Tue, Nov 22, 2022 4:28PM • 2:53:35
SUMMARY KEYWORDS
oxytocin, stimulate, manage, helps, patient, inflammation, increase, good, drug, decrease, inhibit, angiotensin, free radicals, hormone, effect, inflammatory process, part, system, inflammatory, interleukin
00:00
Got a work check it on yours just sign in just to make sure that the notes okay so yes all right so if you’ve heard for early day earlier okay just keep that we’ll just keep that open Hello. Hey how you doing? Great to see you here. So where are you located? I think you’re muted what doesn’t show it though? No. Are you in Reno is there can you hear me?
25:46
Yeah I can hear you. Can you hear me? Yeah, I hear you hey Doc can you hear me?
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Yep I’m going to be driving soon you know that cars.
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Okay here let me see if I can figure out what’s not what’s not working. I don’t think he can hear us make sure the sound is on at the bottom of the screen there.
26:17
It has to be because you wouldn’t be I wouldn’t be able to hear either. Yeah.
26:29
Thank you. So Nana owed email the first time last week. Oh, thanks. So like March 15 2022, or chronic fatigue syndrome. Oh, I think so. Okay, like that one. I thought that was the topic and also they saw different guys so I looked, and last Tuesday Wednesday sent out a thing for here.
26:58
Wednesday is Farshid summary reason? I don’t hear none of you. Let me try my iPad.
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Yeah, let me see.
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Yeah, I got this thing.
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Things started at 404 for Jacob Teitelbaum. Yeah, that was back. Back in March of 20.2, but I don’t know why I got it. Awesome. I thought you just switched the ice but actually it was my doctor about a year for a PhD. But you and I don’t do you know if any Lombardi
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a bill Bill, are you there to disappear? I’m here. Now. Do you know if any Liberty I’ll put you on our money Lombardi? No. He takes us out immunity. I’m shooting some other stuff but he
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used to be
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the head of the winmore Peterson foundation. That does work for chronic fatigue and other autoimmune diseases.
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So that you might know
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I’m involved with him we I he developed technology patterns to pull the smell out of the terpene the terpenes how the marijuana are odorless cigarettes. So that way if you have a joint you know, or a cigarette like that, you know, you won’t go back to work smelling like a doper.
28:53
So a message from Joel he can’t get any sound for some reason.
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Yeah, no
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anyone okay, I can hear you. Can you guys hear me now? Yeah, we can hear you. Gotcha. I figured it out. Before but
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that’s it your speaker was off or something? There was like my computer the other day that it turned off my internet. computer genius I finally figured out how to enable it so it would get my Internet back. So just like why right so I didn’t imagine that for like a day or you know, half a day or whatever. So, kind of a middle and I said okay, I’m gonna try it. But I’m always afraid because these messages come up that warn you not to do this and that.
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So all right, all right. Yeah. There’s the man. We’re good. Okay, give me a second here.
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Just get the horse up.
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So let’s wait 510 minutes right. So get the people going. Like 510 minutes. Definitely. All right. eyeglass.
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Got to have the glasses, right.
31:02
Yes, you should be showing up as William Clearfield now.
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Now that you can get your volume I’m on his computer. Oh, is that it? Okay. You got it. You got you got a good guy running the show.
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Oh, is that it? Okay, he’s running it. Resume you because you’re in your car. Okay, I get it. He’s on his way to Tahoe.
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Jealous.
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Yeah, it’s supposed to be a few nice nights.
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Right so Bill to get a b&b up there I stepped away okay.
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So, I was wearing Clearfield so you’re in Reno them? Yes, we share our safety eras given.
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Obviously, we don’t want anybody to die. What we’re built in the temple so there are certain compromises you’ll have.
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Joe, I’m going to mute myself because I’m going to be in a car and it’s loud. Okay. Okay. You betcha. You got it right. Definitely. Okay. All right. All right, Dr. Loss, it’s all yours. Have a safe drive. And we’ll do I’ll be on though I’ll be listening. Cool.
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And fancy with a sub, I don’t know where to mute myself. Oh, well, I can mute you if you want. Yeah, well, or leave me open and let say if I say noise or anything I want to show you know it’s not coming up on the bottom of the share screen.
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I mean. So I don’t know. Robin.
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None of my controls are coming up even to leave a meeting raising or coming up. Bro. Let me try escaping. Okay, I got it. I got it. That was weird. I did have the full screen but it blocked everything out. Of course I’ve never had before.
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Oh, here’s the little slow difference in
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iPad. Yeah. Okay, so how many people we have 1813 13
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Okay.
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13 is good. It’s getting cold. That’s why
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people are shopping.
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Shopping. Yeah, maybe we need to provide some heaters here. Summerlin not that cold. Okay, comparing to the New York
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we’re 45 right now.
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Well, I think in your area, it’s more hotter than us, right? In Nevada. It’s cold.
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It can swing 60 degrees. In a day. We were in day and night. This went down to like 17 at night.
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Yeah, yeah, the desert. Yeah, it’s part of we did
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about 20 to 40 degree variance between day and night. Were
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right, so you want to give them another start a five or a 10 or you want to start now. It’s
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I know your class is pretty long.
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It’s too Oh yeah. I tried to stop it. At 10 I’ll record it to you recorded that’s fine. That’s good. Well, the reason it’s collected it’s longer just because I think even myself I feel all this is new information as as medical doctors ups as medical doctors. We only know about oxytocin. It’s causing contraction and the uterus during delivery so and we inject pregnant women during delivery to help them to see ease the process of delivery. And also we learn from the medical school that oxytocin helps to port nursing. Right Do you remember that reflects the baby sucks on the nipples and then goes up to the brain and then you can secrete oxytocin oxytocin because the contraction that’s what we learned in medical school. But recently they find out that oxytocin can be can be our anti aging drug and can be the best anti inflammatory antioxidant and possibly anti cancer agent in our body natural thing and that’s what we’re going to learn today. And I think it’s good if we watch this doctor. She’s a dermatologist. And she’s also been surprised by the broad spectrum effect of oxytocin in our body. Especially she’s a dermatologist so she’s seeing the effect of the oxytocin on the skin and how it’s helping and slowing the aging process of the skin. And so let’s hear what she said. I think we can learn a lot from her. And then we can build up on what she is presenting to us. Often new information. Were the things that I collect from all this research that they have done about oxytocin and let’s go ahead and hear what she will say. Oops, can you hear her? Can you hear it? No. Not yet. Okay, so I think I need to do something here. I think I when I do share, you need to do share with voice and then you do share. And then when you click on it, it will work. Now how about now? Yes. Okay.
38:28
Well, thank you so much for joining me today. Um, so my first question is, you know, can you just give a quick synopsis about your pilot clinical study regarding oxytocin and skin aging and also can you kind of divulge into a little bit about your findings as well?
38:42
Sure. Well, thank you for having me. Well, I was a little curious about oxytocin and how as you said, it affects the skin aging and I wanted to delve into that a little bit. I was really happy to find that there’s been some bench work showing that oxytocin is affecting the skin. And I was very surprised to find that the skin actually produces oxytocin. There was a study showing that when the skin is caressed that it does release oxytocin. Other studies show that it does bind receptors in the skin and then what it does is it turns off, the senescence associated secretory phenotype SASP so it SASP does normally is it will secrete interleukins il one il six other proteases and this creates kind of a low level inflammatory or, you know, a little bit of a destructive picture for this scan and causes are aging. But oxytocin when it’s present turns this off, so it has more of a protective effect for the scan and an effect keeps it healthier and actually looking better. So what I wanted to do is see does this translate clinically? Can we see this in people? And so I took a small group of patients, six, six women, and I did some photography with the Canfield system and how everything’s standardized. We also use a skin age score that had been previously published and that made it very easy to quantify and look at how well or healthy their skin is for their age. The nice thing about this skin age scores that a correlates with your age. So if you’re 50, you should score about a 50. If you score 40, that means you’re looking very good for your age, and vice versa. If you score 60 Then you’re looking older for your age, so it was a nice tool to use. I also question them on their lifetime sun exposure, because as we all know that the sun also contributes to skin aging. And, and they were kind enough to collect their urine for 24 hours because that’s how we had to measure the oxytocin. So when we got all this information together I was just amazed to find that there was a correlation a linear correlation between the level of oxytocin and the amount that their score their SAT score decreased. So in effect, the better they looked they they had a higher oxytocin score, in spite of sun exposure. So one lady in my study, she had the highest oxytocin level, but she also had one of the highest sun lifetime exposure scores, but she looked the best for her age relatively so it was very interesting. And then I also had a patient where her skin looked not as good for her age. And she actually reported a very low level of lifetime sun exposure and her oxytocin level was low. So it just came together beautifully.
42:01
That’s awesome to hear and very interesting. So my we kind of touched on this a little bit beforehand being a what sparked this idea to conduct a study on oxytocin and skin aging.
42:12
So I’ve been in practice almost 20 years and I’ve gotten to know a lot of my patients very well. Most of them are women and we like to chit chat and they tell me a little bit about their lives and it’s just struck me over the years how people who find a new love are there and in love they just have this glow right we talk about the glow and they just look radiant, and vice versa. Unfortunately, I’ve had patients where maybe a spouse has died or they you know, they have a long term relationship that broke up and they’re just devastated and the life just seems to disappear. out of their skin. They just really look you know, not as vibrant, they look maybe more dull. And just their skin almost looks depleted, if you will. And so I got to thinking about this because we all associate oxytocin as the love hormone, right? So the love hormone and we know that it’s released during intercourse, we know it’s involved in birthing. But, you know, this is kind of a new idea of is it involved in other things and looking at it in the skin so I was pleasantly surprised as I mentioned earlier to find that oxytocin is involved in the scan. And I dug a little bit deeper into that because I thought, Well, why do we have this in our body? Why would the body be reacting to a social situation a physical situation, to make us look better to make us look healthier? While I figured it has to go beyond that? And it does there is preliminary research in every system of the body showing that oxytocin has a positive effect. For instance, in the GI tract, they are finding that oxytocin levels affect your sensation of being full. It’s related to your appetite, and that lower oxytocin levels are correlated with obesity. So that’s just one example. And so I find that this whole system is almost undiscovered and that we are supposed to be more social with each other
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in on that, you know, what was one of the most interesting things that you found out through this study.
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So that is probably the most interesting I feel I mean, as a dermatologist, you know, and in practice for so long, obviously, I know about the scan. I was unaware of oxytocin’s role in this scan, and I found that that was was fantastic. But this whole social interaction system so I coined it the oxytocin social exchange system, because the more that we interact with one another on a physical level, the healthier we are, and it’s almost this positive feedback loop that we really haven’t been paying attention to. And all of these years we’ve known that you know, getting a hug from someone will will make you feel good, It’ll calm you down. Some people have shown that it will decrease your blood pressure temporarily or your heart rate but I think we were unaware how much further it goes and it really has to do with our well being physically and mentally. You know, we need to really take time out of these busy modern lives that we have and we need to find time for love and endearment. And, you know, you if you don’t have anyone to hug you hug a dog I mean that has been shown to help or get a massage, because stroking this skin does release oxytocin. So there are so many things that we can do to make ourselves feel better and be healthier.
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Absolutely. And you know, my one last question I have here is, you know, what kind of impact do you think this kind of research will have on the dermatology and like skincare beauty industry?
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So I’m working with a pharmaceutical company looking at a botanical that mimics that oxytocin like effect in the skin and to date has been fantastic. The results are better than I expected. I’m very excited. So I think this has been almost a missing part of our skincare routine. But on a day to day level, I think that dermatologists when and even just any kind of doctor when we see our patients we need to remind them to you know, get off devices and interact with with their friends and family and loved ones because it’s just so important for us and I think this past year has really shown me a lot of people have been very isolated and it’s just not healthy for us not just mentally but physically we need that interaction. That’s what we’re here for.
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Okay, so I think we learn something from her right Sherr can we learn that this is kind of been a new information new discovery and that we need?
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You okay, can you see the PowerPoint? Can you hear me guys?
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Yes, we got the PowerPoint.
48:25
So we learn. We learned that oxytocin is not just for birding and for nursing. That’s an old school we learn from Dr. Nicola. I think her name is that it’s more than that it helps in slowing the process of the aging of the skin. But also it helps in in managing obesity by like when the patients has oxytocin or the oxytocin has been given and helps to increase the satiety and that the patient will not feel hungry anymore. And that may helps in managing obesity but also oxytocin helps to do to induce lipo lysis and shrinking of the fat cells directly and introduce fatty oxidized fatty acid oxidation. So it does help to manage those extra weight or extra fat. So we can use it for managing we can use it for weight loss management. But there’s many, many other applications and we’re going to learn about all the clinical applications of oxytocin to the point. I think oxytocin needs to be recognized as a system. And it’s not just neurogenic system but also its peripheral. Because we have receptors and we have oxytocin being released as a hormone in the blood. And as you see the tissue is producing it, the muscles producing it and there’s receptors there. So it’s a powerful hormone, hormone neurotransmitter that we have receptors all over the body and some of the action of the six hormone is mediated by oxytocin. I just learned recently that mushroom ecstasy works through oxytocin to increase oxytocin level mushroom, and I think the therapeutic effect of mushroom may be mediated by oxytocin. And so we are learning a lot about oxytocin to the point I am kind of finding that oxytocin may be the only drug in the planet that can modulate most of the chemistry of your body, the biochemistry of the body, the hormones level that redox the immune balance, it can be modulated by oxytocin and it can restore the homeostasis so can we say the oxytocin system is like in the computer we have subjects called reset factory when your computer gets crashed. You go ahead and find the reset factory and and the whole computer goes back to to the previous setting and get rid from all the crashing. And we can say this is what’s happening with oxytocin system. If you press on oxytocin, and other words, oxytocin increase in the body whether endogenous ones which we can stimulated by many different ways, stroking the skin, making love socializing, sitting here together with the same think tank talking to each other here. All of this can increase the oxytocin and can help us in our and healing and resetting the homeostasis and managing chronic disease and preventing it across all medical specialities. And that’s what we’re going to learn we will not learn how the oxytocin the facility of oxytocin and how it’s helping for example, and stimulating the gonads whether there’s six whether it is the testis or to operate to secrete six hormone androgen and estrogen associate here by releasing the the hypothalamus pituitary gland adding gonad releasing hormones, right and soundly. digitalizing hormone and follicle stimulating hormone all this can be released and stimulate the secretion of the androgen and the progesterone and estrogen can can oxytocin be a replacement for six hormone therapy? We don’t have proof for that. We need to have clinical studies to see if we could just give oxytocin will help a woman with postmenopausal but I know it would help so we don’t need that much a large dose of androgen, androgen and estrogen and progesterone and DHEA and that’s what we need to conduct those clinical trials and find out you know, women’s with oxytocin, how much of the second six or one they need versus women without oxytocin and we find out that oxytocin also would help to manage any side effects that’s coming up from those six hormone therapy. It definitely helped to increase the insulin sensitivity it helps the secretion of insulin so it doesn’t help to manage patient with diabetic and preventing from happening. It does help in managing inflammatory autoimmune. Disease, whether it’s th one dominant or PS two dominant, and we know that the th $1, th two dominant inflammatory autoimmune diseases, they have a component of th 17 and both sides of the aisle and the th 17 as part of the pattern first pathophysiology of the automatic triad, so it’s not just th one it’s also th two had sorry th 17 and allergy for example, or systemic lupus is not just th two dominant but also there’s some kids 17 And just inhibiting the th 17 polarization will help in managing all this inflammatory diseases, autoimmune diseases, whether it’s th one or th two dominant, because you’re taking care of the th 17 Part of it. And as you see it here at inhibiting interleukin six very clearly here. Well, oxytocin also helps to stimulate the thymus gland and stimulate the secretion of tyrosine peptides and it helps in enhancing the immune system against the pathogens and cancers in general, but also helps to give you that self tolerance and so it’s stimulated T Rex which will help to prevent the body from attacking his own self antigen and T arrays also helps in managing autoimmune disease and inflammatory disease. And also oxytocin if you see it here. It also helped to suppress that hypo telomerase budgetary added not access, so we don’t want to have an excess of cortisone. Why? Because too much of cortisone can lead to all the complication we know which is diabetic hypertension, osteoporosis, you don’t want to have overactive cortisone, and also constant high cortisone can suppress the immune system and put the patient at risk of cancer infection. So oxytocin helps to dump and and degrees and buffer the level of the cortisone to the physiological level that we are looking for. And so we need to have cortisone, but we need it to be in bursts and times we need it when we have stress. When we have inflammation we need to have that burst of cortisone, but we don’t want to have a cortisone being released constantly in a slow rate, where it will suppress the immune system and break the shield of the immune system against the emergence of cancer and the surveillance or the immune surveillance of the cancer. So, so yes, we see that oxytocin helps increase the growth, growth. Hormones, which is very critical for cell proliferation and differentiation and renewing of the cell. Especially the stem cells in your body. You need to have some some growth factor there. And I think Insulin helps in maintaining that level that we need at physiological level. We see that oxytocin helps again and glucose uptake it helps to stimulate the fatty fatty acid oxidation, it helps to induce like lysis so it helps to manage we can use it to manage weight loss you can use for managing a diabetic and also it goes vasodilation as well, as you see it here and it’s improved endothelial function, right. And it helps to stimulate the nitric oxide and all of this would help in managing metabolic syndrome in general, whether it is hypertension or diabetes or obesity. All of this can be oxytocin can benefit and you can be used to manage metabolic syndrome. Whether giving oxytocin intro nasally or injecting the Ronda batiko to international unit. I think it’s a dose to start with per day, but you can go up to 10. If you see here that oxytocin also helps to stimulate the bone formation those two blasts and helps it and so you can use it to manage oxytocin of the proceeds. And there’s lots of studies in clinical studies about that. And impossibly estrogen and androgen works by those six hormone works the anabolic effect of estrogen and testosterone work. On the bone mediated by release of oxytocin. And also we can see that the oxytocin helps in increasing the colonic mortality, which is possibly this can be good for a patient with constipation, especially with irritable bowel syndrome and they have constipated dominant of this IBS, then we can definitely use it to increase the bowel movement and get rid from all this toxins and our body.
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Oxytocin also secrete this our tea or natural or erotic peptides so it helps to get rid from all this excess fluid. It slows down the heart rate, so we can use this for treating myocardial infarction. Angina also has energetic effects. So if you have myocardial infarction, and you’re giving them CTOs that I think just helps the pain as well. But increasing the Nitro ureteric peptides it does help to get rid from all this excess fluid and soul that we don’t we need in our body. And that’s that’s a good thing for patients with with heart failure to be giving them oxytocin right. And if you have my cardio angina and all that stuff, you want to slow down the heart rate. And so it will help also hypertension because you are getting rid from the excess of the fluid and you’re slowing the heart rate like beta blocker and you are getting rid from flexes of fluid like diuretic so it’s a natural drug to manage hypertension. Not just that because we learned that oxytocin helps in slowing the process of the aging possibly it has an anti wrinkling effect and it helps to rejuvenate the skin and getting rid from the excess of the fluid and it’s anti inflammatory and the oxygen I think if we use intranasal oxytocin, we can get rid from the baggy eyes which must have the people above 50 Or you know, complaining of it, it’s hard to get rid from it. So possibly this will be a good option for managing baggy eyes which is those little the swelling and edema and inflammation that’s happening under the lead which possibly because of the aging and all that stuff. Oxytocin helps in also manage the leaky gut syndrome and leaky brain syndrome. And how is that because oxytocin stimulate the tight junctions and prevent the leakage of the free radicals from the gutter into the blood and also it helps the the formation of the barrier and in the blood brain barrier. You know, those blood vessels that are tight junction I think oxytocin helps to build it and increase that that barrier to prevent the leakage of toxins from the blood into into the brain, so we can use oxytocin to manage leaky gut and leaky brain syndrome. Oxytocin also helps to increase the breathing. And so this can be used for sleep apnea, sleep apnea, that problem they have apnea and so this stimulates the breathing process and because it has anti inflammatory and anti oxygen, so it will help in managing any lung diseases. Whether it was fibrosis or inflammatory or infection. It helps to decrease the damage, the inflammatory damage that’s chemic damage on the lung when when we have respiratory diseases so I can use it for lung diseases. We already know that oxytocin, it’s good for we use it for delivery of the you know, the baby helps to induce contraction of the uterus. So we already know that it’s involved in the process of, of, of nursing. And that’s why you know, the farmers they use oxytocin to increase the amount of the milk produced from from the cows, right, they actually injecting oxytocin into the cows. Is that mean there’s some oxytocin in the milk cow that’s possible. But it’s, I don’t see any harm in having oxytocin in the milk. What else we can see here we see that oxytocin helps to increase the activity of the vision helps increase the activity of the smell, taste hearing, so you need to improve all this to five senses that that you have maybe the six senses, but the five senses for sure, so you can hear better you can smell better with with increased oxytocin. In addition to that the oxytocin helps to create that bonding relationship between the mother and the child and between the person and his and the owner of the dog owner and the dog create that bonding to the point they’re rejecting dogs with oxytocin to increase that bonding and between the owner and the dog. It also helps to increase the monogamy relationship and it decrease the cheating process as well. They inject guys and they find out they they don’t have any more interest in porn and all that stuff. They’re more into monogamy and I think this will be a good solution for many, many managing the number of divorce that we have and lack of interest with with your spouse maybe with with with time you get bored and you want to look for differences if you give them oxytocin that may keep them together and increase that bonding and increase that monogamy and and decrease the divorce rate and all that consequence of the divorce rate which you know the children they get lost in from in between all these problems. Okay, oxytocin helps to increase the social recognition face recognition helps in in our behavior, and definitely it helps to increase the focus. So you can use it for Attention Deficiency Syndrome and you can use it for people with antisocial behavior because it does help to increase that passion. It helps with depression so you can use it for managing who don’t yet and anxiety and it does have anorexic effect. So it does help to decrease the appetite. And so I can we can use it for weight loss better than any other drugs. I mean, there’s drugs called the semaglutide out there, but the mechanism of oxytocin semaglutide are the same. They are the same pathway. They work on glucagon peptide, same signaling and some of research they say it’s not good even to use them together because they may cancel each other although some research that they say they have synergy effect but the semaglutide is Big Pharma product and and there’s some study that says it can lead to pancreatic cancer, some some studies, and so I prefer oxytocin, better way of managing weight loss even if it’s slower than semaglutide it’s still more safer if give me a choice between oxytocin and it’s another tie that will use oxytocin. Yeah, can you hear me?
1:05:34
Yeah, I didn’t want to interrupt you but you’ve got a big gray box is blocking some of your slide.
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I don’t know if you could see that. Ah, no. Can you see it now? Yeah, it’s
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still there. It’s blocking. It’s underneath the earring and the insulin is blocking some
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of the words.
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Okay, but they don’t see it. So even if I do in fact flip it. It’s still there. Yes. Okay, so what I would do I need to go ahead and and, and then share it again. Can you see it now? No,
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we’re back to the gallery view.
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Okay, now can you see it?
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It’s you’re starting the screen. Sharing. And yeah, you still got a big it’s a bigger gray block now. A little little smaller.
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Okay. Now what about
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what about now? Yeah, it’s
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still there.
1:06:33
Yeah. I don’t know how to control this. It’s not is it affecting the quarterback now?
1:06:42
Yeah, it’s still there. I don’t know what’s going on.
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Just changing shapes now. Okay, I think it’s probably censorship by the government. Yeah. They’re like one. No, they would target other stuff.
1:06:58
I don’t think they Okay. Okay. Okay. Okay. I think
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with your connection,
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what about now? Yeah, it’s still there.
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I noticed that the other day Doctor Who lost I think it might be something with your computer because I did see it on Monday. Yeah, if you look at my screen from the iPad, you can see
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- You still see it? Even if I removed all this thing. Yeah, I
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think it has something to do with memory. I don’t know. It’s still doable. Okay. Let’s stop sharing. And try it again. That did home. What about now to help us out there now? Now we got your full screen. Yeah, but now we’ve got your full screen of your laptop. Okay. That brings him back up. Like expander zoom back. Now. What about now?
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Now it’s gone. Yep.
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Okay. Okay, Dr. Mike, you there. Yep. Okay, that’s good. Well, now we know it’s very clear that oxytocin it’s, it’s, it’s like a reset. homeostatic reset bottom button for for for, for the humans in the animals right. So if you increase it, see how all this change is going to happen? And we can summarize the change into or we can categorize them into three things. It restored the metabolism, and I’m talking about the hormones and all those factors that we talked about all those parameters, physiological parameters, restore them, right. So it restored the metabolism. It restored the immune balance, right as you see it’s it’s balancing the immune system. It’s inhibiting that extra immune, hyper immune response. It’s suppressing the hyper immune response, that there’s excessive inflammation that we don’t need, it’s causing more destruction in our body especially that mediated by to NewCon, six and th 17 and neutrophilia. So it’s, it’s balancing the immune system, it’s restoring the metabolism. And we saw that it’s restoring the glucose hormones, right. It has the if you improve that leaky gut and you improve that, all this you can buffer the redox by doing that, because you’re preventing the leakage on the free radicals and also to stimulate the the expression of antioxidant enzymes and stimulate anti inflammatory cytokines. So it does buffer the redox as well and inhibit the NOx enzyme. It stimulate the parasympathetic, and we know the parasympathetic, it’s an anti inflammatory arm of economic nervous system and inhibit the sympathetic system which has inflammatory hormones. So it’s just helps to balance the whole physiological process of your body that metabolism redox immune, and that’s what we do when we manage chronic diseases as chronic disease prevention management specialist. We’re different from the mainstream medicine mainstream medicine. Like a neurologist when he tried to manage dementia will say Okay, so what’s the problem with dementia? We have less amount of acetylcholine, and that is the problem. Okay. And what how we can manage that increase the bioavailability of oxytocin. So that’s the metabolic narrowminded channel tunnel vision of the neurologist and he will just prescribe you a drug that will decrease acetylcholine so he’s fixing the metabolic part of the metabolic process, but he is not fixing what COEs the decrease in acetylcholine. And what’s caused the degeneration of the neurons is the neurologist thinks about how to slow the degeneration of the neuron now, and that’s where we as chronic disease prevention management doctors, we say in addition to increasing acetylcholine bioavailability by using a big pharma drug that hypothetical illustrates, I think we need to also think of how we can slow the degeneration of the of the neurons and the big the mainstream medicine they say there is no way to slow the degeneration of the neurons. They don’t have that kind of image. For us. We say yes, we can. What goes a degeneration Well x is a free radicals and inflammation. We will see that dementia is not just decrease in acetylcholine bioavailability but also it’s because of there’s an inflammatory process. There’s imbalance of the immune system. There’s two active th one and th 17 that needs to be balanced, needs to be shifted to th two and we need to increase the T rec in order to decrease the inflammatory factor of the pathological factor of dementia, that the mainstream medicine they don’t even consider that right. We think that this is the case. So we give drugs that helps to balance the immune system. We get late for example, thymosin beta, we can give oxytocin oxytocin can help that as a peptide to balance the immune system. We give it to appointment peptide, and also we think about, oh, well, they’re also too much of free radicals as well and reactive oxygen species. It’s the reason why it’s inducing apoptosis and possibly some leakage of the if there’s any leaky gut syndrome, those free radical generators that’s been linked from the gut into the blood, it may aggravate the and speed the process of degeneration because it will add more free radicals there and add more inflammation irritation. So I said as chronic disease prevention medical doctor will say, Okay, we need to fix the leaky gut, right. The neurologist they don’t even consider that. They say, Oh, look, you got gastroenterology because it got some drugs. It’s not my business. And then we think, Oh, okay, the patient has diabetic and that that’s mean he has too much sugar in his blood and sugar get oxidized in the blood and become glycans and they become free radicals generator and that may also be the process of degeneration of the neurons. And as I said, if you haven’t yet we need to fix that. Hypertension is causing all this pressure on the blood vessels going to deal more into to this function. It’s causing arthrosclerosis and generating all this micro ischemia and all that stuff. So we think we need to manage the hypertension, we need to stop then you’re just going to go to your family physicians to fix your blood pressure, but the high blood pressure is speeding the process of dementia. Another thing is that we think, oh well sympathetic. is obviously too much at St. Benedict is inflammatory, parasympathetic is anti inflammatory. So those patient with dementia, they may have stressed and they may have too much excess of sympathetic activities. So we need to work on that. And oxytocin can can balance that right and have the sympathetic stimulate the parasympathetic and you can decrease inflammation and the process of the degeneration and help the patient with with dementia to the point that at some companies, they are having some electrical devices to put in your neck there and stimulate the vagus nerve and this may help and slowing the process of degeneration because it’s it dumps it buffered the redox and so we look at all the free radicals screen all the free radical generators in the body not just and we look at there’s any vitamin D deficiency that will decrease the expression of antioxidant enzyme, and you need to fix that and see if there’s any other vitamins or any other malabsorption needs to be addressed because we need to restore the whole Parliament six hormones for example needs to be fixed as well. Because if you have low androgen, notice the estrogen you will have in the tear dysfunction and also you have low expression of antioxidant enzyme and you have too much free radical production as well. And so we need to fix that and it will improve endothelial function and we know that part of dementia is some sort of there’s vascular dementia where you have some decrease in kind of micro ischemia vascular abnormality, which we call this chemical effect, that makes me the process of the division we call them vascular dementia, right? And all this needs to be addressed. Neurologists that will not do that we as chronic disease prevention management, we need to consider all of this then we start managing it. So that’s the reason the outcome that’s coming up from Dr. William Bill with his patients is better than a specialist because we are addressing all the different angles to manage chronic diseases that affect that organ and cannot be managed by just, you know, tunnel vision and focusing on just fixing the acetylcholine bioavailability it has to be managed as a whole and look at the root cause and find out what caused the decrease was stuck when it was a degeneration and how we can slow the process of degeneration by balancing the immune system by balancing the redox Aeneas by restoring the metabolism and not just acetylcholine but all other metabolic process that needs to be restored back to normal. And oxytocin is the drug of the choice can really restore the old homeostasis and slow the degeneration process of all the organs not just for for dementia but all the organs in your body by affecting or by restoring the metabolism the hormones restoring the physiology of the immune system, the balance of the immune system and the redox status. This is just an again another illustration that shows how the clinical application of oxytocin in managing chronic diseases whether it’s inflammation or ulcers, all this you know we were ready to explain it and the previous night.
1:17:31
So, we said that we are proposing a new system a new biological system we call oxytocin system if you Google Moxie presented you will not find it. So something we invented as a group. How CGPM and your group Academy of Osteopathic right integrative osteopathic society we come up with respecting the oxytocin as a system not just a drug that helps in delivery and helps in nursing. But it’s it’s a system that can restore the homeostasis and can be used to manage all chronic disease across all medical specialities. Including it helps to prevent cancer and possibly use it for cancer management as well. So we are respecting oxytocin. And we are saying that it’s a complete biological system that is not been discovered needs to be discovered and needs to be elaborated. We need to investigate more about it. We need to conduct more clinical trials about it and see how we can benefit from the use of oxytocin in managing. As I said, chronic disease across all medical speciality, I’m talking about the genetic disease, autoimmune disease, inflammatory disease, pain, metabolic aging process, dry tinnitus, damage, there’s many many conditions stroke, cardiovascular diseases, weight loss, hypertension, diabetes, right all of this we can we can use oxytocin as an adjunct or the main treatment for all these conditions. And as I said, it’s a system that has receptors not just in the nervous system, and the brain. But also it’s it’s all over us but our feelings Central. So we have receptors in the muscles and the bones and the skin and just produce there as well. Preferably not just in posterior pituitary before we think it stopped producing. No, it’s produced all over the body as a part of hormone or hormones and neurotransmitters. And also we have receptors in the brain and the central nervous system and also in the periphery and in the tissues. And, and so collectively we can call is that a system similar to kind of go into cannabinoid system, right? I just recently I just find out that mushroom therapy activity works by raising of oxytocin and six hormone also can work. Some of the mechanism works by increasing the oxytocin. So there’s a lot of mechanism of actions of those drugs are mediated by increasing the oxytocin and oxytocin is a nitric oxide by the way, so an increasing the cyclic GMP, that’s how it mediated sanction. But,
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um, so
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we see here, how we stimulate oxytocin in the body you know, before when in medical school, we only know what about oxytocin if you, the baby is sucks on the nipple. It goes that reflects, right? Which sends a signal to the brain and then secretes the hypothalamus the hypothalamus will secrete or the pursuant to the statutory part of the Pacific land. The posterior pituitary portion of the Patric land will secrete oxytocin in the blood and then it goes into the breast and stimulate the contraction of the breast but also stimulate the contraction of the uterus at the same time. And gives that tickling passionate feeling that’s why you know women’s they’d like to hear this voice of the of the kid. It just increased their dopamine and oxytocin because the happy molecules, the serotonin, they hear the voice of the kid and they feel attracted to it because anything piece of dopamine in the end makes them happy as well. And so they’d like to see the baby face and all that stuff. And so that’s, that’s what we learned, but it’s not just that actually oxytocin involved and our relationship with our spouse, that when we see the attraction and the sexual attraction, all that stuff, we oxytocin increase, and that gives you that that that attraction, feeling the bonding feeling that the orgasm that you did that we’re looking for the sexual sensation will enhanced by oxytocin so it’s not just for the babies but also it’s for us for the ability for the sexual relationship and the bonding and making love definitely based oxytocin stroking the skin can increase a massage when you go to the massage you feel more relaxed and sleepy and happy and dopamine is agrees and you want to do more of massage. I myself and I myself and my wife, we massage me up all asleep because it definitely helped to block the pain also if you have back pain and she massage it oxytocin is a very powerful energetic because it increases the dopamine it increases the endorphins in your brain, it stimulate the serotonin so it gives you that happiness and what drives us what moves us to do anything, it’s the it’s the dopamine, and anything that increases dopamine and oxytocin, of course, oxytocin is a dopamine makes us to move to it and do it right. And even if you have two things that increase dopamine, which one is going to move, you’re going to move to the direction where it goes the the highest dopamine right? And so our instant thoughts and drive and motion and movement. It decisions it’s all based on the release of oxytocin and the degrees of dopamine because dopamine is rewarding, and that gives you the happiness and excitement of doing the thing that you want to do. And so what stimulate oxytocin again, stroking the skin massaging, probiotics, possibly Yes. What else? Abdominal Breathing that may help to increase the vagus nerve and vagus nerve stimulate oxytocin. Oxytocin stimulate the vagus nerve. Nursing Yes, as you see sucking the nipples, actually sizing, smelling perfume, reading and enjoying what you’re reading. It isn’t oxytocin, meditation, cuddling, touch nice tasty food can increase oxytocin nice music. Right. That’s why Dr. Mike beamer he likes to be part of the battle music pan band and even he changed all the schedule from Thursday from Friday to Thursday to Monday. Just because he wants to attend the music because he’s a good guitar player, by the way, so maybe he’s going to bring his guitar when we meet at the aprm so we can he can entertain us with his voice and with his guitar, right Dr. Mike Beamer and also you know, visual thing, especially the beauty, the nature or the beauty of your wife, or your spouse or girlfriend. All of this helps to stimulate oxytocin so it’s not just sucking the nipples anymore and if you want to go more deeper into chemistry, and then you want to see how oxytocin chemistry wise, helps in managing chronic diseases, and gave me that helps to manage metabolic syndrome specifically as we see it here. We can see that oxytocin stimulate the APK. You know, the APK. It’s the it’s a it’s a, it’s a system of proteins of enzymes and signaling that will definitely stimulate what we call the mitochondrial uncoupling. And when you when you are inducing mitochondria and coupling What’s that mean? Mitochondria uncoupling. We know that mitochondria, the electron transport chain is coupled with with production of ATP right, okay. And so, we see the electrons that are moving around the electron transport chain and then it will be picked up by the oxygen at the end. And then as the electron passes the electron transport chain the hydrogen will be pumped out. And then you create the transform this energy of electricity into hydrogen gradients, right. And then the hydrogen gradients will will start moving inside the mitochondria matrix. So the ATP synthase channel and that will convert the hydrogen gradients into energy of ATP right and that’s a coupling, right? And so basically, the hydrogen goes in and then the hydrogen will react with the with reactive oxygen species. So the mitochondria is a source of ATP and it’s a source of free radicals. And in order to, of course, you have all this oxygen is going to pick up those electrons inside that mitochondria matrix, and they become free radicals. And they’re going to wait for the hydrogen for that’s going to be pumped in. It’s going to be going along with their gradients. And drive the ATP production but ATP synthase, to react with this superoxide and free radicals to become water. And so some of those free radicals will not be waiting for those hydrogens to come in and kind of neutralize those superoxide radicals so they will be released out and the mitochondria produce a burst of free radicals which is very essential. But too much of free radicals from mitochondria is not good. It can cause all this irritation inflammation. And so if I uncouple this process of electron transport chain ATP by having proton channels that will allow protons to influx in and out so that is we need to have illustration for that now, next time when I have a presentation I’ll show this will help to neutralize more those free radicals and decrease the free radicals production on the mitochondria. And this is T RS will be reduced by the mitochondria traveling and doing that you can manage oxidative cell damage. So what’s the signal and increase the expression of those proteins? That will cause uncoupling of mitochondria and decrease the free radical production is the APK singling Okay? Which is otherwise the energy of a spade kinase. It’s just enzyme or a signaling molecule that are protein that’s designed to stimulate the adding of phosphate group to the enzymes and that’s how you turn them on. You turned on those cascade of enzymes and that will possibly be the expression activity of those uncoupling proteins. And eventually it will be to decrease the Ross production for the mitochondria and decrease oxidative damage. And it will decrease inflammation, right and general and doing that so it’s kind of an anti inflammatory anti opposite effect, stimulating the ANP PK by oxytocin and this will help to if you have inflamed pancreas, it will decrease inflammation so produce more insulin, but also in the body, the insulin receptors they get more they become more sensitive because the insulin receptors they get blocked by oxidation. And so if you’re able to decrease the absolute death for free radicals, increased oxidation has recently increased their sensitivity. And definitely this will pose a drop in the blood sugar, right increase the sugar uptake. And in addition to that, as you see it here that oxytocin stimulate the lipo lysis and it helps to decrease the it stimulate the fatty acid oxidation and also a decrease the inflammatory process in
1:30:19
the of the of the white pack sales. We know the white fat cells they are they’re producing lots of inflammatory cytokines and they produce lots of free radicals. So definitely oxytocin would help and dumping all this inflammatory process and and doing that you will be decreasing the LDL and the cholesterol by freezing the fatty acid oxidation burning those fat and decreasing and turning those white fat into brown fat right all this good things that we’re going to learn in the coming slide as well. And all of this would help to manage Office funerals right. So if you decrease the inflammatory process if you put the need to function. If you decrease the LDL cholesterol, right, all of this would help to manage the office corrosives here. In addition to that oxytocin increase the nitric oxide and it buffer the dark so this is good for managing the myocardial infarction angina, because negative side is the vasodilation. Right? We we actually we treat angina by giving them nitroglycerin. So oxytocin is an extra side donner, by the way, so it’s like nitroglycerin for the heart. In addition to that, if you decrease the inflammatory process of the white fat by turning into brown fat, and you decrease the free radical productions and you decrease the inflammatory cytokines definitely all of this will and will stimulate the muscles regeneration and anabolic process of the of the muscle and the protein building up the muscle. So oxytocin helps in increasing the mass and regeneration of the muscles. So this is just shows you the whole mechanism here, and oxytocin also inhibit the mTOR. And if you’d have done to her what would happen is stimulate autophagy right, and you get rid from all the senescence cells, cancer cells inflammasomes. And this will also stimulate the mitochondria renewal because that’s one of the way is that autophagy possibly mediated by mythology. And so oxytocin stimulate the mitochondrial biogenesis and activation and when you activate the mitochondria inside inflammasome or cancer cells, it will induce mitophagy and it will blow up those and kill those cancer cells and induce autophagy for those bad cells that you need by decreasing mTOR signaling activities there. We can go more in chemistry, possibly next time. But there’s just a general here but in general oxytocin just by knowing it had been nach oxidase, which is enzymes that produce the free radicals. And that’s oxidase stimulate by sympathetic, right when you have too much sympathetic you have too much activity of Nash produce too much free radicals which will aggravate any existing inflammation or induce inflammation and just inhibiting that and inhibiting th 17 and 17, interleukin six and everything all this inflammation mediated by introduced in six we can manage all chronic disease across all medical specialties, or possibly just by knowing it buffered redox. And it modulate the immune system by inhibiting the natural and decreasing the free radical generation and by inhibiting this bad inflammatory process, extra inflammation of th 70. I mean, we need to get 17 Of course, we needed to failure, but we needed to be to a certain degree where it helps us to kill the bacteria on the fungus, but too much of a hyper inflammation, too much of engineering sex and too much of an overactive of this inflammatory process is mediated by D ID, 17. And 17 and six, it’s not good, then it becomes self destruction, right? All this neutrophils such secreting proteases and hydrolytic enzymes and exosomes and all that and cause more damage. You want to suppress that, right? You don’t want to have too much of inflammation that goes self destruction and we find out that rheumatoid arthritis yes is th one dominant but also it has some th 17 components and this is th one and we find out that systemic lupus is th one but it has TSM 10 damage so P can. So obstacles can be used for both and we can get read from this overactive th 17 atrophied and it’s causing damage of the joints and and both sides of the aisle right. Or or the dementia we have inflammatory process and part of its yet 70 interleukin six right and we can still the process of inflammation destruction and degeneration of the neurons is by blocking interleukin six along with blocking the next exam as well. So we can use it for even cancer cancer for example. If the inflammation is polarized into th 17 to six interferon. You cannot really kill cancer with neutrophils, right you need cytotoxic T cells so if you block this, then what would happen your immune system will be resumed as polarization into th one cytotoxic T cells to kill those cancer cells right he’s excited LOOKS AT T cells. And so it helps to modulate the immune system and if histological process where you get rid from those cancer cells and those pathogens at the same time, you know, dump it in a way Do not be hyper inflamed and hyper immune and that’s what’s happening with COVID. If you see COVID But, you know normally when we have viruses and we be attacked by virus, your macrophages will eat the virus and the macrophage when they eat the virus they use it what we call the toll like receptor, I said tastebuds. And normally those macrophage when they they degrade and they taste the virus, they polarize into one and they will secrete interleukin 12 And they will secrete interferon gamma and that will polarize the lymphatic system into the lymphocytes into life episodes into th one right and then th one will stimulate the sending toxic T cells and that’s how you can get rid from those cell that’s been infected with virus. COVID virus is so smart. Okay, so it’s pulling our immune system. It’s not like flu virus, flu virus, you get th one high. You don’t get th 17 When you see th 17 That’s me and introducing six that’s mean it’s bacteria infection. So this COVID virus, it’s it’s so smart. It’s fooling the system. It’s fooling the immune system to protect itself so they can pull off right and they can spread in the body and destroy the host. So what they will do, they will fool the immune system and polarize the immune system into tears seperti neutrophilia Really you cannot get read from the spire, especially the intracellular virus. With with neutrophils you need cytotoxic T cells, but they will fill the immune system and make it polarized into jihad. 78 neutrophilia right that’s what you see in COVID type seeing a trophy Leah you seem sexy see that the diamonds because interleukin six was Holbert produced stimulate the clotting process so it definitely at least visibly diverse. So how would splitting the system? Right So normally the microphone would have testifiers supposed to be polarizing and term one. th one it’s the spike protein, the spike protein it blocks the h2 and what is h2? h2 is the angiotensin converting enzyme, right. And, and as to its part of the renin angiotensin system and reading angiotensin system before we think oh, it’s just the process to control the blood pressure and right so when you have a drop in the blood pressure, your kidneys do secrete meaning and that meaning convert angiotensinogen into angiotensin and angiotensin will convert into angiotensin two angiotensin one to angiotensin two and in the lung, right, remember that okay. And then angiotensin two is the vesicle structure and it took reasonable pressure. That’s what we learned in medical school. But now it’s different. It’s not just about the constructor, angiotensin tube, it’s also it’s it’s an inflammatory signal. When it reacts with angiotensin two type one receptor the signaling is not just causing the construction but it’s also causing inflammation and which kind of inflammation we have three kinds inflammation, th one mediated inflammation to D mediate inflammation, th two inflammation right? These two which are the allergy kids 17 We use it to fight the bacteria and fungus and th one we use it for fighting inflammation to fight cancer and virus. And so the what happened is that the polarization is when you stimulate the angiotensin two type one receptor by angiotensin two it polarized more into T at 17. And in neutral feelings, so that’s kind of inflammation. That’s that’s moving. And so the spike protein blocks the ACE two. What is nice too, is enzyme that converts the angiotensin two to angiotensin one set.
1:39:54
And so when it turns out that detention one seven, angiotensin one seven is actually vasodilator and anti inflammatory. So in that reading angiotensin system, there’s two there’s two arms and two receptors. There is the inflammatory arm where the angiotensin combined with angiotensin two type one receptor right that goes via construction and in signaling of inflammation especially polarization for th 17 and 17 and it should have been six and then there is the other arm but IG attention to can also convert into angiotensin one seven and an angiotensin one seven will react with mass receptor and use the vasodilation and anti plummet anti blemish which opposing that angiotensin two type one receptor. There is another group another side another arm of angiotensin system, which mediated by angiotensin two type two receptor and Ace two. They both they combined together and they turned angiotensin two into angiotensin one seven and that’s the anti inflammatory peptide. That’s not i hexa. Right. And so it’s good to add the hexa when you’re managing COVID. Why? Because the COVID SPIKE protein blocks that ace two blocks the anti inflammatory arm blocks, the vasodilator arm of renin angiotensin system leading to overactive angiotensin two type one receptor which signals via construction this signal sympathetic over activities right and sympathetic release norepinephrine, norepinephrine, stimulate the nerves and draining free radicals and causing more inflammation and it stimulate the polarization of the immune system fatigue 17 News for failure. So it’s all caused by the spike blocking the ace to the anti inflammatory arm of renin angiotensin system allowing this over active angiotensin two type one receptor signaling that leads to nitro philia to polarization immune system to th 17 To introduce six and interleukin six stimulate the clotting the thrombocytosis. And that’s the reason we have the high D dimers. In this patient, that’s why we have hyper inflammation but what kind of inflammation the inflammation that has too much replenish appeals. That’s why we see neutrophils normally neutrophils, even bacteria not found it’s not not a virus, but it’s fooling the immune system as polarizing it from the right immune response which supposed to be polarizing into th one and cytotoxic T cells to get rid from this virus. And so that’s the reason we propose. Laws are 10 hydroxychloroquine and ivermectin because all those drugs do inhibit the T at 17 polarization. That’s why we use ivermectin to manage recession, right, because we’re Sasha it’s inflammatory and masturbate. state 17 And we use it for managing also systemic lupus because part of systemic lupus inflammation is th 17 It’s FDA approved hydroxychloroquine to be mad to be to be used for systemic lupus because the inflammation of systemic lupus is th two th 17 So you blocking the T 17 part by using hydroxychloroquine. But those people and Dr. fallacy he does not know that there’s three kinds of inflammation. He does not know that the inflammation that is caused by the COVID It’s th 17 dominant is the same inflammation that recession is producing the same inflammation that systemic lupus is producing. That’s why we use the drug of sister of the of the recession, which is ivermectin and we use the drug of the systemic lupus which is hydroxychloroquine. But those people they just, they either they don’t have any clue what they’re talking about. They don’t talk about mechanism of action. They are doing clinical trials, but maybe because of my personality as an intp. I like that to dig deep into mechanism of action as a start, and then I will do clinical trials to back up the mechanism of action and it hasn’t that synergy, like me and Dr. Petra makalah and all this group. We have that understanding. I mean, they are very good in clinical trials and bring all the studies but I like to back what they’re saying with mechanism of action. But that’s because I’m an introvert, not an extrovert. And so, knowing that we can use oxytocin to manage COVID Okay, covenant fashion. Why because oxytocin is not just the for the srtf Natori LTS 17, anti inflammatory drugs, not just that, it also inhibit the directly and indirectly, it inhibit the binding of the spike protein to the ace. So inhibit the blockage of the anti inflammatory arm of renin angiotensin system, right. So it’s balancing the Rena angiotensin system and preventing the upper activation of the inflammatory arm of renin angiotensin system which mediated by angiotensin two type one receptor. So it’s an anti inflammatory it’s antiviral right by blocking that and not just that it also stimulate the mucous secretion nasal mucus secretion and the quality of the mucus secretion which it produced the lactoferrin and electro Ferran will form a complex with a spike routine preventing it from attacking eggs to not just that oxytocin stimulate the inhibit the protease that is responsible to prime the spike protein in order to react with ace. So it does have antiviral effect. So it’s good, right, same like methylene blue. ivermectin, oxytocin can do the same job, but it’s better because it increases the mucus production. The tear production is the parasympathetic, which is the anti inflammatory part of the autonomic nervous system. So can you tell me which is about a methylene blue oxytocin? Well, you know, there’s methylene blue has something extra which is the for the dynamic therapy that oxytocin does not have, but the rest oxytocin is better as an anti inflammatory and increasing the mucus secretion all that stuff, but methylene blue have an extra afforded nm therapists good teeth together, and that’s what we do. We combine them together by the way, and use an intranasal but it’s better than oxytocin better than hydroxychloroquine is better than ivermectin because it’s natural product that does the same thing that those those two drugs does, right. So it does have anti inflammatory effect as you see it here. And it does stimulate the expression of antioxidants and it did have the Lux enzyme so you can get rid from others peroxides and peroxy nitrates and and so which is the reason why we have this fader of multi organ failure of the COVID because of this mass, hyper inflammation and activation of sympathetic and inhibiting the antioxidants and stimulating the oxidants I see it here that leads to multiple failure of organs and all that we can inhibit that by using oxytocin and not just limiting and treating COVID but also preventing it because when you do the intranasal oxytocin, decrease the secretion of the makers and electric Fern, you you are trapping those viruses preventing it from attaching to the h2. So it’s a preventive. I wish we know this before. We will be we will be definitely put it as part of the protocol and maybe the first line treatment for COVID is oxytocin and then we use methylene blue and at that time, we did not have that much inflammation now we know. So any infection, any viral infection, I mean, actually any infection it’s good to be adding oxytocin as the first line treatment because of the increasing the mucus production quality and it’s anti inflammatory because it also enhance the production of immunoglobulins as well, you globin a the secretory ones. So we want to be making sure that when if you want to be protected against the flu viruses and the COVID and all that stuff, start using especially during the winter, start using oxytocin along with vitamin D and things that we know helps in preventing infection. Okay, so what’s the time now? 930 When I come to not 10 We can stop at 10. Two hours will be enough. And then we can finish up the next session maybe next time, but I don’t want to, you know, overload you with all this information. You know, I did the same thing yesterday in my session. They stopped me attend because it’s too much people they want to digest the information and then they want to apply it on their patients. And then we want to hear it from you guys. So and I like this interactive, reactive relationship between us so we can learn from each other. It’s not going to be one way. So it’s a protective effect of oxytocin through its anti inflammatory agents and grow the model of sepsis induced acute lung injury. So if I have mice to group of mice and I induce injury in the lungs of those mice by an injecting for example, bacteria like polysaccharides and both of my sister, mice, mice, mice,
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to group of mice, right. And I inject the bacteria like water saccharides in both of them. I want to induce damage. Inflammation, inflammation into the lungs. And then I inject while in one group I will inject oxytocin and other one non note citizen and then we’ll see that the mice with oxytocin. They survive longer than the one without and then I take their lungs and I dissect them and I can see that the damaging effect of the like bacteria like polysaccharide is going to be less the inflammatory process, the fibrosis, the damaging is going to be less than those lines that’s been sliced from the mice that’s been exposed to the oxytocin versus the one without oxytocin right. So this gives me an indication that I can use to manage all kinds of respiratory disease where it’s inflammatory septic fibrosis because it was system six mediate the lung fibrosis by the way, so I can use oxytocin and managing old lung diseases, ischemic lung diseases, well, because it has it’s a badger dilation effect antioxidant effect, so it will inhibit the reperfusion damaging that’s happening because of the of the of the oxygens and turning into free radicals and at least a damaging what you call very perfusion, injury effect of the of the ischemia. Especially after they opened, they open up those blood vessels of ischemia, then you would have a flow of oxygen with the blood and oxygen will turn into free radicals that cause more inflammation, more damage. It’s called the reperfusion injury that’s happening in the lung and also there happens in the heart and oxytocin will help that will prevent that so I can use it for both lung ischemia and common embolism. And possibly I can use it for angina and myocardial infarction and really can use it for any inflammatory process any discharge of any autoimmune and inflammatory process in any order any chronic disease affecting any organ we’re sticking with autoimmune inflammatory allergy naming, right? Oxytocin can be an adjuvant or it could be the main treatment and it does help to start the process of the damaging and heal. Helps and managing all this inflammatory process because of its anti inflammatory effect because of its data dilation. What does that
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what’s what’s what’s the dose and how do you administer it?
1:52:27
We have to row right now we think it’s the best way of doing it. Enter nasal which might doctor might be producing it up to 100 international units per day. So basically, you can spray twice in at night and then twice during the day. That’s the Max gives you around 100 if you pump them twice, two times in one nostril Max, but if you want to just start with just pumping it once in each nostril at night, and then you can go up to twice, two times. And that gives you up to 100 international unit. So he has the vial of contained tea towels international units. So it’s you know, for 30 days, or you can inject it well, it’s very important to have the intranasal part because you want to get the oxytocin to the brain and get that the good effect of oxytocin on the central nervous system, but also you want to get some peripheral effect more also when you’re doing weight loss. So injecting up to 10 international units around the vertical start with two. That’s another way. So, up to 10 for subcutaneous
1:53:38
let me summarize for the question here. Real quick. So what we came up with guises in the study is that the normal dosage is 12 to 24 units at a time. And so what we did is we designed it in such a way that one spray of the nasal spray delivers 12 units since that’s the amount generally discussed in the literature. So then you can multiply that out. And you know, the action of the drug is just a few hours, maybe, you know, it peaks in about one hour, and then it slowly goes down over the course of about three or four hours. So after about four hours, you know the drugs mostly worn off, but it also has a positive feedback loop. So when you stimulate the oxytocin system, it causes the body to release more oxytocin to it’s like it you know, when it sees there’s some happening it sometimes will increase it more, but 12 units in each nostril. So total 24 units in the morning, and then repeat that at bedtime. And we’ve that’s what most people have been doing and getting a good effect in so it’s a total of 48 units in a day. So it’s a very conservative dose. And you know, if you needed to go up from there, you surely could. The other aspect would be that. All right, well consider the patients if they have other problems with their nose. In other words, just what before you give it no spray so we make sure and ask them you know, do you have problems with your sinuses and nose that we might you know, cause us to think they will work well for him. But I haven’t really had much of that. So 12 to 24 units am and pm is a good starting point. You can double it from there if you wanted to and still be at 50% of the maximum dose. And then the other thing I would say is if you wanted to start conservatively, do it once at bedtime, right? Just do one spread each fastball at bedtime and then say you know do that for a week or a few days and when you know the if the patient’s doing okay then you know bump it up to using it in the morning too. But we haven’t had any problems. We also offer it with methylene blue, it makes with the oxytocin and that’s got some fans so when we talk about photodynamic therapy and other things we can do, the intranasal, oxytocin probably has around 5% of the dose gets through so that puts it in line with the injectable dosage just do so but it goes directly for from the cribriform plate into the brain structures of the olfactory nerve center and the the facial nerve of the can’t remember the name of the nerve at this point. The you know, the facial nerve, I forgot the name of it, that also shares the cribriform plate with the olfactory nerve. So those are the two methods by which the drug gets through into the brain and enters the spine or the CSF at that point. But anyway, I just wanted to clarify that that pharmaceuticals part of it because Dr. Wallace has done a lot to show what the drug can and can’t do. But you’re right. We need to temper that with a little bit of practical something. So anyway, thanks for letting me interrupt. Thank
1:56:53
you very much. Dr. Beamer. I thought the last night you know how maybe it wasn’t going through when when I put the orders through. But I thought I was putting the orders through Well, I intended the orders to be two sprays in each nostril at bedtime for the patients. And then you said I thought we said well, you know we can do twice a day so I thought it was two sprays in each nostril B ID but you’re saying it’s one spray and each nostril B ID.
1:57:24
Right and most of your prescriptions have been coming through is just at that time. That’s how Debbie’s ascending and that’s fine. So you might just want next time you speak to your patients, let them know that if they wanted if they were doing well, they can increase the 2am and pm but I will agree most of yours were ordered that way. Although I think
1:57:43
they were but I intended them to be ordered two sprays in each nostril.
1:57:47
Well, you have told him to do that. Dr. Joseph 1000 international units, so it won’t be enough
1:57:54
to say oh, there’s 3600 units in a jar in a bottle. Right. So so so
1:57:59
so so when we discussed that yesterday. So that’s sort of the idea is if we build ourselves up, we kind of want to do two sprays and each nostril twice a day. Because that’s the maximum dose Correct.
1:58:13
That’s when you want to do personalized so that the patient will you want to see your patients how they feel about it you want because we are the frontier and leading this so we are establishing those protocols. And we want to make sure that you know you don’t give them the high maximum dose and they may end up with some problems that we don’t aware about. So I start with slow and we go up you got my
1:58:36
Yeah, and that’s sensible. You know Dr. Joseph, your dosages have been 24 units typically. And if you bump them up to twice a day, then you go to 48 we’re kind of recommend
1:58:47
no my no mitosis have been two sprays in each nostril. So that’s 12 and 12 and 12 and 12. That’s 4048 units Q HS that’s what I that’s what I was ordering them as because sprays in these
1:59:04
schools. We need to talk to Debbie about that because they’re not coming through that way
1:59:08
from okay. That’s that’s what I figured was there.
1:59:13
Yeah, yeah. But I didn’t know Yeah, but we’ll talk about that. I can fix all that for you. That’s no problem. But the recommendation basically and what you did is fine, you know, to start with once a day and then go to twice a day. But yeah, you’re at 24 You could go to 48 real easy. That’s no problem. We’ve had no issues with that. You know, we have had some people doing a little bit more than that for tinnitus and some other like, you know, I guess conditions where we know the patient has a condition that in the literature there is a higher dose merited. You know, what can I just been one of them so we have a few people doing it, but really most people are am and pm and it’s doing great. The feedback has been very good. We should talk more about it. But you know, and I’d love to hear from people what their patient responses are a bit every everything I’ve heard so far is good. We had one case of tinnitus where the patient felt it made it worse, but they only did it for two days. So I don’t know really what the outcome of that was like, you know, that’s just kind of a failure treatments.
2:00:12
Dr. Shari reporting the opposite. He said I have a patient with tonight’s and they feel better. And yeah, I’ve heard more.
2:00:21
You know, so that’s a tougher condition. I’m sure there’s many many causes of tinnitus. Some of them some of you know hearing loss could be permanent from Gosh communicator depends on what what injury has been caused, you know, some
2:00:34
but the other thing is some of the things when when we look at the pathways, some of it is immediate gratification, but the other parts are the things that are consistent with regenerative medicine where you know, it takes three to six months to to regenerate anything while really six months and so, you know, things that are, you know, stimulating autophagy you know, stimulating the bone marrow, you know, things like that. I can imagine that or it was just even cardiac repair. I mean, I was just reading an article that the it’s the epicardium right in between the parry whilst it’s part of the pericardium. inside part of the pericardium is the area where the the cardiac muscle precursor progenitor stem cells, are they can they can be stimulated specially with acute cardiac injury, you know, those are regenerative processes or healing of the you know, if the if the brain has a lot of neuro inflammation or chronic pain causing structural changes within the brain, such in areas where oxytocin normally affects parts of the brain that may be involved with neuroplasticity in perception of pain. And you know, I’ll leave it at that, but those processes take time. So I can imagine that there’s there’s, there’s long term benefits that remains to be seen. And then there’s some of the immediate benefits where it does help with acute pain. We’ve seen that my mother said her sacral iliac joint pain is so bad in the morning. It gives her the dry heaves and within about a half an hour to 45 minutes after doing the oxytocin. The pain goes away. And she’s somebody who knows, you know, she’s tried all the different things and so she knows that this is very effective and so that’s what I’m saying. I think there’s more to it. We can’t draw a conclusion after two days. You know,
2:02:50
I agree with you 100%. I think it takes, you know, several months for what and if you look at the drug itself, and you know, it reminds me that the more we look at it, it’s almost like the other hormones are a nutraceutical. It does a million different jobs. And by the end of, you know, review, what is the what is the outcome of what, you know, what are the prominent clinical features, out of all these things, you know, and I think, you know, that’s something that remains to be seen, but I think we’re seeing that, just like every other hormone, you know, if you have no testosterone, you don’t die. If you don’t have any extra IO, you don’t die. And likewise, there’s no medical illness that’s specifically kind of caused by low testosterone you have the syndrome of all these various different degenerations that occur when we don’t have a hormone. So I think that’s kind of the way I look at oxytocin. It’s like another hormone. It’s not 1,000% critical that if you don’t have 100% oxytocin system function that you’re going to just die or get some disease you’re not, but you’re just going to be debilitated. So it’s just like having low estrogen just like having low testosterone. You know, there’s a multifaceted thing that we’re learning about here. And I think and I don’t know that it’s well defined as to how what it does exactly, but I bet we’re gonna find out.
2:04:09
Oh, yeah. I was wondering, have you seen patient I said, the onset of action is within 20 minutes, but the fact does not like last beyond 30 to 40 minutes. So yeah.
2:04:28
I Dr. Patel, I don’t disagree with you, you know, like I’ve looked at the pharmacokinetic charts and it does as its maximum effect in about one hour and then it precipitously drops off around
2:04:42
euphoric effect that you’re feeling that
2:04:44
Yeah, right. And then three hours the drugs mostly on your system, but but
2:04:49
the healing effect is not dropping. It’s continuing.
2:04:54
Like in fact, like I’m talking about headache. When we give the patient a headache, you you can break the headache within 20 minutes, but then if it lasts 30 For him, I told her that just use it every hour.
2:05:11
Right? I think you’re right, because up to up to a reasonable dose, so well, will 24 units alleviate the headache for an hour
2:05:22
I guess what she says she is okay. That lasts for one hour, then instead of increasing the dose just be increased the frequency.
2:05:34
Yep. I agree with you about that. And I would just let’s, I think what I would do though, is maybe a maximum every two to three hours for three play for
2:05:47
maybe 234 doses and then probably it will last a little longer. But I was just wondering that how often you see the receptor insensitivity because that that is one of my concern.
2:06:07
That’s a tough one. I just don’t know. I don’t have any. I just haven’t seen any data.
2:06:11
Oh, we’re gonna talk about my grant migraine. Maybe not this time, but maybe in the next Monday. Because of the timing thing and we still
2:06:20
I’ll tell you this, Dr. Patel, on your on your question about headaches. I met a neurologist who is a headache specialist from Birmingham, Alabama. And I’ve developed a conversation going on with her and she’s very interested in oxytocin for migraine headaches. So and she’s done some research on it. So I will I’m, I’m hoping that we will be at a forum and she will be there, and I’ll have a chance to visit with her again. But I’ve forgotten her name at the moment in my email, but this is somebody who’s very interested in his studied oxytocin for migraine headaches, so maybe they would be able to tell us I know one of her interests is in getting more bioavailability out of the nasal spray, and she suggested that there are some products out there that are like unit dose little nose sprayer, sort of like they use for the opiate reversal drug you know that the paramedics have they put it in your nose, they squirt it up your nose, but it’s like a real it’s a lot more than a nasal spray, put it that way. And she was saying maybe look at that. I don’t know. I haven’t done it yet.
2:07:30
It’s a delivery spray. It gets into the gray form plate so it gets passed to the bottom of the scope.
2:07:37
That’s an area where we could do some grooming. So that’s the level that’s that’s anyway, that’s one of
2:07:43
the other dynamic therapies another option by but we got to talk about the opposite dose and as I said, it’s increasing the dopamine and serotonin and it gives you that feeling of instant relief and happiness in thing and then and then wears down the happy molecule. Maybe that wears down but the fantasy of oxytocin it will continue because it’s changing the epigenetics and the expression of the genes and the protein machines and machinery of the proteins in your body. But it takes process as they said it’s a regenerative process. It’s it’s expression of protein and all this it takes time to be build up. So maybe yes, you know, increasing the frequency but eventually the long term effect of oxytocin will be built up from the expression of the acquisitive expression of epigenetics that would change and modify the expression of antioxidant enzymes and anti inflammatory cytokines. And as you see here, I mean it’s very good cardiovascular protective drug. If somebody has ischemia or angina, myocardial infarction, I mean it does everything it increases nitric oxide so it helps to increase the blood flow. It’s energetic as equivalent as morphine it regenerate the muscles it stimulate the stem cells of the muscles, so it fills up that gap of the necrosis. And also it has anti fibrotic. So you get rid from the scar tissue. You don’t want that. And it’s antioxidant. So it buffered the redox it’s increasing the parasympathetic, so it has anti inflammatory slows down the heart which is very important when you have mitochondrial function, angina, increased endothelial function and increased nitric oxide by availability, I mean exceeds the nitric oxide production. It does, as I said, anti inflammatory so it’s good for any lung disease, or even lung fibrosis did long term and infection, inflammation, allergy, whatever, just helps in all different aspects and managing all those inflammatory process and it’s good for fatty liver as well and it gets read from the fat it’s good for metabolic syndrome in general, whether it’s a pretension, weight, or obesity or diabetes or, and because it also does stimulate the heart to secrete nitric retic peptide. So it helps to get rid from excess of fluid and excess of salt. So it that’s good for the heart, especially when you have heart failure. But it’s just good for blood pressure as well. So it just have general cardiovascular protection and it’s a good drug for managing with Ebola syndrome in general. So again, we talked about COVID mechanism. And we know that oxytocin it can be used to prevent the infection by stimulating the secretion of the makers and electroformed luxafor And we’re gonna see that in the coming slides and how was inhibiting protease which inhibit the priming of the spike protein. And so it has an antiviral effect by doing that. In addition, if it’s anti inflammatory, it’s anti oxidant. We talked about inhibition, inhibition of the th 17 interleukin six and increase the T Rex and inhabiting inflammatory cytokines and stimulating the anti inflammatory cytokines and stimulating the T Rex. All of this helps to decrease the inflammation and restore the homeostasis and reverse the pathophysiology of the of the of the COVID. And we talked about all of this and this is just to show you how the COVID virus spike protein will interfere with renin angiotensin system how it’s increasing that activity are of the angiotensin two type one receptor signaling which leads to that inflammatory cytokines which mainly is Ts 17 M 17 ones and how this virus it’s causing inflammation. I’m reviewing inflammation, hyperimmune response and inflammation especially if he had 17 Diamonds all over the body I mean, all organs of the body which leads to multiple organ failure, including the lung at the heart and please do myocarditis, encephalitis. I agree bait any underlying chronic disease that makes that worse at this grossest more essences, is really devastating disease because of the effect of the spike protein and hijacking the renin angiotensin system and of course, when you hijack the minion angiotensin system what will happen to you, Steven overstimulate the angiotensin two types of angiotensin two type one receptor signaling that leads to activation of the sympathetic when you have over activation, sympathetic release of norepinephrine and they stimulate the box and generate free radicals and because more and more inflammation here and what oxytocin does, it doesn’t have it doesn’t pathetic directly and stimulate the parasympathetic inhibit. It blocks the or inhibit the blockage of the ACE two. So it restored the renin angiotensin system back to normal activities, especially the anti inflammatory arm and it’s suppressed the inflammatory arm by doing that, and so the angiotensin two can convert into angiotensin one seven which is diet unacceptable as the reason I will like to add the protocol of managing COVID Adding dye hexa and it will be good if Dr might be can develop the intra nasal dye hexa versus the oral by AXA, which is angiotensin one seven I think it’s under Jensen for that this is anti inflammatory versus angiotensin two. As you see it oxytocin increase the simulation of estradiol which is very important. It does stimulate the mucus production and the electro fair and associate here and the lactoferrin it’s very good because it will react with appropriate glycans and and it will be it will interact with the spike protein and prevent them from blocking the h2. In addition to that, we see oxytocin stimulates inhibit the serine protease which prevent the priming of the spike protein and reacting with a stew. We know that looks it doesn’t stimulate the thymus and stimulate the release of the thymus and possibly alpha and helps to balance the immune system and possibly inhibiting the th 17 and stimulate the polarization of the immune system into th one and cytotoxic T cells. It’s very important to kill the virus and get bread from it. In addition to that, we say that oxytocin stimulate the parasympathetic, parasympathetic, stimulate the tears and secretion of saliva and the quality of it because it will increase the lactoferrin inside of them. And this will help to neutralize those viruses and prevent the virus in addition to to managing it. And this is just again how COVID is affecting the whole system of the body and how the oxytocin it helps to reverse it, reverse it by the facility of the oxytocin. We talked about that. Oxytocin helps to it’s a cardio protective drug, it’s also respiratory protective drug, and also it’s a newer protective drug as well. And they made a study experiment where they have two group of mice. One group they injected with the same thing but like polysaccharide bacteria, other ones like what’s great about that process, right? So we injected toxins into groups of devices and then you inject oxytocin, one group and non another group. So we’ve we find out that the mice with oxytocin, they survive longer. And then when we dissect the brain of this true group of mice, as we find out when with oxytocin, they have less inflammation less micro gliosis. And so it does have anti inflammatory effect that decrease that the turning of the microglia into gliosis, and inflammation, knowing that and I can use justified using oxytocin to manage all the neuro inflammatory disease of the brain systemic, multiple sclerosis, even degenerative disease dementia, because there was part of inflammation there. We can use for Parkinson disease, we can use it for encephalitis and because all oxytocin does help in acid anti inflammatory and helps to alleviate the micro gliosis and restore them back into micro Lee. In other words, that’s at that anti inflammatory effect there in the brain. So I think it’s a good drug for I said, You’re protective for managing degenerative neurological diseases and inflammatory diseases. And you can see how that oxytocin blocks that inflammation from the start you know, the inflammation starts when the microphones you start eating those local polysaccharides and tasting it using the toll like receptors you see there, and then that will irritate inflame or
2:17:40
turn those the macrophages or microglia into which direction in case of like polysaccharides it’s coming from the bacteria. So those microglia are macrophages they become what am serving microglia and so m 17 microglia 17, which polarize the whole leaf T cells into T and 17 and interleukin six, and you see that how Chitose is inhibiting the inflammation and the turning of those microglia into BIOSIS. From the starch from the time they combined with the lipo polysaccharides as you see it here, they’re blocking the whole signaling and transformation of those macrophages interactive macrophages in this case, it’s going to be turning into muscley and 17 and microglia 17 which will secrete interleukin six, which will polarize the naive T cells. into th 17. Right? You get that stimulation for fields and neutrophilia. Okay, so So we see that oxytocin does help to increase the expression of antioxidant enzyme inhibited the oxidant enzyme the KNOX enzyme didn’t have the expression of oxidative enzymes, it stimulate the expression of anti inflammatory cytokines. It happened the polarization of the immune system into th 17 interleukin six optic with interleukin six as you see it here. And so it does, it’s a powerful anti inflammatory drug, right and also it stimulate the GABA and GABA went up its mechanism it blocks the calcium entry and so it blocks the the whole irritation inflammation goes calcium and trade Kasmin flux etc can lead to release of the free radicals from the basil particularly on and initiate the whole inflammatory process. So a GABA GABA receptor and government drug is not just suppressing the pain but also to decrease the inflammation as well. And oxytocin enhance the GABA receptor and the expression of GABA and activity activity of GABA and it didn’t have a deficit and defamatory cytokines. Especially th 17 which is interleukin six and interleukin one B and also the tumor necrosis factor alpha. So I can’t use or justify use actually goes into manage all your inflammatory disease whether it is because inflammation is part of the general regeneration or the autoimmune like multiple sclerosis or. And the other thing of the use of oxytocin, we can use it for dementia. And we can use it for dementia and we can justify it because oxytocin does inhibit the activity of acetylcholine stress, which means it increases acetylcholine bioavailability so that’s number one. So the neurologist will come to you and say, you know how looks it doesn’t work for dementia and dementia. We have less acetylcholine does it does the same thing like drug that we’re giving you and that’s it totally destroys inhibitors and say yes, it didn’t create it didn’t have it. That’s green Australia’s bioavailability so this will justify using it now the other thing dementia pathology it’s because of misfolding of the proteins, whether it’s the seller which the plagues, or or the intersect, which is the neurofibrillary and the tuber teams, and oxytocin does inhibit them. So building of those proteins into tau, the tau protein or the plagues, and even if they form those misfolded protein interests Ciloxan Silla, it helps to recycle them as well as it goes along with you add methylene blue, with Curcumin with oxytocin, I think you can get the best results of managing dementia. So oxytocin works in all different angle. It works in this anti inflammatory, balanced immune system. So it’s inhibiting with th 17 and possibly shifting the th one it’s a th two that’s what you need and increasing T regs and it’s what you need to manage dementia. And also, it didn’t have a buffer the redox and inhibit those oxidative enzyme and increased expression of antioxidants and so we can clear all those free radicals that induces apoptosis and degeneration through the process of degeneration. So you’re working on the redox. You’re working on the view and then metabolically, you are working on increasing the acetylcholine by inhibiting acetylcholine stress. So it works with the three pillars that we are using to manage chronic diseases and this is just shows you how the oxytocin inhibiting all the signaling process and the pathway that lead to the misfolding of the tau protein and beta amyloid proteins and formation of the plagues extracellular or intracellular, the neurofibrillary tangles. Okay, what’s the time now is it 10 And then we need to stop so yet another time to stop and we can finish maybe next time. Okay, so we said that we really don’t have much of studies and clinical trials of using intranasal oxytocin to manage patient with Parkinson but we have Dr. Patel here she’s using it for patient with Parkinson. I think she they are the patients experienced great results along with using dye hexa because they hexa also helps to inhibit the inflammatory process. We know that dye hexa is the angiotensin one seven right. And that will inhibit the th 17 interleukin six as well, because it’s the other arm of the NG angiotensin system is the anti inflammatory arm. And so using Daya hexa using oxytocin I think and even using some neck for those patients to neutralize all this free radicals we know that the Parkinson is because of degeneration of the dopaminergic neurons and inflammatory hosts an inflammatory process. And let’s say for example, the patient will develop manifest Parkinson if the 75% of their diplomatic neurons are inactive. And most of the time 50% of them are completely dead. And then 25% are stunned by inflammation and what’s been function is 25% and it’s not enough really to put the brake on on the muscles and so you will have this excessive movement. Parkinson’s disease was shattering because you don’t have much of brakes that the dopamine does and adjusting and toning the muscles so that motion smooth way and so yeah, the patients are having this tremor thing of the Parkinson but if we are able to reverse the sun in inflamed, understand or inflamed era that’s been stung by inflammation that 25% I think we can help you know decrease those manifestations, Parkinson disease and possibly reverse it I’m not talking about completely reversing it because you have 50% already been dead but 25% has been done. We can restore their function by giving IV glutathione but too much or by being with a Tiana is not good because if you would have too much of glutamate and glutamate will stimulate the NMDA the glutamate receptors and causing more calcium influx. And more inflammation. So it’s good for short term but using it too much is not good because of the atomic toxicity unless you adding that to it possibly it helps to recycle that excess of glutamine I think he’s so a doctor’s name is Dr. David he used IV glutathione and you can see the instant relieve of the tremoring and shivering of the patient with with Pakistan. But you cannot really do it too much because of the glutamate unless you add NAC to recycle it. But we can also use
2:25:57
you don’t see that response all the time. Right. I seen that patient monitor to time and then it’s just tracked, right? For those who are listening again and just I want them to know that
2:26:13
that’s because of the glutamate part of the glutathione and it’s not good, it’s toxic and it’s causing the inflammation more damaged because it’s similarly the NMDA receptor and cause the calcium influx and it’s causing activation of the KNOX enzyme generate free radicals and causing more inflammation. And so it gives you remember that the term that you use the bypass the biphasic one where you have the response to the opposite, you remember that term that you use,
2:26:38
right hormesis biphasic response so I
2:26:41
basic response. So that’s what’s happening to the glutathione. And the reason is because of the glutamate, it’s toxic. And so we can use other things. So we use IV glutathione. One time that’s fine, but then you use oxytocin, you use the hexa you use at GGC that because it stimulates the sex hormones. And all of this will help and in acid anti inflammatory and possibly reverse this, those stand dopaminergic neurons and gain their gain their functions and put the brake and possibly helps the tremor and all that manifestation of parkinson to be reversed and then you need to continue continue doing all of this it costs too much money, yes, to slow the progression of the degeneration of the neurons. So you need to optimize the health of the patient. Is that enough to just give them enough? No, you need to really see if you can detox the patient manage the leaky gut, manage the toxins, see the sex hormones see the vitamin D sees the vitamin B six, it’s it’s gonna be as much as you optimize the body because they have genetic problems. And you are working against the flow of the genetic errors, and it’s cost too much of money. And yes, to maintain those patients. It’s just and I think those people have this problems and anybody with chronic disease with genetic errors, they need to be having their own budget and money and funds for them for slowing the progress of this degeneration to live longer. And it’s costly. It’s like treating cancer as well. Cancer is more expensive than of course the autoimmune diseases. And so they made a test same thing and in the state of using bacteria like polysaccharide they use another toxic drug or rotting on and they that induce a dopaminergic neuron damage right so they have to group of mice and they jack those Roxy non toxic and both of them and then oxytocin, one oxytocin and none and other one other group and they slice the brain and they find that there is a neuro protective effect of oxytocin in the dopaminergic neurons, which justify us to start giving intranasal oxytocin to patient with Parkinson disease. Do we need clinical trials? Yes, we do. We need we need clinical trials. And that’s why you are here to help me to put together those clinical trials even case not necessarily clinical trials, the formal ones, just click case reports. It’s good enough to justify and using circles because this person has been past FDA their safety there we are pre purchasing. Do I need to spend a lot of money and putting clinical trials to prove it? No, because it’s not a new drug out of the blue. It’s something we are repurposing it and we just have hundreds of cases showing it’s effective then yes it justify us to repurposing it and doing it it’s legal and you can do it. I said Doctor repurposing drug it’s it’s legal for you to do it and if you see the benefit of it, do it please. So obviously those does modulate the microglia and help them micro gliosis. Again, it promote the GABA and GABA is not just inhabiting the pain signaling and hyperpolarizing the near wells, but also it has an anti inflammatory effect. Because if you have an O some GABA receptors and have the calcium channels and we know that influx of calcium can generate the free radicals are and released from the particular one and the mitochondria and use inflammation and use microblade uses right that’s how the glutamate receptors work right? So it’s opposing that. And so it has very strong neuro protective effect. I think are we done for today? I think we are 10pm. Now, we can finish the whole slides, which is another 50 slides already finished. 50 Maybe? Yeah,
2:30:34
we’re getting there. We’re we’re it is now 10 o’clock but it’s up to you guys what you want to drive Decker clear fields meeting we just got it’s
2:30:44
a seven o’clock our time on the Pacific so it’s not too bad for us if you wanted to stay longer.
2:30:51
Well, I don’t want to be overloading you with all this information and get bored and then people leaving we have 16 people that begin to make sure
2:31:05
Yep, we’ve got
2:31:08
can oxytocin be used for brain injuries
2:31:12
and what is the best way
2:31:14
and then the other slides we can use it for traumatic brain injury and I have slides for that because of its anti inflammatory antioxidants and stimulate the GABA it didn’t have it. The susceptive pathway because oxytocin is part of the descending energetic pathway and it definitely has those this pain. This is circle and the pain neuroplasticity of the amygdala. And at the spinal cord level, those vicious circle of pain signaling that’s connected to the sympathetic and that led to all this post traumatic syndrome and all this brain traumatic brain injury mechanism. Yes, I think it’s a good thing for for both and for complex regional pain syndrome and all of that it’s in the coming slides. So when we maybe come next time, we’re going to talk about how it’s working and traumatic brain injury and post traumatic syndrome and complex pain syndrome as well. Okay, and drug addiction as well. Right, right.
2:32:25
What is the best way to measure oxytocin?
2:32:29
Did you hear that doctor? She said 24 hours of unity collection to measure the oxytocin. They’re treating it like cortisone. Right? I think that the best perfect way there is some saliva testing of oxytocin. Is that reliable, not as reliable as 25 for our collection of the urine, and I think using chromatography you can detect small quantities of oxytocin, it’s same we can treat it the same way that we use in treating the drug abuse and all this narcotics in the urine. We I think it’s the best way but it has to be 24 hours collection because of the production of oxytocin our bodies up and down. And if you go into give extra genius oxytocin exogenous oxytocin, I think the 24 hour urine collection will be the optimal way of measuring it.
2:33:29
And another question is, Can oxytocin be used for low IgM level?
2:33:35
Four, it does enhance the immune system in general, including IgM IgG IgA, it does increase the bone marrow release. So it enhance the increase the white blood cells count and it I think it’s stimulate the lymph the thymus disagreed all this info points are timeless since peptides so yes, I think it’s it’s, it’s, it’s an immune enhancer against the pathogens, but it gives you that tolerance as well against your own self antigen by stimulating the PDL one and T Rex. So yes, the answer is yes.
2:34:19
IgM would not increase it.
2:34:23
If it’s illogical I’m talking about physiological level not the
2:34:28
measure in the serum.
2:34:33
Right. So we need IgM to protect us against the bacteria bacteria infection, right. And that’s what I’m talking about. I’m not talking about any excessive pathological level and general enhance this is what the Nordic enhance the immune system in general, but at the physiological level, not the pathological not excessive, unbalanced immune enhancement.
2:34:57
Okay. Okay. And then doc wanted me to announce that next week is Dr. David Lefkowitz, O N m, and addiction. And then he also wanted to wish everyone a happy Thanksgiving.
2:35:13
Okay, great, beautiful.
2:35:14
Thank you. This morning already, I am patient advocate. I’m also a member of a Parkinson’s support group and not as a patient but as a caregiver. And I don’t know quite how I feel so bad because I don’t know how to talk to the people in the group that most of them are old, decrepit and suffering and they’re there. They’ve been sold, you know, so much the medicines and oh, what’s the new medicine coming down the pipe and it’s all really toxic, awful stuff. And I feel so bad for these people. So how can we get this information? To the to them without making them feel like I’m a medicine man selling, you know, weird stuff?
2:36:09
I don’t know if they can is that do you think our sitting here that the patients can benefit because we’re using a lot of medical terminology right? So I can
2:36:18
get him to do it. I I’m thinking that the one who’s leading the group now has is a patient and she’s in really bad shape because she has many medical problems besides the but she has a super brain. And if I could get her to watch the video, you know, watch this. I think she might be more open. But I thought maybe there was some way to condense some information into something I could hand out or or just to introduce him to the concept
2:36:52
for what works sometimes in those cases, ma’am is a test patient or to a patient advocate or to you know, someone who’s been able to try it and can can speak to what it did for them. Sometimes that can can help that situation and group
2:37:10
have somebody who would be willing to speak to them to do you know, I
2:37:14
Well, this is the mechanism how it works right? You get the doctors here they get interested and excited and then those doctors they will reach out to Dr. Mike beamer because he’s the pharmacist who has the hub and data and material he has also material, all that stuff. And then he will give all this material to that doctor to our patients will be connected to the Dr. Mike Beamer and Dr. Mike beamer has that good public breaking down information for the patients and he has time for that because that’s his job right? He’s the one who’s giving the medications and telling them with instructions on based on what the doctor is recommending. But he can add more to it based on the pharmaceutical and pharma dynamic and all that good stuff so he can add the material for those patients. And his relationship with his patients are great. So if you can connect Mike beamer to do all this material along with the patient advocate. It’s a triangle of relationship between a patient doctor and possibly, you know, advocate like yourself to move things in a good way
2:38:23
and this is also a suggestion Maria, since it’s part of my come in part of my profession too. Usually there’s a on duty nurse or someone that you can connect with that understands a little bit of this stuff and is more on our side and I think that’d be a great way to say ease this into Beamer.
2:38:49
Yeah, absolutely. I’m willing to help however I can.
2:38:52
We are open for patients to come here and listen, all that stuff. No problem for that. I don’t know if this information is too heavy for them. And they get a little bit frustrated because of the oldest, too much of medical terminology and maybe they need somebody to break it down. But I don’t know if this time did I break it down to make it easy. I use a lot of medical terminology for the same time and trying to relate to the to the public or to just a general understanding.
2:39:23
If you want more Parkinson’s to participate, I think if you had the first part where you explain, you know all about oxytocin and how it works and how many things it does besides just what you might be aiming for. And then combine the just Parkinson’s if we had one small, you know, condensed lecture like that it would be easier to get them started. Yeah.
2:39:54
He is very good. He speaks that native language of English that I don’t speak, and he can, you know, with his southern accent and all that stuff you need. You need all those kind of, you know, language skills and communication and using whatever the American culture are using to simplify things and make things easy for them. Which I like that because I grew up outside, overseas and also here, born here. I stayed, but you know, I don’t feel myself I’m relating to the public. Like my femur goes
2:40:28
you know, I have a quick comment. I know it’s late. But um, look, I understand your situation that you Dr. Melissa. I see the name. Maria. You know, this is something you know, especially when I first got into anti aging medicine. You know, I wanted to go tell everybody you know if I could just get them to see it.
2:40:50
You know, big mouth shut sometimes because I’m afraid I’ll scare.
2:40:54
Well, well, yeah, I mean, that’s what I did. I mean, then I found out. I had you know, after I had all of these tools to help people that you know, most people either didn’t believe me. You know, there’s so much, you know, so many levels of development that, you know, we’ve gone through most of us recovering regular doctors to get to this point. And, you know, and then with with the FDA, you know the rules and regulations you cannot advertise if you if you create pamphlets, and it’s a paper trail, you know, so eventually I got to the point where the only way it worked is that people eventually seek sought me and and I, I I basically retired myself from trying to convince people you know, it’s it’s unfortunate that this is the way it is that you know, people are misinformed. And you know, and the truth it reveals itself through the literature for people like us that translate. But the you know, you know, just like we were indoctrinated in a certain way of understanding things. The popular the general population is indoctrinated and they have to be at the point. Yeah, unfortunately, where they have opened up their mind to the, to the point where they’re looking for other solutions. And we can’t go around convincing people that that’s just, you know, this
2:42:32
is complete, right? Yeah, exactly.
2:42:34
So I I understand your pain. That’s what I’m trying to say.
2:42:39
It’s yeah, it’s very frustrating. And it’s it’s so frustrating to hear these things and know that so many people can be helped, but we’re just our hands are tied because because of what just what you said so where we are, but I think I will maybe try to get the one I was telling you about to watch this. And even our discussion at the end here that we’re doing right now could help her see and our viewpoint and the fact that we just want to help and maybe she would be more open to figuring out how we can do that.
2:43:16
Well, another thing to think about is that it’s not really a pharmaceutical drug. It’s a bodily hormone. And, and we’re not giving a drug we’re giving a natural bodily hormone to replete a potential deficiency or malfunction of this, the systems that it operates within. So you know, it’s just like maybe saying to somebody, you know, get your thyroid supplement or get, you know, your testosterone or sex hormones. Balanced, you know, it’s more in that world than it is like a pharmaceutical intervention. And it is an FDA approved drug and it’s also bodily hormones. So it’s quite safe in that regard. So, you know, there are some positives that would translate to the public more easily than maybe some other things.
2:44:07
So it’s a love hormone. It’s the power of love you tell them you’re gonna be healed by power.
2:44:13
Away, they’ll then they’ll then they’ll, they’ll for sure think you’re Solid Snake.
2:44:18
But what’s that? That’s reality. I mean, basically, I hear a lot of events that people they go to the church and they they heal or went through to the mosque or went to the big you can park the lands and they heal and part of it it could be because of the excitement and the oxytocin kicks up and give them that euphoria and that the serotonin and dopamine in those happy molecules and endorphins, even as I said before the mushroom and ecstasy if you go and you look at the mechanism, it’s mediated by oxytocin. Oxytocin goes up. And so this social gathering the way that we feel about it, and we feel happy, and that’s why we attend to the social gathering. It makes us excited and happy. At the same time, it gives that that that healing part, that healing function as well because oxytocin is anti inflammatory, and antioxidant and it does have anti cancer. We’re going to talk about in the coming slides as well. So we need to really give some credibility for all those stories about people are going to the church and they feel better or they hear the voice of the Scriptures and they read the Bible and they feel great. And we’ve talked about reading in first slides, especially the information that that gives you hope that entertain you that excites you, that takes the depression out. It definitely increased oxytocin, and it’s not a placebo and if more because before, even in a pharmaceutical setting, we divide the people with placebo versus giving treatment. But we need to consider that that part of oxytocin and the placebo as well. Because if you tell the patient Hey, this drug is going to help you because even if you give them normal saline and you tell them it’s there’s medical medicine, and it is going to help and all that stuff, just because of the expectation that’s going to help it may increase oxytocin, and it does give you physical treatment. So those are things that we need to consider it when we’re doing clinical trials. And it’s something we need to think about why people are in love and people are having good relationship with their spouse and having sex and all that stuff. They look younger, they look healthier, their blood pressure drops, their insulin is good, their sugar is good. Why versus the PEEP bars person who has been divorced and having bad relationship lonely, they get sick and they age fast and they look good, you know, like the dermatologist. I mean, she spoke in the video there. And that explanation is there is that oxytocin is high in those patients who are happy and excited and satisfied versus the people who are lonely and with no love with no passion with no massage with no sex with no skin stroking, and all that stuff. So this kind of things we need to consider a serious thing. It’s not anymore, but I see what I need. I know Dr. Fauci and the mainstream medicine may consider this as a snake oil, but it’s not snake oil anymore. Because now we have chemistry and that chemistry mechanism faction will make those mainstream men on the board
2:47:29
best. It makes sense. Excellent. Yes. Hey, I put my number in my email and my phone number in the chat for you if you need it. Yeah, I’m gonna have to split guys. It’s getting late for me where I’m at. But thank you for everything and I’ll catch y’all next time.
2:47:48
Thank you, everybody, and good night and thank you, everybody have a happy face. When we have time. I mean, when we schedule another one, we can finish all the slides.
2:47:57
Sounds like a plan. Thank you very much for the presentation. Bye, everybody.
2:48:02
Happy Thanksgiving. Bye.
2:48:07
Now I gotta end this. Hey, bud.
2:48:13
Raw, great class. Great class. Happy Thanksgiving. You know? We already lose Maria. Oh, good. Good luck. Good luck with what you’re doing.
2:48:29
I will need it. We have our Christmas meeting on the first so I’m nice. I’ll talk to Mike Beamer. Yeah, yeah, like being able to talk to him and see what he suggests and go from there. No, I think it’s silent.
2:48:48
It’s kind of interesting
2:48:51
yeah, I I introduced some of the charcoal thing last time to her and she seemed open but but you know, it’s, it’s really hard when you’re fighting so many aspects of your health to let anything else come into your brain. As you’re already so stressed, she’s really stressed and she’s heading the whole group now because we’ve lost so many people to COVID and what have you.
2:49:25
Anyway, we keep trying, saying a prayer for
2:49:30
sure. Thank you. Yeah, all the prayers we can get.
2:49:35
Man and it’s only gonna get worse. I hate to say that.
2:49:38
No, it is because, you know, the stress of, you know, the stress of turning on the TV and listening to anything is good too.
2:49:50
One TV, I don’t even own one.
2:49:55
But I could Yeah, you can either. Listen to it and weep or you can listen to it and learn and try to think of ways to me ameliorate the pain and suffering.
2:50:13
And I didn’t ask you, John. Doc usually finishes off the is there anything you have to say? But it’s interesting. I have you and Marie on this talk. At the same time, Marie and I work together several times a week and we do it in depth. We do this taco Tuesday with you dudes on Tuesday. Maria and I have a separate meeting we put together every Saturday at 1pm we review these topics and ask the same question every week. What good what good can we do? It’s interesting and the reason I’m talking to because we have you both on. We also still have a television studio here. And Marie’s involved with that she’s been helping me clean that up. Plus she has a healing center where she does her thing. So she’s very, very much involved and extremely dedicated for at least 40 years I know of. And so anyway, if we’re trying to distribute information and help this group we do have a television studio we’re putting together and we’ve had that working before I just gotta clean it out and turn it on. But that might be an option that we can all work on later the spread the information to spread the word and do some good. We just have to be discreet because neither everybody wants to hear what we have to say. Amen to that. I’d love an invite to that meeting. Lovely to be part of that. Well, I sent an email to Murray today and I said we got to speak to Joe. We got to get this
2:51:49
out for a month or so.
2:51:53
We’re thanking Joe and Bill and everybody else we’re trying to do some good and everyone’s appreciated
2:51:59
you know kind of a local meeting but we it would be good to have a kind of a video thing going unless you want to come out here.
2:52:07
I like road trips. Yeah, I could. Let’s be honest with this, I think there are a couple of people in need a break. Phil, you’ve been with us for years and years. If we can work it out. So you come out here and check out our scene. And we also have a VA Center and we have a pretty good reputation around here ourselves and a couple of other nice guys. We can get your ass out here. Right? See what we’re doing. I think we should work toward that. Agree I would I would love it. You know that sounds like a plan. Yeah, buddy else. Anybody else have anything to add or say
2:52:43
nope. Cool. All right. Thanks again.
2:52:51
Toby. I just wanted to say Happy Thanksgiving to you. I was hoping you’d speak up. Yay. Thanksgiving. Thank you. You too.
2:53:00
Okay. Good Vibes every time she speaks.
2:53:04
I know right. That’s how we should end our resume.
2:53:10
Yeah. Have fun with the turkey or your You betcha. All right, guys. Okay, bye. Have a wonderful
2:53:23
Thanksgiving. Thank you. Bye.