Tue, Jan 17, 2023 4:54PM • 1:58:09
SUMMARY KEYWORDS
estrogen, skin, women, inflammation, hair, hormones, put, increases, myasthenia gravis, alpha reductase, estradiol, problem, works, week, menopause, good, great, regulates, acne, testosterone
SPEAKERS
Bill Clearfield
01:05
Get More guide like every week. More what like I’d like wow.
Bill Clearfield 01:12
Yeah, your background was blurred a little bit.
01:15
Yeah.
Bill Clearfield 01:16
Just, you know, just sort of sort of ethereal there.
01:20
That girl.
Bill Clearfield 01:24
Our speaker is is Dr. Gersh and she’s usually a few minutes late so can have something he wants to bring up if he comes in comes on time if not, well, I’ll try out a little something that I’m doing
01:39
for the
Bill Clearfield 01:43
doing a thing at South Lake on so on Friday, so
01:47
I’ll do a short short little gizmo What are you up to?
01:53
Oh me John Burgess.
Bill Clearfield 01:55
You John Burgess. Yeah,
01:56
I’m blowing smoke up the ass of all the academic and precipitate precipitate participating. Dean’s of the new osteopathic medical school in Hagerstown, Maryland, it opens in 2025. I’m going to make them an offer they might refuse with they shouldn’t and that is to include an integrative medical department. In their program. It’d be the first one in the United States, when that’d be a sum. Wouldn’t that be something I’m also right, you know, this is near Washington, DC, and we have a few friends here. I don’t, I don’t have any enemies. So we can talk and I’m trying to so I’m trying to see I’m making them the offer if they want to do integrative medicine, we will offer them the finest integrative physicians in the world if they want, if they want, but they might want a few things too, but like I’m going to offer them my offer office for rotations for the students that type of thing. Will say doll attitude, isn’t it.
Bill Clearfield 03:07
It’s something like that what’s happened in row 10. Row 10
03:11
is doing beautifully. absolutely beautifully. It’s coming around. So no problems there. Everything’s good. Okay,
Bill Clearfield 03:23
when do we start to set up shop?
03:28
Well, Brian O’Donnell, our patient advocacy group leader has already built the house there. It’ll be completely done by this year. And it’s astounding and the people he has met there have also been astounding, including a couple of physicians who are there with us are ahead of us are near us that type of thing. They’re doing the stem cells in the regenerative medicine and a few other good things, and they could use our help. So I’m also making them
04:01
here’s a year later on page 21. The same for the IGE antibody as you can see there, the testing done in July. Sorry about that. So you still there John
04:24
you’re muted.
04:31
Everything in rotana is going good especially with stem cells and exosomes. I just don’t know what the laws are in the United States anymore. I have a feeling the laws are the laws
Bill Clearfield 04:42
are what every time you see a patient you’re committing seven felonies. Start with if you start with that, that premise. You’re probably committing seven felonies. Right. And it could be it could be a felony of omission too. It could be you know, well you didn’t do this and you didn’t do that. So
05:10
that’s why we’re out of the United States, at least for the time being so we can figure out who’s who and what’s right.
05:18
I still remember my law professors saying if you practice good medicine, you’re gonna break the law 100 times a day.
Bill Clearfield 05:27
Well, that’s pretty much they just said the same thing. Exactly. No.
05:31
Yeah. So So Dr.
Bill Clearfield 05:36
Gersh is our police girl. She’s our speaker tonight but she’s usually about 10 to 15 minutes late. So can if you have something because it’s almost five o’clock. So we will. We will as soon as she gets here, start with her. And Dr. Manzini from last week is on with us. Here is Nina he would like email addresses where? From CAD everyone. No worries. We got it covered. He would like your email addresses if you’re interested in his you know in his company and his lab, the lab test that we talked about last week on the on the room with rheumatology, the rheumatic disease, or rheumatoid arthritis. I you know, I don’t keep a list. I mean, I have the master list. But I don’t I don’t keep a list of you know, everybody who attends every week. I’m sure there must be a way to do it resume but I mean, it’s just too much work for me to do on all on my own. So. So while we’re waiting for our speaker, who will be here she’s usually here by 515 June, which is usually late which tells me that so I can always prepare something but Dr. Crowley has a case I guess, or
06:57
well, I Yeah.
07:01
Sure. I and I’ll, I’ll share my screen here. If I can figure out how to do it. Just to show you a little bit of that detail on the sky.
07:18
200 pounds and six foot
07:28
okay, come on screen
07:32
share
07:40
you guys see that? Yep, we got it. Cool. So Gavin Chandler is my CEO of Trosky. And he’s been having some challenges with his eyes and just recently thinking that it was something not real big of a problem because one of his neighbors is a top retina eye specialist. He presented this information to me and I thought I’d share it on myasthenia gravis, which is probably what is diagnosis is going to be and wondered if you guys had any tidbits of clinical wisdom that you can share. He’s, you know, he believes in cannabis. He sees the importance of it but he’s still mainly a ivory tower medicine, you know, guy, so you know, he presented with asthenopia and in mid October, he started getting Diplo diplopia the day before Halloween. During the next six weeks, it became intermittent MRI with and without contrast the brain was negative. All blood works normal as ophthalmologists suggested the fourth cranial nerve weakness palsy Sunday before Christmas that diplopia went from intermittent to continuous. subsequent evaluation was able to confirm classic symptoms of fourth cranial nerve policy. With vs. strabismus in his right eye. They recommended prism glasses and wait and see. Last week new symptoms drooping right eyelid suggested something other than fourth nerve policy. Subsequently eval with both the ophthalmologist and neuro ophthalmologist suggested a diagnosis of myasthenia gravis. So he’s wearing a patch he has very difficult time seen he’s lost his depth perception. And these are all the blood tests that have been run so far. And he’s not responding well. Fight so stickman is 50 years old. 200 pounds, six foot. He indicated that he just swam 2000 yards and 40 minutes no muscle issues at all. And he hadn’t been swimming for a while. So he’s, he’s in pretty good shape. So does anyone have any suggestions? I didn’t know if you know looking at his microbiome, looking at his plasma halogens, all the things that I’ve been learning about and finding success with and a lot of other conditions. I haven’t worked with myasthenia gravis at all
Bill Clearfield 11:21
mean either. So there’s a couple of suggestions here. Somebody Dr. Dan writes his sister has myasthenia gravis symptoms of gluten free diet is 80% better so certainly couldn’t hurt. And then Dr. Southern would he be able to do a homeopathic evaluation?
11:45
Sure. Okay, so thank you guys.
Bill Clearfield 11:52
Okay, another suggestion Dr. Burgess. Dr. Moray. But that’s usually sort of distal to proximal nerve involvement. Right. That’s my
12:07
my experience with Gamma Ray has been global.
12:11
Yeah, me too. Okay,
12:16
with me it’s been personal because I have now also came close to being wiped out. The IgG brought me back to life but there are other elements that can be thrown into. So I think it’s called Miller Fisher syndrome which can add to this and all of these auto immune related things are there. But anyway, if it’s really getting bad, you can hit the brakes with the IVIG G, but it’s about 40 to $50,000 I guess.
12:48
And I know that IV the IV IBG. Saved my son’s life with the one month old with
13:00
no viral
13:03
sepsis that shut his liver down, and even DIC, but it’s been bleeding his brains as lung kept going and his kidneys weren’t affected. And that totally changed his course.
13:26
Off the topic, but
13:31
how about now that’s on the topic, but I haven’t seen the word used yet. Has anybody even considered again, Berea? A lot of times, a lot of times you hear well, it’s only one. And for the Miller Fisher it’s one in a million generalize gamebreaker one in 100,000. But then you see it popping up and many, many, many more people than that. So I think sometimes it is the cause it is the answer, but not seldom spoken. And
14:03
I’ll bring it up
14:05
thank you very much.
Bill Clearfield 14:07
And then darker Dan has Valtrex for single nerve palsy is with some success.
14:14
It’s that 500 B ID or higher.
14:18
Let Dr. Dan
14:22
I would do hire one grantee ID
14:26
T Id got it Okay,
Bill Clearfield 14:34
great. Okay. See, that’s we got it. We got our little forum here. So
14:38
I love it.
Bill Clearfield 14:41
Okay, so anybody else have any any ideas that if we’re waiting for Dr. girl, she’s usually about 15 minutes late. So she will be here.
14:52
Mary Ellen, is this something that we can use? As well as these other therapies? Yes, they
15:01
weren’t it wasn’t injured.
15:07
I don’t know what happened. We lost or we lost. We lost Yeah. I heard Yes. We heard Yes. Okay, sorry about that.
15:18
Yes, it can be used with it’s not going to interfere with any traditional medication sour inner interactions. But, gel Semyon has been used both in Cambray and myasthenia gravis cases. So it would be a good place to start to see if he gets any type of response.
Bill Clearfield 15:42
No, what would the doses be?
15:45
The dose is 30 C. Okay, and twice a day. Yeah.
Bill Clearfield 15:51
I just want those pellets Right. Or the average
15:55
Yeah, yep. Koran or wherever.
15:59
Okay. All right.
Bill Clearfield 16:03
Okay, anybody else have any other thoughts any any experience with myasthenia gravis or jamboree? Other than Dr. Burgess she’s our walking textbook of Internal Medicine
16:19
only because I had the disease. But since this is a pretty integrated group here I will mention there are a couple of key acupuncture points that can be life saving and these events and I’ll put them in the chat box but there’s something we should all know because when you’re dealing with arthritis, auto immune and you want to put the brakes on a little bit. You hit these couple of acupuncture points, so I’ll just throw them in the chat and you guys can serpent search them. As you want. But they work they work they work so I’ll type them in now.
16:53
Thank you. Thank you. Okay.
Bill Clearfield 16:56
All right. Well, I don’t know you’re gonna report
17:00
back to us when we I will definitely report back to you as we report back to us because his health is is my concern. Not only as a friend, but as my business partner.
Bill Clearfield 17:14
Especially that right. So, Okay, anybody else have anything to contribute? So, if you’re in if you need some do seek CME credits or you’re in the Reno area. This week is nomas Nevada Osteopathic Medical Association’s winter conference. It’s at South Lake and valleys. I’m going to be doing the introduction to bioidentical hormones on Friday morning and in the afternoon, a couple of specialty things. You know, I’ll be representing us. They have a they have a unique schedule they they have classes from 630 to 9:30am. And then they go skiing until 4pm. And then they go from classes from Florida, four to seven so and there’s been plenty of snow here. Let me tell you, I didn’t need to move 2500 miles to go live in this. They called it there you go. You can have it. Thank you. We’ve had Wilkes Barre to Wilkes Barre weeks here yesterday had snowed for 12 hours. Wow.
18:25
But what’s the you know what the what? How many feet you have up on the slopes? Like mount rose?
Bill Clearfield 18:33
No, I don’t but a lot. There’s a lot of there. In fact, they were not open for for a while because the roads were were a wreck but it’s if you’re a skier I mean this this is this is the year to do it that we’ve had. In fact they’ve had record precipitation yearly precipitation already for this year with LTE year, two weeks old. So
18:58
Southern California actually hit that record now, which is pretty remarkable.
Bill Clearfield 19:03
So So
19:06
and it’s been in the 40s in Pennsylvania. So hey,
Bill Clearfield 19:09
well, there you go. So now it gets to the 40s here, it’s just been snowing a lot so so we have the South Lake and I think it’s it’s a golden nomas website if you’re if you need CME credits, they have an online component also, though they get to get it there. And I’m thinking about getting to getting together. Clay in person class for us. I can probably hook up with Norma to get do credits. And so I was thinking maybe maybe in the late summer, so we we continue our tradition, so
19:56
Dr. Clearfield Yeah. Michael Gerber here. I don’t know if I have done this correctly, but I tried to do a chat thing here. But a great thing to consider would be neural therapy to the acupuncture points around the eyes. So bladder, bladder, to bladder three and outside of the eye and on the zygoma right. Ability outside of the eye, and probably some back of the head points and maybe large intestine for in the web of the thumb and first finger. So I’ve I’ve restored sight people that had no sight by doing those shots. And just using procaine 1% solution allowed neurotherapy from Germany. Also a homeopathic remedy would be secure to spell it correctly secured Morosa I see you I think it’s correct. Secure Tuberosa is for neurologic central neurological damage is great. Especially for strabismus and little kids and look up PSECU dot Morosa and new the neurotherapy around the eye points.
Bill Clearfield 21:23
And you type in that that and Mike in the chat there how that’s spelled
21:32
just kind of doing the chat
Bill Clearfield 21:35
just go chat and then go to everybody and then if you could spell it right down at the bottom there next to the green.
21:42
Yeah, that’s it every bear we have one
21:45
since I was gonna say since neurotherapy has been brought up in the external injections around the eye you might also want to consider swinging up Palpatine so if we have a neuro therapist you have access to hitting this phenol palatin ganglia can help. Great idea. But it’s tricky but it’s a good way of turning that action off.
22:09
Well, it’s half the distance between the back of the eye and the front of the ear, right above the zygoma. And then you just point down towards the opposite wisdom to and you know two three cc’s of procaine and you can have other stuff to it. But it’s actually a pretty easy shot.
22:35
It’s one it’s
22:37
wonderful guys. Thank you.
22:40
I’ll be and I’ll be in touch count because we have a few other things we get throw in thanks. Cool.
Bill Clearfield 22:47
And then Dr. If you know the acupuncture points Li 11 Li one or Li 14 for life in the web.
22:57
I would I would send them to you, Bill, if that’s okay. Sure.
23:04
Great. Okay. So and
Bill Clearfield 23:09
Li 11 Is that the elbow? Do you 20 is right at the tip of the head. And do you 14 I think is That’s right at C seven. Is that right John?
23:20
Just below C seven seven
Bill Clearfield 23:22
right. So those are your autoimmune points. So I do the battlefield acupuncture, I’d probably throw that in also.
23:34
Your points.
Bill Clearfield 23:36
I find it helpful for just about everything. And yeah, so our anti inflammatory some of our anti inflammatory things that we’ve been using. Mike, you probably know better than I do. Maybe glutathione and acetyl cysteine quercetin and and believe it or not, I’ve actually prepared a lecture on Dr. Colossus favorite methylene blue because I want to I want to I hopefully I hopefully I’ve been able to put it into a usable form. Instead of just, you know, he’s gotta love the guy but he’s just all over the place and then he gets he goes if you’re here a couple of weeks ago, I mean he was going on at that oxytocin on and on and on. And it’s like yeah, it was too much. So hopefully it put it in, in a usable form, but methylene blue is actually quite a quite a impressive substance with many, many uses so and so. So anybody else have anything but try not to lose anybody. We’re still waiting for Dr. Kirsch.
24:51
Yeah, that’s so cute. Tuberosa homeopathically has been quite good. In my hands.
Bill Clearfield 24:59
Okay, good. Okay, great. That’s a new one on me like so.
25:06
So let’s see. We got folks waiting here. Hold on. Okay.
Bill Clearfield 25:17
Okay, so those of you who just joined us, we’re still waiting for Dr. Gersh. She’s usually a few minutes late. And so we’ve been talking about a case for with Dr. Crowley, the colleague of his who’s got some myasthenia gravis, we’re assuming. So we’re getting some ideas from, you know, all over from whoever, whoever is here and we’ve gotten some acupuncture ideas with that and some homeopathic ideas osteo puncture ideas.
25:53
And somebody’s got the screen
Bill Clearfield 25:56
now. That’s not me.
26:01
Mike is a you
26:07
somebody’s got
Bill Clearfield 26:08
somebody’s got it. That’s not me. So
26:13
and it’s not me.
Bill Clearfield 26:18
Okay. So okay, so I’m not sure whose screen this is. But false claim it. Sounds great. So
26:33
looks like Dr. Grover. Okay, so
Bill Clearfield 26:43
take it so you guys something first like
26:47
no, I’m still trying to make my message go out to everyone. I’m not very good hand at this computer.
26:56
I see. Okay, right. Yeah, your click Share Screen but maybe the one right before it is chat.
27:06
One to the left of it. Right.
27:12
This is our you want to you want to click on share screen which should be read on the bottom right next to share
Bill Clearfield 27:28
Okay, all right here I can do it. There we go. Okay, now you got my screen so. Okay, so while we’re still waiting for Dr. Gersh. Want to hear about laboratory studies.
28:16
Can I ask you to define how he made out with the legislature presentation.
28:24
Steve is excellent. Versus late.
28:29
It was well received.
28:30
Oh yeah. We had a great group of patriots.
28:34
Here and skinit postmenopause.
28:36
I’ll send you the link. You can watch me. It was all recorded on C span and put it in the chat.
Bill Clearfield 28:44
We have we have it on our website also. Okay, great. So it’s already up there. So like I said, we’re still waiting for our speaker so I do apologize for the delay here. Steve, you want to give us a brief rundown on on how it went? I know you read it to us last week.
29:10
Oh yeah, this we live in a very patriotic area, Brevard County a staunch Republican base. And so we had I wasn’t the only speaker only barely pa up there or practice practitioner there. Was a speech therapists she gave a she was sitting behind me in the yellow shirt. She she has a sign there. If you can see it about the circulating spike protein detected in the mRNA vaccine. So she gave a very passionate speak as well about vaccine injury. She has a couple autistic children herself that were injured by vaccines. So a lot of speakers up there, you know is beautiful all our representatives here. I think they’re gonna go out there and they’re going to vote for medical freedom as well. So we live in great state. Okay,
Bill Clearfield 29:54
you know, those of us that are not as fortunate we’ll be sitting here envying you. So And with that, just as a reminder, February 21, we have Dr. Peter McCullough will be here with us. And as you know, he’s been he’s actually been very supportive of us since we’re, you know, we’re a small group. I mean, you know, he’s, he’s world famous where they love him. Where the eight and whether you think he’s a crazy person or, or he’s the, you know, in or, you know, he’s he’s the he’s the light out at in the tunnel. He’s always interesting. And, you know, he came to our conference. He’s been he’s been on our webinar before, and I just just add, as a lark sent him an email and said, We like would you still be available for us? And he said, Absolutely. It didn’t even hesitate. So, you know, you know, he takes a lot of a lot of criticism and you know, he’s he’s lost a lot of you know, his credentials have been been revoked, and he’s been Reviled in the media. And he’s still going standing strong. So I don’t know how many of us are, you know, could have have that kind of fortitude. So so he will be here February. 21st. My schedule got my electronic schedule got wiped down. So I’ve been trying to reconstruct it. So next week. I didn’t know who was there. So. So we’ve got it. Next week. We’re gonna have Dr. David Dennis. He is from North Carolina. And he is he does, he’s a he’s a ears nose and throat specialist. And he’s been specializing in Sinus surgeries for eliminating mold toxicity and testing for it and treating it. He was on Dr. Fortunes group last week. And he was really fascinating. He’s a little bit different than Dr. Campbell. He’s got a different take on things. And actually the next week we have Dr. Campbell again, so we’re gonna get mold two weeks in a row. You’re gonna hear two different two very different takes on it. So So Dr. Dennis, he’ll be here next week. He is a surgeon. So he says he can’t find another surgeon that the joint of it needs. He’s sort of Rh so and with that,
32:17
Dr. Gersh Hello, hello, we It sounds okay.
32:24
I’m with my patience for you guys.
Bill Clearfield 32:26
Try. That’s okay. We’ve been waiting for you.
32:30
Looks like you’ve been filling in with a lot of important information.
Bill Clearfield 32:33
Well, yes, we had a case history. Stephen Harper, our PA Stephen. Hartman has been testifying in front of the Florida State Legislature. And then I’ve been just trying to keep everybody entertained and keep them here until we got till you got here. So here you are. So you can introduce yourself and everybody, most of our group knows who you are. And so you know,
33:06
well, I am an integrative OB GYN. So I did both a board certification and residency in OB GYN and then I did the two year fellowship at the University of Arizona in integrative medicine and I did the board certification exam. So I have never looked back after that. And I’m always trying to expand my knowledge and my sort of special interest as a women’s health specialists is everything that has to do with hormones, and everything that’s distinctive about women. For men looking at all the differences like we always look at. Sorry, no problem. We look at the
Bill Clearfield 33:49
I want to I want to thank you for your so you to have been a very good you. No supporter of us. You Dr. Gertz was also at our conference last last March. And she’s been on our webinars a number of times and she’s she’s been a great fan. Great, great supporter
34:08
for our group. So well you guys do great things. And so I’m always supporting the downtrodden as you do, right. We you know, we have to, you know, voice our opinions sometimes, you know, it’s like lost in the wind, but I’m always trying to educate on all the benefits. Of of hormones, because hormones, which are very simple in terms of their, what they do not when you get to a cellular level, but in terms of what they do, which is deliver vital information to cells to give directions for what the cell should do. And yet poor hormones, particularly, estrogen is maligned no and, and so I want people to understand what these hormones do particularly estrogen in the form of estradiol. So this time around, I’ve talked about a number of different things. I’m going to talk about hair and skin and for women and men too, but I always hear from women. They’re very concerned about the status of their hair and their skin, you know, because I’m just having looking in the mirror a lot of people don’t want to look in the mirror anymore. They just like feel very depressed, you know, because, and they’re always like pulling their face up. You know, it’s like, like, that looks better. Okay, so, you know, we don’t like sagging. We don’t like wrinkling. We don’t like round spots. And we don’t like losing our hair. And every one of you I’m sure has seen old ladies in a nursing home. Or in assisted living facility and their hair is very fine. You know, you can see lots of their scalp. Well, nobody likes that. Okay, and this is all estrogen related. And when I use the word estrogen, I’m using it incorrectly. And I’m just telling you up front because it’s just common usage. But estrogen is a family of hormones. It’s no estrogen is the estrogens really, and so there’s different types of estrogen. So it’s like B vitamins. No one says, Take a B vitamin, what B vitamin. There’s like 12 B vitamins. So estrogens are a family of hormones. And the one that the ovary makes, which is the one that has the balance effect throughout all the body’s receptors is extra dial. So when I say estrogen, just know I’m doing it wrong, but it’s just common usage, but I’m really saying it’s extra dial Okay, unless I say something else. So we’re going to talk about estrogen but really extra dial and skin and some about the hair. And there’s some things I didn’t make slides up but I’ll I’ll bring it in for a treatment, which I’ll tell you like a little preview would be like low dose, oral minoxidil. I don’t know if any of you have even tried that. Some of the data is looking pretty potentially good. And I’ve been prescribing it but it’s, I don’t have a you have to give here. A long time to grow back so I have to wait a little longer to get some of my feedback. So skin is actually one of the most organ affected organs by menopause. And of course it’s very visible. And one of the areas that skin which I’m not really going to talk about but just a mention because this is so important because when we talk about giving hormone therapy, the mantra for the conventional medical world is stop and don’t give it over a certain age. That makes no sense. It would be like if someone had their thyroid gland removed, we wouldn’t say Oh, well now you’re 65 you don’t get any more thyroid hormone like that’s irrational, right? You just take it for life. If you need it, and you’re deficient, you need to just keep taking it because we’re not growing a new set of ovaries anytime soon. At least I don’t think it’ll be in my lifetime. Maybe in my you know, granddaughters lifetime but um and so we need to think about going on hormones forever. And then the other the mantra is not just that you stop it at any age, but also that you don’t start it if you’ve been out from menopause for 10 years or more. And that also does not make sense. And what do I base that odd? Actually, I base it on the skin. Okay, because there was a lot of research back in the 1990s and early 2000s Before the Women’s Health Initiative, shut everything down and made everyone except us, you know feel hostile to estrogen. And, but there was a lot of data coming out very interesting studies, applying estradiol cream, to skin. And what they found was that in just two weeks, and these were women who had been out in menopause, for any length of time, in just two weeks of applying extra dial to the skin, there was visible reduction in wrinkles. Okay, visible now I will tell you all my secrets, it’s just between us right? Like, like, you know, like when we were in Las Vegas, it stays here but it stays here. too. Okay, so I use compounded estradiol cream every day on my face. And people have said, I look like I have fewer wrinkles. I think I do but they’ve actually published review peer reviewed
39:32
articles where they actually did this and they showed visible reduction in wrinkles. And this is at an older age people had never been on hormones. Also what else is skin that we know clearly improves with estradiol use and that’s the Dinah the vagina is a type of skin. It’s epithelium and we know that at any age, if you put estrogen cream in the vagina or even a tablet or you know, which I don’t think work as well, but if you do, you’re going to see improvement. It doesn’t matter how many years you’ve been out, so clearly the receptors aren’t dead. Also, they had peer reviewed articles back in the 1990s and early 2000s. And they’re coming back now there’s like there’s more interest and it’s coming back in the dermatology literature, using it for wound healing. So what they found is if they put extra dial cream on wounds, it increased the rate of healing so I’ll show you some of that. So I mean skin is really impacted by menopause. And women age very rapidly. If you have any friends and you haven’t seen them for a few years, like you lost track of them with COVID and then they came back into your life and there are a couple say they’re in their mid 50s. And you hadn’t seen them for three years. And you look at we’ll call them John and Mary and you look at John and Mary haven’t seen them in a while. John looks about the same and Mary looks like eight years older, because she didn’t know about hormones. Nobody told her women really age visibly and rapidly. I’ll show you some of that data when they lose their hormones. So and I talked about this over and over. There are receptors throughout the entire body for estrogen and I put like skin here, you know, in yellow, because that’s what we’re really talking about. But as you know, every organ system relates to everything. And I’m not going to go into it much but just as a side note, there’s a gut skin access. I mean, it’s like a big deal. So what goes on in the gut affects the skin, and vice versa. So if you have a dysbiotic gut microbiome is going to translate into problems with the skin. So a lot of kids who have acne, oh my goodness, they really need to clean up their gut and I know you know all that. And it can just by cleaning up the diet, cleaning up the gut, improving like leaky gut, gut barrier function, and improving the gut microbiome. Getting a clean anti inflammatory diet filled with antioxidants and poly phenols and fiber and so on that nurture that gut microbiome, you can clear up acne, I mean tremendous benefits. And for older women, it can really benefit the skin to look way more attractive and be healthier. And of course the hair will look that much better as well. We all know that nutrient deficiencies translate into poor hair. Now, this is a very important little takeaway here. This estrogen is so necessary for skin health, that the skin actually makes estrogen. It also can make testosterone okay and it makes Dihydrotestosterone and when you so you can see in here, the adrenal androgen DHEA s dehydroepiandrosterone sulfate comes to the skin and then it gets broken down to DHEA and then Andrassy nine which can then turn into testosterone. All extra dials here. 17 beta estradiol all comes from testosterone. You can’t make estradiol except from testosterone. So testosterone and estradiol can be made in the skin. That’s why in women, if you measure a circulating level of testosterone, it really may not accurately in any way reflect the tissue level of testosterone. And that also can reflect in women who have excessive facial hair. Or acne and then you measure their circulating testosterone level and it’s not even elevated and you want to like what the heck’s going on here? Well, they’re converting it from the DHEA s that’s coming from the adrenal gland. And women and men both make quite a lot. It does decline with aging, but it makes people make a lot of that and that’s the primary source of tissue testosterone, like in the skin from women. Of course men have plenty of circulating testosterone normally. And then when you have five alpha reductase five alpha reductase is the enzyme it comes in different types, but it converts testosterone into the more aggressive we’ll say active form of testosterone DHT dihydrotestosterone. And what activates or up regulates five alpha reductase to make more DHT it’s inflammation. So aging, which sometimes we talk about inflammation, aging increases the conversion in the skin of testosterone to dihydrotestosterone. And why does that matter? Well, Dihydrotestosterone is what triggers androgenic alopecia, you know, like hair loss in both men and women, and that’s why they give drugs like finasteride to block five alpha reductase. So you don’t get too much Dihydrotestosterone from an men, you know, then they would get loss of hair. androgenic alopecia. The problem is, we need five alpha reductase it’s actually works in the brain as well. And DHT is not evil, we don’t want to like get rid of it in the body. What we want to do is control inflammation. And that is actually one of the reasons why there’s a correlation between men who have hair loss on their head. They often have higher amounts of body hair, like a thicker beard or more hair on their chest or their back or their arms and legs and such and increased risk for cardiovascular events, because it’s the inflammation that is driving the upregulation of five alpha reductase and turning that testosterone higher and higher into DHT. But the solution isn’t really get rid of your five alpha reductase it’s get rid of the inflammation right because it’s inflammation that striping the cardiovascular events, you know, the hair is just a reflection of it, the hair changes and in women the same so if a girl has a lot of inflammation in her body like she’s obese, she has PCOS. Then she’s going to have upregulation of five alpha reductase and end up with too much DHT and the solution is really get rid of all that inflammation like that. That’s not get rid of all your testosterone get rid of the inflammation so you don’t have abnormally upregulated five alpha reductase now, when you have in the skin in men, this is how men get estrogen in their skins 17 beta estradiol in their skin. The enzyme aromatase is present in skin and will convert the testosterone that’s circulating, that gets into the skin and also that’s made in the skin from the adrenal precursors into 17 beta estradiol, so men have plenty of estrogen in their skin, but it’s not circulating. It’s made in the skin and it does so many important things because estrogen turns on and off the inflammatory process. So if you have a cut, and then you get it gets red, and then you know, you get like, obviously the immune system is activated. That’s all triggered by estrogen estrogen turns on the inflammatory response, so that you can fight off invading pathogens, infections, and deal with trauma, and then it turns off the inflammatory switch so that you can then proceed to down regulate that inflammatory response and go into a phase of inflammation downregulation resolution of inflammation and healing. That’s when you get the activation from the platelets of growth factors. And you get new blood vessels formed new tissue, you know, you get all the growth factors. They’re all stimulated by estrogen in the skin. That’s why as men and women age, they heal much slower from injuries to the skin, like a cut or a burn will heal much slower. And as we know, unfortunately, there’s a whole host of people out there who have wounds that never heal. That’s why there were a wound centers everywhere, you know, dealing with non healing wounds, and every one of those people has estrogen deficiency in their skin. And many of the men of course have low levels of testosterone as well. And so that’s actually important for men and for women, they have no produced estrogen from their ovaries. And so that’s a problem and it’s Astra dial, that’s really the critical estrogen that that does the on and off switch. For inflammation promotes growth and growth factors, s drone. So estrogen is the dominant estrogen that’s made in the menopause in fat tissue, predominantly adipose tissue, which also has the enzyme aromatase, and just as five alpha reductase is upregulated becomes more active in its state of inflammation. So too does the enzyme aromatase so inflammation up regulates aromatase, and what happens is, you end up with too much s drone, okay, and S drone can’t be converted to estradiol when you have a lot of inflammation because the enzyme for the conversion is unfortunately downregulated. So you have all this estrogen and estrogen only works on the Alpha receptor for estrogen, which activates the immune cells all the innate immune cells have predominantly Alpha receptor. And so it’s like turning the odd switch for inflammation, but you don’t have the proper off switch. So you get into more chronic states of inflammation, and you can’t go into that anti inflammatory Resolution Phase. That’s like people who had COVID and had a cytokine storm. It’s like they knew how to make inflammation, but they didn’t do a great job of it because they had dysfunctional inflammation and they couldn’t turn it off. And that’s what happens to women in menopause, when all they have is a lot of estrogen and they don’t have the extra dial. That’s why it’s so important when we give hormone replacement to women to give them adequate amounts of extra dial because when you have plenty of extra dial it actually downregulates the enzyme aromatase so you don’t get all that exogenous fat produced horrible amount of estrogen. And it’s that’s where the evil twin comes in people know that when women have too much of estrogen. They they have some problems that happen in their body, but they’re not distinguishing that from estradiol. And so it all gets lumped into the same basket and then they say, you know estrogen or is evil, but it’s not estrogen is evil, inflammation. Unregulated, uncontrolled, inflammation is evil. And then it, you know, creates this overproduction of s stone that has nothing to do with ovarian produced estradiol or giving estradiol to women in menopause as hormone replacement therapy, which actually will prevent that chronic state of inflammation. And allow the immune system to be properly regulated. So, you know, it’s just complicated. You know, that the estrogen receptors, I mentioned estrogen only works on the Alpha estradiol works on all the receptors alpha and beta and the membrane receptors, and they’re different. They interact with one another. They can up and down regulate each other. So it’s important to just take away that estrogens are not all the same. estriol is a whole different bag of worms. estriol only works on the beta receptor, which down regulates alpha, which is essential in pregnancy. estriol is the hormone the estrogen made by the placenta in large quantities, and it down regulates when you have high beta downregulates alpha, which down regulates the innate immune system, which is why pregnant women do not have as robust an immune response to infections like COVID, chickenpox, the flu virus and so on. And they’re more likely to have problems. It also down regulates the innate immune system, so you have fewer inflammatory cytokines. So that’s why autoimmune diseases particularly like MS will often go into remission during pregnancy only to flare horribly when pregnancy is over. But, so we don’t want to mimic pregnancy. It’s a whole unique hormonal miliar designed to allow an alien to grow in a woman you know, known as the fetus, right? So our immune systems don’t destroy it. And it’s a very calculated balance between inflammation to allow insulin to be produced more by having little insulin resistance, so you put on more fat and you get more sugar to the baby. Anyway, we don’t want to try to mimic pregnancy in women who are postmenopausal. So remember, estriol is great in pregnancy, and everyone makes some of it from estradiol, but we don’t want to give large amounts because we’re doing all kinds of things we don’t understand to the innate immune system, and that we’re not going to don’t go there. We don’t have any good data. So when we look at estrogen in the skin, like it, there’s an interaction with IGF one, so some people say, down with IGF one, you know, it’s like pro cancer. And I know that’s talked about by a lot of people, but of course we need IGF one, like everything in life, we want the right balance, because IGF one insulin like growth factor one is actually really important for skin health. So we never want to go into chronic fasting. So we know that when you do periodic fasting it down regulates growth hormone, it’s down regulates IGF one, and that is good because then you don’t have growth or, like, proliferation, and that’s what triggers autophagy or rejuvenation of internal cells. But we don’t want that all the time. We want this beautiful balance of fasting and eating. We want to have burning, and we want to have growth and proliferation all in a controlled state. So that’s why we never want to be in a constant state of fasting because then we won’t make IGF one and IGF one is really important. For reupload, the legalization for having proper skin fibroblast function, and SIBO sites and so on. So it’s interesting, there’s a very strong relationship between estrogen and they’ve linked it to estrogen receptor alpha. That you can actually have anti inflammatory effects. So everything when it’s in the right proportions, the right balance works beautifully to keep the skin beautifully functioning in all respects. And it turns out that when they look at male and female skin, estrogen receptors seem to be an equal sort of balance. And look what happens when we get old, the when they looked at people now these are not women, or men on any kind of hormone replacement therapy. So we don’t know we don’t have data. Well, like I hope that it’s better if you’re on hormones, but we just have no data because nobody’s studying it. But we know that the estrogen receptor beta in people who are not on hormone therapy is actually significantly decreased in the epidermis of the skin. So maybe it’s use it or lose it, you know, and that’s, you know, so that’s a part of the problem, but we do know that when you apply estrogen directly to the skin, even in older people, it still shows benefit, but like everything younger is always better. And I personally think although I can prove it, that if we keep hormones going indefinitely, we will not see the loss of to any significant degree that we do have receptor function. Okay.
56:25
You know what I should go into?
56:29
Yeah, that I didn’t put this right. Okay. So now we’ve got the slide and slide deck mode properly. Okay. So now, menopause is a huge impact throughout the entire body and the skin as well. So if we look at an I have a lot of slides that are a little repetitious, so I won’t like say it too many times over and over, but look at some of the things that happen to all the skin layers, every single layer of the skin. You know, if you haven’t looked at it lately, you know, you can just Google you know, skin and you’ll see you know, the epidermis, dermis, and then all the different types of appendages within skin, like all of these different types of tissue types within skin, they every one of them 100% have estrogen receptors. So when you don’t have enough estrogen in the skin,
57:20
and you know, in women, you don’t have enough. There’s not enough conversion locally. The skin of women is not designed to make the same kinds of estrogen as we age. It just doesn’t have the same capability because it’s designed to get most of the estrogen in the skin from the ovarian production. And men are designed to make it more locally in the skin. Women have that capability, but it’s not as strong. The same thing by the way in the brain. So after menopause, women cannot get as much estradiol in the brain, they live in a state of estrogen deficiency of estradiol in their brain. And in the reproductive years. For example, men, men’s brains make six to eight times as much extra dial to the conversion of androgen precursors as women’s brains, but women do fine because they get all that extra doll from their ovaries. But after menopause, women do not do as well in their brain. That’s why they have two and a half fold times the number the incidence of Alzheimer’s. Well the same kind of happens in the skin. That’s why women have much more rapid aging of their skin. As well compared to men. And you probably have noticed that so there’s a decrease in collagen. And this is actually very, very rapid and significant decrease in the water, fat layers elasticity in the actual thickness of the skin. In fact, if you looked at older skin, sometimes it’s like Whoa, it’s like translucent. It’s so thin, right? It’s like you can just see like they’re invisible, like invisible, you know? So that’s a terrible thing for skin. And when they touch anything, they bruise so readily because they have like no cushion whatsoever in their skin. So when we look at all these different types of skin cells, estrogen has beneficial effects on everyone, the cretinous sites, the dermal fibroblasts and Lando sites, hair follicles, hair growth, sebaceous glands and the sebum production and the app requin glands, the ability to make new blood vessels for wound healing, all the immune responses and skin cancer. Of course, I’m sure you all know skin cancers are much more prevalent as people age because their skin is not as resilient and it can’t the immune system of the skin becomes hampered when hormones decrease and the immune system becomes dysregulated and of course pigmentation. We’ve all seen so called age spots. Well, that will be much less if women have adequate estrogen in their skin. And so when you don’t have enough estrogen, you know you get no you don’t have the same ability to defend against oxidative stress in the skin which underlies all kinds of problems. As I mentioned, you have lower thickening of the skin thinner collagen and reduced elasticity. So you get skin that sagging, it doesn’t bounce back and especially around the neck and the jawline and the cheeks. That’s why plastic surgeons are so busy doing neck lifts and jaw lifts and all that kind of stuff. And then the increased wrinkles and fine lines, particularly you know the the lines above the lip and around the corners of the eyes and a lot of dryness. I mean, women after menopause like everything is I could think like dried up, they have Dr vagina, they have dry eyes, they have dry mouth, less saliva and dry skin and that’s very unpleasant, you know, reduced vascularity so it doesn’t heal as well. And all the protective mechanisms are not are impaired and you know manifest by impaired wound healing or hair loss pigment changes in higher rates of skin cancers. So women see a very rapid aging of their skin, even beginning in the peri menopausal years, and it’s shown that skin thickness can go down by over 1% in terms of its collagen content, you know, so this is really a problem and it can rise you know as you get older you can lose more and more at a faster rate. So in the types of collagen fibers like type one and type three can decrease by around 30% in just the first five years of menopause so think about that close to a third of all the collagen in the skin is gone in the first five years of menopause. Think how that translates into rapid aging. With all of these you know the thinning and the collagen goes down the fat goes down. And so this is related not to age, it’s related to loss of estrogen. So so many times they talk about it’s an aging problem. I don’t think of it as aging. I think of it as deficiencies and you have a deficiency of estrogen and you get a deficiency of elastin and you get a deficiency of sleep, the proper seat bumps and so on. And like I mentioned, there’s a lot of data to show that by giving estrogen we can really delay I can’t say you’re not going to have aging of skin but you can really, really decrease it and remember I mentioned that androgens can also be converted from the adrenal into estrogen, but in elderly people, the amount that’s even in their best case scenario of being able to convert it, the amount of adrenal DHEA s can be down like to only 10 to 20% of the peak levels. In earlier years. So that it even impedes the ability to make skin produced estrogen, you know, even even worse. So here’s like one study that showed that if you take this as oral estrogen because that’s what they studied, back in the day so six months of oral estrogen increased skin collagen by about six and a half percent. So that’s that’s a good store and that’s with just oral estrogen. And they Another study showed that one year of oral estrogen can increase the thickness of the dermis by 30%. I mean, I don’t know why any woman wouldn’t want to be on estrogen. I mean, it’s like it’s it’s not just going to make her skin better. It makes everything better. But every woman I mean, the I have a plastic surgeons office next to my office. It’s packed with women all the time. I keep thinking, why are these women not on estrogen? You know, it’s like drives me crazy. And they had like a study that I mentioned that showed the topical administration of estrogen increased cretinous I proliferation, epidermal thickness in just two weeks of use. And so there’s like quite a few studies I told you in the 1990s, early 2000s, there was so much interest in estrogen for skin health. And it just dissipated after the Women’s Health Initiative. But there’s a little bit of a comeback now, but just a little bit and so at topical you know, use of topical estrogen clearly increases collagen, it increases the elastin fibers of fiber land that will make the skin more elastic so that you know if you pull it, it springs back. Nobody wants to pull their skin in it just drops right. We want to have the youngest healthiest skin possible. And estrogen increases growth factors, as I mentioned, to improve dermal fibroblast proliferation. And it actually, you know, is very good for lowering down regulating the inflammatory response. Remember, if you don’t have the proper estrogen around, you go into a pro inflammatory state, and then you have over output from the immune cells. They’re like weapons of mass destruction without control when you don’t have proper estradiol. And you get released of these really toxic enzymes that do a lot of damage, like matrix metalloproteinases. And of course that’s happening in the brain just as a note from the microglia, the modified macrophages in the brain that is a contributor to creating all the damage of the neurons in the brain from these uncontrolled immune cells. What also happens in the skin which causes degradation of the skin. And so in talking about the elastin, we’ll go down. Like I said, I put a lot of similar slides, but you can have I’ll give you all my slides and if you ever want to look at it, you can and so women who were on estrogen for like five years after menopause had significantly when they measured significantly fewer wrinkles. I mean, come on, ladies, why would you not like by that right? And I’ve talked, you know, over and over about wound healing. It accelerates re epithelialization improves granulation tissue. And so just think about women who have surgery when they have to have surgery and they have healing from surgery. Women who have hormones on board will do so much better with any kind of surgical procedure. And after when women over 65, who are on estrogen replacement therapy, they were much less likely to develop a venous ulceration or a pressure sore. So I don’t know about you, but I’ve had relatives who have gotten pressure sores, and you can see I mean, they’re just skin is just they lie in a certain way and they just get a pressure sore. You know, these two cubed is ulcers, and they’re so hard and so slow to heal, and women on hormones, they’re just less likely and people die from these decubitus ulcers, and they can change the quality of life so much and it doesn’t take much to do it. I had one patient who got a terrible pressure sore and this was at a local hospital because she accidentally fell and broke her leg and it wasn’t like it was her lower leg it wasn’t even that bad. But they put her in bed and told her now don’t move too much because you know your leg has to be set and they just said you know it kind of stay put so she lived there for quite a few hours. And then when they checked her to take her to surgery because they had to put like a pin in her in her bone. They found that she had already just a few hours of lying flat and nobody moved her properly, that she’d already gotten a pressure sore on her coccyx area. It was horrible. And it took like a year practically to heal that thing. It was a nightmare. She was going to wound clinic all the time. So all that for nothing. But if she’d been on hormones. This was you know, I hadn’t had her on hormones. I had just met her when this happened and she would have healed so much faster and so much better. And probably never would have gotten the pressure sore in the in the first place. And all the inflammatory response, as I mentioned is all modulated by estrogen so you don’t get this chronic state of inflammation that can promote chronic wounds. So you know, we just know that nothing works well after menopause when you don’t have enough estrogen. But when you give estrogen you get much better re epithelial causation. There are studies that show that estrogen use prior and after creating a wound. You know, these are like studies show that it’s much better when you have the hormones on board. And when they gave estrogen therapy to get a good level, the postmenopausal women’s wounds healed in at a comparable speed to the younger women. And so I mean that that’s like rejuvenation, or we start early. So once again, it’s not about how many years you have, it’s how much estrogen you have in your body makes all the difference in the world. So these are like I just kept putting data together and putting these slides so like I said it’s a little bit repetitious, but you know, tumor tissue growth factor beta is really important. I know some people like think that it’s bad, but it’s only bad like everything else when things are dysregulated but we need it for healing and old women do not make proper growth factors like TGF beta, and it’s reversed and you make enough growth factors. Not just TGF beta but all the growth factors when you have enough extra dial on board so you can heal wounds. And I mentioned this because I have an aunt don’t tell her I said this she is elderly and she had a skin cancer. And boy did it ever take a long time they had to do a pretty wide excision. It took forever it took months to heal that wound and you know she was not my patient. But finally I was able to work with her and her doctor and we actually even though she’s older, we got her on hormones. And she’s been fine ever since. So it’s just wonderful to see the benefits of hormones and in terms of accelerating wound healing. So you know, when you look at once you see the extracellular matrix is more normal. You have proper collagen deposition, and proper collagen synthesis and control of those out of control matrix metalloproteinases. So we want everything right. We want it when we want it and we don’t want it when we don’t want it in terms of pigmentation. I’m sure you’ve all seen women who get and then you know, we’ll get like age spots. And it turns out that the melanocytes are very responsive to estrogen. And this is where the confusion has come in. Because hyperpigmentation like melasma increases in pregnancy and with the use of oral contraceptives. But take note, that’s not because it’s so it’s not human bioidentical Astra dial, it’s a different type of estrogen. So that’s where you have to get it clear and not put them all in the same basket. So pregnancy is actually a pro inflammatory state. And I keep having to tell people that women who become pregnant have to become a little inflammatory. Because what happens is they have they immediately get altered gut microbiome and then they have leaky gut. This is intended by nature, but it’s a fine line to keep them under the threshold of developing pregnancy induced hypertension, gestational diabetes, preeclampsia and so on. But you develop a gut dysbiosis leaky gut and that increases inflammation, which triggers increased insulin resistance, higher levels of insulin, higher levels of glucose for the purpose of trying to fatten up the pregnant woman fast because in the ancient times, when humans came on earth, there wasn’t a lot of food around and pregnant women needed to store a lot of fat so that they could have like spare food, like for nursing, and to get through in case there wasn’t any food, and also to fatten up the baby so that you had to have higher blood in Split sugar and insulin levels, okay? And that’s because of the different hormones so we don’t want to compare pregnancy and the status of the immune system and pregnancy to like non pregnant states. So when we see that melanocytes are upregulated.
1:12:32
So melanocytes will become more active in an inflamed environment, which happens in pregnancy. So you get hyperpigmentation and melasma in some women, and also oral contraceptives, because oral contraceptives are not the same as having normal estrogen, like in a reproductive age woman and oral contraceptives are pro inflammatory. That’s why they increase the risk of blood clots. Everyone knows that well blood clots don’t live in isolation. It’s part of the inflammatory response is to activate platelets to clot and not only do they clot, but they wall off infections creating abscess cavity so you know can be life saving. And then platelets will then become changed during the the resolution of inflammation produce growth factors, which help heal and resolve instek inflammation, but in pregnancy, it just goes into the pro inflammatory state. It’s because the birth control pills go into the body as as stone, which is the on switch for inflammation without the off switch. So think of birth control pills and pregnancy as pro inflammatory and inflammation, triggers hyperpigmentation and that’s why aging which is like inflammation, aging causes melanocytes to make more pigment. So if you have patients that have age spots, they have melasma. That’s a sign of inflammation that you need to tackle, okay. I mean, don’t just give them bleaching agents. I mean, I’m like that’s kind of toxic bleaching agents, but that’s what they use right on on melanocyte created melasma and age spots, but it’s really poison, but that’s really not addressing the underlying issue, which is systemic inflammation, which also includes inflammation in the skin and aging skin shows a lot of inflammation with pro inflammatory cytokines in the treatment matrix metalloproteinases and of course chronic states of inflammation lead to DNA breakage, and that’s why skin cancer is the number one most prevalent cancer that there is an estrogen has all of these cytoprotective effects to attenuate reactive oxygen species in the skin and maintain proper control. And also if you have adequate estrogen, by the way, then you will have fewer inflammation markers like if someone goes out and gets too much sun UV light you know, which is of course synergy and if it’s too much UV light, then it turns out that if estrogen helps protect against damage from UV light, and the skin cancers that can develop from such things. In terms of estrogen and hair. There’s a strong relationship women who have wonderful estrogen in their body great level, they have the beautiful hair that they look like the hair commercials, okay, assuming it’s not actual What do you call it? You know, the little hair extras? You know, the fake hairs that they put on whatever extenders? Yeah, I don’t happen that maybe I should get them but I don’t have hair extenders. But that is what makes a lot of women feel better when they use the fake hair extenders because their hair is so thin and estrogen is wonderful for growing hair. It improves you know the growth factors of transcription and reduces cytokines in the in the hair follicles and hair estrogen helps promote length of antigen. So hair has three phases antigen which is growing catagen which is resting and then from catagen resting it goes into telogen which is falling out and once it gets into ketogenic can’t go back to antigen. So as you probably know some women can grow their hair all the way down well below their butts and others. It just gets to the shoulder. That’s the antigen face and the hair is designated into how long your hair will stay in a growing phase and based on genetics and in women it estrogen so women who have better levels and production of estrogen will have longer, thicker hair because their hair will stay in the growing phase longer so that they can grow it longer. And hair. Estrogen affects not only the growth rate and the time spent in antigen but also helps when you have adequate estrogen to have more hair in the frontal part of the scalp. So if you see women and they have really thin hair in the front, then that’s a sign that they probably don’t have adequate estrogen. It’s not just about testosterone, it’s about estrogen hopes and hair density decreases of course, with age so women have you know, like fewer earplugs coming out of their their scalp and it’s this typically starts in the early 40s. So that’s why I’m very promoting of starting hormone, hormone replacement. In the perimenopause, we know that vascular changes and a lot of bone loss. collagen loss, you know is loss long before the final menstrual period. Remember that’s an artificially made up designated definition 12 consecutive months without a period that’s the end of the road, not the big middle or the beginning. And problems happen as estrogen levels decline. Also, if you start women on estrogen during the perimenopause, they’re less likely to have these crazy spikes and dips because they have like a safety net where they can’t get below a certain amount. So we talked about the hair of phases and estrogen prolongs the growth phase and when women go on breast cancer treatment, which typically involves aromatase inhibitors to block the production of estrogen, they will invariably lose a lot of hair get a lot of hair thinning. And I don’t think anyone even tells them about that. There’s so many problems with aromatase inhibitors, that and I feel that they’re overused but that’s another story for another day talking about breast cancer treatment. And, you know, we don’t want as women or men either we don’t want to lose like all our hair, and estrogen decreases the amount of time that the hair is lost and prolongs antigen growth phase and helps to maintain a hair distribution that includes a lot of hair in the front as well. And so this is are all really important things estrogen receptors are involved in you know, the all the different aspects just like of every layer of the skin every it’s everything involving the hair. As well is involved with estrogen. Now I put together a few little tips. Soap is not great for skin. I personally just share all my little secrets if you want to. I use shea butter I think is fantastic. It has a lot of healing properties and you can get it’s very affordable. You can get organic and you just work it into a paste and you can put it like on your face and then you can wash it off and like get a little washcloth and just kind of wipe it off and your skin is perfectly clean. Like unless you have a lot of grease or something you know you don’t really what the heck do you need like soap on your face for and you know if you want them what I like to use is more shea butter you know and just kind of leave it put it on the face and then put a layer on you know and just you can use it and hot hot showers actually love hot baths but they’re not great for skin. Okay, they take out all the the oils and such and we overwash our skin and take off the protective coatings and oils so we don’t need to do that. And you know, be careful of any kind of sunscreen use make sure it’s not toxic and preferably a mineral based eating a lot of antioxidants and phyto estrogens, most all the foods that you think has magical ingredients. They’re actually phyto estrogens, like resveratrol, you know these are poly phenols that’s actually a phyto estrogen quercetin that’s a phyto estrogen allergic acid that turns into your listened that’s phyto estrogen Of course. The lignans that come from like seeds like flax seeds. Those are phyto estrogens. isoflavones from soy. Those are phyto estrogens. I mean almost all these magical polyphenols. Turns out they’re actually phyto estrogens, but they’re really good for the skin. So it’s I call It’s nature’s gift to us. And there’s actually some data if you eat three ounces of unprocessed soy, like soybeans or at Emami it will be very good for your skin.
1:21:35
cortisol. Cortisol is a type of a you know, it’s a catabolic hormone, it breaks skin down. So we all know people who have Cushing’s disease will have stretch marks in their skin. Their skin is really literally kind of disintegrating. So we do not want to have a lot of stress and high cortisol unless we really want to accelerate the skin breakdown and aging which we don’t, okay, exercise actually improves skin so the image or anything that that exercise doesn’t help I don’t think so. It’s like magic. So exercise is great for the skin. And then some of the products that you can look at is hyaluronic acid can be healthy, you can put on topically or take orally, collagen, it’s a mixed bag, but there is some data that if you actually consume collagen, it actually improves your collagen but not I don’t think if you don’t have estrogen on board, everything works better when you have estrogen not when you don’t. And all you know antioxidant vitamins and protein you can’t repair if you don’t have enough protein, and as we age, we definitely need more protein. So we I mean, we don’t want to give tons of protein to young people. But once we get like in our 60s and older, especially, you know women, we really need to have more protein in our diet, particularly at breakfast. By the way, having a lot of protein for breakfast helps regulate the appetite for the rest of the day. And then you know, there’s conventional products, you know, retinols and different like salicylic acid, you know, finasteride, not a fan, low dose minoxidil I want to mention so that’s become all the rage. And I can go very very low doses like point five milligrams what I’m typically doing is it comes as a commercial product at 2.5 milligrams, minoxidil, you can and then you cut the tablet in half, so you get 1.25 milligrams. Take it once a morning in the morning. Most people tolerate it. I haven’t had any problems. Like I said, I’ve only been using it for a couple of months. I have to wait and see it takes time for hair to grow back. But the published data on low dose minoxidil for all forms of alopecia androgenic even our alopecia yada and a few VMs it helps to grow the hair back from a few VMs too. So of course that’s not to not be used in isolation. You need to do all the other things in terms of diet and so on. And then there are people doing all these other things like micro needling, PRP, plastic surgery, different kinds of lasers and peels. In my office. We do a type of appeal called WW IPL and we’re getting amazing results. I use it for people to try to get more like a jumpstart. Well it’s great for acne scarring, and that’s such a downer for people to have acne scarring so this is pretty good. And also for wrinkles. So it kind of gives you a jumpstart on getting rid of of wrinkles. I already mentioned all the phyto estrogens but they are amazing. They also reduce skin cancers by eating all these foods with phyto estrogens which is basically a plant based diet because all nuts and seeds and legumes and whole grains, vegetables, fruits, they all have phyto estrogens so if you eat a plant based diet you’re gonna get plenty. I mentioned resveratrol in the skin of red grapes and it increases the functionality and lifespan of mitochondria by abreco. up regulating mitochondrial superoxide dismutase which works in the presence of estrogen to maintain proper mitochondrial function and health. So resveratrol is a food you know it’s from a food but it can act as a like a replacement for estrogen like that’s like a miracle. That’s true for all of these phyto estrogens. So aging doesn’t have to be, you know, as dismal as it is painted in in many ways we can we can maintain beautiful skin by maintaining a great diet, exercising, controlling stress and taking hormones. How simple is that? We can all do it. Thank you
1:26:12
excellent. As usual, fantastic sharing great talk as usual, Dr. Grisham.
1:26:31
Well, thanks for thanks for hanging in there with me and you know, we want make people happy and like they will enjoy looking in the mirror and touching their skin and have other people touching them so that they can feel good about themselves inside and outside.
Bill Clearfield 1:26:50
Thank you so much. We have lots of comments and questions for you. So
1:26:57
let’s take it from the top. So okay, um,
Bill Clearfield 1:27:05
someone had asked how do you increase prolactin levels to treat treatment resistant something left out I’m not sure that was that might have been before you got here. But
1:27:16
okay, increasing prolactin. That’s the question. Give me a late nipples. Right.
Bill Clearfield 1:27:25
Okay, there’s a couple of drugs that do it. I think I’ve put some answers there a spiritual spiritual, does it spiritual rescue them? Yes, we give reglan, opioids. We’ll do it oatmeal barley from Greek Nazism.
1:27:46
Okay, that’s all nice to me. Thank you.
Bill Clearfield 1:27:51
What’s the dose of estradiol for skin and wrinkles? And what base Do you have a compound in?
1:27:57
Okay, so this is my own thing. Now the compounding pharmacy that I use, most commonly is harbor so they’re in Costa Mesa but they ship like they have like licenses and like almost every state to and they made their own product that I call like the hormone skin cream that combines estrogen progesterone, and also some other little like peptides and some acids and antioxidants. So they have like their own special formula. My patients actually love it. So if it’s something that you want to be like consider just contact harbor compounding pharmacy, and you can do it with your patients. And I have some of my own daughters using it. They love it for myself as well. I have a use estradiol cream. It comes in a little syringe, and the concentration is it’s one milligram per point one milliliter. So if you have a syringe that has three centimeters, three milliliters, then each little line is one milligram of estradiol. So each little line on this little like it’s like a tuberculin syringe kind of thing. So I usually put a couple of milligrams of extra dial on my face every day and it will be absorbed. So when you give the product that they use the car that harbor compounding makes is pretty small, okay. But what I’m using is like two milligrams so I that’s part of my hormone dosing, so I include that in my dosing, but rather than like we have women who put like estrogen creams and such that they’re using, and they’re putting it like on their inner arm or on their thigh and then it’s like it occurred to me like, as I learn more and more about skin and I read the research is like, what the heck do I care about, you know, particularly my inner arm or my leg, you know, I want it on my face. So I just started doing it myself, just my own creation, and it does get absorbed because I’ve measured the levels. I mean, why would it not get absorbed through the skin if it’s absorbed through other parts of the skin? It’s all concocted anyway, Nature never intended us to give hormones to the skin. We just adapted this skin to that purpose, you know, and so I just like put it about my eyes and I put it like, like between my eyebrows and around my upper lip. You know, other places people tend to wrinkle, and I think it really helps. So I just use like a couple of milligrams a day of estradiol but there’s no reason if you have patients that are applying there. They’re on an estrogen that’s compounded now obviously I wouldn’t do this with a commercial alcohol based gel. I wouldn’t put alcohol product on my face, nor would I use it Pat. I mean, how would a patch help but if you’re using compounded estrogen and a cream you can talk to your compounding pharmacy and get it in a concentrated little form. And then instead of putting it somewhere else, just don’t put on their face. I guarantee you it’s absorbed. And then you get like double benefits. You get systemic benefits and you get local Skin Benefits. That’s what I
Bill Clearfield 1:31:05
- Oh, okay, that’s a new one on me. So, but just to be clear if it’s it’s just play an extra dial right? It’s
1:31:13
ln s for dial the Y combo. Those are what I use what I use this as plain as for dial the product that harbor compounding makes it they market is the blend of estrogen. They have some estriol in it. They have progesterone and they have all this other like you know, skin related stuff like acids and vitamin C and antioxidants and stuff like that. So they have their own special blend, but um for me and my patients love it. Okay, but for me personally, I’m just taking straight old estradiol cream, nothing else in it, and I’m just applying it directly to my face because I read the literature, you know, I read all these studies, and that’s what they use straight estradiol, right to the skin two weeks, you get reduced wrinkles, you know, you have rapid healing like okay, that told me.
1:32:01
Great, great.
Bill Clearfield 1:32:03
Next one is Dr. Horvitz. I’m not sure I understand the question. Use topical hormones as well for normal HRT with bio identical question mark. I’m not sure what that yeah,
1:32:13
so that’s, you know, but if you’re you can use right what I do is if some if a woman is on compounded estrogen, estradiol cream, then I tell her to start applying all or some of it to her face. If she is using a patch or an alcohol based gel like Astra gel or dividual. I’m not going to put alcohol based gels on their face, and a patch is not useful for that purpose. Then I use the product from Harbor that has these smaller doses and all this other, you know, like magic stuff mixed in with it. So it’s not part of their hormone replacement therapy at all. It’s strictly a skincare product. So So I individualize it based on whatever my patient happens to be using because for my patients I use it all you know, I base it on their age, their personal choice, the cost issues, you know, finances so I don’t just use the same thing on everybody. I I’ll use the entire array of every type of product out there.
Bill Clearfield 1:33:21
What’s the dose of the facial estrogen I know you just answered it. So just so we’re clear.
1:33:27
When I when I use myself, it’s one milligram per point, one mil. Right. Okay.
Bill Clearfield 1:33:38
Dr. Mani Rankin says again, we’d like to know the dose for the facial and I’ve seen it mixed with G H K you whatever that is,
1:33:46
well that sounds like a peptide but if you talk to the like harbor or your own personal you know, choice of compounding pharmacies, they can you know, concoct stuff like that too. I like I said the special skin formulation that harbor makes I believe they include some different peptides as well as some estrogen and project but there I didn’t talk about progesterone. Progesterone also can be beneficial to the skin. There’s published data on that as well. I don’t use progesterone cream on my face, but you know, that can be also included. And I would never on a woman put testosterone on her face ever because that can potentially grow hair and that would not make your woman patient happy trust me.
Bill Clearfield 1:34:31
Can women aged 83 who had ovarian cancer use estradiol cream?
1:34:37
Well not if you ask the general public of doctors you know the general doctor population. In my opinion, you’re never too old because if you can resurrect I mean, we have data showing estrogen receptor beta goes down in skin. We know that there are changes with age but we know that you can have benefits to the skin to the vagina. Yep, no data, I mean zero data on women in their 80s Starting estrogen we have no data. So I would definitely document document document that you know, you discuss it with the patient. She understand there’s no published data on on benefits or safety but she wants to try it. She’s fully informed. And you know, it’s FDA approved for bones when you I mean in the 80s is getting up there, but when you look at what they’re doing for bone, they’re starting women, like around 50 on Prolia, you know, Prolia it’s like crazy stuff, and you can’t get people off of it. There’s no long term data, and it’s actually been kind of bad mouse now more and more by the rheumatologist and the endocrinologist because there’s like no exit strategy for that drug ever. When you stop it, the bone just disappears. And, you know, bisphosphonates is they’re terrible in terms of long term kids, no long term use and they came up with this ridiculous like expression that after five years of use, you have to stop it. You have to stop it because it’s toxic, but they call it taking a drug holiday like you’re going on a vacation. It’s like the craziest talk about marketing, right? Oh, you’re going on a drug holiday. They don’t say you got to stop it because it’s really toxic. No they say drug holiday, you know, and now the American College of Physicians just this past week came out with their new recommendations for treating osteoporosis. The first line of therapy, bisphosphonates and they included zero they even put a little addendum we did not even address estrogen at all, in our paper, not at all was not even touched on. Like how horrible is that? They didn’t even bring up the subject of hormones for women for bone health. It’s, you know, collagen is very key to joint health. Bone Health, skin health, actually vascular health. What structure in the body doesn’t involve collagen, right? And collagen is essential to life and you make collagen in the presence of estradiol and you can’t make collagen properly in an estradiol deficient body, and the solution isn’t a bisphosphonate. And the other thing about bones is that extra dial not only prevents uncontrolled bone loss to the action of the osteo class and specialized modified macrophages in the bone, but they also stimulate osteoblast to make more bone is all controlled to the special cells in the bone called osteocytes, which control the osteo class and the osteoblast so that you have this perfect balance of bone removal and bone building and that only and only is controlled by estradiol does no drug that does that. So anyway you know, you can see that collagen is essential for everything. So the solution is not a bisphosphonate or polio, but that’s what the conventional medical world is doing. So if I had an 83 year old who has osteoporosis you know, like the idea of putting on those drugs is so like, not pleasant to me. So I would rather put her on estrogen, even at 83 to try to help her bones to be better. And that is not the standard of care. That is my care.
Bill Clearfield 1:38:19
And I know you’ve touched on this before but just so you know, the recommendations that a female 10 years post menopause, if she has not been on estrogen or hormones is not to be put on them. And after 10 years, 10 years on hormone replacement, they should be stopped. I mean, no, that’s the official recommendation. Official.
1:38:40
Well, there’s there is no official for when to stop. But the of course the mantra that came out of the Women’s Health Initiative was smallest dose for shortest time. And originally they said stop after five years, you know, some said okay, 10 years, but the general feeling in the medical community is that once you hit 60, you should just stop hormones, just stop them abruptly, which by the way increases the risk of a heart attack in a woman. It’s like crazy, you know, so they just say okay, you’re 60 you’re too old to be on hormones anymore. You’re just stop them. Like what you know, and you know what we can always give you Prozac, by the way that’s what Medicare recommends. They say at age 65. We you know, because that’s when Medicare comes into play, you know, so if you’re 65 and you still been on hormones, they say we’re not going to cover this, you’re too old. But here’s some solutions. You can go on Prozac or bisphosphonate that’s literally in their literature. I’ve seen the letters and that is crazy, because that’s not exactly a replacement. So but so the general public the general doctor community is stop hormones at age 60. Don’t start them if you’re over 60 That’s kind of how it goes. And I
Bill Clearfield 1:39:51
I don’t know if it’s changed but when I started doing this, it was the first line that was was Beneful axon Effexor that was that was supposed to be
1:40:02
well, that effects are Yes. And that was taxall was a popular.
Bill Clearfield 1:40:08
Yeah. Right. And then after that it was that doesn’t work then either. Quantity, specifically mentioned synthetic progesterone and then grab a pen and then grab a pen
1:40:23
and Gabapentin is like now the go to for everything right because you can’t use opioids so oh my god, it seems like this by the way. There’s data that if you give post operative elderly people elderly being defined as 65 plus, if you give them Gabapentin post operatively you increase their mortality. There you go.
Bill Clearfield 1:40:43
Okay, I’m just telling you what,
1:40:44
I know. I know but I’m just the new data is not very encouraging for Gabapentin postoperatively and for pain in elderly people not so great. I know it’s a problem. But yeah, I know that it’s insanity. And the you know, the unwarranted fear of human bioidentical hormones is so bizarre you know, when you think about it, it’s just so crazy, like no one has that fear for thyroid hormone, like, it’s just another hormone,
Bill Clearfield 1:41:12
thyroid, thyroid hormones or if the TSH is greater than 10 You Synthroid if it’s four and a half to 10, and they have symptoms you Synthroid, if it’s under four and a half, you’re crazy. That’s that’s the that’s everything
1:41:29
for sure with thyroid, but at least they don’t say at a certain age, you have to stop it. If you’re on. At least they don’t say you’re too old for thyroid hormone, like they say for women who are too old to have estrogen in your body. So get it out, get it
Bill Clearfield 1:41:42
out. Treatment options for hormonal acne after you clean up the diet and no gut dysbiosis
1:41:48
Well, I interesting I actually that’s skin product that I told you about that harbor compounding makes it has the estrogen the progesterone and then they’re like little peptides and the vitamin C and the acids and I mean, that’s not they’re not they don’t even market that they’ve marketed for wrinkles, but I’m using it for acne, I’m getting great response okay. Now I also used by Ronan lactone. Spironolactone is a pharmaceutical that blocks the conversion of testosterone to dihydrotestosterone. So it’s kind of but it’s doesn’t seem to have like, it’s not like a universal blocker of five alpha reductase and it lowers the production of testosterone. And acne is a huge problem for causing depression and so on. And there’s actually published studies that if you use spironolactone, that virtually 100% of women will have 100% clearance of acne by two years. And what you do is you get them to clearance. And that could be three months, six months, one year, whatever it takes, and then you start dropping the dose, okay, so you don’t stay you go to whatever dose you have to with a maximum of 100 milligrams twice a day. And then once you hold steady and you’ve cleared the acne, you start dropping the dose and and while you’re cleaning up the diet, and then you can get them off of it. So this is not a lifetime drug use this is to get things under control while you’re cleaning up the inflammation and and by the way, oh my gosh, stress has such an effect on the skin. I mentioned like cortisol and they’ve done studies where you can actually treat severe acne with hypnotherapy, nothing else just hypnotherapy and have total clearance. So stress is not a small component of acne. So if you have patients that have a lot of acne, always think what’s going on in their lives. You know, these are stressed out people now it’s of course bi directional acne causes stress stress causes acne but if you don’t address the stress component, you’re never going to really clear the acne.
Bill Clearfield 1:43:54
Regarding DHT and men in large prostates current paradigm is five alpha reductase inhibitors, would you suggest trying to lower inflammation instead? For example?
1:44:06
I would Oh, yeah, like Curcumin is great for that, you know, the absorbable type of turmeric so you know, lifestyle. So when men have an enlarged prostate, and remember, I don’t really deal a ton with men, but an enlarged prostate is a sign of inflammation. of the prostate, okay. And the prostate is the analogous Oregon to the female uterus, okay. And that’s sort of an interesting thing. And it also can make estrogen locally inside itself. And so remember inflammation also up regulates aromatase, and you’ll convert your androgens into estrogens and that will happen in the prostate itself. So everything you can do to lower inflammation is going to improve prostate health. The reality is that if you have a guy who literally can’t pee, because his prostate is really obstruct causing an obstruction problem, then he might need to have surgery or maybe he does need to go on the big gun pharmaceuticals while you’re working on it. So everything that I do works best as a preventative or not. So great within stage disease, whether it’s end stage heart failure, kidney failure, the most severe stages of osteoporosis or an enlarged prostate. I don’t really know how to make a really, really enlarged prostate just shrink away. So I’m much better at prevention than I am at like curing a really enlarged prostate. We’re stuck you know, once it’s that big and it’s causing obstruction, but if it’s early stage, inflammation on some bigger more, you know, measuring inflammation markers, we can intervene before it keeps growing, and that’s where where I do best is prevent we
Bill Clearfield 1:45:53
we had on a few weeks ago. It’s in our It’s on our website video is Dr. Evans is an integrative radiologist, interventional radiologist, he does embolization of the prosthetic arteries. And he seems to have a pretty good track record with reducing prostate sizes, especially really enlarged prostates that were
1:46:16
that’s so interesting because you know, they do uterine artery embolization. Right. During fibroids, and they’re the analogous organs so it had to be somebody think of that, right?
Bill Clearfield 1:46:27
Yeah. So it for those of you out there in TV land, it is on our website, but stocker Evans is an integral, integrative radiology and just to remind everybody aos rd.org/webinars. That’s where the while all of our videos are including this one will be.
1:46:51
Let me see. See, I
Bill Clearfield 1:46:57
lost my place since I quit then. Okay, another paradigm for GYN is to place women on hormonal contraceptives. To treat uterine cysts. This is Dr. Mr. Hartman to spite prolactin shut off progesterone, testosterone and estrogen, which is the reason for proliferative disease. But would you suggest it as estrogen that is causing this perhaps a less barbaric method than birth control should be standard? Um,
1:47:27
I use birth control for like emergency medical use, like if someone reproductive age woman is having massive bleeding with her periods and like super anemic and so on. But you know, I’m using it as a drug to try to control the bleeding. But I really feel sad that we don’t have better contraceptives out there, because I don’t want people to have unwanted pregnancies. But you have to always keep in mind that birth control pills are pro inflammatory. They lower T regulatory cells. They cause gut dysbiosis circadian rhythm disorder. They can increase suicidal ideation. In younger women. You never if you start early, like in your teens, which we don’t have data after 20 but we have data published if you start birth control pills in your teens, which is so standard now you increase the lifetime risk for cardiovascular events in women, and you will never optimize bone health. The amount of bone that’s made in the first five years after puberty is really dramatic. It’s like 40% of bone is acquired in the first four years after you know the monarchy. And that’s often the years that girls are put on birth control pills now, so they’re put on birth control pills during their both their most robust bone growing years, so they never optimize that they also don’t optimize joint health because without proper desperate dial you don’t create the proper health of ligaments and tendons. So we’re seeing injuries to like shoulders when the girls go out. They’re dancing and they’re doing like Zumba classes, and they’re doing nothing and they’re tearing, ripping and tearing, you know, their shoulders and their hips and knees and they’re getting labrum tears and all this crazy stuff at a very young age, you know, so and you’re changing the hormone receptors, you know, because just like use it or lose it so the hormone receptors are going to be more dysfunctional. So I am not a fan obviously of unwanted pregnancies but I’m really not a fan of chronic long term birth control pill use for any purpose. I think if they’re going to be used to try to use them at an older age and try to try to keep it to as few months or years as possible, but I don’t have the solution to for contraceptives. You know, I’d love to say I invented something and it’s great. So I recommend using all the different barrier methods and using two at a time if necessary. And I don’t even know what to say in all the states where you know, they’ll you know, decapitate the doctors if if the girl you know, has a medical abortion or something. So we have a lot of problems, you know, in many of the states now, they can’t the dermatologist can’t use Spironolactone they can’t use not that I’m in lover of Accutane, but you know, they can’t use drugs that have Tourette genic effects because there’s no option if something happens by accident. So you know, we live in a complex world, but um, birth control pills are not health pills and so they can be used in emergency situations to treat particular situations, but I would definitely not consider them health pills. If
1:50:42
there’s something to do
Bill Clearfield 1:50:44
for men when skin is super thin and easily bruises and heals poorly. Um,
1:50:50
well, I I think that progesterone cream for men could on the skin could have a lot of potential benefit. I don’t know I have a lot of data on that. But we do know there is benefit to progesterone, and men certainly need progesterone. And I think that that would be a good thing to do. And also maintain their testosterone. I’m not saying put testosterone all over their face although I think you could definitely put it in the hair growing areas. But I don’t, but I think everything in a man that maintains health requires adequate testosterone and that you know, is really a problem. When men don’t have enough and much of the benefit of testosterone I would say at least half is from his conversion within the different tissues themselves and Oregon’s into estradiol because testosterone turns into extra dial. So men need that testosterone for skin health. And I don’t know if a lot of data on giving testosterone cream on the face, but I would experiment with it. And you know, I would also consider progesterone cream as well. And then system, systemic testosterone and be proactive once again. You know, late stage skin conditions are harder to deal with too. Of course.
Bill Clearfield 1:52:12
What would a dose be for a male for progesterone?
1:52:17
Well, this is okay, so this is concocted by me. Okay. So like 20 milligrams. Okay.
Bill Clearfield 1:52:24
Would you use a cream or cream okay. Do we use topical II in men and women for venous stasis ulcers?
1:52:35
Oh, you know, vitamin E is great for skin. I use it for like when women have Vitus you know, it could be from whatever you know contact dermatitis. It could be like the the labile skin is like irritated from a yeast infection from the east coming out. If you take a vitamin E gel cap like a good one, and you put a pin in it and you press out the oil from in that little Vitamin E gel cap. You can put it on any skin anywhere and it really promotes healing. So I’m glad that whoever brought that up. That’s a very good comment because vitamin E is very good for skin vitamin.
Bill Clearfield 1:53:13
We’ve used it for scars and things for a long time. That’s really
1:53:15
good. Yeah, yeah. Um,
Bill Clearfield 1:53:19
when using tamoxifen and breast cancer and the skin crepes Is there a treatment for that? So
1:53:28
okay, well, you know, maybe more protein put hyaluronic acid on it. I’m just guessing here.
Bill Clearfield 1:53:37
Um, sounds like age spots are similar to having a camp versus nine grams which signals increased insulin resistance?
1:53:45
Well, it cantos has now cans definitely shows insulin resistance. So what was the first part?
Bill Clearfield 1:53:52
Ah spots.
1:53:53
Oh, yeah, yeah. So yeah, if you think about it, that’s a very good point. Right. It kept those with Narcan is an inflammatory process that’s related to insulin resistance and you have hyperpigmentation. So there you go. Insulin resistance is an inflammatory status, and so is hyperpigmented pigmentation. But so often that’s not really thought about like, what is the significance of this hyperpigmentation? Why is this happening and it’s, you know, upregulation of the production of, of melanin by the melanocytes because of inflammation.
Bill Clearfield 1:54:26
What about vitamin C at all?
1:54:29
Oh, yeah. Vitamin C is great for skin. They have so many commercial products with vitamin C. Basically anything that takes down, inflammation in the skin is going to be good for the skin. So vitamin C, at all antioxidants.
Bill Clearfield 1:54:42
Yes. Great tip. Great talk, as always, a couple of comments got got about a half a dozen of those. How high a dose do you use for topical estradiol?
1:54:54
The most I’ve ever used as four milligrams total
1:54:57
a day.
Bill Clearfield 1:55:01
Wonderful presentation. Can you put your website back up? I don’t know. Was that directed to you or to me? Not sure. You’ll have your website. Can you put that in for us?
1:55:15
There you go.
1:55:16
Come visit me.
Bill Clearfield 1:55:18
You go. Okay.
1:55:20
Okay, that’s my books.
1:55:22
And I’m gonna write a new one on breast cancer. That’s my next one coming up.
Bill Clearfield 1:55:28
Will we have all the slides to reference refer?
1:55:31
I can send them to you. Okay, I’ll send you
Bill Clearfield 1:55:35
and we’ll put them up. You typo.
1:55:36
Sorry guys. I just didn’t I put this together kind of fast. So sorry.
Bill Clearfield 1:55:41
We’re we’re not and it’ll be on our website aos rd.org/webinars. And I think that’s about it. A couple of more great presentations. And thank you so much again, you know, we really appreciate it. I mean, this has been almost two hours and it went by like, like like in and thanks
1:56:03
so much.
1:56:04
Yeah, it’s always nice when I can join my tribe.
Bill Clearfield 1:56:07
And it gave gave Stephen Hartman some time to string a couple of war tennis rackets. Well, while I have to give you a hard time about it, you know that
1:56:19
you can’t do too productive things.
Bill Clearfield 1:56:21
That’s right. So thank you, again, thank you so much. I really appreciate it. We love having you on. And I think we’re going to try and get something together for the end of the summer for our group, so I hope you’ll be you’ll be part of it. Oh, that sounds great. Next week. Next week, we’re going to have Dr. Donald Danis. He is a en chi surgeon and he deals with mold and mold toxicity different than Dr. Campbell. So and it just worked out that the weekend the week after that we have Dr. Campbell back so yeah, so we have to we’re gonna have two weeks of mold and mold toxicity but you’re going to hear some very different things. So Dr. Dennis is a good old boy from North Carolina and he’s got a little bit of an accent and he’s got he’s got some unique perspective on things. And again, thank you again, Dr. Gersh. As always, Dr. Smith was supposed to be on and she keeps dodging me now so if you get in touch with her, please tell her we’re looking for and February 21 Peter McCollum will be here. Tell your friends tell your enemies and you know, it’ll be fireworks as always. With him, so. Okay. Um, thank you all so much. I’m gonna say good night. Unless anybody else have any other questions, comments, John.
1:57:49
Oh, wonderful. Thank you. Okay.
Bill Clearfield 1:57:54
And thank you so much. And I hope to see you soon in person, their doctor garage, so
1:58:00
that’d be great. So everybody, take care
1:58:03
and good night. Hey,