Mon, May 08, 2023 4:33PM • 2:37:26
SUMMARY KEYWORDS
methylene blue, milligrams, patients, decreases, increases, methylene, inhibits, nitric oxide, good, blue, working, dose, talking, iv, mitochondrial dysfunction, give, oxidative stress, effect, vaccines, years
SPEAKERS
Bill Clearfield
00:00
Yep, yeah,
00:01
there is a there is a nasal adapter and tried to raise commercially available Yeah, there is a good bioavailability it doesn’t absorb because people aren’t always congested, like Yeah, I’m congested right now just
Bill Clearfield 00:13
you have to use it three or four times. Yeah, you have to use it three or four times. He
00:16
puts so many milligrams of stuff up there. Yeah. Well, that’s
00:22
pharmacy can make them be creative there and Megan way, you know,
00:27
so, so Doctor Kalasa did you use the Quicksilver sublingual?
00:33
I did and Robin was that I’m afraid of swallowing it because I think about all the time but to my liver, it’s gone. It goes go brown.
00:40
Everything goes to your liver,
00:42
but not not everything. If you If YES 100 by fasting process you can get better than so I know everything goes delivered by so that’s when you want to do it throw sublingual or inter nasal.
00:56
Right it goes to you by a little time before it gets the liver as your as your body takes it around. The first slipper pass of wedding the first liver pass is a technique to have a bigger concentration, wherever you put it when you use sublingual or topical. It’s not something that protects the liver. What protects the liver is that you put in real testosterone and not a fake testosterone.
01:25
That methyl testosterone,
01:27
right it’s all all the damage and stuff that you think you know about oral testosterone has come from methyltestosterone it’s the same thing with progesterone. They say progesterone was horrible when they use medroxyprogesterone not progesterone. Same idea. It’s it’s they they like to produces bad information or becomes an urban myth. And everybody thinks that’s the thing when you keep it to the actual hormone and and you could swallow it no reason you can’t swallow it. But you the longer you hold it in your mouth, the higher peak you’re going to get very quickly. But it’ll go it’ll get absorbed all the way down to your digestive tract, probably very little. By the time it gets to the stomach.
02:24
You know, one thing I did read, you know, for years and years, they told me that calcified train was incompatible with every steroid except betamethasone. And I was like, I don’t know why that is and I went back and looked through all the thing and it turned out it was a one sentence thing in a mark manual in a Merck manual from like 50 years ago. And I was like, there was nothing else on it. It was completely wrong. We sold it for years. It’s never been a problem. And I testified every time Yeah, well anyway we got tonight. We’re really blessed to have with us Clearfield from the Academy of oxidative stress disorders and
03:06
oh, excuse me. Yeah, well, yeah, well, I thought you had you were caught in the AOS D so that’s the American Osteopathic.
Bill Clearfield 03:13
Well, we were the American Osteopathic Society of rheumatic diseases at one point and change, right. Yeah, we’ve we’ve changed. And we’re at the moment we’re still unaffiliated, but I think we’re getting closer here. So you guys all know our story, and I’m not going to go into it again. But yeah, I actually had somebody come up to me so I was at the AME and G meeting last weekend and I actually had one of the doctors come up to me and say he wanted to apologize. He was at the at the meeting that where they decertified us, and he said he was too intimidated to vote to vote with me. So for whatever, whatever that was worth.
03:57
I bet there’s a lot more. Well, yeah.
03:59
Politics, it’s nice to do some politics, somebody called a Big Pharma. You know, they got a little bit irritated from you recording in progress. You’re making it difficult for the Big Pharma to make money. So that’s why they
Bill Clearfield 04:12
Yeah, I don’t think so. I got there’s 50 of us. You know, I don’t think the 50 of us matter when we’re going to matter. One hill of beans too big.
04:21
I agree with you. So well. It’s great. And it’s also good to know that you’re a faff rose, ba, ma and dogma
Bill Clearfield 04:29
Yeah. So you know, that’s a forum, a couple of a forums and a couple of medical acupuncture degrees there. I’m not sure I don’t remember which ones are which I think the the last two are the acupuncture and this one is a forum. So I got those totally.
04:46
No, you’re very well qualified to speak to. So I’m really glad that you picked this topic, because it’s nice to hear somebody else kind of present a point of view on Yeah,
Bill Clearfield 04:55
yeah. Yeah. So the whole the whole point was that, you know, Dr. alasa, you know, you’ve been singing the praises of methylene blue ever since the second I met you and I just had to put it in my own in my own words and sort of in my own my own head and and so I could figure out you know, what it was you what, what I could use it for, you know, what was practical, what was in the literature, and I just tried to make a little bit of sense more sense out of it. So hopefully this is sort of like a Cliff’s Notes version. On the i My latest projects are, I’m writing. I’m writing lectures and papers on the summaries of 40 years. As an anti aging physician A to Z. And so that’s what I’ve been doing. So the methylene blue here, what we’ll have is the last few slides I’ll have are sort of a summary and that’s kind of what I’m doing for everything so, so for there’s a lot of acupuncture in there. And there’s, you know, simple things that we can do. And so, in the 80s I had autism, adrenal fatigue, and endocrinology of anxiety but again, just just the just the highlights of that kind of thing. And the battlefield acupuncture I don’t know if any, you guys know what that is your acupuncture for acute pretty much any kind of acute problems. So anyway, tonight’s topic is going to be methylene blue and this is a my my take on it. I’m sure Dr. Lawson will have lots of comments and but what I did was I went and tried, we went through the literature, I tried to make sense of it and you know, and to sort of categorize things so that we had like a, a list of this is what it’s what it’s used for. And here’s the here’s the here’s the proof for it. I always write this only because I never know when it’s going to these are going to turn into CME lectures, and so they always make you write this I know find relevant financial relationships within edge eligible companies and I’m getting a little bit better at the cartoons and whatnot here. And again, objective so what is it? How does it work? What are the effects, clinical uses and side effects and contraindications? So what is it? It’s a it’s a it’s a stain, it’s actually it was made as a wool stain in 18 set was developed in Germany in 1876. And it was a blue dye. And you know, those those places weren’t very clean. At that time. I don’t know how clean they are now, but it was noticed that around using this this dye to die things blew a lot of bacteria cells, it was a lot cleaner around the methylene blue stained areas than then other areas. And it was then used to stain and visualize cells and microbes and it could actually distinguish between live and dead living organisms. This This was the age of the microscope was was just starting to be used and highlighted at anatomical structures it stained tuberculosis or TB bacteria, it stained a malarial parasites and it actually killed them. So this was a you know, one of those sort of discoveries. That was like a whoopsie kind of thing. You know, it was a lot of things that were not not not expected. Sort of like Viagra, I guess. And, you know, some of these weight loss drugs, you know that we’re using the diabetes drugs for weight loss. So methylene blue inhibits guanylate cyclase. It prevents smooth muscle relaxation. It treats cyanide poisoning and it actually lowers the levels of methemoglobin and it’s FDA approved for methemoglobinemia. It is a nitric oxide synthase inhibitor it lowers nitric oxide, and that actually becomes important at higher doses. It inhibits the conversion of L arginine to L citrulline. So it will actually lower growth hormone also. So I’ve sort of categorized it here and so on the left the the metabolic functions of methylene blue, and on the right here are is the is the reference for it. So it increases oxygen consumption by up to 37 to 70%. It increases ATP production, it increases glucose utilization it increases the NAD NADH ratio and NPK ratios also decreases lactic acid production so it’s an it increases energy where we add here okay, acts as an antioxidant. It prevents intraperitoneal postop adhesion. So put a post you can use it as a, you know, as a sort of as a is a wash post, post operatively. It acts as an alternative electron donor in the mitochondrial electron transport chain. It completely inhibits monoamine oxidase a so it’s an anti depressant and in partially inhibits monoamine oxidase oxidase B, it increases cerebral blood flow. So just from this, you know, this list of 1010 metabolic functions you can you can extrapolate the, you know what, you know what it’s used for being a hormone guy I looked at what its effect on hormones, and the effects of methylene blue on hormones. For I have a I have a list of increases and decreases at the end. What I have here for you are doses and uses of older hormones. And what this is what on the right hand side what methylene blue does to hormones, so it increases testosterone, sperm count and motility. We can use it as one of the one of the entities that we can use to increase testosterone without using testosterone. It decreases estrogen and acts as an aromatase inhibitor. It increases the uptake and increases ATP levels of progesterone. It Up regulates IGF one, it increases free T three and decreases TSH. Remember TSH and free T three are inversely related. It decreases cortisol levels. It decreases DHEA has no there was no literature I could find on pregnenolone although pregnenolone increases prolactin and methylene blue decreases prolactin so there’s an inference there and a decrease the cyclic a&p activity of oxytocin. So this is just a little summary. Methylene blue will increase testosterone, progesterone IGF one free T three and DHEA it will decrease estradiol cortisol, pregnenolone, prolactin and oxytocin. There’s the references for all of those. Its effect on pro inflammatory cytokines. It is useful in septic shock patients. One milligram per kilogram IV will increase vascular resistance, which is a which is it will increase mean arterial pressure so it’s used for septic shock without a decrease in cardiac output. It will decrease the cytokines interleukin 1268 12, TN and TNF alpha nitric oxide increases in septic shock resulting in arterial vaso delectation and so make methylene blue or block this nitric oxide effect Now normally when you want nitrous oxide because you want to increase vascular perfusion, but in this case in septic shock, you want to do the opposite methylene blue ameliorates says platinum induced neurotoxicity by enhancing any oxidative capacity, energy metabolizes and suppresses inflammatory parameters and oxidative stress. So methylene blue is useful for cisplatin induced neurotoxicity and anything that’s that’s similar to it these are the clinical uses of methylene blue methemoglobinemia. It’s FDA approved vaso pelagic syndrome, which is what we just described septic shock syndrome, pain reduction prior to anesthesia, malaria, that prevents whatever I falsify my induced encephalopathy. Or not, that’s something I don’t really deal with very at all, and identifies parathyroid gland in surgical situations as a stain. It’s an antiviral, antibacterial and antifungal agent. We’ll talk a little bit about parasites also it’s an anti depressant. It’s useful in autism. It’s an anti neoplastic it is useful for traumatic brain injury recovery and there’s a few miscellaneous indications also. So you can see it’s quite it’s you know, as quite a widespread and you know, we’ve been learning about this, you know, over the past two and a half, three years. You know, all of these sort of the joys of methylene blue and hopefully, we have it sort of in a succinct form here. Somebody’s clinking glasses there. So hepatobiliary syndrome of microbiology identification, and identifies intestinal lumen lesions. It’s an antidote for heparin toxicity. It can help relieve High Flow priapism outsiders disease, it can lessen the symptoms, and it can relieve the resistant plaque of psoriasis. So methemoglobinemia is, is oxidized hemoglobin loses his ability to carry oxygen. First to go converts the first three, you got to increase nitric oxide cortisol and pro inflammatory cytokines. Symptoms or cyanosis. To see on exertion, confusion, seizures, brain fog, coma, metabolic acidosis headaches, inappropriate giddiness, you get a chocolate brown looking urine etiologies, there’s a congenital type and this is usually sort of a cosmetic type issue. The patients have a lot of cyanosis there’s also a cytochrome B five reductase deficiency and then there’s a hemoglobin and glutamate, replacing veiling deficiency and that’s, that’s the one you’ll see in the surgical issues. The etiologies of methemoglobinemia are all of these here. They can anesthetics can do that. So you get that you get this with anesthesia. Also, under under two years of age, some of these oral oral agents can actually create a situation of methemoglobinemia aura gel and bisol you know to use that for teething cyanide and carbon monoxide poisoning. Sodium nitrate Amyl, nitrate poisoning heavy metal toxicity, fluoride, formaldehyde, chlorine dioxide based cleaning products. COVID-19 dapsone anti malarial drugs can all cause methemoglobinemia. Just a couple of notes on the cane anesthetics methylene blue quickens post anesthetic awakening by up to anywhere from 15 to 40. minutes. cyanide poisoning methylene blue accepts electrons and acts as a redox agent increases ATP increases in a de NADH ratio maintains blood pressure left ventricular control contractility body temperature decreases the oxygen deficit and decreases serum lactate levels and COVID-19 improves foods oxygenation and respiratory rate. So you know that Dr. alasa was early on this early usually it’s a one milligram per kilogram. As an IV, you can get up to four milligrams per kilogram anything higher than that you’re going to you’re gonna run into some toxicity. You can start at 0.1 to 0.2 milliliters per kilogram over 30 minutes. You don’t do as an IV as a push or an i m or a bolus you have to do it as a slow IV, especially for methemoglobinemia. orally it can begin filled five milligrams twice a day and increase it to 20 milligrams twice a day as tolerated. It’s contraindicated with G six PD deficiency, and you need to monitor the liver and renal function that you need to reduce the dose by about 40%. If they have some liver or renal impairment. You need to be careful with SSRIs SNRIs and MAO inhibitors, you can get a serotonin syndrome. Basal collegiate syndrome is pretty much what we discussed. Just a minute ago. It’s hypotension despite normal or increased cardiac output. It’s associated with a high mortality especially after cardiopulmonary bypass. Methylene blue has a positive nitric oxide regulatory mechanism it will decrease nitric oxide and increase with systemic vascular resistance. And so what you get you get that an outpouring of of vascular dilatation itself in itself methylene blue is not a vasoconstrictor it blocks the cyclic GMP pathway releasing cyclic a&p and facilitates vasoconstriction. The dose here is two milligrams per kilogram IV followed by a continuous infusion. Early intervention in the O R results in less mortality and morbidity versus late use 0% in the O R versus 21%. So I’m not sure how many anesthesia steps Steezy ologists. We have here but those are the FDA approved indications for pain relief. It’s an anti inflammatory, it reduces sodium potassium exchange in cells and it will help with the nerves, the nerves, the innervation tissue also, it decreases again nitric oxide signaling cytokine activity and and it decreases inflammasome formation, decreases swelling, edema and tissue destruction and is effective for low back pain and for pure anus at night. It decreased again decreases nitric oxide signaling. It blocks GTP conversion to cyclic GMP that results in inhibition of smooth muscle relaxation. It decreases toll like receptor for which activates NF Kappa Beta interleukins one B six TNF alpha, it decreases the binding of NF Kappa Beta and p 53. which affords pain relief. It Up regulates TGF beta receptors. It is synergistic with morphine and CCK the neurohormone that decreases inflammatory mediators and it down regulates the P to xr receptor, the main pain or transmission pathway located in the dorsal root gland ganglia and central terminal of the primary efferent pathways. That’s a long way of saying it dampens inflammation and it is a fairly potent pain reliever. It decreases inflammasome expression these are intracellular multiple protein complexes that process cytokine precursors into mature forms. It induces programmed inflammatory cell death. It inhibits influent inflammasome formation by decreasing cytokines and reactive oxidative stress and it reduces inflammatory inflammatory cytokines interleukin one B six and TNF alpha, the end result is decreased tissue the degradation and swelling sodium reduction methylene blue inhibits sodium entrance through injured cell membranes. It acts as a gate IMOs mobilizing open port blocker rather than as an activator of sodium movement and it decreases neural firings in the microglia in the brain. The end result here is block cation blockade of pain transmission. Methylene blue administered in cutaneous tissue results in death of nerve endings. It blocks nerve conduction while destroying nerve endings around painful lumbar discs. Patient satisfaction with injectable methylene blue was at 91% versus 0.7% In a placebo group. As an anti malarial agent, it was first reported versus plasmodium in 1891 that used in combination what other team has been in which is Wormwood to produce, reduce malaria and gamma sites. And just as a personal note, my daughter had been in Africa for four years and she ended up with a pretty severe case of malaria pneumonia and, and she had the liver damage also and whatever they were doing when they weren’t weren’t working, wasn’t were not working and we use some warm wood and I did I did have some methylene blue, this was in 2000. This was in 2010. So I did have a little experience with it way back then. I got it at a western wall there. That was in Nairobi methylene blue is potent inhibitor effects on otherwise drug resistant plasmodium species, and it remains effective and rarely turns resistant. I and this is just a personal opinion, I think we you know, was abandoned for over almost 100 years and so, bugs like to live and, you know, they’ve got they get used to whatever whatever it is we’re trying to treat them with and so we tried out this methylene blue after 100 years, and all of a sudden you know, they’re not they’re susceptible to it. I fo stem I induced encephalopathy. It’s an alkylating agent that treats pediatric sarcomas and major side effect is hemorrhage X hemorrhagic cystitis and neurotoxicity symptoms or somnolence, neuro neurologic deterioration and coma methylene blue 100% eliminated the chemo induced encephalopathy. This was 50 milligrams IV Q four hours typically need four doses. Resolution time was 72 hours. So again, this isn’t anything that I deal with but if you deal with pediatric cancers, you know, keep this in mind. IV IV methylene blue for the parathyroid glands will stain them and you’ll be able to identify them. Sensitivity rate is 78.6% similar to ultrasound or radio nuclear, right nuclear nuclear imaging 6% adverse reaction rate 95% of the patients with reactions were an SSRI so those two don’t mix methylene blue is useful as an adjunct to standard pre op imaging by facilitating more rapid identification of abnormal parathyroids. As an anti viral it’s a preventative or therapeutic against the influenza virus h one n one and the source COVID to two to three milligrams per kilogram per day in divided doses for seven to 10 days. We’ll have the source for you there. Protocol included using n acetyl cysteine 1500 milligrams plus vitamin C. It’s active against flavor viruses with the sort of the African dengue, dengue viruses Zika viruses, West Nile yellow fever, Japanese encephalitis and tick borne virus, encephalitis. It inhibits hepatitis C when used with photodynamic therapy. Herpes Simplex one is inactivated by low dose methylene blue blue and photodynamic therapy and inactivate HIV one parvo virus HCV. Again with photodynamic therapy, as an antibacterial and as potent antibacterial activity against Staph aureus, Mersa, Staph, epidermidis and Klebsiella pneumonia. You mix it with silver nanoparticles and it’s effective against gram negative bacteria. E. coli, gram positive bacteria Staph aureus, methylene, blue and silver are more effective in a combination they exhibit high photostability and oxygen SIG singlet yield methylene blue and photodynamic therapy evidently killed selective drug resistant acidobacteria Pseudomonas and multi drug resistant Klebsiella it dose of 50 milligrams per liter and red light of 80 joules per centimeter. It’s effective against Mersa when used with a red light when used with the helium a laser at 632.8 nanit, then a meters and at 665 and 830 nanometers and has a high bacterial effect on periodontal pathogens. I think Mike you’ve had some you have some sort of contraption that can do that. Methylene blue may be used prophylactically against colonization of beta lactam bacteria without promoting resistance. It’s an anti fungal, it’s mediated through the mitochondria mitochondrial dysfunction and disruption of the redox and membrane homos homeostasis it’s active against Candida albicans tropicalis and cruise I. It disrupts the mitochondria and the redox status of fungal infections. It disrupts fungal membrane integrity, and inhibits the yeast to hyphal transition transition that is essential for survival for the fungal virulence in the host body. So it’s useful against yeast also, here are all the references for that this 153 was the reference for HIV and SARS. As a diagnostic in for parasites and methylene blue provides contrast between parasitic structures as compared to saline or an iodine MT is a therapeutic agent and may be administered alone or with red light or in combination with other anti parasitic agents. And it’s a sub susceptible to all of these parasites are susceptible to all to methylene blue trip Sonia leishmania toxoplasma neospora. You can read them here. The microspore idol malaria, visceral leishmaniasis, African sleeping sickness toxoplasmosis. giardia, Chagas disease, Cryptosporidium toxoplasma, gondii and Cephalo ozium species and noseeums species. Those here would be 60 to 130 milligrams twice a day orally, they can be used sequentially or simultaneously with light therapy or other anti parasitic agents as an anti depressant and has anti depressant, anti anxiety oolitic and neuro protective properties, short and long term remedies for bipolar depression with without mania episodes, useful for depression and comorbidities and outsiders and Parkinson’s disease inhibits monoamine oxidase a completely and it partially inhibits Mattawan and monoamine oxidase B. It’s a non selective inhibitor of nitric oxide synthase and guanylate cyclase and inhibits nitrous oxide and cyclic a&p, which have which results in an anti depressant effect. high doses of nitric oxide are a critical regulator of neuro inflammation, and it has a contrasting effect in the central nervous system. low concentrations of nitric nitric oxide are neuro protective and mediate physiological signaling. High concentrations are neurotoxic, increasing concentrations of nitric oxide, enhance the production of relative nitric species, nitrogen species and reactive oxidative species which are associated with an increase in pro inflammatory cytokines methylene blue tempers mitochondrial dysfunction and redox imbalance and and dysfunction is linked to mood anxiety, depression and psychosis. Those here would be 15 to 100 milligrams a day, start at the low dose and take it up slowly. Here are the references for that. In autism, the shank three mutation is frequently associated with the autistic spectrum. Shank three mutation leads to an increase of calcium ions, calcium ion influx activates nitric oxide speed read nitric oxide species and it activates leading leading to a dramatic nitric oxide formation elevated nitric oxide leads to aberrant signaling pathways targeting intracellular proteins resulting in synaptic neuronal and behavioral deficits. Mitochondrial metabolic dysfunction results with elevated oxidative stress methylene blue leads to a reduction of the electron transport complex genes and it results in significantly lowered pyruvate dehydrogenase 35%. pyruvate dehydrogenase converts the pyruvate to Acetyl Co A, it results in an abnormal pyruvate lactate level this can actually measure that and it affects up to 80% of ASD patients. It can symptoms include fatigue, gastro intestinal disorders, unusual types of neuro developmental regression, seizures, epilepsy and motor delay. So this is that’s a mitochondrial dysfunction. So biomarkers for mitochondrial dysfunction direct ones here are lactate pyruvate and I lactate to pyruvate ratio ubiquinone alanine to lysine ratio and acetyl carnitine. Indirectly you can get a CK level carnitine level as T LT and ammonia level and here’s the labs to order for that. You can use those as biomarkers. mitochondrial dysfunction is prevalent in autistic spectrum and about 5% versus the general population of point A 1%. ASD signs and symptoms with elevated mitochondrial dysfunction have elevated lactate levels and 78% of patients and pyruvate levels and 45% of the patients. This results in developmental regression, seizures, motor delay, gi abnormalities, and it’s somewhat higher in the female gender than the Autism Autism Spectrum itself. Autism Spectrum is usually about five to seven males to one female, so it’s a little bit higher with mitochondrial dysfunction here, set almost 80% indications are not associated with genetic abnormalities. You can use for the for the genetic for these markers of blood urine saliva or central CSF fluid, dry biomarkers, your history and these are, you know, functional MRIs, ultrasounds as a way to diagnose remedies for mitochondrial dysfunction. And you know, this is this is kind of a hot topic at the moment and this is not just for autism. The ketogenic diet Coenzyme Q A with PQ Q 100 milligrams with 20 of PQ Q increased the Coenzyme Q A by 100 milligrams for every risk factor, either depending on what you’re dealing with. So things like diabetes, high high cholesterol, family history increase up to 600 milligrams, 100 milligrams for each risk. Risk Factor, vitamin B 250 to 400 milligrams, creatine, five grams per day, l arginine. You can use if a patient said had a stroke 500 milligrams per kilogram per day for up to three days and 100 milligrams to 300 milligrams orally after that, l carnitine. 100 To 1000 milligrams IV or orally methylated B complex, mixed tocopherols vitamin E, vitamin C five milligrams per kilogram per day Alpha Lipoic Acid 50 to 200 milligrams per day. Luke or van I don’t really recommend that one. And methylene blue started five to 10 milligrams per day and you want to use point five to four milligrams per kilogram per day. That’s your that’s sort of your end dose there. This is just kind of a schematic of the same thing. These are tools to manage mitochondrial dysfunction. Any neoplastic properties methylene blue, plus photodynamic therapy induces massive cell death of tumor cells, normal cells are resistant to the methylene blue photodynamic therapy so it will kill the cancer cells and leave the good cells alone. It increases oxygenation to the abnormal cells and increases ATP and exhibits catalytic power on cells possessing aerobic Onko lysis cancer cells switch from oxygen glucose, glucose oxygen oxygenation to glucose fermentation. This was known as the Warburg effect, increased rate of glucose uptake and professional preferential production of lactate. Glucose stores get depleted fatty acids and proteins are then consumed. You get abnormal glucose metabolism plus mitochondrial dysfunction as an app that brings out your cancer. Methylene blue selectively seeks out cancer cells and alters their metabolism. Methylene blue plus photodynamic therapy dissociates nitric oxide from the cytochrome c enzymes and restores cancer cells to normal. Prostate cancer methylene blue plus photodynamic therapy reduces the viability of androgen dependent and androgen independent prostate cancer cells. It suppresses prostate cancer tumors by inhibiting colony formation that disrupts prostate cancer cell migration in pancreatic cancer it decreases the growth and viability of pancreatic tumor cells in a dose and time dependent manner compared to the placebo melanomas, the methylene blue plus, photodynamic therapy promotes a decrease of 99% Decrease in tumor volume and 75% and tumor weight methylene blue plus photodynamic therapy downregulates proliferating cell nuclear antigens, bladder cancer methylene blue as multiple multimedia reactions throughout the intro cellular proteins, RNA DNA with a decrease with loss of cytoplasmic granular granularity methylene blue cytotoxic effects is initiated in the cellular membranes and intracellular mitochondria in the endometrial cancer methylene blue and cervical injection ensures a mapping of the pelvic and in for Pyro aortic structures with good global detection rate in thyroid cancer. It also is useful for tumor localization. lymphomas in inhibits e two e two is a loop helix transcription factor. It’s essential for B lymphocyte proliferation, e two a mutations are associated with a beta cell leukemias and lymphomas. It preserves kidney function with sis platinum therapy. We mentioned that earlier sis platinum is an anti neoplastic agent 70 to 90% effective for head, neck and gonet at ovaries and breast cancers. A third of cisplatin patients experience nephrotoxicity due to reabsorption and assists platinum by the proximal tubules cell death in the proximal tubules is due to the reactive oxidative stress cytokines involved or TNF alpha TGF beta and interleukin six methylene blue at four milligrams per kilogram IV reverses the CES platinum induced reactive oxidative stress and you will pee blue there were the references for that. Traumatic brain injury. Methylene blue treatment signal significantly reduces neuronal mitochondrial dysfunction and increases ATP production caused by oxygen glucose deprivation. Methylene blue reduces neuronal apoptosis and increases blood brain barrier integrity and improves cognition and motor function caused by traumatic brain injury it significantly improves neurological function. It inhibits microglial activation decreases brain edema increases autophagy methylene blue treatment minimizes traumatic brain injury lesion size, behavioral deficits and neuronal degeneration dose one hour after traumatic brain injury you have known milligram per kilogram, six hours a half milligram per kilogram, and then a dose of one milligram per kilogram daily for three days. That’s pretty acute treatment. There are the references for that. Compatibility biliary syndrome, pulmonary vaso delimitation due to increased cyclic GMP methylene blue increases your oxygenation decreases our alveolar arterial difference for partial pressure of oxygenation and decreases that guanylate cyclase. For microbiology identification. Methylene blue easily identifies h pylori and identifies intestinal luminal lesions. It acts as an antidote for heparin toxicity if the patient is Protamine sensitive. It will relieves High Flow priapism, and it functions in an alternative electron carrier enhances brain metabolism attenuates the formation of amyloid plaques and neurofibrillary tangles. It partially repairs mitochondrial function. It increases cellular oxygen oxygenation and glucose uptake and ATP production is neuroprotective by improving astrocytes, cellular respiration, and it relieves resistant plaque and psoriasis. There are the references for that. So side effects are the ones you see here. Abdominal pain, chest pain. Vertigo, headache, sweating, confusion, high blood pressure, shortness of breath, rapid heart rate tremor, the skin in your turn can turn blue or bluish green, red blood cell reduction and jaundice in infants. And I’ve heard some instances in the oral form of some numbness or decreased sensitivity, tongue contraindications or hypersensitivity to methylene blue Renal Insufficiency relatively contraindicated with GCC six PD deficiency and Heinz body anemia. It interacts with SSRIs This is where you will usually cease any type of side effects and MAO inhibitors can cause it serotonin syndrome, and it does interact with dapsone. We mentioned it reused for TB and an oxidized oxidized hemoglobin causes hemolysis key takeaways that methylene blue is mediated through mitochondrial dysfunction and disruption of redox and membrane homeostasis inhibits nitric oxide signaling it decreases cytokine activity, it reduces inflammasome the methylene blue inhibits guanylate cyclase which is used for treatment in it prevents a smooth muscle which prevents smooth muscle relaxation. It’s used for cyanide poisoning and methyl methemoglobinemia. It is a nitric oxide synthase inhibitor. It inhibits l arginine to L citrulline. Here are the this is just a recap of the metal metabolic effects increases oxygenation ATP glucose utilization NAD to NADH ratio decreases lactic acid production it acts as an antioxidant. It prevents intraperitoneal postop adhesions, it acts as an alternate alternative electron donor. It inhibits monoamine oxidase a and partially monoamine oxidase B. It increases cerebral blood flow. Its effect on hormones it increases testosterone, progesterone IGF one free T three and d h DHEA. It decreases estrogen, cortisol, pregnenolone, prolactin and oxytocin. It’s useful for clinical uses are these syndromes which we we just discussed and a couple of pearls here on hepatic biliary syndrome. It’s useful for Microbiology identification, intestinal lumen lesions, an antidote for Heparin, HiFlo, priapism outsiders disease symptoms and plaque psoriasis. I just mentioned the side effects. So the last few slides or summary that you can you can sort of copy and you keep by your off your, your deskside hypersensitivity, severe renal insufficiency, it interacts with SSRIs and MAO inhibitors and interacts with dapsone. And here are the references and so quite a bit of information. Remember, we’re all on Tuesdays every Tuesday night. In fact, tomorrow night we have 10 Probably one for us. 5pm Anybody wants to get on and doesn’t have our link. You can get me at either here or Dr. alasa and put my put my cell phone one or my email address. Do CTR vi l nine@gmail.com. You can put it in the in the link there and any questions go through the chat.
44:39
Yeah, we got some in the chat here mill. Let me let me see if I can go through this real quick. One of the things we somebody asks is what dose will inhibit nitric oxide. And should we use nitric oxide supplement? When you know well if you’re
Bill Clearfield 44:57
if you’re if you’re wanting to use methylene blue that they sort of kind of counteract each other. So so there’s you know, there’s a specific reason to be using methylene blue. So the nitric oxide would probably you know, sort of not be indicated with it. I think the dose is half milligram to four milligrams of methylene blue will inhibit nitric oxide per kilogram.
45:24
Yeah, it’s inhibiting that guanylate synthase that reduces the production of nitric oxide, the earliest inducible nitric maker guide so
45:34
let me add something here. Very important. It’s all about the dose of Michelangelo and lower dose because it buffered redox. It’s damaging free radicals that increase the size right. And eventually it happened in the highest terms which we needed. When we have vegetables like shock or septic shock. So we talking about the dosing for using does not interfere with nitric oxide in fact, increasing I can say bioavailability because it helps to scavenge free radicals so the fertilizers will not be active nitroxide So that’s me side. But what I chose, it doesn’t have it the negative side synthase especially the inducible nitric oxide synthase because there’s two types of cameras and they’re usable which are the microphones has it and then the endothelial one which identity and sales. It’s mainly focused on the use of nitric oxide which we need it when we have septic shock we have too much negative side effects nitrate that’s not the lighter side is a problem is also the peroxynitrite which is scabbard free radical that goes damaging. That’s where we need to stop the nitric oxide, especially the abusable one from over producing this nitric oxide which will turn into peroxynitrite. So that’s very clear. You can still use nitric oxide supplement with methylene blue in fact, they have synergistic effect because at low dose, it’s basically a redox buffer more than everything that I could cite someplace.
46:53
Okay. But you know, and I would also add to that, guys that it depends on what you use as a supplement for nitric oxide. If you use something like that Berkeley life, nitric oxide, where you’re making nitric oxide directly from either sodium nitrate and vitamin C or whatever, the forgot his name. But anyway, the guy had the nitric oxide, right. If you use that product, it would still create nitric oxide because it’s not relying on the synthesis of it. But if he tried to use things like arginine or citrulline, or something like that, it wouldn’t work as well because the that pathway is the one that’s blocked. So for Bill, what medicine How long would you see testosterone increase levels? That’s a good question. So if you put your patient on methylene blue neuron, you know be as 100 milligrams a day,
Bill Clearfield 47:45
one to two mil one to two milligrams per kilogram, and it will you’ll you’ll, you’ll start seeing an increase in about six weeks.
47:56
What concrete Do you think we would see a
Bill Clearfield 47:58
heavy one or no, it probably maybe maybe about 10 to 15%. You know, not terrible? Not a big increase. Okay, okay. But again, one of the one of the other ones I’m working things I’m working on is 20 ways to increase or decrease hormones with not with non hormonal substances so that’s that’s in there.
48:18
So that’s really interesting. So Becky, really estrogen levels so much are the hormones because that’s okay. Okay, do you think that’s because influence the receptors, the receptor sensitivity? Yeah,
Bill Clearfield 48:33
it’s exactly okay. For psoriasis, do you
48:37
I’m curious. Yeah. Oh, sorry. I just wanted to just chime in. So it seems like the commonality really, is that it has everything to do with the level of oxidative stress and that methylene blue at low doses, but like you said, taking or Dr. beamer he talked about taking the arginine are the precursors to activating nitrogen oxide, I’m sorry, oxidase synthase. It seems like it has more to do with the level of oxidative stress, as opposed to it inhibits this and inhibits that meaning that it’s almost like anything that is really high in oxidative stress. Then it gets buffered and so there’s an abnormality, when there’s that high level of oxidative stress when there’s not the high level of oxidative stress, then it’s not going to inhibit anything. Is that a good way to see it? Do you think?
49:43
No What do you think? Sad again. What Dr. Joseph
49:52
saying is sometimes sometimes we’re looking through the lens of 100 different things that that methylene blue effects that it didn’t this and increases that inhibits this, but really it seems like it’s only buffering things are affecting things that are having too much oxidative stress, right? That’s exactly under a certain ceiling of oxidative stress. It’s not affecting that. Is that sort of that that’s that’s kind of resonating.
Bill Clearfield 50:19
It is. Yeah. So let me
50:22
protect your Joseph that ties in with some of the comments that you’ve made about or observations that you share with us about your patients, which is, you know, with some of these redox related therapies, the patients that are kind of worse off or at a more dire situation or quote unquote, have worse oxidative stress, tend to be the better responders or have a more significant response and then you know, somebody with a less a lesser degree of dysfunction, you know, there’s there there is less impact.
50:52
Yeah, absolutely. Like so somebody is just looking to feel like they’ve got more energy or the more focus that they’re already fairly healthy. They take the methylene blue and not necessarily going to feel this like surge of energy. But it’s not like it’s not doing anything it’s going to buffer against anything happening. That’s the way I see it. But yeah, those that that are very sick in fact, they treated somebody with IV methylene blue that was having a cytokine storm about three years ago. And he went from, you know, barely being able to stand up to and he was lethargic to standing up and having a normal conversation. So yeah, it seems like it’s the level of oxidative stress. You know, when we do take the methylene blue, either IBD or orally, that that’s when you really feel it. That’s what makes that big dramatic difference. All the other things are going to be sort of subclinical and almost always positive effects, even if you don’t feel it
Bill Clearfield 51:57
well again, so the point is that, you know, in high doses high high nitric oxide is especially in like surgical situations is not a good thing. You know, we’re you know, the nitric oxide people are always telling us more, take more, take more, take more well, you know, there’s a ceiling here and you know, sometimes we can get in trouble you know, having too much on board and so now you have at least we have in our pocket something that we know that will that can reverse it, you know if necessary.
52:26
Great idea. Yeah. Great. Point.
Bill Clearfield 52:30
Mike, maybe you can help me with this for psoriasis. Do you use tarp? I’ve never had had this topic.
52:34
Okay, we’ve we’ve had some people do this. Let me tell you about what methylene blue topically like from a dermatology point of view. I’ve used it quite a bit on different things and what I will tell you in my opinion, is that without phototherapy just methylene blue like you know in a in a cream. It’s about it’s about as strong as it is a lower strength or medium strength steroids so like I’d compare it to Flo sit alone maybe bet betamethasone valerate or triamcinolone. You know, it’s in that category. It’s not stronger than triamcinolone in terms of of the effective cholsey But it’s not like clo beta Sol where like we’ll give psoriasis a complete kind of beat down but so called beta Sol is a big concern because it is the go to drug or even Halo beta Sol for psoriasis and that really does damage your skin. Dermatologists never talk about the systemic effects of absorbed super potent steroids but they must have some systemic effect. You know, so I think if we can use methylene blue, I think in combination potentially with a mild steroid for a balanced effect. I think that would be really good. Dr. Hepburn has used a both methylene blue and ivermectin in her practice of dermatology and kind of evaluated it for psoriasis with good results and phototherapy as your lecturer Dr. Bill mentioned, that is great with psoriasis that is very bad, and a person that a candidate to use the biologics and doesn’t want to use them using topical methylene blue and photodynamic therapy is like a big gun treatment for severe plaque psoriasis
Bill Clearfield 54:24
Okay, and maybe apropos of nothing but BPC 157 also contract sort of counteracts the long term effects of the potent corticosteroids. So really, it’ll actually reverse that reverse, kind of topical topical or even injectable you know, we will do it I am so it makes it easy. It’s hypertension a contraindication. I don’t think so. Mike What do you say? I don’t think I’ve
54:55
ever seen probably got hundreds of patients on it. And I’ve never had one person come in
Bill Clearfield 54:59
or five not either. Is it safe to use with saline or just dextrose? We usually put it in
55:06
the five that’s a really good question. I get a lot. Do you have an opinion on that bill?
Bill Clearfield 55:09
Not really. I mean, we just use the five W’s. So
55:13
I do recommend D five we’ve had people do saline. But one thing I will say about injectable methylene blue is it can’t clump. And one of the things is is really important that it’s not refrigerated and you don’t take it out of the fridge. You know and just use it it tends to clump or even fall out of solution when you put the injectable product in the fridge. So be cautious about that with clumping and I know you can see it sometimes in the line that you know and so and that goes cause people concern so we do recommend using a filter with it just to be safe. I don’t think that there’s any problem. Really that would happen if like a little if a pedal you know if there was some kind of congealing and there was a higher little temper because you’re giving it very slowly hopefully, but you know, but I think my impression and I can’t speak to this for the technical or scientific means but I think sailings more prone to clumping index groups. Rookie five so if you can use D five that’s a better choice. That’s
Bill Clearfield 56:17
yeah, I just I don’t bother with we know we know why
56:21
why not? I know what the instructions say to why why?
Bill Clearfield 56:26
I mean, you know, that’s not something we need to we need to you know, stick our neck out on our necks outs out far enough as it is.
56:33
No, I’m with you. Yeah, I don’t recommend it. Yeah, okay. There’s
Bill Clearfield 56:35
has there’s a mix carry IV methylene blue.
56:40
We do it’s it’s a lot cheaper. To use to be guys. It used to be like 1500 bucks for the probe a blue or whatever. And now it’s $275 which is a great decrease in price. But it’s still pretty expensive. That’s 400 milligrams of IV drug. So you know, it kind of get expensive. We do have I think with the new popularity and public publicity that methylene blue is getting more of the ivy pharmacies to do sterile pharmacy are getting interested. So I do have somebody that we’re talking to that’s kind of kicking tires about how much they might be able to sell to help get that phrase down a little for
Bill Clearfield 57:20
how about the price? That was 100 milligrams. You said?
57:24
Yeah, it’s 10 milligrams per mil, and it’s a 10 cc vial. So so total 100 milligrams, and then that’s 275 bucks. You can shop around by being tried to find it and Henry Schein and that’s the best price we can get is about that.
Bill Clearfield 57:40
What about what about the oral?
57:43
The oral which we are very reasonable on it because he saw a lot of it. We’re about I think the highest price is $1.20 a capsule. would anybody buy the 100 for about a buck apiece basically a buck apiece for a little bit.
Bill Clearfield 57:54
Does it end there well under to any dose or?
57:58
Yeah, now I will say this guys, we’ve been getting higher doses because I’ve been working with the Lyme Disease Society i L A d s group, and they are accustomed to using some higher doses than we’ve used in our group and we aren’t having any problems but they’re getting getting people 45 and 50 milligrams twice a day. So we’ve gone up to carrying capsules up to 100 milligrams or I think maybe 120 milligrams even. Those are a tad bit more. But they’re all the most expensive ones like $1.50 So then
Bill Clearfield 58:34
if it has any depressant effects, should it be tapered off when about the stop? The same just like any other Mao Mao inhibitor I don’t think there’s a whole lot of you know, withdrawal from from them
58:47
by itself if you just have a patient on methylene blue and they’re not on an antidepressant. Yeah, then I don’t think you need to do much team. Yeah, I don’t know. I don’t. But if they’re all in one, then you’ve got it. They got a different matter and you got to have a case by case talk.
59:03
Can I have something? Yeah, so I you know, I’ve had several patients asked me about that because they looked online and they see that and of course they get concerned which I can understand. When I do the literature searches or the last literature search I did on this. I had about four or five studies come up. And they were basically the only studies that I found, and they all seem to be with sort of more drug overdose scenarios. We’re talking situations where a patient came in they had taken up an entire bottle of Zoloft, an entire bottle of the effects or an entire bottle of clonazepam and they’re using the methylene blue to help buffer the redox to detoxify the toxic effects to keep the patient alive. And of course they have to get very, very high doses of methylene blue, we’re talking up to around 2400 milligrams in the span of 24 hours. And yeah, the patient was a case study, the patients started to exhibit signs of serotonin syndrome, for which they I don’t remember exactly how they addressed it. I’m sure they turned the methylene blue off at that point, but it wasn’t significant, and the patient ended up surviving. And so and I don’t want to, again, stick my neck out too far. But that was the common thread. There were other cases where they gave methylene blue during the surgery. And again the dose was pretty significant compared to you know, what we typically take and so the point is, these are more extreme cases and the cases that were present presented were not cases where patients you know where they died. These are cases that patients exhibited signs of serotonin serotonin syndrome, but but they ended up sort of being fine afterwards. So to say, for our low dose says that we’re using no you have to get off of your antidepressant, I think is I don’t I don’t think that we have anything to be afraid of with moderate doses of antidepressants,
1:01:39
and I agree with Dr. Yeah, I do. I do agree with you that this is a common question. It’s really important one if you guys want to talk about it for me I have talked to some psychiatrists about serotonin syndrome, and MAO inhibitors and anti depressants. One of the things they have said to me is that it’s slow onset, it’s not usually something that happens quickly. It’s very dose dependent. And we are using pretty low doses methylene blue but we are talking about raising them and I am seeing dosages kind of probably nowadays, we’ll probably the average dose is double what it was when we started this. So and that’s I think good because we’ve all gotten more confident as we learned. But I agree with you I think some patients can remain on an on an SSRI or something without having symptoms. I think you just have to monitor and also make sure they’re not like failing to tell you you know what I mean? Like they’re like, I’m not going to tell you I see a psychiatrist little little medications I’m being given your My integrative medicine doctor, you know, so make sure they share it with you, because the people that we have had on methylene blue and I prescence the doctors were not told you know, by the patient that they were on antidepressant, but the psychiatrists basically say is they don’t expect to see it and think of it this way. If the person’s on 10 milligrams of citalopram. You could probably double that to 20 and there’s not going to be any problem. So there’s not this huge problem with methylene blue because it would be like it’s not going to be as significant as doubling the dose of the antidepressant. So but if they’re on you know, 300 milligrams a day is Soloff. And there I will be trained to go with it. Then we got that’s a high risk patient there. So it really depends on what antidepressant they’re on what the dosage is, what they have life they have a depressant is and how much they need it and whether or not they can stand the dosage increase anyway, so you just got to sort all that out and I’d be happy to. I just I always tell everybody, just do it on a case by case basis and ask get constant.
1:03:37
You ever question? Is it truly a side effect or is it that the methylene blue is you know, by optimizing mitochondrial function buffering redox intracellularly in the neurons is improving their function and improving the amount of neurotransmitter production naturally, then, that is the medication itself that is overdoing it. You know, the antidepressant that is, you know, is working too good. You know that, oh, things are
1:04:11
happening. Dr. Joseph like when you when you inhibit monoamine oxidase a, you’re inhibiting the metabolism of all catecholamines. You’re you know, I mean, so so it’s not just the serotonin and norepinephrine and some of these other things, too, can go along with it. So, but I agree with you, it’s a I think it’s a fairly mild effect and and low doses of antidepressants because you don’t see a problem with other chemicals.
1:04:38
And so and so it’s inhibiting and in my way, simply because in that scenario, then it must be because MRA is having, you know, a much higher redox reaction,
1:04:52
just direct it’s incorrect. It’s a it’s just a direct antagonist.
1:04:57
It’s just a direct antagonist, so it’s not He’s alive.
1:05:00
He’s from metabolism. Methylene blue competes for metabolism with catecholamines. At Mao a, as Dr. Clearfield pointed out,
1:05:09
okay. All right. Thank you. That clears some things up.
Bill Clearfield 1:05:14
Hydroponics, I know his body anemia,
1:05:17
you know, is my question. I don’t know what that is. I know it’s really serious.
Bill Clearfield 1:05:21
To Hemolytic Anemia is what it is. So he can come from propylene glycol, that’s the usual
1:05:27
source. Is it reversible or is well again
Bill Clearfield 1:05:31
methylene blue is a is a an antidote. Okay. So, okay. So, and again, again, it’s you know, depends on the severity of it. G six PD deficiency, you know, quite frankly, I don’t know if I’ve ever seen one, but, but, but I patient had one I wouldn’t. I probably wouldn’t, wouldn’t just stay away from methylene blue. I don’t know Mike well, how you feel about I agree.
1:05:55
Yes. contraindication.
Bill Clearfield 1:06:00
What level of GFR should methylene blue not be used? I’m probably under 30. Under 30. Any evidence? Yeah, I think we did mention a non alcoholic fatty liver disease. Use it with an acetyl cysteine and photodynamic therapy. Again, one to 211 to two milligrams IV for two days and then five to 10 milligrams twice a day. You can use that for several weeks actually. So
1:06:35
if you didn’t if you actually ever tried it, because I tried. I never noticed any difference on methylene blue at any of those. Like performance wise or anything for myself at least.
1:06:49
Are you talking about taking methylene blue yourself? Yeah, I’ve
1:06:51
taken like 1020 30 milligrams. I’ve tested it out on the tennis court to see if it changes my ability to play or perform I need to haven’t noticed any difference.
1:07:01
Okay, that’s a great that’s a great anecdote I that’s a really for coming from you. That’s really good because I can notice some differences myself, but you know, I’ve been on it for a long time, you know, but yeah, it’s interesting, like what would happen if you took you know, a 100 milligram dose, but you see a change in your athletic performance? Yeah. I yeah, I That’s great to know. I don’t know I
1:07:22
like on that note, that goes back to what I said earlier. I mean, if you’re, you know, you’re a peak performer, you’re healthy, you’re younger, you’re your body is already buffering the redox and balancing oxidation reduction reactions, appropriately so, so any advantages with the animal subclinical just just as a generalization and that it’s the, it’s the patients with with uncontrolled diseases, high levels of oxidative stress, that are the ones that actually feel a difference more dramatically. Does that resonate? Yes, yeah, definitely a
Bill Clearfield 1:08:03
motor measuring it starting to stop lifting weights all the time, Steve.
1:08:08
Nice to find this the problem here.
1:08:10
Yeah. The other thing is that he said, I didn’t notice any difference in my performance. The question is that are you comparing it to creating those ones or storing the ATP is it’s going to be different. I mean, mitochondria activates that mitochondria, but it does not really cause increase in the storage of the ADP versus creatine when we use it for increasing the detriments and performance. So here’s the thing. It’s it’s and it’s good for intellectual and cognitive function, but how you can measure it and how you can detect it. It’s just, it’s difficult to be that on a subjective way. There’s a reason.
1:08:52
Yeah, I’ve prescribed it a couple of times that I’ve had maybe two or three female patients, they’ll tell you like they felt fantastic they felt like described as Super Woman, and it seemed to last couple sessions and then I get it saturated, whatever it was to saturate and they felt no further benefit after that.
1:09:09
I think you’re exactly right.
1:09:12
And so they give them that happy molecule does give them the kick. They want more of that kick. So when they did reply to then they say, oh, there’s no way a difference. It’s relative. It’s, I don’t think you know, you can assess methylene blue, by by your own self, you need to really have some objective way of measuring the efficacy of maximum
1:09:38
bid now. I bought a hyperbaric chamber is coming in the mail this week. We’re wondering if we’ll combine methylene blue with the hyperbaric and maybe we can see some potentiation or synergy
1:09:48
there. Yeah, I’ll come over and try that.
1:09:53
Yeah, you know, I really do see methylene blue, just again, just as a generalization is for myself as an insurance plan. You know what I mean? It’s, you know, it’s an insurance plan. It’s like, I don’t want a one it’s like having an umbrella to cover for any, you know, you know, steep increases of oxidative stress or you know, we don’t know when we’re gonna get hit with the next variant or whatever is coming at us. So so having the methylene blue on board is that is that you know, that buffer against the extremes and then you know, having the the light available we had so we the gentleman at church, he he literally he had the worst chronic sinusitis. I’ve seen that in the wildlife, I actually treated him with two rounds of antibiotics, both for two weeks and he still had pain in his cheeks he, he said very, very thick nasal secretions and just miserable. And then we gave them methylene blue in the nasal spray with the intra nasal light. And within a few days, he felt that he was cleared up practically all the way so we just let them keep it just keep
1:11:13
and when he when he did his nasal why she said the first time and he could not remember that he didn’t have anything come out in the nasal watch. No green, no yellow No, no scabs. He was very very pleased.
1:11:30
Yeah, that was rapid and you know, these these, these people they don’t exaggerate the you know, this is very real. That was very dramatic, something I had never seen before until using methylene blue. So, you know, the greatness and the beauty of it is, is in certain situations, but I understand, Stefan, you know, you’re you’re trying to optimize your athletic performance and it makes sense. I mean, if you’re, if you’re oxidative stress levels are going higher as you’re you’re working your body more or you know, or maybe it’s helping with the mitochondrial function, but I think in your situation still, you know, because that umbrella you’re, you’re still in the sweet zone. Those oxidative stress levels are not so abnormal, abnormal enough to buffer or maybe the effects are subclinical, it’s just hard to measure. But yeah, you know, there are situations where people can absolutely feel it but I understand your situation now and even in my situation, I you know, I thought, you know, I was when I would run, you know, is it helping? It’s not helping, it was very difficult to tell. Yeah.
1:12:45
Something very, very important to hear and appreciate. That will help to detox spike proteins. And the only drug that helps to prevent spike protein to polymerize into into prions into premiums, which leads to Alzheimer, and evidence of that Gribble company, which is a company who were selling compounds in plasma, in order to make sure those guys Mark completely free from any germs, whether it’s viral bacteria, or fungus, they put methylene blue in it, and then they pass the red light on it just to disinfect the blood completely from any germs and the methylene blue does have a tendency to attract a spike. proteins. It also has a tendency to attract to any viral RNA or DNA, bacteria, DNA and RNAs. They just have more tendency even with big viral than then then your own cells, DNA. And so it’s a detox for the RNA spike vaccine or vaccine injury and also as we talked for, for the protein itself, that itself I would definitely recommend it for all the patients who are meaning COVID. Post COVID syndrome or COVID. Acute or I think it’s the best treatment for patient with with vaccine injured from from the spine protein. Oh, the speical according to Dr. Celebi, spike up and
1:14:20
over again. Well here Our next question is that lead Dr. Clearfield Did you mentioned anything in your lecture about recurrent UTI
Bill Clearfield 1:14:27
no I don’t I didn’t didn’t really come across anything like that. I
1:14:31
I wouldn’t discourage that. You know there is a you didn’t find anything either. I didn’t. Yeah, I’ve been asked about that. I think what it was like when you said the UTI. Well, hold on a second. There used to be an FDA approved drug that had 50 milligrams of methylene blue in it. And with datamine and some other things. It was an old time drug. And it was removed from the market for lack of effectiveness for UTI and because you know that we got Cipro and some of the other things are working better. So I wanted to bring that up but I have not people I think remember that. But I don’t know how effective it really is for UTI and I haven’t really kind of
1:15:12
it’s very effective, right? Dr. Joseph James has a case where all the antibiotics failed to manage her doctor’s visit. Do you remember that case when you give her methylene blue? either? Oh, yeah,
1:15:24
this was a case with this was a young female 20 years old who had recurring surgeries like multiple surgeries like 25 of them for your other stricture your readers the year you read.
1:15:42
Flex reflex
1:15:44
reflex. Yeah. And so she had significant stenosis regardless of how many delimitations they did. And so she she had sort of a persistent hydronephrosis all the time in both kidneys. And the particular situation was she she had, I believe it was the Delta virus infection which was more severe and she was really having difficulty and so she was in Texas, Houston, and her mother was was very concerned and so i i overnighted methylene blue to her. And she got it just in time and took it. She was just about to go to the hospital because she was feeling like she was having some difficulty breathing. Also at the same time, she she knows when she’s having kidney infections because of the the level of pain was increasing. And then she kind of kept sort of a chronic sort of pain in our kidneys as well. So there’s probably some, like a low, maybe a low grade infection all the time or maybe pressure and well, not only did she improve pretty quickly from the COVID infection, but after she finished the methylene blue, I think I gave her about 10 or 14 days worth. She She told her mother, she’s like, wow, you know, my kidneys actually feel great. What is that? Stuff? And so, you know, without having a any objective lab testing, it became obvious that the methylene blue would would be very effective for her to take on a regular basis, not only to you know, and I gave her a red light as well that she could shine, the one that has very deep penetration, two prongs, a very deep front of penetration that we were using for more deeper tissue cases that she could aim at or kidneys as well. But yeah, that that’s a great situation. Where the methylene blue was a true hero. Hero.
1:18:04
That’s awesome. Yeah. Okay, well,
1:18:08
yeah, so you know, I don’t you know, not say that and I’m not trying to exaggerate to make methylene blue look better than it actually is. But those are real cases where that was the prime determinant, just like with the cytokine storm, or, you know, extreme situations chronic hydronephrosis and why not, try methylene blue if you’re having a, a low grade UTI, and you can even eight if you have a red light, a more penetrating red light, you can aim in that the bladder. For apps, maybe that works. Why not try?
1:18:47
Yeah, you bring up a good point. And that brings us to our next question. And by the way, Dr. Claire,
1:18:51
can you go ahead and see the study here they’re putting it on.
1:18:54
Yeah, there’s one here and, and this is the drug I was talking about with methamphetamine and and, and notice they call it a urinary antiseptic. They’re not calling it a urinary, you know, antibiotic, antibiotic.
1:19:10
It was it was a spectrum of killing all the germs and the biofilm without much resistance. It’s not just for bacteria, but it’s I think it’s, I think it’s a good this is a good study.
1:19:24
Do you guys know what Methamphetamine is? A theonomy breaks down into formaldehyde in your urine. So it’s actually creating formaldehyde in your urine. And that’s, that’s the active ingredient in that drug really? Methylene if
Bill Clearfield 1:19:41
I can add in a one that I’ve used quite quite a bit for a long time. 30 years as Barry Burgess will Garrus is a homeopathic remedy. And that’s quite effective for pretty much any type of urinary any type of urinary issue. The liquid is better than the than the than the the pill form. We’re having trouble finding the liquid these days. We’ve we’ve had we’ve had successes where we had a one year old baby was going to have a nephrectomy, and we gave it the the very Baris and save the Save the baby’s kidney on it. I had chronic urine urinary infections pretty much for its whole life. So we gave it some of that and six weeks later, six weeks later, urine was cleared and surgery was cancelled cancelled and that was 15 years ago. Still, it’s not a baby anymore, and it still has both its kidneys. So and we’ve used that a lot for patients especially females who have chronic urinary infections, it seems to work quite nicely it’s it’s very non toxic at all. That pellet forms not quite as good as the liquids and I don’t seem to be able to find a liquids these days, but But it works quite nicely. So that would be probably my go to before methylene blue, but that’s just me.
1:21:05
Okay, well done. We got another question for you. I think you’ve covered this in your slides, but you might need to dose for malaria and dengue.
Bill Clearfield 1:21:16
What is I don’t have it off the top of my head raising real
1:21:18
high dose was like 60 to 120
Bill Clearfield 1:21:20
milligrams a day. I think it was I’d have to go back to the slides and see that
1:21:27
we could look that up but it’s gonna be in the it’s gonna be and you know, the other thing just a dosage. Two milligrams per kilogram is about as high as you want to go before he started to see side effects and some of these studies are recommending dosages higher than two milligrams per kilogram. So just be cautious that above two milligrams per kilogram, which is a stout dose, that could be a 150 milligram dose.
Bill Clearfield 1:21:52
Yeah. So um, I’ll make the you know, I don’t have it right now off the top of my head. You know, once we start talking about things that my my mature brain is starting to get a little bit sort of confused here. So
1:22:11
it will be in your in your references because you referenced all your studies. So what’s the next connected question we have is, let’s see. Oh, dermatology of methylene blue. Here you go. I think because the ivermectin topical yes. The answer is less than 1%. So yeah, that’s ivermectin and methylene. Blue can be used together and topical is 1% of the ivermectin dose, the methylene. Blue dose is point 1%. Okay, question for you. Dr. Clearfield does methylene blue increase vitamin C uptake or decrease or can you use together in an IV?
Bill Clearfield 1:22:57
I wouldn’t use it together. Again, this is another one that I’m usually not sure about these things vitamin C seems seems to affect a lot of other substances so I usually try to do that separately. I don’t know You know, you probably know better than I do. Mike. I agree. But you know, it’s used for you know, a lot of in a lot you know, as as an anti any viral and any anti bacterial and then use it with a lot of other substances, but it seems to lice, some some, some nutrients and, you know, sort of inactivates them, the main one being glutathione. So you really need to keep those separated. Does methylene blue increase IV I know I don’t know the answer to that one. You know that when Mike
1:23:45
bio does methylene blue note he says is there a benefit to pass methylene blue ID through UV lights before it goes into patient? No.
Bill Clearfield 1:23:56
No, the question the question before IV does methylene blue increase IV vitamin C uptake? No. Okay. All right. So methylene blue and biofilm Yes, Candida? Yes. Yeah. Is there a worry about any supplements or medication interaction? Yeah, the SSRIs you know, the antidepressants that those are the ones you need?
1:24:22
St. John’s Wort right. So,
Bill Clearfield 1:24:23
Sammy also, me I recently prescribed my liposomal methylene blue and capsules the bottle indicates needs to refrigerate you mentioned not refrigerating. Again, you need to refrigerate the liposomal ones Mike.
1:24:43
Yeah, let me let me clarify what I meant. When I was talking when we were talking about that refrigerate it what I was talking about is if you like for example, if you take and you and you have a vial of sterile methylene blue, and let’s say you make up a couple of bags the day before for your patients coming in the next day, right? Let’s say up to patients command or you make them up that morning, and then you throw them in the refrigerator to get cold and keep them cool, you know, and hopefully sterile and all that kind of stuff. The question is, don’t do that. They need to be really at room temperature before you administer it. And same thing with the vial like don’t put the unused portion of the vial in the fridge or space, the good place to store it. But if you’re going to use it, you need to really let it come to room temperature. Shake it good and make sure that you know it hasn’t got any like congealing of the methylene blue in it or anything like that. So that’s just what the sterile now with the liposomal stuff. Really what that is is liposomal cream and they’re just putting it in capsules. Okay, so yeah, you can refrigerate liposomal capsules. I’m not sure how much that’s needed. We know that methylene blue penetrates really really well but maybe for cancer therapies that’s needed or something like that. But yeah, I would follow the manufacturer or the pharmacies instructions. If you bought something they say refrigerated I would do so that just from my comments were regardless, the IV and IV admixture. Okay.
Bill Clearfield 1:26:14
Even if the vial has been punctured methylene blue still not needing refrigeration?
1:26:18
That’s a good question. Now the vials are single use vials they are not preserved. Okay, so there is no preservative in it other than the methylene blue. So yeah, if you’re going to puncture a vial, I think it’s best to use the whole vial and make bags. If you know what I mean like especially if you know that you’re going to use them very quickly, like within one or two days. You know, you might just make up your bags and put them in the fridge and then just be done with the vial. Technically, a non preserved sterile product once you puncture the vial, you know you’re supposed to use it maybe within 24 or 48 hours or toss. it But I would definitely recommend refrigerating that. the key is we refrigerated for sterility reasons and that’s a good thing for sterility. But it also the reduction in temperature causes the methylene blue to be less soluble in water somehow And it just tends to clump more. I’m not trying to overstate this because I don’t think it happens often. And don’t think it happens every time, but it’s just something that can happen. So I’m just calling your attention I have had phone calls with people who literally had a patient with the IV and there are when they’re like there’s a club and the line, what do I do so.
1:27:42
read it before it was something that was my point. Yeah,
1:27:45
it was very interactive. So I don’t like to mix it with anything unless you have a filter if you have a micro filter and all that you’re safe because nothing would pass above 100 nanometer but the monkland blue is an antibiotic is very it’s preservative itself shine red light on it, if you want to warm it up just right next to you. It just helps to kill any germs anything like that. But again, you know, trying to use them, it’s better to use the whole thing. So just to keep a peace of mind. And I think you need to have patients scheduled for that day where it will be worth it to open a vial or it might be what will come up with smaller IV doses if necessary.
Bill Clearfield 1:28:36
Yeah, I tend to do something like this. I get it and you can use it right away. So it’s not sitting around so yeah, absolutely. For sure. I learned that one the hard way would exosomes I had a storage tank that had 10, exosomes in it and defrost. So if you know how much those are about $40,000 worth of exosomes that you know down the drain so that that happened once that’ll that won’t happen again. That was that was not a good day. It’s a bad day.
1:29:11
Dr. Patel and I have a question regarding the dose. What we are seeing the dose to be used, but when I use that those two milligram or even one milligram per kilogram, it’s very high. dose for delivering in by intravenous route. When I’m doing more than like 10 to 15 milligram patient starts having some shapes and some reactions. So So I have a big question that how many of our attendees are using the IV methylene blue and have no reaction at the doses which you are mentioning? I think well
1:30:05
above 25 milligram at once. Yeah. IV test because I think it’s enough to even for my dad when he has that problem. I did recommend to him five medical recommend IV 100 milligram at all. And I don’t like to be recommending those I don’t is because we don’t have much of cases to prove it’s there’s any difference. Like there’s anybody used 100 IV, I mean, all I will, I’m okay with that. But I believe it’s a different scenario.
1:30:35
So that’s what I want to just make sure that everybody understands that if they end up getting the IV methylene blue and start injecting and patient having reaction they don’t know what to do next. So patients many times have chills. Now I have I’m not giving more than 15 milligram and I have not seen reactions to the patients those who experience the reactions. They don’t want to go even near it.
Bill Clearfield 1:31:06
So is it the dose or the or how fast you’re running it?
1:31:11
No, we are not running fast. It’s the dose. I mean, I don’t think that you can I mean to 250 ml bag. You can run an hour and a half. That’s not fast.
1:31:27
Yeah. Dr. Patel, my understanding is that your patients are are pretty ill and yeah,
1:31:35
that’s it yeah. You said all cancer patients cancer patients
1:31:42
yeah so so I’m totally agree with you that you know, we we have to combat this conservatively even though the the literature says there’s a certain amount of milligrams per kilogram and I’m just, you know, coming from an intuitive standpoint, even the gentleman I treated with cytokine storm, I believe it’s 10 milligrams per milliliter correct for yes, the okay and I believe I only gave him one, one cc in a bag of 500 cc bag of normal saline, and he improved dramatically, but you know, I can’t really but he was in his home. You know, I can imagine in the hospital setting in the emergency room, you know, that’s the place to do the very, very high doses. Like I said, the one case of drug overdose of antidepressants and benzodiazepines. The patient was given you know, somewhere around 100 milligrams of methylene blue per hour.
1:32:49
So what I’m using in the long haul are with the with the, with really a problems with the neuro inflammation. So if if the organs are not working Africa effectively, would you give IV which I’m thinking of giving one patient who has come with the wrong color, nothing is working, dried, oral, but it’s not working well. So if I give her IV do what would I expect her? I mean, good effects, yes. But what would be the the side effects that that I should be ready for?
1:33:35
Again, if you do 20,000,025 milligram you don’t go above that. I don’t see any side effects will happen. And you will see the patient has more clear, vivid mind and the fog is a runaway Do you know that if you take a tough so that patient just one hour from Jake from doing the methylene blue, our brain is literally blue in color, like blue blue. So that’s the the reason why I like ivermectin versus I mean methylene. Blue versus ivermectin for most COVID. Because I remember that not penetrate the brain. We don’t want it to be penetrated the brain.
1:34:08
This is a long haul. Yeah. She had we didn’t November. And
1:34:17
the neuroglia gliosis. They have the neuroglia gliosis is causing belongil. There’s inflammation of their brain and that’s causing the brain fog. And you are both your visit the mitochondrial function plus you’re inhibiting that yet 17 With methylene blue, you will not get that results if you’re using ivermectin with those patients, so I will do like IV methylene blue. I will expect the patient would have with their their brain fog will be cleared after that. And in addition to other things you do oxytocin NAC things that we talked about
1:34:55
you Yeah, I was gonna say you know my
1:34:59
ID or you would you give neck as a oral
1:35:03
IV to, to in this case are severe and you want to get some rapid results you can give NAC IV you can give meds and blue IV you can also inject to international units of oxytocin, the roundup radical things like that or it’s a nasal. Those are three drugs that are and then Benadryl. I will definitely give them Benadryl 25 in the ground. 50 milligram at night, and now you can get Benadryl IV as well and they will feel very good by watching their butts COVID-19 And Raj and headache and all that stuff. And after one hour of IV Benadryl 50 milligrams she’s completely cleared. So Benadryl, methylene blue
1:35:46
and Mac I’d be asleep for a week. Yeah.
1:35:51
The one thing that my patients
1:35:55
Yeah, well, I’m gonna do a presentation in about two or three weeks on a mast cell inhibitor that I really, really really like. And I had to find it okay, because you’re right, there’s there’s we, you know, it’s hard to find. It’s either going to be sedation or it’s going to be not strong enough. And there’s one called up and Lexa Knox I can finally pronounce it. And I mean this this, this drug is it’s affecting the th 17 th one it’s MASL stabiliser, you know, because histamine Dhokla trains there’s studies showing its effects on neuro inflammation. It’s fantastic. It’s not today.
1:36:42
Those are you doing?
1:36:44
I’m getting it from pure pharmacy in Carmel, Indiana. And then 10 milligrams, three times a day is needed. And you know the names it’s one dose or it’s 40. Sorry, yeah, comes in 40 milligrams, and it’s 40 milligrams three times a day as needed. What was the question?
1:37:11
What was the name of the medicine? It’s
1:37:15
am Lexa Knox. So it’s A M is and Mary L E. X is an x ray. A n is a Nancy Oh x is an x ray. And now my The other thing I’m working on for post COVID You know for the brain fog part of post COVID long haulers because another thing you know, I’ve been focusing actually for, for physical performance on the methylation cycle and that’s a whole nother lecture. Like myself. I had my my physical performance was great. But I still had issues with brain fog, you know, some good days and bad days. But the other approach I’m going at is this idea that and they said it at the conference down in Texas, about the brain not being able to detox at night or how important it is. And this idea of the lymphatic drainage occur, having difficulty because of perhaps there’s difficulty in the pumping action due to hypertension as sympathetic overactivity. And you know, the functioning of the hypothalamus is not working as well, as you know, due to the neuro inflammation in general, but trying to figure out how to get that delta wave sleep, which is a requirement in order to get into the REM sleep in order to get the full detox effect. I think that’s the part that no matter what we do is inhibiting our ability to get past the, the brain fog part. And, you know, you know, and that’s where I’m actually considering. And people you know, how we think of sleep apnea is like, you know, you either have it or you don’t, I’ve been digging to think of it as, as an optimizing approach that look, if you’re not getting better, I don’t care if you’re 30 or 40, or whatever. We got to check it. I don’t care if you don’t look like somebody who has sleep apnea, we’re never going to know. And so optimizing sleep, just for the purpose of helping the brain to detox, I think is a fantastic idea. And then there’s delta, delta wave inducing peptide and nasal which you’re aware of. Dr. Patel, I know
1:39:44
nothing about BSIV DSRIP
1:39:47
is they now even make it in a nasal spray form? Pure pharmacy, so we start combining some of these things and then thinking and this is again, this is intuitive medicine here. I’m still looking forward at the, you know, direct evidence that hey, they took a long haul or put them on a CPAP machine measure, they’ve put them on a CPAP machine, and it took the SAP and they got better but I’m thinking that that’s the that’s the thing. That’s that’s stopping us from actually giving these people better. And I know from my journey, it’s just like, it seems like no matter what I try, all the things that should work don’t necessarily work and it makes me think I’m wondering if that has something to do with the sleep, that we don’t realize that we’re not detoxing or releasing the the, the cerebral spinal fluid or the production of the CSF in by the the fourth, the fourth ventricles are not able to get that fluid out of the brain.
1:40:51
Just you’ll remember that a while ago you were saying that you’re used summary. prednisone or called f I’m not too sure. Some some type of cortisone and you heard Heriot.
1:41:13
Watt Yeah, I mean, steroids fix everything right. The problem is the underlying problem is still there. So I’m having to take I was having exactly I’m having to take the low dose hydrocortisone. Yes, it allows me to function is great or a shot at catalog is like wonderful. But yeah, we agree. We’re on the same page. It’s not fixing the underlying problem, which is the inability of the brain to detoxify properly at night. Due to something
1:41:47
that it before. tightwad tyrosine I mean, a timeless in beta peptide that works on a neuro inflammation. And he works on that and
1:42:04
it’s great, it’s great, but what if there’s a there’s enough neuro inflammation that there’s enough sympathetic overdrive, and there’s just enough sleep apnea along with the brain swell enough brain swelling neuro edema, and there’s just enough sleep apnea?
1:42:27
Says Benadryl? Well
1:42:35
they have a very strong perspective about Benadryl. Okay, and we have two cases I think presented with Bas COVID-19. First of all, Benadryl is the best drug because it’s non selective antihistamine. So it covers all listing receptors. And when I tried to bring it up in FLCC they thought it because why because they use so you know, all those selected the new ones, them coming to Dean and all those ones those ones that not penetrate the brain and it’s not. It’s for allergy, but it does not get into the brain for the reason because they don’t want to have a scenario effectively. No, we want this today to affect the reason why, because most COVID-19 They have mast cell activation syndrome. And their brain is full of histamine. And the only way and even not just that, you know the neurons and reticular formation for insomnia. It’s actually histaminergic neurons. So you do have overactive histamines, and that leads to the insomnia. Now all the drugs that we use for sleeping, it does pose a problem next day which is a you know you feel groggy and fatigue and you don’t get the quality of sleep. Benadryl gives you the quality of sleep that you’re looking for without the side effects of addiction and rebounded dependency. And I would do recommend strongly because I see American in front of me especially with my wife, she has this problem and she went to the hospital I was not thinking but they will give her IV Benadryl and they give it to her, and in one hours she’s completely sold from headache, rash, fatigue, nausea, vomiting, all that stuff. So is the spike protein. You activate the muscle directly? Yes, we saw that. And when I presented the spike protein, activate the muscles and it’s part of the big part of the medical surgical scope. So giving Benadryl you can start with 25 milligram If the patient cannot sleep and if you don’t, the patient does not sleep as he doesn’t have deep sleep that you’re looking for. Whatever you’re doing is not going to work. And the reason especially to break code, because we need to detox the brain. Yes,
1:44:43
I do recommend of measuring the spike protein in long haulers or or the antibodies or anything measurement not not just the yes or no.
1:44:58
Do you mean you make this micro G and we can measure the history? Yeah,
1:45:00
yeah, yeah, there are people who are doing that. Yeah, there is. The patient ratio is Oh, I did that. And I It has not gone down. And I’m I have continued to remain sane. So there is not much reported on that. So I
1:45:18
don’t want to don’t depart with the mainstream medicine, the big pharma about detecting spike protein in the urine and the feces as a clinical they using it for environmental you remember when they went to the sewage and they are detecting spike protein there to know that there’s an epidemic or not that similar tests you can use for for a stool testing, but the big pharma does not want this test. To be FDA approved. The reason why because this will negate the whole idea about this is biodegradable, RNA and there are some patches are not biodegradable, they stay longer. So this will definitely defeat their purpose of selling vaccine and and it’s not something good for them to be FDA approving the spike protein testing
1:46:06
specifically about that. And Dr. Lawson was was there. Brian Cole is working on a test strip or this but and there is coming from the pathologies staining world. They’re working on something like that. But that is some lab. Oh, the antibody test is out there but they’re talking to like a home test strip or something that you could use in your office. That would you know, is not
1:46:35
sensitive. You want the antigen you want the gene itself on a spike RNAs, that’s what you want to detect, right?
1:46:43
They can stain it and you can use a UV light or something to see the stain.
1:46:48
The good Big Pharma does not want us to be practicing those FDA approval. For those tests. Because it will definitely damage our reputation of the vaccine when because they say oh, you know this bag or T will finish in a couple of days, maybe months and a completely or there will be no spike protein. And think about that we have those micro T continues in one year. So this vaccine is biodegradable. It’s it’s not true and they don’t want any company to be proving what it is. They are using it in epidemiology to detect let’s say if you have an epidemic in a certain area, they go to the sewage and they take the spike protein there and they say that the dynamic is high in this area because we detect spike protein in this image.
1:47:36
I have a question regarding if let’s say that the validity of doing the spike protein assay or not. So if you do the spike protein assay and if you find that many percentage of patients with the long haul. They do have persistent presence of spragg protein like like any persistent diseases like Lyme disease, they have a persistent positive presence of antigen. So if we find that, then our approach would be wouldn’t that be different than what we are? We are just saying the man who’s got paid for it? I understand that. I understand that. But just but but let’s say that if you have to really think if it is present, then how would we treat that for those patients?
1:48:35
Bedlam blue is the best way of detoxing, we know that metabolize affinity to attract a spike protein and not just that, even the spike RNAs and that’s evidence medlem Blue we use for viral infection, and it has a tendency to react with the RNAs. The other names of the viruses and bacteria are more negative redox potential than the human RNA so they prefer attracting to those pathogenic RNAs versus human RNase and DNase. So yes, so what I’m saying is that methylene blue is the best way of detoxing those spike proteins and RNAs. You add the Maglev, Benadryl, which is for the mast cell activation syndrome. I think it’s the best thing out there because we have publication for it. Then we add oxytocin, right, and then you had the MAC. I think all of this would definitely help and maybe some other kids 17 averages that Dr. juicer James, this dimension about it, it’s gonna present it and also KDP which I’m going to present it you know, the melanocytes stimulating hormone peptides, the three amino acids, this is a very good one as well. I’m going to present it maybe one month from now, but I think you have the tools now you have the Benadryl methylene blue Max goes in and many peptides that we talked about, and I think we have the ability to manage capaz COVID-19, especially when so many are very important. You know, if you don’t manage insomnia, everything you do is not going to work. So very important to ask this question. I use sleeping at night very well, and they don’t sleep at night very well, especially with this post. COVID give them Benadryl 25 milligram at night, and they will not wake up crying all that stuff. If they did not get the 2500 milligrams is not enough for them to sleep. You’re gonna go up to 50 I have a lot of people here in this room. They have some insomnia and all that stuff and and myself, okay because I also have what we call the irritable bladder syndrome. I wake up at night a lot because my I have neurogenic bladder, and because of the histamine blockers or anti muscarinic it’s just a miracle because now I don’t wake up at night as much with with with Benadryl, so it’s good for that. And then why I like Benadryl for some reason you don’t know is that 50% I have we have chance of having cats, right? Birds Well, according to book publications, it does help to decrease the risk of cancer because it shifts the immune system to th one and we already are only our immune system is compromised whether from COVID From the fungal infections from the environmental from the food is very rich with all those triggers of muscles. And because we are in this 2023 All of us we have some degree of muscle activation syndrome that increase the risk of having cancer replaying this cancer solely by us hit normalcy say religiously, or once a week or twice a week just to just my sleep and balanced immune system to prevent having the cancer because we’re looking for anything that reduced the cancer from flip of the coin 50% So this is something I was definitely recommended. On upset now especially with the lifestyle we’re living and the style, the city style and the food that we’re eating. Now if you talk about people are snipping in the mountains where they’re not exposed to those those carcinogens and are not exposed to those muscle activation syndrome, drugs or chemicals they may not need the manager but that’s because we live this plastic environment. And what are the things about plastic? I went to Dr. Bethel house and I have a dinner and she has the food of India is the best because they have the spices and all that so and although there’s no means it’s vegetarian but it’s so delicious. She might not use plastic at all. I didn’t see any plastic in front of me even the water bottles from glass and all of what she’s doing. It’s real. It’s working because those plastic that we have definitely triggered the mass activation and put us at risk of having cancer
1:52:39
let me make myself let me make myself clear. Sorry to jump in like this. I want to make sure that we’re clear and understanding what I tried to say earlier. I do take Benadryl okay, I do take Benadryl and and it has absolutely improved my sleep. And, and you know, it makes sense because, you know, post COVID Fatigue is mast cell activation syndrome, as far as I’m concerned, and the evidence is all over the literature. Or you could make that conclusion. The way I see it. Okay. And but even if you get a good night’s rest the thing that we don’t know, this is why I’m trying to introduce new people don’t actually know if they have sleep apnea, okay. And or they have mild sleep apnea and with enough neuro inflammation it seems that we’re talking about chronic people. We’re not getting better from anything. We’re not talking about somebody who took Benadryl and then they felt better. You know what I mean? We’re talking about somebody who is still chronically having brain fog, and you know, myself included, but I have all these tools to alleviate it. How come has not gone? Okay. Is it because my brain is unable to detox at night because I have sleep apnea? You hear I’m saying because I have sleep apnea. Now, F FLCC mentioned it in a lecture I’m going to listen to you know, hopefully we’ll have the recording I can listen to it, they get I spoke to an EMT very successfully and to everybody at that conference. We’re, we’re we’re amazing that there anybody you talk to was a superstar their BMT guy said I can tell by talking to you have sleep apnea. He said, People don’t realize it is the thing that you know, they get to a certain point and then they get whacked with some issue or disease or something and they just can’t seem to recover. He said it’s because you have sleep apnea. There is a famous osteopath in England. Now they they do more like chiropractic over there, and he’s developed something called the parent method. He’s become super successful with it as far as getting chronic fatigue patients better because he treated the the old chronic fatigue before COVID care came around with techniques, cranial sacral and and you know, last sinus lymphatic drainage and somebody went to one of my patients went to one of his trainings in Los Angeles. And she said, his technique this is what she said that she that was being taught to the people being trained that there’s there’s too much autonomic dysfunction, which is disrupting the ability of the fourth ventricle to link the lymphatic system that drains the fourth ventricle to drain it out of the head. Okay, so his technique is to is such that it affects the autonomic nervous system allowing for the lymphatic drainage to happen allowing for delta wave sleep to happen, because you need delta wave sleep in order to have that lymphatic drainage leaves the brain that lymphatic drainage contains the detoxing from the neurons that happens in the middle of the night. So my question is what happens if you can do that and it takes a long time, you know, the natural way like a couple of years is what she said, What happens if you have sleep apnea, but you don’t get delta wave sleep? You might think that you’re fine, but it’s never been measured, and you’re never getting better. You’re still waking up with a headache. You’re still having brain fog. Is it because you are not getting enough delta wave sleep, which is the phase where the detox detoxification, and the drainage of the lymph fluid occurs? That’s what I’m trying to say. So we can do everything, all these amazing things that we’re doing and we’re missing the big the big point. You see what I’m saying? And these people have long Howler there was an article that even showed they were able to show that COVID can get to the brain, from the skull, bone marrow, and from there, it’s into the cyst into the brain through the millennials. And they are able to demonstrate this and show this and prove this. As far as I know, this was a study out of Germany, this is recently recently put out there. So what if somebody is virally shedding because they have trouble clearing the virus, they’re getting a consistent amount despite leaking into their brain from from the skull bone marrow. They have persistent neuro inflammation, autonomic dysfunction, their brain is trying to detox at night, but it can’t quite because they’ve got a low grade sleep apnea, they don’t get delta wave sleep, and the fourth ventricle is unable to drain itself or that those toxins are unable to drain out of the fourth ventricle through the lymphatics out of the head so they remain persistently inflamed and yes, the the modalities that we’re doing are going to help, you’re going to make the patient feel better. And it’s going to help detoxify display, and the antihistamines are going to calm down the mast cells, but the cycle just keeps going. Because the underlying problem is still there. So that that was the big point I was trying to make. I think this is the big aha, something that I’m certainly going to dig deeper in. But and I’m actually going to get sleep study myself. And I go first, but I think I think we might be surprised that this is the underlying underlying problem that we’re we weren’t able to see before. Certainly wasn’t
1:59:01
a big question. We are seeing the bird Danijel. But as anybody’s seen the report that they you can get sleepy and better sleep at night. With Benadryl, but what kind of sleep is there? Is it a delta wave sleep or it is REM sleep or what or what kind of sleep is that? Because it has to it has to improve the sleep whether in a word phase, you have more time
1:59:33
you have this idea because in so many ways, this is a blocking. So we see that this is just more instead of using any other Steve help aids, which does not interfere with the pathology this is like you are stopping the histamines from causing insomnia. I myself when I take it, I go into deep sleep where I don’t even remember I mean it’s the only thing that we need to see if there’s delta wave or not with Benadryl. That’s why we’re gonna see it and try to figure it out or started to search it and see if there’s any publication on it. That’s the thing about some sleep apnea thing. Yes, of course, the balcony on the inflammation, ischemia, you will have, it will trigger an inflammation of the brain. Using glue is one way to help but basically they don’t like to stick oxygen in their mouth. So is there any other options that besides giving continued oxygen at night? I will try with them with Magnum to at night maybe help to definitely need to check the Doxy oximeter, but my love was very effective to PS oxygenation of the brain. I saw that a patient with COVID 19 her oxygen is like 50 and blood pressure is around 60 over 40 And when I give her the IV methylene blue, our oxygen saturation went up to around 80 to 90. It’s like a miracle front of you with with that case, and our blood pressure went up to normal. So those that methylene blue helps to increase oxygenation and helps to possibly maybe that will be another answer for sleep apnea. They don’t want to have autism. We want to try and see, especially for mild cases, but in severe sleep apnea cases you really need to stick that up to you know, do some sort of jaw surgery where you’re bored there’s many methods of helping to specially experimental apnea, to tighten up the throat, central happiness, it’s very difficult to treat. I don’t know anything that helps more than maybe methylene blue but there’s everybody knows about Central
2:01:51
and I’m 100% on board that you know the dry everything that we’re doing. I guess I’m talking about those that nothing seems to get rid of it completely. They’re still it’s going on and on for months and months. And I’m even thinking like, what if what if it was something where they say they showed up with mild sleep apnea? And then they did one of the conservative you know, masks or even like an intra nasal device, and it’s pressure, it just maintains the pressure that you know that you’re able to get that air and I don’t want to do that. Are you kidding me? Of course not. But if it’s maybe it’s something that you do for a certain amount of time until the brain inflammation goes away. If you see it from that angle. The neuro inflammation goes away that the brain is detoxing. We’re finally getting rid of the spike proteins detoxifying and that you finally get over it because my concern is that it just the longer we go with neuro inflammation, the more likely it’s going to turn into autoimmunity and other things, then it’s a chronic chronic problem. You know, if there’s a way that we can do even you know what a month or to have sleep of have sleep apnea treatment of the CPAP device, you know, and maybe that clears it up and maybe you don’t have to do it forever and ever everyday. But you know, I’m at the point now where I’m pretty sure most people if nothing else, is working. They’ll be agreeable, if they understand it, to say let’s give this a try. Let’s at least measure it and see where we stand because if you can’t detoxify the brain that this is more of an Aha. You know, again based on the the conference based on other things, other evidences. You know, I can see how how you just can’t get but in fact, we have the gentleman, the guy with the chronic sinusitis. He didn’t know nothing’s going to work for him. He’s got some other issues he needs to eat. Well, he actually has a CPAP machine he’s got that actually use it because his neuroinflammation at this point, I can’t everything I’m doing nothing seems to work. Then oxytocin nasal spray, and methylene blue is a situation where you know what, maybe we have to do the CPAP there’s just no choice and I hate that word. If it’s gonna work or not, I certainly don’t have a problem doing it. Alright,
2:04:25
regarding the question for Dr.
2:04:31
Dr. Colleen, Colleen, you bet you’ve been here Hellions using some methylene blue and Scott some other comments here but once you share with us what you got going on Colleen? You got to unmute yourself.
2:04:48
I know I just did. I’ve been talking to Dr. Clearfield Well, yeah, I’m just back when we were still on subject talking about urinary tract infections. I have a patient with prostatitis really causing problems for him to urinate. So I’ve just given him methylene blue. I’ll let everybody know what his reaction is. So let’s see I’m experimenting and I newly put three patients to with long COVID brain fog. I know actually three on 80 milligrams, B ID of methylene blue and one of Force One is vaccine injured. Of course I have the nasal spray with the oxytocin. I was giving them ivermectin I’ve kind of backed off on that after a week. And I did for measurements of what was going on lymphocyte map Cyrax laboratories and the array 12 as well as the viral Trio which is a lab test by immuno Sciences Laboratory. in Beverly Hills for EBV HVV six herpes and SARS. COVID. Two and all of them. All of them are showing extremely high levels of EBV and they’re fatigued and they have brain fog so we’ll see how it goes. They’ve only been on it two weeks now.
2:06:47
Right let me let me answer doctor but down the question about that. Benadryl and the delta wave. Here’s the article. They say slow wave sleep inducing effects of first generation that’s very important that we use first generation histamine antagonists which has been under one of them. And the prison study was reformatted to see if the first generation histamine antagonists are useful, sedated, hypnotic drugs. It increases the electoral EEG, our spectra of the Delta band Okay, and frontal cortex and the theta band, the hippocampus and also this edge a dash one and timeless used in the study useful in degrees. That’s a good thing in the sleep latency. So that’s mean it makes the people focus their birthdays, and instead of waiting all night to try just to get it to trigger the sleep and decrease that ingredient the sleep duration which is very important, which is the slow wave sleep which is the delta one and the rate the rapid eye movement. That’s one you don’t want to wander with a dreamy sneeze during the slow wave sleep was decreased by one antagonist. Four reduction in sleep latency from greatest to least. So what I’m saying is that I think everyone Benadryl is good for insomnia does not have my shows. Another word, early morning clogging and fatigue. There’s some people are sensitive, and that’s where you need to just do it. Some people 50 will be enough. Some people will 25 Too much above 25 is going to be too much for them. So that’s where you need to gouge the dose. But again, the reason I like it just because I saw published articles, I think either in Harvard or MIT clinic where it says that helps to it helps increase the immune surveillance against cancer. And knowing all of this and not only that spike routine is mast cell activation diagnostic, then I would strongly recommend at least twice a week or just to adjust the sleep cycle and the patient can go with all natural ones like glycine I hear about there’s a good thing about glycine helps in a natural way of sleep, but it’s very important to control or manage the sleep and then if you actually balcony of course, you need to manage your mental and blue does not work then I think giving oxygen CPAP it’s it’s critically important.
2:09:24
Okay, well, Dr. Clearfield Do you have anything you want to wrap up with already?
Bill Clearfield 2:09:31
I know it kind of got lost in the weeds a little bit here.
2:09:35
Well, we kind of got off topic which we stray a little bit sometimes Yeah.
Bill Clearfield 2:09:38
No, it’s okay. So this is let me see here. I’m not sure where this came from. Okay. Again, so this is you know, we tried to give you kind of a succinct This is how it works. This is what this is what we use it for. Anybody wants the slides, I can either send it to Dr. Her loss or just get in touch with me. And, you know, we’ll get to those. And, you know, you know, all good thoughts, all good topics. And so I hope you got like at least an overview or you know, sort of sort of system succinct way of thinking about using methylene blue. That’s pretty much the bottom line. So
2:10:28
yeah, well tell us about who you have tomorrow night. What do we have?
Bill Clearfield 2:10:31
We have Ken Crowley tomorrow night it was on here he’s you know, he’s he’s a regular for both of us. I mean, we’re doing he’s just doing cannabis one on one. So we’re kind of kind of starting over from the beginning.
2:10:45
We’re gonna start with the Beatles White Album and move forward. Yeah.
Bill Clearfield 2:10:49
If anybody if anybody’s interested. I don’t know Can I can I solicit just if anybody’s interested. I have a couple of students coming to Reno on the weekend of June 17 and 18th. And we’re going to do some hands on instructing we’re doing we’re going to do a hormone pellet insertion, we’re gonna do Botox fillers, PDO threads, and we’ll do some hormone cases too. So if anybody’s interested. And let me know. And there’s my email address. And if you want to come to Reno for a weekend or for a few days, it’s weather’s pretty good. And it’s row, Reno Rodeo weekend too. So there’s stuff to do here. So if anybody’s interested in that, those of you don’t know we’re on tomorrow night and every Tuesday night. We’re sort of we sort of do a parallel track with Dr. Hall ASA, and we have different topics. But we were sort of like linked arm and arm here, traipsing into the into the sunset. So so we have Tuesday nights on Zoom. And again, if you’re interested, here’s my email address, and you know, we’ll get you the link for that. Let’s like this, you know, it’s it’s free and anybody wants to present anything, please let me know. And that’s pretty much it. I guess. I don’t know. Anything else.
2:12:24
That’s great. That’s great. And I don’t want for coming. We really appreciate your time back.
2:12:28
Next Monday. We’re going to have I mean, Dr. Elizabeth, from FLCC. And she’s going to talk about COVID and kids. That’s going to be a very great lecture. Hopefully I guess.
2:12:42
I’ve seen a guy it’s very good. I don’t know if were you there for that Decker lesson. She presented she’s very good and she’s not very knowledgeable about vaccines. She’s been on the forefront of the pediatric use of vaccines. She’s one of the people who participates in like the governance and like her state of what vaccines are required by for children to go to school, this kind of thing. So she’s really got an interesting perspective on COVID vaccines and their role in children and all that kind of stuff. So in great depth of knowledge on other vaccines to and interestingly, she’s not all against vaccines, she really does like some certain vaccines and think they’re extremely important, but others aren’t up to par and she’ll give you the reasons why. But it’s pretty cool lecture. I hope you’ve enjoyed it. Okay, that’s it. Thank
Bill Clearfield 2:13:35
you. Thank you, everybody. We’ll see you again, and hopefully he’ll be on tomorrow night.
2:13:42
Okay, it’ll be great. Thanks.
2:13:44
Thank you. Okay, thank you, everybody. Tonight.
Bill Clearfield 2:34:52
They were absolutely working. Okay, the last two sets of points are actually centering points. This one right here is called Shin Min. For spirits gate. It’s a spirit Yeah. And it’s supposed to sort of open up the the upper consciousness to a higher list. In Chinese medicine, there’s a lot of flowery language that Hi, there everybody again, this is Dr. Bill Clearfield and this is our veteran Joel and we’re going to be performing Battle