it could be active and passive. We’re going to talk about it. Passive immune therapy is where you are providing immune therapy from outside the body to do the to do the work. While active. immune therapy is is inducing your immune system to react and to kill the cancer cells. So either you are bringing immune therapy from outside the cells, whether it is antibodies or virus. Or T lymphocytes from outside and they will attack the cancer cells of that patient. So bring it from out so that’s a passive like giving anti serum to the patient who has virus infection versus giving weak antigen which is a vaccine that would activate the immune system to kill the cancer. So, so there’s passive and active when we give antibodies to the patient that’s passive because antibodies will kill that cancer or kill that virus. So this passive immunity when you are activating your immune system of the patient activate the immune system of the patient to produce cytotoxic T cells or antibodies then that is an active immune therapy. And so in immune therapy, we have two kinds we have passive immunotherapy and we have active passive is using anti tumor antibodies. So yes, antibodies can kill cancer, but is that enough? No, you need to really have cytotoxic T cells. So just antibodies is not going to be enough or you can have multispecific antibodies were that antibodies will take the macrophages and T cells and cancer cells and bring them all together and activate them and and kill the cancer cells. Or you engineer viruses Oh, there’s viruses ready by natural They’re engineered and you give them to the patient and those viruses will specifically infect those cancer cells. So there’s some of them are naturally natural virus that has tropism to the cancer cells. or man made engineering of viruses where they will have tropism and attraction to the cancer cells and then they attack them and destroy them. The other thing you can do is using card cells, car T cells and TCR we’re going to study them in the in the coming slides or you take T lymphocytes from outside from another patients and you give it to the patient with cancer so those to emphasize will, will attack and destroy the cancer cells of the patient. We’re going to study each one of these of this passive energy okay, are you there guys? Can you hear me? Maybe Okay. On and Off know if everybody can you hear me guys? hear you fine. Okay. Long Keilor Okay, great. So, um, so so we’re going to talk about active therapies and passive therapies. And we know that the active therapies are therapeutic vaccines and we’re going to talk about how we can develop vaccine for tumor. We’re going to talk about the cytokine treatments, giving patients interferon gamma or interleukin 12 All those types of times to really activate your immune system for the patient to kill the cancer. And we’re gonna talk about the, the antibody blockades
40:41
which is the antibodies that will block the PDL one and CTLA four and we’re gonna talk about them and counting size and details. So, so we can use either passive immunity or active immunity or autoimmune therapy or we can use both passive and active immune therapies together which is better. The more in tune tumor the more you combine it therapy. The better mono therapy is not working for cancer. Radiotherapy by itself is not going to work chemotherapy by itself, photodynamic therapy, it’s better if we do all of them. So we can really target that cancer cells from all different angles. So mono therapy in cancer is not working. And the way that Big Pharma is in forcing us to do mono therapy is not really for the best interest of the patient or to heal the patient is to get data you’re giving data that this drug works by itself and that’s what they need because if you do is combined, then those big pharma cannot prove that DEA that their drugs is working. So that’s why they are interfering with our resume. And they are telling to the oncologist Oh, you only use this drug you cannot use it with other things. If you use this and they are dictating the regimen. So is that regimen that the dictating is for treating the cancer or for proving that dogs so that company makes money and prove through good drugs for the FDA. It’s really most of the regimen that’s been adopted by the mainstream medicine is really to prove that drug that’s why they told they tell the patients oh if you take this you cannot go to other doctors or other integrative doctors and taking CBD or for taking other drugs. You have to keep taking this and if you do take other drugs that other doctors think it’s the best interest for you to combine it. That’s what we do and for treatment, then they will dismiss you and they say okay, you know we you you are not our patients anymore and and they will not work with you because we work with the patients because it violates the regimen that’s been dictated by the Big Pharma. So that is where US US integrative doctors are different integrative doctors, we don’t care about what the Big Pharma is telling us. We care about how we can treat the patients and if combining therapy will work and help to heal the patient cure the patient. That’s what we are looking for. And that’s why we call ourselves integrative doctors or we call ourself as chronic disease prevention management doctor or regenerative Doctor integrative Alliance Doctor whatever name our interest is the patient. So so we go in here and see the passive therapies as we said it could be by giving patient antibodies and just naked antibodies and those antibodies will attract cancer and opsonized cancer cells and possibly activate complements and make holes into cancer cells and kill the cancer. So that’s one way is giving antibodies although antibodies by itself is not that effective in killing cancer, you really need to have cytotoxic T cells in order to kill cancer effectively, or you take the antibodies and all of this our passive immune therapeutic antibodies, you add them a radioactive and those antibodies will link to the cancer and those radio active substance will radiate and increase the free radicals in the cells and induce apoptosis and kill the cancer or you link that departees with toxins. So when the antibodies linked to attach to the cancer cells, those toxins will make holes into the tumor and blow them up. Or you have chemotherapy and you link it to the antibodies as a target therapy. of chemotherapy, right. You want to direct those chemotherapy to go into the cancer. So they take the antibodies, and they use it as the targeting agent to deliver those chemotherapy into the cancer. And that’s called target therapy, and it needs to be done. In the big pharma Of course, in the lab. Or if you I want to have cytokines like interferon gamma until you can chew and want to get them all into the cancer cells. I can do bodies and give that way. Or I will give antibodies and we’ll optimize the tumor and then this will cause attraction of natural killer cells and natural killer cells will kill the tumor. So that’s another way.
45:33
Another thing is that those antibodies will activate the complement and complements will make holes into the tumor and destroy them. So this is how this is what we call the passive immunity those are methods that we are using for passive immunity here using antibodies, but also we can kill cancer passively by either having viruses that naturally have a tropism of attaching to the cancer and destroy the cancer and there’s a lot of companies are developing those viruses they are adding viruses and many different kinds of viruses, that has tendency to attach to the cancer and and and proliferate and divide inside the cancer cells and kill them. So we can pick those cancer cells with those viruses that’s naturally present in the cancer cells or we take those viruses and we engineer them. We put give them receptors that would have tropism to the cancer cells and destroy and destroy the cancer cells and there is some success of certain cancer using viral and as you see here, the virus will infect those cancer cells and they will proliferate divide know the cells that also activate the immune system by doing that, right. Okay, the other option is giving antibodies that will attach to the cancer cells, and also that will attach to the T cells and to the natural killer cells. So bringing all those components, natural killer cells and T cells to kill the tumor. So the antibodies it’s helps to put those components the cancer cells together with natural killer cells and bring them bring them toward the cancer cells to destroy them and T cells to destroy the cancer cells. That’s that’s one way that that those antibodies can be engineered. To bring the cancer cells next to natural killer cells, and to the T cells associate here and that’s one way of killing cancer. That card cells or car T cells, you know those chimeric antigen receptors, and what is it? It’s, it’s what happens especially in hematological, cancers like leukemia, their cells are are those tumor cells they are not mun genic. Those tumor cells, their major histocompatibility complex is being affected. And so they’re not good in presenting. They’re, they’re another word they’re not good in presenting they’re the macrophages themselves. are not good at presenting those antigen tu tu tu tu to the immune system. And because of that, we can go ahead and engineer those T cells, especially the cytotoxic T cells, and have them attacking those cancer cells regardless. So, so let’s say leukemia, in order for cytotoxic T cells to attack and destroy leukemic cells or cancer cells, those leukemic cells or cancer cells, they have to present their antigen and measure has to come build the complex type one. And then the cytotoxic T cells will be able to combine with both with the antigen and the major has to compared to complex type one. If those kinds of cells are not developing will are not developing the major histocompatibility complex type one in a normal way, and there’s the fact they’re like those chemic cells they don’t really develop very good. They don’t have that very good measures to combat the complex type one, it’s defected. So the toxic T cells cannot recognize them and destroy them.
50:00
Because the cytotoxic T cells, the T cell receptors, they have to they own they can only attack a cancer cells that has intact measures to compare to the complex type one and the measures to compare the contrast presenting the tumor antigens. Okay. So in that case, what I need is I need to change the cytotoxic T cells and the way that they will combine with the cancer cells, regardless of their major has to combat the complex like those you can excel, they don’t develop well. They don’t have a good measure of the complex that present their antigens. So what I would do I take the cytotoxic T cells receptor, the T cell receptor, and I will engineering how I engineer it, I will take the outer portion of the cytotoxic T cell receptor, the T cell receptor, the lymphocytes receptors and I will put antibodies, I will keep the inside the genetic makeup of the inside of this cytotoxic T cell receptors. But the outside I will engineer it so it will look like antibodies antibodies, they don’t really need majors to go by the complex and the tumor cells to be presenting it to the cytotoxic T cells. antibodies can attack with any antigen that’s foreign, but you don’t need to have it in presented in a major as to combat the complex type one. And that’s the beauty of it. So, the card cells is cytotoxic T cells a hybrid of antibodies and a cytotoxic T cells where the outer portion is antibody of the receptor, the inner portion of cytotoxic T cell receptor is is still it’s the it’s a cytotoxic T so that portion is still there. And so what will happen the cytotoxic T cells can easily combine with the new chemic cells and and destroy them the same mechanism of cytotoxic T cell toxicity or cytotoxic T cells that what they do they secrete side toxins that that perforates and make holes into the membranes of the cancer and blow them up. So that was called the cart chimeric antigen receptor. And so what we do we take the blood from the patient and we extract we get the cytotoxic T cells and then we engineer the cytotoxic T cells. We infect them with maybe antigen or genes that will express cytotoxic T cell receptors will go kart receptors that the outer portion is antibody then to portion is the the T cell receptor and we then we inject them back into the patients and we can have better results in destroying hematological cancers which is the Leukemia lymphocyte lymphoma and but we don’t see much in solid tumors okay. So those are data other other other way of doing it, or other way of enhancing your immune system. Or another word or developing what we call a very effective cytotoxic T lymphocytes. So, we know the cytotoxic lymphocytes, if we can make their receptor a more effective and attaching the cancer cells especially when you have a cancer cells that has low immunogenicity, that the decided toxic T cells of the patient is unable to recognize them because they are low immunogenic and that way we can go ahead and take those cytotoxic T cells or T lymphocytes and doxepin lymphocytes and then engineer them, infect them with genes that will express more effective T cell receptors that is more effective. They’re not antibodies, they’re T cell receptors, but they are more robust in attacking those low immunogenic tumors. We can have better results by engineering and reinforcing or making the T cell receptors more effective and combining those tumor with low immunogenicity. And then of course, when those cytotoxic T cells and robust engineered cytotoxic T cells combined with the tumor, they secrete those types of toxins that will blow up the tumor and cause the tumor. So that’s one way of doing things.
54:53
The other thing is taking the lymphocytes you know take the blood from the patients and and isolate all the lymphocytes. Okay. And and then what we do we treat them with in vitro with interferon interleukin two or interferon gamma and make them more enhanced. It’s like training soldiers, right? You take the soldiers, you train them, they become special forces like what Putin is sending Special Forces operation. Same thing so you take those lymphocytes from the patients and you train them you you expose them to introduce and to so they become Special Forces special enhanced cytotoxic lymphocytes and T lymphocytes in general are not sure more enhancing natural killer cells but being treated with cytokines that that stimulate them and then you you give them back to the patients all of this is passive immunity you know, you’re giving to the patient’s immune therapy from outside you’re not activating the patient’s immune system, the patient’s immune system is not the one attacking the cancer is the immune therapy that you are giving it to the patients whether it decided toxic immune therapy or it has antibodies. I mean therapy. But when we are talking about active immune therapy, that’s mean you’re activating the immune system have the patience to attack and destroy the cancer and we can you do that by giving the patient cytokines right you give them interleukin two or interferon gamma, you give them thymosin alpha. So all of this is cytokines that day, I think they proven to do can chew and to Perone gamma. They’re going to sign the Django site or the monocyte economy stimulating factors that is not being FDA approved. But interleukin two and interferon gamma are two cytokines that you can inject them into the patient’s it will be nice. If those cytokines and those antibodies that we’ll talk about all of them. It’s good if we load them inside platelets, nanoparticles and giving them to the patients in the form of nanomedicine which is better because the state nanoparticles loaded with antibodies loaded with cytokines well with type photosensitizers are loaded with chemotherapy, whatever you can load anything right and then cargo and then on the size of Vedas at a particle size of 100 nanometer around that they have more tendency to carry all this though the drugs sold as drugs into that pathology because the pathology whether it’s cancer, infection, or inflammation, their blood vessels are leaky to this size of nanoparticles which is around 100 nanometric and learning inside of platelets than a particle I think it’s the best option best wise so you can get them into the pathology because the normal tissue their blood vessels cannot really allow those big, big particles to pass through. They’re more tight. They’re not leaky, but the pathology are leaky. So those nano particles can get into the tumor without getting into the normal tissue and that minimizes side effects. Because if you give naked chemotherapy to give naked antibodies, those everywhere, and then you have the side effects that you don’t want and then you dilute those effects of the chemotherapy or antibodies or cytokines that you’re giving. And so it’s better if we load them inside nano particles and the best is plate it’s not a party, not the first PolyBase or PLGA the synthetics because the synthetic still they be recognized by the body as foreign. So the macrophages the liver will take them and the lung would take them and they don’t get into the target pathology. It’s better to use their own natural Postville, lipid membranes or red blood cells and apply to Titus Barrows evidence shows I did a lot of work on it but cells, it’s not that effective as platelets and we have the technology to do that. If you need to be trained. We can help you with that and get you trained to do nano technology. We have a lot of doctors are doing it. And with great success. What else? We have also therapeutic cancer vaccines. So what we do, there’s many way you can do it in a big pharma way where they take the dendritic cells and then they engineer them. They they infect them with a virus that expressed that ditions so those direct sales were already being sensitized to the tumor antigen, and then you inject them back into the body and then the dendritic cells will activate your immune system pulverize it to to h1 Inside the toxic T cells and kill the cancer. So this is what’s called the direct cell therapy. So you take the the or you take the monocytes from the blood, and then you grow them in vitro and you add them plated lysates when you add the platelet lysate and you bait them,
1:00:20
they become the dreaded cells, those, those monocytes and those they become dendritic cells in vitro. And then you can go ahead and expose them to the tumor antigens or infect them with the virus or change their genes by CRISPR technology and introduce the genes of the tumor to those atrophic cells. So they become sensitized as integrative oncology, the way we can do it, so we don’t need the engineering and labs of the Big Pharma. We can take a tumor and take the tumor biopsy and then do tumor lysis by sonication. And then sensitize your dendritic cells culture which is incubated with date the place date so peanuts I take this so easy to take platelets to break it down and get the pigment lysate chain to painted with your monocytes that’s coming from the blood which will turn into the clinic cells, and then you take the tumor biopsy you sonicated very powerfully and you turn and then you narrow it of course medical trip, and then you sensitize those dendritic cells and those dendritic cells will become sensitive to that antigens. They’re ready and injected into the body and what would happen they would activate the naive T cells and polarize into th one and th one when dendritic cells with M one and DC ones definitely will activate the cytotoxic T cells and kill the cancer. So that’s one way of doing it in a clinical level, instead of doing it in the lab where you need you know the system fistic ated lab that the other thing that we need to learn is to our use to kill cancer is to block those. The PD one and CTLA four with antibodies, and I think we talked about it before is that those tumor cells they express on their surface antigens, we call them PD one. And when this PD one, combined with Pdl, one of the cytotoxic T lymphocytes, what would happen? They turn them off. So let’s say you have a tumor is being attacked by cytotoxic T cells right. And what will happen here, as a T cell receptors is combining with with the antigen of the tumor on the majors to compel the complex type one, there is in this T cell receptors there is a CU stimulators and CU inhibitors and those cu stimulators do activate the lymphocytes, the cytotoxic T lymphocytes and cool and laboratories they will inhibit the cytotoxic T lymphocytes. And if the tumors is expressing PD one, they will react with PDL one which is the cool inhibitor and they will close out they will turn the cytotoxic T cells off. So those tumor cells yes you will see are attached by cytotoxic T cells, but they’re being turned off by the PD one PDL one reaction which is PD one from the tumor PDL one from the cytotoxic T lymphocytes. So, what I would do to turn on the cytotoxic T cells and activate them at day so they can kill the tumor cells is to develop antibodies that blocks either the PD one or PDL one and we have it. It’s an FDA approved and we can go ahead and give it to the patients. And Dr. Patel is one of the doctors in my group. She’s doing it and she’s giving those PD one inhibitors, those antibodies to block those PD one those antigens pressed by the tumor, so they prevent the tumor from an activation in the brain on the cytotoxic T lymphocytes and activate the cytotoxic T lymphocyte to kill the cancer. Um, the other thing is that the T regs, they do have CTLA four and they inhabit those macrophages, the M one and turn them into M regs because of the CTLA four. So what I would do to prevent that from happening and preventing those macrophages from being turned off and become M reg is giving antibodies that block CTLA four and that will turn and that will turn on the those macrophages and it switched it from M reg into m one. And that would help to activate the immune system to kill the cancer. So giving both giving
1:05:14
anti PDL one or anti PD one. Giving the CTLA four would definitely help to enhance the immune system in attacking and destroying the cancer. Again, he has the problem. Okay. The problem of getting those antibodies nakedly as they are doing currently right now what makes excitements of what we call them immune and colleges they call themselves immune from colleges. Is that when you give those antibodies especially when you give CTLA four antibodies for example, yes, you will be activating your immune system Yes, you will be turning your M you will be activating and turning them Rex into M ones. And you will be activating the cytotoxic T cells to kill the cancer but also activating the immune system to attack your self antigens. So when you give those antibodies it does help to kill the cancer. But at the same time it will reactivate the immune system to kill or attack yourself antigens. So what we need exactly we need to deliver those antibodies, those blockade antibodies into the Constitution and how we can do it using nanotechnology loaded inside nanoparticles and inside the cargo inside that envelope. And that envelope will go specifically to those thicker tissue which is the cancer versus the normal tissue. And that’s what Dr. Patel is doing currently. And that would distinguish her from other doctors so that other doctors they didn’t even get naked and they end up with reactive collides and trigger autoimmune diseases and that will definitely deplete the root system. Again, it goes to cancer to flourish. But if you can get those antibodies into the cancer into the cancer tissue, then you will spare the immune other immune system that is very important to be kept tolerance to yourself antigen and that’s the problem with those antibodies currently only solution right now is using platelets nanoparticle there’s a company who’s doing it. mainstream companies working on it. It’s called Scylla therapeutic I think, and they are developing this technique update this article, but they’re using PNGa to make those articles more stable. Clinically, we don’t need it because we’re not selling the drugs. We’re just mixing it and giving to the patient immediately. So you don’t need to have a long life shelf things you need to PNGa but this is the best way of delivering drugs into pathology using nanotechnology. So again, we can use that so there’s many many antibody blockades as you see here, when the cytotoxic T cells combined with tumor, there is cool stimulators, the coolant temperatures, and we need to develop antibodies that will activate the cool stimulators and inhibit the cool inhibitors in order to keep those cytotoxic T cells active destroying the cancer. And so there’s only a few of those antibodies being developed which is PDL a and CTLA. Four, which is here page, right. It’s called the pembrolizumab. And if it involves your voice and Katrina, Katrina, those are two drugs that’s been FDA approved. And I think Dr. Patel is using it with with with great success. So we it’s very important to to look at all those methods of treating cancer and use them all
1:08:57
in addition to that, beside the immune therapy. Beside the metabolic therapy, which is chemotherapy. Beside the radiotherapy we sign up for the dynamic therapy. We also need to focus on changing the tumor microenvironment to make it a hostile environment instead of being a favorable environment for the tumor. And the tumor cells do secrete chemicals that makes the environment favorable for the tumor to grow. They secrete chemicals that will polarize the immune system away from th one and m one talked about the big turn into becoming th 17 by secreting interleukin six or th two by secreting interleukin four interleukin 10 T regs and we need to go ahead and polarize them back to the th one and one we use those Patrick sound inhibitor T and 17 that helps to polarize the immune system in darker to each one so we’re given those metrics so on I don’t like to say it will always immune system to do h1 or h2. I like to say it’s competitive 17 And you’re doing that then this would help to polarize the immune system to to h1 right when you are stopping the tumor from pulverizes the immune system Good 17 Then automatically they will be polarizing into th one and killed against so so that’s why those different song works. They polarize the immune system to the h1 but indirectly by inhibiting the th 17 or giving IDs to me. Why
1:10:24
don’t you say that? What to give for changing th 17 to th one?
1:10:33
No, no, when we have tumor. Tumor cells secrete interleukin 17 interleukin six and they polarize the immune system away from th one you got my point, right. Okay, so what I would do in order to keep the immune system moving to th one is to inhabit the T at 70. And if you do that, then those naive T cells will be valuable to be polarized with th one instead of going to Dn 17 and use this immune reaction. That’s inflammation that will not kill the cancer. Those neutrophils we need cytotoxic T cells so if you’d have it that polarization if you had 17 wishes induced by the tumor cells away to evey I know why to avoid the cytotoxic T cells, right? You polarize them away from them. And those cancers they that’s what they do. It’s the same like COVID virus, the COVID viruses what they do, they have the ace to activating angiotensin, which leads to anti activating overactive angiotensin type two one angiotensin two type one receptor, which leads the production of interleukin six, polarizing the immune system away from toxic tissue which has been important to kill those infected cells with this COVID-19 buyers. So the virus of COVID were say my tumor, they both of them, they activated 17 and polarize the immune system get 17 but we’re just going to do kinetics, which will exhaust the immune system and preventing it from moving to the right direction, which is th one m one cytotoxic T cells, you got my point. So what we’re doing, we’re inhabiting that organization to keep the polarization moving to protect you on one side of toxic T cells. So that’s what we do with them. Those nodes that axon for example, a metal metal and blue or ivermectin or using a hydroxychloroquine. All of this drugs do and have it the TS 70. Now, the beauty view if you hear that lecture of Dr. Valle, which is he has a very nice slide where he shows all the common pathophysiology this is how you looked at the pattern going back to this yellow sheet of, of degenerative and autoimmune and cancer and allergy is over activity at 70 overlap and if you inhibit that, you can help to manage that the patient. It’s not completely it’s just an adjunct. But of course, you need to work on other things. But this helps to definitely improve the patient’s condition just by inhibiting the useless authorization and overactive polarization of th 17 And to do with six and interferon because anything you can sex if it’s all very active, it goes coagulation, and it goes fibrosis and both fibrosis and calculation is not good. Because fibrosis will squeeze the blood vessels so preventing the lymphocytes fundamental training the tumor, and then God Galatians The platelets when it’s been active, it will form a shield around the tumor and preventing it to be exposed to the cytotoxic T cells. So overactive interleukin six is not good. And that’s
1:13:46
what about peptides. So yeah, so that’s what
1:13:49
I’m talking about. So let’s say in the tumor, you have the polarization of the immune system go into th 17 And it’s going to th two and T Rex, right. So what you need you need to block the th 17 Right. But also do you have drugs that will help the polarization of the immune system to th one so you need to do that. So you need to block all the pathways that is away from th one on one a block the pathway of theism, G and you block the pathway that goes to th to use antihistamine you block the pathway that goes to the GSM Dean which is allowed. But also do we have drugs that polarize the immune system gets run? Yes, we have interferon gamma we have thymosin alpha, but very important when you’re given different dama. Here’s the problem increases the expression of the tumor cells to the PD one which will switch off their tumor cells. So very important that you get antibodies against the PD one. So you give them a treat and you give them different on gamma together. You have more effective but if you get into growth but stoma by itself, yes bars, th one you get a sign and you get enough of cytotoxic T cells, but then the tumor what they do, right, they will turn it off, decided by expressing the big one on the surface and turn off the cytotoxic T cells. And that’s where one of the thing about people are doing the CBD. The cannabinoid do and have an expression of the PD one on the tumor cells. That’s a that’s a good thing. So if we do CBD, and you do with it, no does not brickstone And you do interferon gamma. All of this would help and advantaging the cancer so you need to learn all the tricks of the cancer and tried to reverse it. But just shooting in the dark and following the regimen, the big pharma who are dictating that want to therapy to get down at them care about the patients. All of that needs to be dismissed and we need to get all those information, all those research publications and learn and and translate into protocols which are doing Dr. Patel with with great success.
1:15:58
So in other words, if you are not using interferon gamma, you should not be using the TF one or thymosin Alpha.
1:16:11
No, you can you can still need to know but to bring it together they both they will help the boys HGH work synergistically.
1:16:19
But then you said that also it stimulates the PA
1:16:23
Yeah, so they will stimulate the PD one so that’s me expression the bladder, okay. So you need to add up the blocker Danti PD one antibodies blockades.
1:16:35
In this previous slide, it said PD one blocker Keytruda Keytruda is Pdl, one
1:16:44
PDL one or PDL one
1:16:48
right. Yeah. But it’s a really big one is a new one, which is
1:16:54
right, right. So either way, your block that you activate the cytotoxic T cells, can you kill the cancer by giving a different gamma by itself at that that’s where the problems. Now let’s go back to say, this isn’t for the lecture last night was Dr. Boyce. And I slept in the middle of his lecture. I don’t know what happened to me and I feel guilty about it. So I apologize for Dr. Bill about it. Because I was ready to add those things because he has it all in his sights. And we just need to you know, discuss it and talk about it. The other thing is that in allergies, you have th two which is th two dominant immune disease but also you have some th 17 as well. And an allergy is also if you can go those naproxen would help the patient but of course, you still need to have the th two and allergies and autoimmune diseases like multiple sclerosis, there is th one and th 17 So if you have the th one only it’s not going to work which they did it they inherited with antibodies that blocks and different gamma and the disease didn’t become worse because you still have an activity at 17. So you really need to act inhibited 17 So you need to block the th 17 entities work in order to really effectively manage multiple sclerosis. And manage them twice. So then 17 is actually everywhere, even though it doesn’t Buddhism there is overactive into kids 17 interleukin six that’s why low dose Naltrexone works no well no no not not axon is not just in everything did 17 interleukin six production but also it has other activities of course it activate the NPK we know about it talked about we have a big lecture on it. And also those not so it does help to induce apoptosis and kill the cancer cells. So there’s many other activities and it does increase the expression of the opioid receptors. And that’s good for pain right? And it is sensitive to pain but Dr. Williams said increase the Kathleen’s I think it’s more increasing the sensitivity to to the opioid until the end capitalism endorphins by increasing the expression of the opioid receptors. So those are the things that that’s
1:19:22
the meal also mentioned that if you give the naltrexone and CBD in one slide it said that if you gave the there was a study at first and then you gave the naltrexone there was only 22% inhibition, whereas you give Lana toxin first, and then followed by CBD, there was 35% increase. So you one is going to use it. One should use their naltrexone first followed by the CBD, right
1:19:58
because not just some possibly it’s increased expression of the CBD receptors as an expression of the opioid receptors. So that’s the beauty of it. So that’s the mechanism so you’re raising the sensitivity of the CBD without axon so people are doing that. Both together are more effective in any applications including alcohol addiction. Use both of them it’s it’s better
1:20:25
mitophagy Can you talk about in relation to about the mitophagy so
1:20:32
activate de MK MBK which is I didn’t even want to say kinases then it does help in activating the mitophagy in general could be causing stimulation of the mitophagy directly of the mitochondria, but just activating a mvk leads to activation of the of the mitophagy the mitosis by blowing up my garbage is blowing up the mitochondria and releasing the cytochrome oxidase which will induce apoptosis of the cell. So it seems like not the zones and the polyphenols and the Yucatan. All of them works on the same mechanism by blowing up the mitochondria and using up Aptos so it seems like
1:21:25
not to use the Metformin right
1:21:29
I use my car man use could be done you can use those not trick so don’t use polyphenols. They all works in that that similar pathway. Again, combining all this talk tell us why we want to do both Brookdale prevention, which we can just use it as an oral dose. But when you go to cancer treatment, I like IVs I like high dose I don’t want to go with Dodo. So I like high dose because high dose curcumin high dose it’s better because generate the free radicals as well. That you need to destroy the cancer. So if you do cancer treatment, it’s better to do IV versus doing or you do prevention of cancer you can go ahead and be at a cocktail and be before that’s how I see it. Because no dose curcumin IV is more effective than giving it low high dose Curcumin is more better than low dose curcumin in treating cancer and polyphenols in general. And also IV nitric zone is better than taking the tablets when you manage cancer preventing cancer just give tablet but when you manage cancer, I prefer IVs as much as I can. This is my perspective. I didn’t know if others will agree with that. But anyway, so anyway, so when we’re treating cancer we need to go through stages we need to kill the cancer. So we can release those antigens and then a macrophage will take them and eat them and then presenting to the lymphocytes, right and activate those lymphocytes. And we can enhance that process by doing vaccines dendritic cells, right take monocytes from the blood, grow it into platelets lysate states turn into dendritic cells and then sensitize them with the cancer antigens, taking biopsy of the cancer and sonicated turn it into antigen and then introduce it to those dendritic cells and then inject them back into the tumor and then we can activate the whole process also by giving cytokines right whether you’re training that you’re giving cytokines in vitro, to the lymphocytes, as we talked about the passive immunity, or you inject them into the body, activate your Dungeness, emphasize to kill the cancer. And then also, as we said, we need to block or use antibody blockades that would help to activate the immune system. Activated cytotoxic T cells turn those macrophages from N breaks into m one and N habit the T Rex by using CTLA four antibodies. But again, if you’re gonna give antibodies, please use the standard particle. I think that’s that’s better so and then what you need to do. The next thing you need to do is see here, you need to make sure those lymphocytes do infiltrate the tumor. So in order for the sample size to be infiltrating the tumor and turn the tumor into hock tumor, not cold, because what does the tumor is they they, they they activate their fibroblast and the fibrosis too much where they will squeeze the blood vessels right. And also they disagree too. Much VGF which is vascular endothelial growth factor and those BGF will stimulate the blood growth vessels but they are kinky, but visibles What’s that mean kinky that they are kinked so yes, they will increase the sugar supply and nutrition supply to the tumor, but they will because of the kinky thing and will prevent the lymphocytes. Those are big in size to pass into the tumor. And so we need to normalize the vasculature of the tumor by giving Avastin that intimidate the BGS the basketball at the girl facts, and not too much were used. There will be no blood vessels that if you don’t have no blood business, a tumor, then you don’t have none besides going to the tumor, but normalizing so too much of BGF will those bases become torches and kinky, and they get easily squeezed by the fibrosis and parasites will not be infiltrated. So you need to normalize it, but not too much of a Bastien where you you goes
1:26:02
a decrease in the growth of the blood vessels. There will be no even no way for the lymphocytes to go into the tumor. So you need to normalize and so the investor needs to be giving in the dose that will normalize the vasculature not to destroy the blood vessels of the tumor completely because if you destroy them, and this method or with the technology this protocol then you will not allow that emphasize from going into the tumor although there is some treatment of tumor where you destroy them completely. Yes, if you destroy them completely, where they will be known attrition and no walks in the tumor, that’s fine. You do that. But don’t destroy them where you don’t get you get the nutrition there but you don’t get the lymphocytes. We need the blood vessels to be big enough to allow the lymphocytes to infiltrate the tumor so they turn from cold to hot tumor. So giving anti fibrotic drugs like laws our time it’s good shock waiting the tumor is good to break those fibrosis and allow the lymphocytes to infiltrate there and if the lymphocytes infiltrate there and you have the all the cytokines introduced for the transforming drugs, the transforming growth factor and polarizing the immune system and why then the immune system will not be effect. You see a lot of immune cells there but they are active. So very important to polarize the immune system to one th one and activate them using the antibody blockade that we talked about. And then if they say that tumor are not immunogenic, like leukemia cells, not to mutagenic dimensions to cover the complex type one is not perfectly well developed, they’re defected. Then you may consider doing cartels T cells for those patients or enhancing the T lymphocytes. T lymphocytes that’s activity over to T cell receptors. That’s that’s the rebound. You can engineer them and infiltrate them into injected back to to the patients. But again, it’s very important to all those tracks whether it’s chemo or photosensitizers, so those repurposing drugs that would change the tumor microenvironment or those antibodies that polarize the immune system to th one or any of those repurposing drugs. If you’re giving anything injectable, please use the nanotechnology and the best nanotechnology is using platelets nanoparticles which I can help you to develop that in your clinic not just for cancer, but all different obligations. So I think I’m done with part one of integrative oncology. It was a long night. I don’t know if I was rambling here. But I was trying to simplify the information and break it down to simplify it so everybody can really process it easily than just giving you hard terminology. medical term, I try to break it down. I don’t know if I succeed succeeding that or not, but if not just please ask questions and we try to elaborate and learn from you. And it’s all about both ways. So go ahead. The mic is yours. And, Dr. Bill, I know you’re falling asleep.
1:29:19
No, I’m here. Anybody have any questions?
1:29:27
This Dr. Patel, Dr. halacha. You repeatedly mentioned polarized immune system to him when to th one but how do you polarize em one
1:29:41
the same drugs that you are using to polarize teach when they are together if you if you enable the drugs that polarize them, one is the drugs the polarizer th one and two the cytotoxic T cells. So some interferon gamma, always the immune system into m one th one. It starts with M one and then when you provide them one on one secreting cytokines that polarize the mood, the T cells into th one and th one will start secreting chemicals that will turn the name CDA into cytotoxic T cells and cytotoxic T cells will grab the tumor and destroy
1:30:19
it now if patient has a cancer patient has a low lymphocyte count. A total white cell count is completely normal. But if they have a low lymphocyte count, then how are we going does that reflect? The patient has the low lymphocyte count into tumor number one and if it is so, then how do you handle and on their mapping? They have a low City Board and high comparatively high ICD eight but still city poor city yet count is is high. I will go
1:31:00
by Muslim Alpha still because otherwise the immune system to channel one and it will activate the whole immune cells in general but it will lean more to CDI. Um, you want to get famous and read that no because thymosin alpha, it does help to increase the production of the lymphocytes in general. But more to see the exam it does increase the CD for NCDA but more to CD they got my point. So I’ll continue giving interferon gamma and thymus and alpha for those patients because thymus an alpha will increase the lymphocytes in general, which is the naive T cells. And T cells eventually will polarize more into th one is a well known name system. So do you have to know the th y in the city for the cytotoxic T cells. So the diagnosis is the name of T cells and that’s me it will increase the city for at the CDN but more in the city. They got my point. I’ll continue giving thymosin alpha and interferon gamma. I don’t know if you want to give colony stimulating factor that kind of site on a psycho corrosivity but it’s not a DA approved as you saw there and the problem with that may be the MG MG recovery stimulating factor granulocyte monocyte colony stimulating factor the GM
1:32:35
CSF
1:32:37
they’re giving it sometimes for those patients to increase the white blood cells in general. Remember, those factors that they injected to the body will increase the production of white blood cells? Like Neupogen. Right, right. So that’s it that’s the kind of state was
1:32:53
a stimulating factor, right?
1:32:55
So but it’s not up the pool, and there’s a problem with it because you may be releasing stem cells from the bone marrow that will differentiate in the tumor. So you may decrease the burden of the tumor. So that’s the problem. That’s the reason why I did not approve it. But although some doctors have given it to patients with cancer when they have no white blood cells, that’s the only way they can better for me I will I won’t do interferon gamma time was in alpha. I will make impossibly patients has too much of interleukin six. And if they do then they have too much of an intro field that will exhaust the immune system and the white blood cells will be moving to that direction. So you’ll give vision ivermectin what would you give our give low dose Naltrexone if you want to give ivermectin that’s fine again maximum 17 antifungal drugs they are very effective and have a drug gsmd See see what so we have fungal infection. Those antifungal drugs by nature they kill the fungus but also they decrease the th 17 interleukin six which is part of that decrease inflammation and kill the bug so that’s what you need. Right? When you have Sasha you have the mites and then you have too much overactivity at 17. So that’s ivermectin when they used it, which is very effective drug combining steroids. It kills the bite, but also it decrease the inflammation, the th 17 inflammation and everybody here needs to know that there’s three kinds of inflammation. There is th one inflammation, there is th 17 inflammation and there is th two inflammation which is the other sheets and then th 17 inflammation which gives you neutrophils and then the th one inflammation which gives you the cytotoxic T cells and most of the diseases you have a combination like rheumatoid arthritis, TF 17 and th one both of them and allergies. You will see th two and T and 17 are active, but some diseases they have more than 17 than then the th one or th two like ulcerative colitis, it’s more of th 17 damage to h2 inflammation. While Crohn’s disease it’s both it’s really th one th 17 And so we manage it. We need to block both polarization. It’s a combination it’s most of the time, but they had 17 blockage which is actually so from the lecture of Dr. Bailey’s today. He’s using nothing Sonic is treating all the diseases, almost all chronic disease across the board that indicate that he had 17 overactivity. It’s the pathophysiology of all the chronic disease. out there.
1:35:41
You agree with me, Dr. Bill? Actually, I do. Yes.
1:35:45
So what about then then did Dupuytren’s contracture where there is a overactive production of Collagenase information of the tissue so so that that you would consider as a autoimmune process,
1:36:02
Well part of it part of it, because you know, that diabetic, they do have too much of reactivity at 17 and interleukin six Do you know, interleukin six, simulate fibrosis? That’s one Dukan six too much of it can lead to provide Gnosis that’s the reason that explained why the patient would pass COVID-19 They have lung fibrosis is because you can six so I think mediated by introducing six so if you give something that inhibits interleukin six at the at 17. It could be part of the management of the material contraction.
1:36:37
So this patient has Hashimotos thyroiditis, hypothyroidism, and Jupiter ins contracture. So as you motos thyroiditis I have corrected by by the LDI for the Hashi. motorcyles varieties, however, and I have given her the low dose Naltrexone too, but I I have not made a dent in her do patrons contraction. So I was just wondering that how to I mean, yes if I had a college in age, I can probably inject but it’s not available to the physician like us except the hand surgeons. So I don’t know.
1:37:24
Maybe Maybe topical not that song or injecting naltrexone maybe will work. But I would have a Dr. Mike beamer has a very good formula for that. He combines things together. He said he’s like a wizard, right?
1:37:39
No, I talked to Mike. And he said that calendula is is it’s different. It’s not fibrosis, it’s a different animal so Alright, so he doesn’t have a topical thing local will not work well
1:37:57
on steroids that what they do mainstream they do steroids Okay. Which will help to suppress the immune system including the th 17. But I would recommend and try just do topical natrix sawnwood shockwaves and see what would happen and possibly giving some injection of steroids. That doesn’t work. So you go step by step. If
1:38:19
I told her that if, if it doesn’t get better, then that’s what we will do.
1:38:24
Right? That’s the only thing I think it will work I mean, yes, steroids is the last thing you resort to do. But if you can do things without using steroids, that’s that’s better. So that’s how I see it. I don’t know. What do you think Dr. Bill Are you there anybody? There?
1:38:42
I think I think you covered it all.
1:38:44
Okay, anybody. We will cover that there was second part. Maybe we’ll cover during the conference and the conference will be very fast.
1:38:55
We have you scheduled for two weeks from today. Okay,
1:38:58
so that’s mean next week are eager to. So the second part, oh, we’re gonna do the second part in the conference and you want to be here.
1:39:08
Well, you know, the conference is starting from scratch, so they’re gonna have to, you know, you’re gonna have to Well, that’s up
1:39:12
to you. I’m just trying to tell the people here in a second, right. That’d be very interesting. So we’d like you to attend it, whether it’s going to be a conference or
1:39:20
Well, we are if we already have this, then you know, you know, well, if everybody’s coming to the conference, you know, at least online. We can do it that
1:39:27
way. Okay, whatever you like. Okay. All right.
1:39:31
Next week, just just just for your information. And please spread the word we have. Jacob Teitelbaum will be here. And as you know, he is the father of chronic fatigue syndrome. He’ll also be speaking virtually at our conference on Sunday. But he’ll be here next Tuesday. Night, same time same station. Those of you who are interested if you go to aos rd, I’m going to put it in the chat room chat again.org/event That will take you to our website. For the conference. We’re two weeks away, and we have an all star lineup, including Ken Crowley’s going to be giving us a lunchtime talk on CBT and his company trophy. David Kahn. is going to be there I think right David? And we have college pharmacy coming also. And you know if you’ve seen the lineup of speakers, you know a 4am can’t can’t do a better job. We have really high quality speakers coming in please support us in one way or another. We would love to have you there. But if you can’t make it online and there was discounts for that as our d.org/event it will take you to our website and registration pages is there the whole lineup is there and any any other information you might need. Anybody have any questions about anything concerning that? You can get me either at I’m going to put my email here. Dr. Bill nine@gmail.com Or my cell is 570-816-8221. Okay. Like I said, we would love to have, you know, a really big crowd Saturday night Dr. Peter Macola. I’m sure everyone here knows knows that name will be here. They’ll give us a lecture here. There’ll be the last speaker on Saturday night, and then there’s a reception for him out on the patio at the Flamingo hotel after that. So, Sunday, we have Felice Gersh who she’s spoken to this group a couple of times, and she’s a permanent speaker at 484 AM. And just as coincidence would have it yesterday, I don’t know and you get the pure encapsulations catalog. It’s a really, I don’t think anybody would even print this stuff anymore. It came in the mail. It’s a couple of 100 pages I flipped open one page and there she was. There was some formula that she had she had formulated for menopause a woman and there was her picture of the same one that we used in our advertisements by the way. So she’s there Kathleen O’Neil Smith, you’ve heard her her immunity talks. We have Richard Marsh coming. She is our local infertility specialists. We have Joseph Lillo, who is lipids, lipid ologists. Dr. Anwar, as far as I know, is still coming. He’s coming all the way from Pakistan. He is an acupuncturist and elite laser acupuncturist and Dr. Speier Of course, you know is our patriarch. He’ll be there can’t dance stalk we’ve heard him he got himself in the COVID kerfuffle about a year ago and he spoke to us about for about two hours without looking at a piece of paper or a slide. Which, if you remember his talk, which was amazing if you need state credits, pain management, David les Gibbets is going to be doing that again. Ethics we have Dr. Cruz coming again. And also Dr. Stock also qualifies for medical ethics and suicide prevention. So those are all the western state requirements and they will all be satisfied at our conference also. So Dr. Crowley, you have anything you want to add?
1:43:58
No data for? No Dr. Bill. Okay, just looking forward to this awesome event that you have with so much CME. Yeah, okay. Oh, by the way,
1:44:07
another thing that we are now up just went red 26 CMEs, not 24. That just happened last night. And I can try to squeeze one more in. I’m not sure if I can.
Bill Clearfield 1:44:21
So but we’re up to 26 CMEs an AMA and AOA so, you know, qualify for both. So that’s that’s kind of a feather in our capital. So. So anybody else have any other questions, comments? We have, you know, some new folks one as we always do. Dr. Peskin will be speaking to us at the end of March about his work. And anybody have any topics that you’d like to bring up? Please let me know. And, you know, we’re welcome to always welcome to newcomers. So we’ve got a couple of great talks there. Dr. aulassa very stimulating and, you know, the usual attaboys so we can’t thank you enough. You know, for being the impetus for this group and for your own and for all the work that you do. We’re looking forward to seeing you at our you know, in Vegas in two weeks, and please spread the word Dr. Patel will be there will be will be online with talking also about chronic fatigue syndrome. Anybody else here that I left out Dr. Burgess? Joel Peterson you know, they do a combination. Suicide Prevention.
1:45:37
I hope I didn’t leave anybody else out. That’s about it. There’s a little kerfuffle with the hotel about registration. So if you tried to register the hotel, and they told you it was sold out, let me know.
1:45:59
For stocks, okay, because yeah, and they gave you a higher price than what was originally quoted. Also, let me know, just send me a message. Because we’re having a little little issue with them.
1:46:10
I can call them I’ll just call them and tell them this is a group and if they did not do it, what I will do, I will call you.
1:46:16
Well, you need to let me know and we’ll get our, you know, we have a hotel coordinator working for us. We’ll get we’ll get that together. I think
1:46:28
I’m gonna book it tonight or tomorrow.
1:46:31
I think Dr. Cruise went next door to Harrison. They gave her the same price that the hotel gave us, but they’re playing a little they’re playing some games there. So let me know if they if they tell you it’s sold out. Let me know. Okay.
1:46:42
Okay. I’ll call them and find out. All right. Okay.
Bill Clearfield 1:46:45
Anything else? going once going twice. Same time next week, Jacob Teitelbaum, you here. And, you know, everybody, you should all should all know that. Anyone? Okay, I thank you so much. I know it’s getting late. We’ll see you again. Same time, same station. Have a good evening. Guys. Okay, have a good night, everybody. Thank you. Everybody. For birthday thing
1:47:18
is that me?